10-K – Annual report [Section 13 and 15(d), not S-K Item 405]

Leap Therapeutics has filed a 10-K – Annual report [Section 13 and 15(d), not S-K Item 405] with the U.S. Securities and Exchange Commission (Filing, 10-K, Leap Therapeutics, 2017, MAR 31, 2017, View Source [SID1234521991]).

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Spectrum Pharmaceuticals Highlights Three Abstracts on ROLONTIS™ (eflapegrastim) and BELEODAQ® (belinostat) for injection at the American Association for Cancer Research (AACR) Annual Meeting in Washington, D.C., April 1-5, 2017

On March 31, 2017 Spectrum Pharmaceuticals (NasdaqGS: SPPI), a biotechnology company with fully integrated commercial and drug development operations with a primary focus in Hematology and Oncology, reported key presentations of clinical and scientific data related to its products at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting being held in Washington, D.C., from April 1-5, 2017 (Press release, Spectrum Pharmaceuticals, MAR 31, 2017, View Source [SID1234518393]).

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The following ROLONTIS (eflapegrastim) related abstract is being presented at the AACR (Free AACR Whitepaper) meeting:

Monday, April 3, 2017:

Abstract # Type Title First Author Time
1347 Poster In vivo efficacy of eflapegrastim in rats with chemotherapy-induced neutropenia Kim 8:00 AM -12:00 PM

The following key BELEODAQ (belinostat) for injection related abstracts are being presented at the AACR (Free AACR Whitepaper) meeting:

Monday, April 3, 2017:

Abstract # Type Title First Author Time
1059 Poster Enhanced anti-tumor efficacy of a checkpoint inhibitor in combination with the HDAC inhibitor belinostat in a murine hepato-cellular carcinoma preclinical model Llopiz 8:00 AM-12:00 PM

2018 Poster Synergistic interactions between PLK1 and HDAC inhibitors in non-Hodgkin’s lymphoma cells occur in vitro and in vivo and proceed through multiple mechanisms Nguyen 1:00 PM-5:00 PM

For more information about the AACR (Free AACR Whitepaper) meeting and for a complete list of abstracts, please refer to the conference website at View Source!/4292.

20-F – Annual and transition report of foreign private issuers [Sections 13 or 15(d)]

(Filing, Annual, Akari Therapeutics, 2016, MAR 31, 2017, View Source [SID1234518355])

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20-F – Annual and transition report of foreign private issuers [Sections 13 or 15(d)]

(Filing, Annual, Nymox, 2016, MAR 31, 2017, View Source [SID1234518382])

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ASTRAZENECA COMPLETES AGREEMENT WITH TERSERA THERAPEUTICS FOR COMMERCIAL RIGHTS TO ZOLADEX IN THE US AND CANADA

On March 31, 2017 AstraZeneca reported that it has completed the agreement with TerSera Therapeutics LLC for the commercial rights to Zoladex (goserelin acetate implant) in the US and Canada (Press release, AstraZeneca, MAR 31, 2017, View Source [SID1234518408]). Zoladex is an injectable luteinising hormone-releasing medicine, used to treat prostate cancer, breast cancer and certain benign gynaecological disorders. It was first approved in the US and Canada in 1989.

Under the terms of the agreement, AstraZeneca has received a payment of $250 million from TerSera for the commercial rights to the medicine in the US and Canada. As AstraZeneca will maintain a significant ongoing interest in Zoladex in the US and Canada, the payment will be reported as Externalisation Revenue in the Company’s financial statements, and will be booked in the first quarter of 2017.

AstraZeneca will receive future sales-related income through milestones totalling up to $70 million, as well as recurring quarterly sales-based payments at mid-teen percent of sales. AstraZeneca will also manufacture and supply Zoladex to TerSera, providing a further source of ongoing income from Zoladex in the US and Canada.

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