On September 4, 2019 SCYNEXIS, Inc. (NASDAQ:SCYX), a biotechnology company delivering innovative therapies for difficult-to-treat and often life-threatening infections, reported that the Company will present in the following investor conferences (Press release, Scynexis, SEP 4, 2019, View Source [SID1234539269]):

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The H.C. Wainwright Global Investment Conference at the Lotte New York Palace Hotel in New York City on Monday, September 9, 2019 at 2:10 p.m. ET.
The Ladenburg Thalmann Healthcare Conference at the Sofitel New York in New York City on Tuesday, September 24, 2019 at 1:30 p.m. ET.
Live webcasts of the presentations will be available on the Investors section of the Company’s website: www.scynexis.com. Replays of the presentations will be available approximately two hours after each event and will be available for two weeks following each presentation.

On September 4, 2019 Nordic Nanovector ASA (OSE: NANO) reported that its CEO, Eduardo Bravo, will participate and present at the following upcoming investor conferences during September (Press release, Nordic Nanovector, SEP 4, 2019, View Source [SID1234539285]):

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Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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Citi 14th Annual Biotech Conference in Boston on 4-5 September
BioCentury 26th Annual NewsMakers in the Biotech Industry 2019 in New York on 6 September
HC Wainwright & Co. 21st Global Investment Conference in New York on 9-10 September
The company presentation will be available on the 5 September on the investors and media page.

For further information, please contact:

IR enquiries
Malene Brondberg, VP Investor Relations and Corporate Communications
Cell: +44-7561-431-762
Email: [email protected]

Media Enquiries
Mark Swallow/David Dible (Citigate Dewe Rogerson)
Tel: +44-207-638-9571
Email: [email protected]

On September 4, 2019 Eli Lilly and Company (NYSE: LLY) reported that it will attend the Morgan Stanley Global Healthcare Conference on Wednesday, September 11, 2019. Daniel Skovronsky, M.D., Ph.D., Lilly’s Chief Scientific Officer and President of Lilly Research Laboratories, will participate in a fireside chat at 1:00 p.m., Eastern Time (Press release, Eli Lilly, SEP 4, 2019, View Source [SID1234539303]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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A live audio webcast will be available on the "Webcasts & Presentations" section of Lilly’s Investor website at View Source A replay of the presentation will be available on this same website for approximately 90 days.

On September 4, 2019 Idera Pharmaceuticals, Inc. (NASDAQ: IDRA) reported that they have entered into an immuno-oncology clinical research collaboration with AbbVie, a global, research-based biopharmaceutical company (Press release, Idera Pharmaceuticals, SEP 4, 2019, View Source [SID1234539270]). The purpose of the collaboration is to conduct a clinical study evaluating whether combinations of an OX40 agonist (ABBV-368), a TLR-9 agonist (tilsotolimod), chemotherapy (nab-paclitaxel) and/or an anti-programmed cell death 1 (PD-1) antagonist (ABBV-181) stimulate the immune system resulting in anti-tumor responses.

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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This Phase 1b, multi-center, open-label study is designed to determine the safety, tolerability, pharmacokinetics and preliminary efficacy of combinations of ABBV-368 plus tilsotolimod in subjects with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC).

The study will test three separate treatment arms:

ABBV-368 plus tilsotolimod;
ABBV-368 plus tilsotolimod and nab-paclitaxel; and
ABBV-368 plus tilsotolimod, nab-paclitaxel and ABBV-181.
Under the terms of the agreement, Idera will provide clinical trial supply of tilsotolimod to AbbVie and AbbVie will be responsible for conduct of the study.

"We are excited to be entering into this additional clinical collaboration, which continues to advance our strategy of exploring the possibilities to further improve patient outcomes harnessing the immune system against difficult to treat cancers, which historically have not generated significant objective response rates through checkpoint inhibition alone," stated Elizabeth A. Tarka, M.D., F.A.C.C., Idera’s Chief Medical Officer. "We look forward to working together with AbbVie to advance our understanding of the combination effect of ABBV-368 and tilsotolimod for these patients."

On September 4, 2019 Sysmex Inostics’ novel SafeSEQ next-generation sequencing cell-free DNA technology, investigators from the Biomedical Research Institute of Malaga [(IBIMA)-CIMES-UMA, Malaga Spain] and collaborators reported have published the first pilot study to examine the use of a non-invasive liquid biopsy in early diagnosis of breast cancer (Press release, Sysmex Inostics, SEP 4, 2019, View Source [SID1234539286]). This study was unique in that the ctDNA analyses was performed before any invasive diagnostic procedure or treatment.

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The SafeSEQ liquid biopsy technology has shown sensitivity down to five mutant molecules in a background of ten thousand normal ones (or 0.05% mutant allele frequency also known as MAF). Utilizing the genes TP53 and PIK3CA, which are commonly mutated in breast cancer, investigators compared the results of traditional standard-of-care tissue biopsy with those of liquid biopsy to determine the degree to which a highly sensitive assay might complement clinical assessment of disease. Of the 13 mutations detected in 10 of the primary breast cancer patients (out of a total of 29 samples) 8 mutations had a variant allele frequency less than 0.39%.

Comparing tissue to liquid biopsy, eight patients had detectable mutations in ctDNA with concordant results between tissue and plasma. Liquid biopsy testing with SafeSEQ detected an additional three patients with ctDNA mutations that were not present in the tissue. The breast cancer samples with detected ctDNA biomarkers were significantly associated with a lower patient age, a higher tumor size, and higher imaging score (indicating higher likelihood of neoplastic disease).

"We have shown in this study how important a sensitive technology is for early detection of breast cancer, as trace amounts of circulating tumor DNA may be lost by the detection method leading to false-negative results", said Dr. Emilio Alba, senior author of the Biomedical Research Institute of Malaga. "Studies of this kind have not been attempted before due to limitations of the technology, and it is great to see Sysmex Inostics leading the path forward for early detection."

The publication "Detection of TP53 and PIK3CA mutations in circulating tumor DNA using Next-Generation Sequencing in the screening process for early breast cancer diagnosis", was published online in the Journal of Clinical Medicine in August of 2019. View Source