Systems Oncology Receives Investment from The Pritzker Organization

On October 22, 2019 Systems Oncology, LLC ("SO") and The Pritzker Organization, LLC ("TPO") reported that Pritzker Family Business Interests advised by TPO have invested in the first closing of SO’s Series B round (Press release, Systems Oncology, OCT 22, 2019, View Source [SID1234542419]). The funding will be used to invest in both discovery research and pre-clinical development to evolve SO’s rapidly expanding pipeline of innovative cancer therapeutics.

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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Systems Oncology leverages big data and AI to discover novel scientific insights into cancer biology. These therapeutic insights are then applied to build therapeutic programs. Specifically, SO’s ExpansiveAI discovery engine allows scientists to integrate and translate big data from hundreds of scientific sources into intelligently linked scientific knowledge, making it possible to uncover truly unique therapeutic opportunities. This cognitive computing platform integrates and connects multiple different kinds of data into multidimensional models, which in turn allows for unprecedented scale and efficiency in applying machine learning to mine trillions of biomedical relationships. This engine enables SO to explore a massive universe of therapeutic opportunities many orders of magnitude more expansive than the human mind can imagine.

"We are honored by the investment from The Pritzker Organization and look forward to them joining us with a seat on our Board of Directors," said Dr. Spyro Mousses, CEO of Systems Oncology. "TPO’s investment is a prestigious recognition for the potential SO has to transform drug discovery and development with AI. They bring a wealth of experience investing in and growing companies and will help us continue to grow for years to come and fulfill our commitment to bring forward breakthrough oncology therapeutics for unmet patient needs."

"We are very excited about the potential for Systems Oncology’s combination of leading-edge AI and outstanding clinical expertise to produce novel cancer therapies," said Joseph Gleberman, TPO Managing Director.

Intensity Therapeutics’ Intratumoral INT230-6 Tumor Regression and Immune Response Activity Data Selected for Oral Presentation at SITC 2019 Conference

On October 22, 2019 Intensity Therapeutics, Inc., a clinical-stage biotechnology company developing proprietary intratumoral immunotherapy products to kill tumors and increase immune system recognition of solid cancers, reported that data from the ongoing clinical trial of its lead product candidate INT230-6 was selected for a podium presentation at the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper)’s (SITC) (Free SITC Whitepaper) 34th Annual Meeting, taking place November 6-10, 2019, in National Harbor, MD (Press release, Intensity Therapeutics, OCT 22, 2019, View Source [SID1234542404]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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Details of the oral presentation are as follows:

Title: Intratumoral INT230-6 injection into solid tumors kills tumors and induces immune cell infiltration leading to abscopal responses and prolonged disease control in multiple refractory cancer types

Abstract Number: O31

Date/Time: Saturday, November 9, 2019, 3:45-4:00 p.m. ET

Session: Concurrent Session 309: Single Agent Phase 1 Clinical Trials

Location: Prince George’s Exhibition Hall C

Presenter: Jacob Thomas, MD, Assistant Professor of Clinical Medicine, University of Southern California

To view the schedule for SITC (Free SITC Whitepaper) 2019, please visit: View Source

About INT230-6

INT230-6, Intensity’s lead product candidate designed for direct intratumoral injection, is comprised of two proven, potent anti-cancer agents and a penetration enhancer molecule that helps disperse the drugs throughout tumors and diffuse into cancer cells. INT230-6 is being evaluated in a Phase 1/2 clinical study (NCT03058289) in patients with various advanced solid tumors. In preclinical studies, INT230-6 eradicated tumors by a combination of direct tumor kill and recruitment of dendritic cells to the tumor micro-environment that induced anti-cancer T-cell activation. Treatment with INT230-6 in in vivo models of severe cancer resulted in substantial improvement in overall survival compared to standard therapies. Further, INT230-6 provided complete responder animals with long-term and durable protection from multiple re-inoculations of the initial cancer. In mouse models, INT230-6 has shown strong synergy with checkpoint blockage, including anti-PD-1 and anti-CTLA4 antibodies. INT230-6 was discovered from Intensity’s DfuseRxSM platform.

Quanterix to Release Third Quarter 2019 Financial Results and Host Conference Call on November 6, 2019

On October 22, 2019 Quanterix Corporation (NASDAQ:QTRX), a company digitizing biomarker analysis with the goal of advancing the science of precision health, reported that it will release its financial results for third quarter 2019 after the close of trading on Wednesday, November 6, 2019 (Press release, Quanterix, OCT 22, 2019, View Source [SID1234542420]). Company management will host a conference call at 4:30 p.m., ET to discuss Quanterix’ financial results and provide a business update. The call will be hosted by Kevin Hrusovsky, Chief Executive Officer, President and Chairman, Quanterix.

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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Individuals interested in listening to the conference call may do so by dialing (833) 686-9351 for domestic callers, or (612) 979-9890 for international callers. Please reference the following conference ID: 5798993. A live webcast will also be available at: View Source The webcast will be available on the Company’s website, View Source, for one year following completion of the call.

Ligand to Report Third Quarter 2019 Results on November 5th

On October 22, 2019 Ligand Pharmaceuticals Incorporated (NASDAQ: LGND) reported third quarter 2019 financial results on November 5, 2019 (Press release, Ligand, OCT 22, 2019, View Source [SID1234542405]). Ligand’s CEO John Higgins, President and COO Matt Foehr and Executive Vice President and CFO Matt Korenberg will host the conference call.

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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Third Quarter 2019 Earnings Call

What:

Ligand conference call to discuss financial results and provide general business updates

When:

Tuesday, November 5, 2019

Time:

4:30 p.m. Eastern time (1:30 p.m. Pacific time)

Conference Call:

(833) 591-4752 within the U.S.

(720) 405-1612 outside the U.S.

Conference ID – 6093759

Webcast:

Live conference call webcast and replay accessible at www.ligand.com

Walgreens, Susan G. Komen and The Leukemia & Lymphoma Society Collaborate to Support Research in Tough-to-Treat Cancers and Increase Access to Care

On October 22, 2019 Walgreens reported a new collaboration with Susan G. Komen and The Leukemia & Lymphoma Society to enable research in tough-to-treat cancers and increase access to care with a pledge to contribute more than $25 million to the organizations, collectively, over the next five years (Press release, The Leukemia & Lymphoma Society, OCT 22, 2019, View Source [SID1234542421]). Through a combination of corporate donations and in-store fundraising, the commitment will enable new research in metastatic breast and pediatric blood cancers, as well as increase access, treatment and support services for those living with these diseases.

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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"At Walgreens, we see the devastating impact of a cancer diagnosis and the challenges people living with cancer and their caregivers face in one of the toughest journeys of their lives," said Richard Ashworth, Walgreens president of operations. "By collaborating with Susan G. Komen and The Leukemia & Lymphoma Society, we aim to advance critical needs in research, expand prevention programs and help families with the everyday challenges of living with cancer."

Walgreens customers can get involved by donating to the organizations during checkout at the more than 9,500 U.S. Walgreens retail pharmacy locations November 3 through 17. The Leukemia & Lymphoma Society and Susan G. Komen are committed to supporting patient services and increasing access to screening and treatments locally and nationally. All donations Walgreens receives in November will be split equally between the two organizations.

"Susan G. Komen is thankful for the support of Walgreens and their customers and excited about the potential of this collaboration to accelerate the pace of research discovery, particularly as it relates to understanding and combating why breast cancers recur and become metastatic," said Paula Schneider, CEO, Susan G. Komen. "Thanks to this partnership, we will be able to help support people touched by breast cancer today, while we spur the development of more effective treatments."

According to Louis DeGennaro, Ph.D., LLS President and CEO, "Our partnership with Walgreens is setting a new standard for what nonprofits and industry can do through collaboration to help more patients. Our investment of nearly $1.3 billion in cancer research is moving the needle, but new therapies can’t help patients who don’t have access to them. Through this partnership, we aim to reach more patients with critical support and services, in their communities."

Breast cancer and blood cancers are complex to treat and remain prevalent in the United States. Currently, more than 3.8 million people living in the U.S. today have been treated for or are living with breast cancer – the most commonly diagnosed cancer in women – and nearly 1.4 million are living with or in remission from blood cancer in the United States.

In support of meeting the critical needs of their communities, Susan G. Komen and The Leukemia & Lymphoma Society will focus on:

Susan G. Komen: Accelerating the pace of research discovery, particularly as it relates to understanding and combating breast cancer recurrence and metastasis, and will support people facing breast cancer today with trustworthy information and by helping them overcome barriers to timely, high-quality health care.
The Leukemia & Lymphoma Society: Accelerating the delivery of cancer treatment advances to pediatric patients and help patients, caregivers and survivors with the financial, emotional and psychological effects of cancer and its treatment.
Walgreens is supporting cancer patients through strategic collaborations with leading cancer organizations, specialized training to enable pharmacists to best serve those battling the disease and a suite of support offerings available through Walgreens more than 300 community-based specialty pharmacies.

Earlier this year, Walgreens launched Feel More Like You. The program offers an integrated approach to cancer care with specially trained Walgreens beauty consultants and pharmacists working in select stores to provide personalized expertise and support to people living with cancer. Most recently as part of Feel More Like You, Walgreens created a ten-part podcast that explores how living with cancer not only impacts health, but identity. With a panel of experts, the first-of-its kind podcast offers advice on what to expect during cancer treatment, and personal stories to help individuals feel more like themselves.

Walgreens and its parent company Walgreens Boots Alliance (WBA) are committed to improving societal health and wellbeing around the world. In May, WBA announced the transatlantic "Collaboration for Cancer Prevention, Research and Support" aimed to develop and facilitate innovative cancer research in the U.S. and Europe, and to share best practices to improve patient care and support. The transatlantic effort and research collaboration includes the European Organization for Research and Treatment of Cancer (EORTC), U.K.’s Macmillan Cancer Support, Susan G. Komen, and The Leukemia & Lymphoma Society. Walgreens Boots Alliance focuses on three priorities in efforts to support cancer programs: working with organizations that advance research, expanding prevention programs and assisting people living with cancer and their loved ones.