Corporate Presentation current as of June 7, 2018

On June 7, 2018 Karyopharm Therapeutics Inc presented the Corporate Presentation is current as of June 7, 2018 (Presentation, Karyopharm, JUN 7, 2018, View Source [SID1234527234]).

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LIDDS: Major European Investment Funds invest 21,7 MSEK in a direct share issue

On June 7, 2018 LIDDS AB (publ) reported that it has decided on a direct share issue to Nyenburgh Holding BV, AESCAP 2.0 and BWG Invest, all being international funds that invests in closely selected European biotech- and pharma companies (Press release, Lidds, JUN 7, 2018, View Source [SID1234555913]). The raised capital will facilitate a fast acceleration of LIDDS’ development projects, including the immune-oncology field where NanoZolid based immuno-active compounds have shown very promising preclinical effects.

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The direct issue of 1 180 000 shares will add approx. 21,7 MSEK to LIDDS. Nyenburgh Holding will maintain as the third largest shareholder in LIDDS and contributes with financial strength, an excellent network and expertize within the sector. AESCAP 2.0, based in Amsterdam, is a current shareholder in LIDDS that invests in next generation medicines and builds a selected portfolio of only 20 companies across Europe and the US. BWG Invest is a top ten shareholder in LIDDS and strengthens its shareholding position through this direct share issue.

The share price of 18,38 SEK is based on volume weighted average of the share price with a 5 % discount. The share issue decision is based on the shareholders authorization on LIDDS Annual Meeting on May 16, 2018.

– The directed share issue to Nyenburgh Holding, AESCAP 2.0 and BWG Invest is an important validation of the NanoZolid technology and we are very pleased to attract these funds to increase their ownership in LIDDS. The share issue adds longer term financing of the company, resources to reach key milestones in our development projects and provides additional financial strength to conduct an effective business development process, says Monica Wallter, CEO of LIDDS.

LIDDS total number of shares after the direct issue will be 23 051 188 and the share capital will amount to 1 221 712,964 SEK when the new shares are registered with the Swedish Companies Registration Office, Bolagsverket. The dilution of shares is 5,1 %.

LIDDS will with the raised capital further accelerate the exciting NanoZolid development projects with the aim to build alliances, collaborations and license agreements.

The directed share issue to Nyenburgh Holding, AESCAP 2.0 and BWG Invest is further strengthening LIDDS owner structure and it confirms the international interest for LIDDS and the NanoZolid technology.

ArQule to Present Clinical Data for its BTK Inhibitor, ARQ 531, at the 23rd Congress of the European Hematology Association (EHA)

On June 7, 2018 ArQule, Inc. (Nasdaq: ARQL) reported clinical data from the company-sponsored ARQ 531-101 Phase 1 dose escalation study in subjects with relapsed or refractory hematologic malignancies will be presented on June 15, 2018 at the EHA (Free EHA Whitepaper) Congress in Stockholm, Sweden (Press release, ArQule, JUN 7, 2018, View Source [SID1234527220]). ARQ 531 is an orally bioavailable, potent and reversible inhibitor of both wild type and C481S-mutant Bruton’s tyrosine kinase (BTK).

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Presentation Details
Friday, June 15, 2018: Chronic lymphocytic leukemia and related disorders – Clinical
Title: A Phase 1 Dose Escalation Study of ARQ 531 in Selected Patients with Relapsed or Refractory Hematologic Malignancies
Location: Poster area
Time:17:30-19:00 CET
Abstract Code: PF355

About BTK and ARQ 531

Bruton’s tyrosine kinase, BTK, is a therapeutic target that has been clinically proven to inhibit B-cell receptor signaling in blood cancers. ARQ 531 is an orally bioavailable, potent and reversible BTK inhibitor. Biochemical and cellular studies have shown that ARQ 531 inhibits both the wild type and C481S-mutant forms of BTK. The C481S mutation is a known resistance mechanism for first generation irreversible BTK inhibitors. In preclinical studies, ARQ 531 has demonstrated good oral bioavailability as well as favorable pharmacokinetic, pharmacodynamic and metabolic properties.

Corporate Presentation, dated June 7, 2018

On June 7, 2018, TG Therapeutics, Inc. (the "Company") presented the corporate presentation at the Jefferies 2018 Global Healthcare Conference, held at the Grand Hyatt Hotel, in New York City (Presentation, TG Therapeutics, JUN 7, 2018, View Source [SID1234527235]).

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Onconova Therapeutics Announces Presentation at the 23rd Congress of the European Hematology Association

On June 7, 2018 Onconova Therapeutics, Inc. (NASDAQ:ONTX), a Phase 3-stage biopharmaceutical company focused on discovering and developing novel products to treat cancer, with a primary focus on myelodysplastic syndromes (MDS), reported a presentation at the 23rd Congress of the European Hematology Association (EHA) (Free EHA Whitepaper) being held June 14-17, 2018 in Stockholm, Sweden (Press release, Onconova, JUN 7, 2018, View Source [SID1234527221]). Dr. Steven Fruchtman, Onconova’s Chief Medical Officer and Senior VP, Research & Development, will be attending the conference.

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