Unum Therapeutics to Present at Upcoming September Investor Conferences

On August 26, 2019 Unum Therapeutics Inc. (NASDAQ: UMRX), a clinical-stage biopharmaceutical company focused on developing curative cell therapies for cancer, reported that Charles Wilson, Ph.D., President and Chief Executive Officer, will present at two upcoming investor conferences in September (Press release, Unum Therapeutics, AUG 26, 2019, View Source [SID1234538998]):

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Morgan Stanley 17th Annual Global Healthcare Conference. Fireside chat on Monday, September 9, 2019 at 11:40 a.m. ET in New York City.

H.C. Wainwright 21st Annual Healthcare Conference. Presentation on Tuesday, September 10, 2019 at 10:25 a.m. ET in New York City.

The presentations will be webcast live, available for replay on the "Events" section of Unum’s investor relations webpage (investors.unumrx.com/events), and archived for approximately 90 days.

Anixa Biosciences to Present at Two Upcoming Investor Conferences

On August 26, 2019 Anixa Biosciences, Inc. (NASDAQ: ANIX), a biotechnology company focused on harnessing the body’s immune system to fight cancer, reported its participation at two upcoming investor conferences in New York City (Press release, Anixa Biosciences, AUG 26, 2019, View Source [SID1234538981]).

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Management will provide an overview of the company’s business during live presentations and will be available to participate in one-on-one meetings with investors who are registered to attend the conferences.

Details of Anixa’s presentations are as follows:

Event:

Rodman & Renshaw’s 21st Annual Global Investment Conference

Date:

Monday, September 9, 2019

Time:

2:35 p.m. EDT

Location:

Holmes I (4th Floor)

Lotte New York Palace Hotel, New York, NY

Event:

Janney Healthcare Conference

Date:

Tuesday, September 10, 2019

Time:

11:50 a.m. EDT

Location:

Bates Room

The Union League Club, New York, NY

The Rodman & Renshaw conference presentation will be webcast live and remain available for 90 days following the presentation. To access the webcast, please visit the investors section of Anixa’s website at View Source

Entry into a Material Definitive Agreement

On August 26, 2019 (the "Effective Date"), Alpine Immune Sciences, Inc. (the "Company") and its wholly-owned subsidiary, AIS Operating Co., Inc. ("AIS" and together with the Company, the "Borrowers"), reported that it has entered into an Amended and Restated Loan and Security Agreement (the "Loan Agreement") with Silicon Valley Bank (the "Bank"), pursuant to which the Bank agreed to extend term loans to the Company with an aggregate principal amount of up to $15.0 million (the "Term Loans") (Filing, 8-K, Alpine Immune Sciences, AUG 26, 2019, View Source [SID1234551115]). The Company intends to use the proceeds to replace and refinance AIS’ existing loan facility pursuant to the Loan and Security Agreement by and between AIS and the Bank dated as of December 16, 2016 (the "Original Agreement"), as well as for potential working capital and other general corporate purposes, including the advancement of the Company’s development programs.

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Borrowings under the Loan Agreement will consist of up to three separate tranches. The initial tranche of $5.0 million was funded on August 26, 2019, $3.0 million of which will be used to repay amounts owing under the Original Agreement. The second tranche of up to $5.0 million is available in multiple advances at the Borrowers’ option at any time through April 30, 2020. The third and final tranche of up to $5.0 million is available in multiple advances at the Borrowers’ option at any time from the date on which Bank receives and approves evidence that the Borrowers have initiated a Phase 2a trial of ALPN-101 in psoriatic arthritis through July 31, 2020. Each term loan advance, other than the final term loan advance, must be in an amount of not less than $0.5 million and, after repayment, no term loan advance may be re-borrowed.

The Term Loans shall accrue interest at a floating per annum rate of 0.25% above the prime rate, subject to a floor of 5.75%, which interest is payable monthly commencing in September 2019. Upon the occurrence and during the continuance of an event of default, a default interest rate will apply that is 4.0% above the otherwise applicable interest rate. The Term Loans are interest only until September 30, 2020, after which the Term Loans will be payable in 34 equal monthly installments of principal plus interest, with the final installment due and payable on July 1, 2023. If Borrowers receive aggregate net new capital of at least $40 million on or prior to June 30, 2020, the Term Loans will be interest-only until June 30, 2021, after which the Term Loans will be payable in 25 equal monthly installments of principal plus interest, with the final installment due and payable on July 1, 2023.
The Borrowers may prepay all, but not less than all, of the Term Loans subject to a prepayment fee equal to $75,000, which represents the deferred portion of the final payment due under the Original Agreement, plus the outstanding principal balance under the Term Loans at the time of such prepayment multiplied by (i) 2.0%, if the prepayment occurs on or prior to the first anniversary of the Effective Date, (ii) 1.0%, if the prepayment occurs after the first anniversary of the Effective Date, but on or prior to the second anniversary of the Effective Date or (iii) 0%, if the prepayment occurs after the second anniversary of the Effective Date, but prior to the maturity date for the Term Loan. A fee in the amount of 5.5% of the Term Loans funded is payable to the Bank on the date on which the Term Loans are prepaid, paid or become due and payable in full.
The Loan Agreement contains customary representations and warranties, events of default (including an event of default upon a material adverse change of the Borrowers) and affirmative and negative covenants, including, among others, covenants that limit or restrict the Borrowers’ ability to, among other things, incur additional indebtedness, grant liens, merge or consolidate, make acquisitions, pay dividends or other distributions or repurchase equity, make investments, dispose of assets, engage in any new line of business, and enter into certain transactions with affiliates, in each case subject to certain exceptions. As security for its obligations under the Loan Agreement, the Borrowers granted the Bank a first priority security interest on substantially all of Borrowers’ assets, except intellectual property, and subject to certain other exceptions.
The foregoing description of the Loan Agreement is not complete and is qualified in its entirety by reference to the full text of the Loan Agreement, a copy of which is filed as Exhibit 10.1 to this Current Report on Form 8-K and is incorporated by reference herein.

Entry into a Material Definitive Agreement.

On August 22, 2019, Applied DNA Sciences, Inc. (the "Company"), reported that it has entered into subscription agreements (the "Subscription Agreement") for a private placement (the "Private Placement") of its Common Stock, par value $.001 per share (the "Common Stock"), with a group of accredited investors, including the Company’s chief executive officer, president and chairman of the board of directors and the chief information officer (the "Investors") (Filing, 8-K, Applied DNA Sciences, AUG 26, 2019, View Source [SID1234539005]). The Private Placement closed with respect to each investor on August 22, 2019. As a result of the Private Placement, the Company expects to issue and sell 1,548,151 shares of Common Stock at a price of $0.27 per share (the "Purchase Price") for total expected gross proceeds of $418,000. The Purchase Price represents the greater of (i) the lower of (x) the closing price per share of Common Stock (as reflected on Nasdaq.com) on August 21, 2019 or (y) the average closing price per share of Common Stock (as reflected on Nasdaq.com) for the five trading days immediately preceding August 22, 2019 and (ii) the consolidated closing bid price per share of Common Stock on August 21, 2019.

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The issuance of the Common Stock will be exempt from the registration requirements of the Securities Act of 1933, as amended (the "Securities Act") pursuant to Section 4(a)(2) of the Securities Act and Regulation D promulgated thereunder and such Common Stock will therefore be restricted. Each investor gave representations that he, she or it was an "accredited investor" (as defined under Rule 501 of Regulation D) and that he, she or it is purchasing such securities without a present view toward a distribution of the securities. In addition, there was no general solicitation conducted in connection with the offer and sale of the securities.

The foregoing description of the Subscription Agreement does not purport to be complete and is subject to, and qualified in its entirety by, the full text of the form of Subscription Agreement, which is attached hereto as Exhibit 10.1, and incorporated herein by reference in its entirety.

Ivy Brain Tumor Center and Salarius Pharmaceuticals Launch Collaborative Partnership to Develop New Cancer Treatment for Glioblastoma

On August 26, 2019 The Ivy Brain Tumor Center at the Barrow Neurological Institute and Salarius Pharmaceuticals, Inc. (Nasdaq: SLRX), reported a collaborative partnership to test Salarius’ therapeutic candidate, Seclidemstat, for the treatment of glioblastoma (Press release, The Ivy Brain Tumor Center, AUG 26, 2019, View Source [SID1234538970]). The organizations will launch what they believe is the most comprehensive pre-clinical study to date, evaluating the effect of targeting LSD1 (lysine-specific histone demethylase 1A), a key enzyme that has increased expression in tumors of brain cancer patients.

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Seclidemstat is a reversible LSD1 inhibitor that works by inhibiting LSD1’s enzymatic and protein-scaffolding functions. It is currently being tested by Salarius in a Phase 1 study for refractory or relapsed Ewing’s sarcoma and a Phase 1 study for Advanced Solid Tumors. Seclidemstat is among the most clinically advanced reversible LSD1 inhibitors in development, and its potential effect on glioblastoma represents a promising new therapeutic treatment option.

"Seclidemstat is highly differentiated LSD1 inhibitor with unique properties that may enable efficacy in a broader range of cancer types. Seclidemstat and/or its analogs have shown the potential for synergies with chemotherapies and other targeted agents. This gives us hope that Seclidemstat may be effective in treating a number of aggressive cancers, including glioblastoma," said Dr. Nader Sanai, director of the Ivy Brain Tumor Center. "Our shared goal with Salarius is to address the lag in new drug development for malignant brain tumors by accelerating early-phase clinical trials for first-in-class agents like Seclidemstat."

The Ivy Brain Tumor Center’s advanced pre-clinical capabilities include well-characterized patient-derived xenograft animal models and state-of-the-art pharmacokinetics and pharmacodynamics core facilities. A key component to this latest endeavor will be to leverage the Ivy Center’s core capabilities in collaboration with Salarius to perform in-house survival studies, advanced animal imaging, toxicology assessment, and in vivo pharmaco-metabolic analyses.

Should the pre-clinical phase provide sufficient evidence for positive drug effects, the program will move to the subsequent clinical evaluation of Seclidemstat. This will take place within the context of a Phase 0 clinical trial, in which researchers will quickly learn if the new regimen is having the desired impact on a patient’s individual tumor.

"Salarius is well positioned and highly-motivated to provide a new therapeutic option for a number of cancers with high unmet medical need," said David Arthur, President and Chief Executive Officer of Salarius Pharmaceuticals. "We are inspired by the Ivy Brain Tumor Center’s unwavering commitment to pursuing advances in glioblastoma treatment and look forward to this creative and vital research partnership."

For more information about the Ivy Brain Tumor Center and the drug development partnership, please visit, www.ivybraintumorcenter.org.