On April 30, 2019 Fate Therapeutics, Inc. (NASDAQ: FATE), a clinical-stage biopharmaceutical company dedicated to the development of programmed cellular immunotherapies for cancer and immune disorders, reported that the Company will host a conference call and live audio webcast on Tuesday, May 7, 2019 at 5:00 p.m. ET to report its first quarter 2019 financial results and provide a corporate update (Press release, Fate Therapeutics, APR 30, 2019, https://ir.fatetherapeutics.com/news-releases/news-release-details/fate-therapeutics-webcast-conference-call-reporting-first-4 [SID1234535489]).

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In order to participate in the conference call, please dial 877-303-6235 (domestic) or 631-291-4837 (international) and refer to conference ID 6444079. The live webcast can be accessed under "Events & Presentations" in the Investors and Media section of the Company’s website at www.fatetherapeutics.com. The archived webcast will be available on the Company’s website beginning approximately two hours after the event.

On April 30, 2019 Exicure, Inc. (OTCQB: XCUR), the pioneer in gene regulatory and immunotherapeutic drugs utilizing spherical nucleic acid (SNA) constructs, reported a poster presentation at ARVO 2019 Annual Meeting in Vancouver, British Columbia (Press release, Exicure, APR 30, 2019, View Source [SID1234535469]). The poster is titled "Spherical Nucleic Acids Exhibit Enhanced Distribution and Persistence Compared to Linear Oligonucleotides in Rat Eyes Following Intravitreal Administration" and will be presented by Bart Anderson, Director of R&D at Exicure.

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Session Date/Times: Tuesday, April 30, 2019 from 11:45 am to 1:30 pm PDT and 4:30 pm to 5:30 pm PDT

Presentation number: 3378, Poster board number A0148

Session track: Drug delivery, drug and gene delivery system, implant delivery

On April 30, 2019 Tetraphase Pharmaceuticals, Inc. (NASDAQ:TTPH), a biopharmaceutical company focused on developing and commercializing novel tetracyclines to treat serious and life-threatening conditions, reported that senior management will be participating at the SunTrust Robinson Humphrey 5th Annual Life Sciences Summit on Tuesday, May 7, 2019 at the Lotte New York Palace Hotel in New York City (Press release, Tetraphase, APR 30, 2019, View Source [SID1234535623]). Guy Macdonald, President and Chief Executive Officer of Tetraphase, will also present a corporate overview at the UBS Global Healthcare Conference on Monday, May 20, 2019 at 1:30 p.m. ET at the Grant Hyatt Hotel in New York City.

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A live audio webcast of the UBS Global Healthcare Conference presentation will be available on the Company’s website at View Source The archived presentation will be available for 30 days.

On April 30, 2019 ALENTIS Therapeutics ("ALENTIS"), a Swiss-French biotech company developing novel therapeutics in advanced liver disease and cancer, reported the completion of a Series A financing of CHF 12.5million (Euro 11.1m; USD 12.5m) (Press release, Alentis Therapeutics, APR 30, 2019, View Source [SID1234556137]). The Swiss venture capital firms BioMedPartners and BB Pureos Bioventures co-led the round and were joined by Bpifrance, Schroder Adveq and the German High-Tech Gründerfonds (HTGF).

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Markus L.E. Ewert, PhD, MBA has joined the company as Chief Executive Officer. Markus was previously CBO at Ablynx, contributing to both its US IPO and highly successful sale to Sanofi. Before, he led global corporate development at GE Healthcare, had leadership positions at Novartis, and has a track record of building businesses based on innovations.

ALENTIS’ lead program is a humanized monoclonal antibody against a target that plays a key role in the pathology of liver fibrosis and hepatocellular carcinoma (HCC). Advanced liver disease and cancer are major clinical challenges world-wide and characterized by a poor outcome and limited therapeutic options.

ALENTIS’ research is powered by its proprietary drug discovery platform, which is based on a prognostic liver disease signature holding promise for the discovery and development of further drug candidates to treat advanced liver diseases and cancer.

ALENTIS is founded on ground-breaking research of the laboratory of Prof. Thomas Baumert, MD at the University of Strasbourg, the Inserm Institute for Viral and Liver Disease, the Laboratory of Excellence HepSYS and the Institut Hospitalo-Universitaire Strasbourg as well as other collaborators, including Prof. Yujin Hoshida, MD at the University of Texas Southwestern in Dallas. SATT Conectus, the organization for accelerating technology transfer in the Alsace territory (France) has been essential in providing, building and securing the IP portfolio that has been licensed to ALENTIS. BaseLaunch, a healthcare accelerator operated by BaselArea.swiss, has been instrumental as an early stage financial and operational supporter in the formation of the company. As a result of this tri-national collaboration, ALENTIS’ headquarters have been incorporated in Basel (Switzerland) with a subsidiary in Strasbourg (France) and a branch in Germany.

Thomas F. Baumert, MD, principal founder of ALENTIS and Professor of Medicine, Head Inserm Research Institute for Viral and Liver Diseases, University of Strasbourg and Strasbourg University Hospitals said: "Together with my colleagues we are excited to be translating our novel approaches and therapeutic compounds with a unique mechanism of action into clinical drug candidates, with the aim of improving the very poor outcomes of patients with advanced liver disease."

Andreas Wallnöfer, former Head of Clinical Research & Exploratory Development at F. Hoffmann-La Roche Ltd and General Partner at BioMedPartners added: "The pre-clinical data set of the ALENTIS lead molecule are most comprehensive and convincing: they support the therapeutic potential in advanced liver disease of different origins. Prof. Baumert’s research is truly translational and links pre-clinic and clinic through a prognostic gene expression signature, which is most valuable to optimally characterize the lead project and fuel further programs."

ALENTIS’ Board of Directors will comprise Neil Goldsmith, a co-founder and Chairman; Andreas Wallnöfer, General Partner at BioMedPartners; Martin Münchbach, Managing Partner at BB Pureos Bioventures; Benoit Barteau, Senior Investment Manager at BPI France, and Prof. Thomas F. Baumert, the principal founder.

On April 30, 2019 Novocure (NASDAQ:NVCR) reported that the International Journal of Radiation Oncology, Biology, Physics, known in the field as the Red Journal, has published the results of an EF-14 post-hoc analysis demonstrating that higher doses of Tumor Treating Fields improved survival in newly diagnosed glioblastoma (GBM) patients (Press release, NovoCure, APR 30, 2019, View Source [SID1234535470]). The Red Journal is the official journal of the American Society for Radiation Oncology. This publication is the first reported analysis demonstrating patient-level dose responses to Tumor Treating Fields.

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"The study provides a definition for Tumor Treating Fields dose and creates a framework for Tumor Treating Fields dosimetry and treatment planning," said Matthew T. Ballo, MD, FACR, Professor and Chair, Department of Radiation Oncology, West Cancer Center & Research Institute in Germantown, Tennessee. "This analysis provides radiation oncologists with a better understanding of the relationship between Tumor Treating Fields dose and survival, and can be used to help optimize outcomes for GBM patients."

The simulation-based, post-hoc analysis included 340 patients from the EF-14 phase 3 pivotal trial, which compared Tumor Treating Fields plus temozolomide versus temozolomide alone for the treatment of newly diagnosed GBM. All EF-14 patients who were on treatment for at least two months and who had MRIs of acceptable quality were included.

The median overall survival and progression free survival were significantly longer when the average dose density in the tumor bed was >0.77 mW/cm3: overall survival (25.2 versus 20.4 months, p=0.003, HR=0.611) and progression free survival (8.5 versus 6.7 months, p=0.02, HR=0.699). For Tumor Treating Fields, dose can be defined as time on therapy times the energy delivered, or cumulative energy.

"With the knowledge gained from this study, we have focused our engineering efforts on evolving our Optune system to improve efficacy and extend survival," said Novocure CEO Asaf Danziger. "We have also developed novel mapping algorithms to optimize treatment planning and are working to incorporate these algorithms into a second generation NovoTAL system. We are excited by the potential of these developments to improve patients’ lives."