On March 12, 2019 BioChain, a US-based company, reported that Epigenomics AG of Germany seriously violated the terms of an ongoing licensing contract by publicly announcing on March 6, 2019 the unilateral termination of BioChain’s licensing right of Septin9 marker in China (Press release, Biochain, MAR 13, 2019, View Source [SID1234534315]). The termination of the contract by Epigenomics is not legally effective.

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BioChain’s CEO, Grace Tian stated that according to the terms of the contract, disputes between the two parties require the parties to go through a mediation and arbitration process. BioChain filed a request with the contractually specified mediation and arbitration center on March 1, 2019 in accordance with the contract, before Epigenomics unilaterally terminated the contract.

BioChain and its affiliates, as the exclusive licensee of Septin9 marker in China, have diligently worked to expand its market position despite challenging market conditions, including the fact that one relevant patent of Epigenomics was invalidated in China and the news was publicly published in May 2018.

Tian said, "Epigenomics’ termination of the Septin9 contract has incurred damages to BioChain’s reputation and investment and BioChain will take further legal actions to protect its interests".

On March 13, 2019 Bellicum Pharmaceuticals presented an Investor Presentations (Press release, Bellicum Pharmaceuticals, MAR 13, 2019, View Source [SID1234534271]).

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On March 13, 2019 BioInvent International AB (OMXS: BINV) reported that the United States Patent and Trademark Office (USPTO) has issued a Notice of Allowance, informing the company that a patent application relevant to its F.I.R.S.T. platform has been allowed and can proceed to grant (Press release, BioInvent, MAR 13, 2019, http://www.bioinvent.com/media/press-releases/releases?id=A2FA3A84867D4C4E [SID1234534288]). The patent is expected to be issued once BioInvent has responded to the Notice. It covers methods for differential biopanning.

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This patent, once issued, strengthens the protection in the US for BioInvent’s unique, function-based F.I.R.S.T. platform, which allows for simultaneous identification of clinically relevant target structures and matching antibodies.

The now allowed application is a so called continuation application based on a US patent that was granted in 2013. A similar patent was granted some years earlier by the European patent office, and it is valid in 20 European countries.

On March 13, 2019 Trovagene, Inc. (Nasdaq: TROV), a clinical-stage oncology therapeutics company, using a precision medicine approach to develop drugs that target cell division (mitosis) for the treatment of leukemias, lymphomas and solid tumor cancers, reported that it has received approximately $3.0 million in proceeds from holders exercising common stock purchase warrants at an exercise price of $6.60 per share (Press release, Trovagene, MAR 13, 2019, View Source [SID1234534289]). The warrants were issued as part of the units sold in the Company’s public offering which closed on June 12, 2018.

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Trovagene is a clinical-stage oncology therapeutics company, using a precision medicine predictive biomarker approach to develop drugs that target cell division (mitosis) for the treatment of leukemias, lymphomas and solid tumor cancers. Onvansertib, its lead drug candidate, is a first-in-class, 3rd generation, highly-selective oral Polo-like Kinase 1 (PLK1) Inhibitor. The Company currently has two ongoing open-label clinical trials: a Phase 1b/2 trial in acute myeloid leukemia (AML) and a Phase 2 trial in metastatic castration-resistant prostate cancer (mCRPC).

"We are pleased with recent activities as more investors are becoming aware of our multi-faceted clinical development program of Onvansertib, a first-in-class, 3rd generation, oral and highly-selective Polo-like Kinase 1 (PLK1) inhibitor," said Thomas Adams, Chief Executive Officer and Chairman of Trovagene. "Our program currently includes three open-label trials – Acute Myeloid Leukemia, metastatic Castration Resistant Prostate Cancer and metastatic Colorectal Cancer – all of which are indications where there is a significant need to bring new treatment options to patients."

On March 13, 2019 Mustang Bio, Inc. ("Mustang") (NASDAQ: MBIO), a company focused on the development of novel immunotherapies based on proprietary chimeric antigen receptor engineered T cell (CAR T) technology and gene therapies for rare diseases, reported that Manuel Litchman, M.D., President and Chief Executive Officer, will present a company overview at Oppenheimer’s 29th Annual Healthcare Conference (Press release, Mustang Bio, MAR 13, 2019, View Source [SID1234534317]). The presentation will take place on Tuesday, March 19, 2019, at 4:30 p.m. EDT at the Westin New York Grand Central in New York City.

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