On May 23, 2024 NMDPSM, a global nonprofit leader in cell therapy, and the CIBMTR (Center for International Blood and Marrow Transplant Research), reported that interim results from the ACCESS trial will be presented as an oral abstract on Friday, May 31 at the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting in Chicago, Ill., demonstrating that adults with hematologic malignancies who received peripheral blood stem cell (PBSC) transplant from HLA-mismatched unrelated donors (MMUD) followed by post-transplant cyclophosphamide (PTCy) graft-versus-host-disease (GvHD) prophylaxis exhibited a 79% overall survival, with a significant 51% GvHD-free, relapse-free survival (GRFS) probability at one-year post transplant (Press release, CIBMTR, MAY 23, 2024, View Source [SID1234643653]). Notably, ASCO (Free ASCO Whitepaper) also selected this abstract to be presented at its 2024 Best of ASCO (Free ASCO Whitepaper) program in July.

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"We want more patients to survive and thrive — results from ACCESS to-date have shown positive, significant transplant outcomes and good quality of life for patients," said Monzr M. Al Malki, M.D., Associate Professor, Department of Hematology & Hematopoietic Cell Transplantation, City of Hope; presenting author and ACCESS study co-chair. "These preliminary data provide strong support for inclusion of this novel treatment approach for patients receiving PBSC from partially matched, unrelated donors and advance current evidence demonstrating how more patients can benefit from the potentially curative therapeutic effects of transplant."

In addition to achieving very good OS and GRFS clinical endpoints, adult participants also exhibited low rates of severe acute and chronic GvHD, both at 9%. The NMDP-sponsored ACCESS trial, conducted through the CIBMTR — a research collaboration between the Medical College of Wisconsin and NMDP — enrolled 70 adult patients with blood cancers and disorders, including acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and acute lymphoblastic leukemia (ALL), from 13 participating transplant centers, like City of Hope. All patients in this stratum received reduced intensity conditioning, most often fludarabine/melphalan (63%) or fludarabine/busulfan (20%), and PBSCs from donors matched at 5-7 of 8 HLA loci, predominantly at the 7/8 match level (67%). Notably, half of patients enrolled in the trial were people of color.

"Historically, barriers in access to transplant have been inhibited by two factors: the low availability of matched, related sibling donors; and the substantial variance of matched, unrelated donor availability on international registries, particularly for patients with diverse ancestry — many of whom already face significant challenges," said study co-author Steven M. Devine, M.D., Chief Medical Officer, NMDP; Senior Scientific Director, CIBMTR. "Our research findings advance our ability to offer more options to patients without a fully matched donor, many of whom are ethnically diverse and have been underserved in receiving potentially life-saving cell therapy."

Addressing Equitable Care: NMDP-led Donor for All Research

Traditionally, finding an available matched, unrelated donor on international registries has been limited for patients with ethnically diverse ancestry – from as low as 29% for Black or African American patients and 48% for Latino and Hispanic patients versus 79% for non-Hispanic Whites. NMDP’s network of transplant centers, many of which participate in CIBMTR trials, are bringing new research to light that is challenging previously established stem cell transplantation science.

ACCESS builds upon findings from the first "Donor for All" trial, a groundbreaking NMDP-sponsored 15-MMUD study, which showed that PTCy was effective in decreasing risk for GvHD in adults with hematologic malignancies receiving bone marrow (BM) transplants from MMUD. Similar to ACCESS, 15-MMUD patients — 48% of whom were ethnically diverse — showed a one-year overall survival (OS) rate of 76% and exhibited a low rate of moderate / severe GvHD. Enrolling now, the OPTIMIZE trial is evaluating whether a reduced dose of PTCy will safely and effectively prevent GvHD while reducing infection risk in patients with hematologic malignancies receiving PBSC HCT from MMUDs. Finally, a recent observational study by the CIBMTR presented at the 2024 Tandem Meetings, reported no discernable differences in OS or GRFS for adult patients with hematologic malignancies using MMUD HCT at an 8/8 or 7/8 HLA match level using PTCy GvHD prophylaxis — increasing the likelihood for patients of all ethnicities of finding a suitable donor to at least 84% and up to 99%.

"Our Donor for All research is the foundational future upon which we are building a new platform protocol using innovative strategies for preventing and treating GvHD, decreasing risk for post-transplant relapse of hematologic malignancies, and in the future, applying MMUD transplant to cure non-malignant conditions, such as sickle cell disease," said Dr. Devine. "Through CIBMTR, we are showing that science can solve the gap in equitable access to transplant, giving new hope to patients worldwide."

2024 ASCO (Free ASCO Whitepaper) Presentation Details

Oral Presentation (Abstract #6503)

Friday, May 31; 2:45-5:45 p.m. CDT; Room S100bc

Post-transplant cyclophosphamide-based graft-versus-host disease prophylaxis following mismatched unrelated donor peripheral blood stem cell (PBSC) transplantation

Monzr M. Al Malki, M.D.

Poster Discussion (Abstract #1528)

Saturday, June 1; 9 a.m. – noon CDT; Hall A

Identifying states for targeted alloHCT access initiatives using social vulnerability, physician density, and unmet need

Samantha Watters, MPH

On May 22, 2024 Xenetic Biosciences, Inc. (NASDAQ:XBIO) ("Xenetic" or the "Company"), a biopharmaceutical company focused on advancing innovative immune-oncology technologies addressing hard to treat oncology indications, reported the appointment of James Parslow, the Company’s Chief Financial Officer, as interim Chief Executive Officer, effective May 16, 2024 (Press release, Xenetic Biosciences, MAY 22, 2024, View Source [SID1234643540]).

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"I am a strong believer in the potential of our innovative immune-oncology technologies addressing hard-to-treat cancers. This management change will allow us to focus our resources on driving our pipeline towards a first in human clinical study and extending our cash runway. We will continue the important work of advancing our programs for the benefit of our shareholders and patients worldwide," stated James Parslow, Interim CEO of the Company.

Xenetic is executing on its plans to advance its DNase-based oncology program towards Phase 1 clinical development for the treatment of pancreatic carcinoma and other locally advanced or metastatic solid tumors. The Company is advancing its ongoing preclinical studies with data expected before year end.

About James Parslow

Mr. Parslow is a seasoned executive with over 35 years of experience providing financial and business leadership to the biotech, e-commerce and clean tech industries. Over the course of his career, Mr. Parslow has demonstrated expertise with strategic planning, general management and operations, budgeting, financial planning and analysis, accessing capital markets, M&A, investor relations, risk management, SOX compliance, and SEC/GAAP reporting. Mr. Parslow has served as the Company’s Chief Financial Officer since April 2017.

On May 22, 2024 AstraZeneca reported its ambition to redefine cancer care with new data across its industry-leading portfolio and pipeline at the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting, 31 May to 4 June 2024 (Press release, AstraZeneca, MAY 22, 2024, View Source [SID1234643504]).

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More than 100 abstracts will feature 25 approved and potential new medicines across the Company’s diverse oncology portfolio and pipeline, including two late-breaking plenary presentations, a special late-breaking abstract session presentation and 15 oral presentations. Highlights include:

LAURA Phase III trial of Tagrisso (osimertinib) in unresectable, Stage III epidermal growth factor receptor-mutated (EGFRm) non-small cell lung cancer (NSCLC) after chemoradiotherapy (CRT) (Plenary LBA4).
ADRIATIC Phase III trial of Imfinzi (durvalumab) in patients with limited-stage small cell lung cancer (LS-SCLC) who had not progressed following concurrent CRT (cCRT) (Plenary LBA5).
DESTINY-Breast06 Phase III trial of Enhertu (trastuzumab deruxtecan) in patients with metastatic hormone receptor (HR)-positive HER2-low and HER2-ultralow metastatic breast cancer following one or more lines of endocrine therapy (LBA1000).
First-in-human, investigator-initiated trial of C-CAR031, a novel autologous armoured Glypican 3 (GPC3) targeting chimeric antigen receptor T cell (CAR-T) therapy, in patients with liver cancer. The CAR-T is based on AZD5851, a novel cell therapy designed by AstraZeneca (Rapid Oral Abstract 4019).
Two late-breaking presentations from the externally sponsored I-SPY2.2 Phase II trial of neoadjuvant datopotamab deruxtecan (Dato-DXd), alone and in combination with Imfinzi, in patients with breast cancer (LBA501 and LBA509).
Dave Fredrickson, Executive Vice President, Oncology Business Unit, AstraZeneca, said: "Our plenary data at ASCO (Free ASCO Whitepaper) show the pioneering role of our medicines in curative-intent lung cancer treatment and highlight progress toward our continued ambition to have a medicine for more than half of all patients treated for lung cancer by 2030. The overwhelming efficacy in the LAURA trial will add to the extensive body of evidence for Tagrisso in EGFR-mutated non-small cell lung cancer, and the impressive survival data from ADRIATIC will show the potential of Imfinzi to transform outcomes in limited-stage small cell lung cancer."

Susan Galbraith, Executive Vice President, Oncology R&D, AstraZeneca, said: "Data from our antibody drug conjugates at ASCO (Free ASCO Whitepaper) underscore the opportunity to replace traditional chemotherapy with these medicines for many patients as we expand their use to new populations. DESTINY-Breast06 results will demonstrate the potential to treat patients across a broader spectrum of HR-positive metastatic breast cancer with Enhertu, including those with HER2-ultralow expression who have never had access to HER2-directed therapy before. We’re also excited by the I-SPY2.2 efficacy and tolerability data for datopotamab deruxtecan plus Imfinzi, which will show the potential of combining antibody drug conjugates with immunotherapy in the early-stage setting."

Transforming treatment expectations across earlier-stage lung cancer settings

Several presentations will reinforce the Company’s progress toward moving lung cancer treatment to earlier stages of disease. These include:

A late-breaking plenary presentation showcasing progression-free survival (PFS) results from the LAURA Phase III trial evaluating Tagrisso in unresectable, Stage III EGFRm NSCLC after CRT. In February, high-level results showed a statistically significant and highly clinically meaningful PFS benefit for Tagrisso in this setting.
A late-breaking plenary presentation highlighting overall survival (OS) and PFS results from the ADRIATIC Phase III trial of Imfinzi in patients with LS-SCLC who had not progressed following cCRT. In April, high-level results from an interim analysis showed a statistically significant and clinically meaningful OS and PFS benefit for Imfinzi in this setting.
An oral presentation of an analysis from the ADAURA Phase III trial of Tagrisso in the adjuvant treatment of early-stage (IB, II and IIIA) EGFRm NSCLC, assessing the potential for circulating tumour DNA-based molecular residual disease to predict disease recurrence.
A rapid oral presentation of an exploratory analysis from the AEGEAN Phase III trial of Imfinzi-based treatment before and after surgery in patients with resectable early-stage (IIA-IIIB) NSCLC, evaluating efficacy in patients with N2 disease (cancer in the lymph nodes on the same side as the affected lung or between the lungs).
A poster presentation of updated OS, PFS and safety results from the COAST Phase II trial of Imfinzi in combination with novel immunotherapies oleclumab, an anti-CD73 monoclonal antibody, and monalizumab, an anti-NKG2A monoclonal antibody, in unresectable, Stage III NSCLC, supporting the PACIFIC-9 Phase III trial in this patient population.
In metastatic lung cancer, the Company will present data that underscore its commitment to extending the benefits of antibody drug conjugates (ADCs) to more patients. A poster presentation will share updated safety and efficacy results, including by PD-L1 expression, from the TROPION-Lung02 Phase Ib trial of datopotamab deruxtecan plus pembrolizumab with or without platinum chemotherapy as 1st-line treatment for patients with advanced NSCLC without actionable genomic alterations. These data build on previously presented results from the TROPION-Lung01 Phase III trial demonstrating the potential of this novel ADC in advanced disease. Datopotamab deruxtecan in combination with immunotherapies is being further explored in multiple Phase III trials in this setting, including AVANZAR, TROPION-Lung07 and TROPION-Lung08.

Redefining the breast cancer treatment landscape with ADCs across subtypes and stages of disease

A late-breaking presentation will showcase efficacy and safety outcomes from the DESTINY-Breast06 Phase III trial. In April, high-level results showed Enhertu demonstrated a statistically significant and clinically meaningful improvement in PFS versus standard-of-care chemotherapy in patients with HR-positive, HER2-low metastatic breast cancer. A clinically meaningful PFS improvement was also seen in patients with HER2-ultralow expression.

An oral presentation will spotlight data from an interim analysis of the dose-expansion phase of the DESTINY-Breast07 Phase Ib/II trial assessing Enhertu alone or in combination with pertuzumab as 1st-line treatment in HER2-positive metastatic breast cancer. These regimens are being further explored in the DESTINY-Breast09 Phase III clinical trial.

Additionally, a poster presentation will share updated OS and PFS results from the DESTINY-Breast03 Phase III trial of Enhertu versus trastuzumab emtansine (T-DM1) in patients with HER2-positive metastatic breast cancer previously treated with trastuzumab and a taxane.

An oral presentation will feature patient-reported outcomes data from the TROPION-Breast01 Phase III trial of datopotamab deruxtecan in patients with inoperable or metastatic HR-positive, HER2-low or negative breast cancer previously treated with endocrine-based therapy and at least one systemic therapy. Previously presented primary results from TROPION-Breast01 showed datopotamab deruxtecan demonstrated a statistically significant and clinically meaningful improvement in PFS versus investigator’s choice of chemotherapy.

Two late-breaking presentations of results from the externally sponsored I-SPY2.2 Phase II trial will highlight the rates of pathologic complete response associated with neoadjuvant datopotamab deruxtecan, alone and in combination with Imfinzi, across breast cancer subtypes.

Advancing the next wave of medicines and combination therapies to attack cancer from multiple angles

A rapid oral presentation will spotlight safety and preliminary efficacy results from an investigator-initiated trial of C-CAR031, a novel autologous armoured Glypican 3 (GPC3) targeting chimeric antigen receptor T cell (CAR-T) therapy that is being investigated for hepatocellular carcinoma. The CAR-T is based on AZD5851, a novel cell therapy designed by AstraZeneca using their transforming growth factor-beta receptor II (TGFβRII) dominant negative armouring platform and is manufactured by AbelZeta Pharmaceuticals Inc. C-CAR031 is being developed in China under a co-development agreement between AbelZeta and AstraZeneca. AstraZeneca’s TGFβRII dominant negative armouring is designed to resist the immuno-suppressive tumour microenvironment and enhance the potential effectiveness of CAR-Ts in solid tumours.

A rapid abstract update will feature updated efficacy data from a Phase I trial of AZD0901, a potential first-in-class ADC targeting Claudin 18.2, which has shown promise as a therapeutic target in gastric cancer. First results were presented at the ASCO (Free ASCO Whitepaper) Plenary Series 2023.

Additionally, a clinical science symposium presentation of the externally sponsored CAPRI Phase II trial will share efficacy and safety results for ceralasertib, an ataxia telangiectasia and rad3-related (ATR) kinase inhibitor, plus Lynparza (olaparib) in patients with platinum-sensitive recurrent high-grade serous ovarian cancer.

Collaboration in the scientific community is critical to improving outcomes for patients. AstraZeneca is collaborating with Daiichi Sankyo Company Limited to develop and commercialise Enhertu and datopotamab deruxtecan, and with MSD (Merck & Co., Inc. in the US and Canada) to develop and commercialise Lynparza. AstraZeneca obtained full oncology rights to monalizumab from Innate Pharma in October 2018 through a co-development and commercialisation agreement initiated in 2015.

Key AstraZeneca presentations during ASCO (Free ASCO Whitepaper) 2024

Lead Author

Abstract Title

Presentation details (CDT)

Lung Cancers

Ramalingam, SS

Osimertinib (osi) after definitive chemoradiotherapy (CRT) in patients (pts) with unresectable stage (stg) III epidermal growth factor receptor-mutated (EGFRm) NSCLC: Primary results of the phase 3 LAURA study.

Abstract #LBA4

Plenary Session

2 June 2024

2:47pm

Spigel, DR

ADRIATIC: durvalumab (D) as consolidation treatment (tx) for patients (pts) with limited-stage small-cell lung cancer (LS-SCLC).

Abstract #LBA5

Plenary Session

2 June 2024

3:21pm

John, T

Molecular residual disease (MRD) analysis from the ADAURA trial of adjuvant (adj) osimertinib in patients (pts) with resected EGFR‑mutated (EGFRm) stage IB–IIIA non-small cell lung cancer (NSCLC).

Abstract #8005

Oral Abstract Session

3 June 2024

9:12am

Heymach, J

Outcomes with perioperative durvalumab (D) in pts with resectable NSCLC and baseline N2 lymph node involvement (N2 R-NSCLC): An exploratory subgroup analysis of AEGEAN.

Abstract #8011

Rapid Oral Abstract Session

2 June 2024

4:36pm

Aggarwal, C

Updated results from COAST, a phase 2 study of durvalumab (D) ± oleclumab (O) or monalizumab (M) in patients (pts) with stage III unresectable non-small cell lung cancer (uNSCLC).

Abstract #8046

Poster Session

3 June 2024

1:30pm

Levy, BP

Datopotamab deruxtecan (Dato-DXd) plus pembrolizumab (pembro) with or without platinum chemotherapy (Pt-CT) as first-line (1L) therapy for advanced non-small cell lung cancer (aNSCLC): Subgroup analysis from TROPION-Lung02.

Abstract #8617

Poster Session

3 June 2024

1:30pm

Janne, PA

Trastuzumab deruxtecan (T-DXd) in patients with HER2-mutant metastatic non–small cell lung cancer (mNSCLC): Final analysis results of DESTINY-Lung02.

Abstract #8543

Poster Session

3 June 2024

1:30pm

Sun, Y

Datopotamab deruxtecan (Dato-DXd) in Chinese patients (pts) with advanced or metastatic non-small cell lung cancer (NSCLC): Results from the phase 1/2 TROPION-PanTumor02 study.

Abstract #8548

Poster Session

3 June 2024

1:30pm

Lisberg, A

Intracranial efficacy of datopotamab deruxtecan (Dato-DXd) in patients (pts) with previously treated advanced/metastatic non-small cell lung cancer (a/m NSCLC) with actionable genomic alterations (AGA): Results from TROPION-Lung05.

Abstract #8593

Poster Session

3 June 2024

1:30pm

Sands, J

Analysis of drug-related interstitial lung disease (ILD) inpatients (pts) treated with datopotamab deruxtecan (Dato-DXd).

Abstract #8623

Poster Session

3 June 2024

1:30pm

Breast Cancers

Curigliano, G

Trastuzumab deruxtecan (T-DXd) vs physician’s choice of chemotherapy (TPC) in patients (pts) with hormone receptor-positive (HR+), human epidermal growth factor receptor 2 (HER2)-low or HER2-ultralow metastatic breast cancer (mBC) with prior endocrine therapy (ET): Primary results from DESTINY-Breast06 (DB-06).

Abstract #LBA1000

Oral Abstract Session

2 June 2024

7:30am

Pernas, S

Datopotamab deruxtecan (Dato-DXd) vs chemotherapy (CT) in previously treated inoperable or metastatic hormone receptor-positive, HER2-negative (HR+/HER2–) breast cancer (BC): Patient-reported outcomes (PROs) from the TROPION-Breast01 study.

Abstract #1006

Oral Abstract Session

1 June 2024

4:24pm

Andre, F

DESTINY-Breast07: Dose-expansion interim analysis of T-DXd monotherapy and T-DXd + pertuzumab in patients with previously untreated HER2+ mBC.

Abstract #1009

Oral Abstract Session

1 June 2024

5:24pm

Shatsky, RA

Rates of pathologic complete response (pCR) after datopotamab deruxtecan (Dato) plus durvalumab (Durva) in the neoadjuvant setting: Results from the I-SPY2.2 trial.

Abstract #LBA501

Oral Abstract Session

3 June 2024

3:12pm

Meisel, J

Rates of pathologic complete response (pCR) after neoadjuvant datopotamab deruxtecan (Dato): Results from the I-SPY2.2 trial.

Abstract #LBA509

Rapid Oral Abstract Session

31 May 2024

2:45pm

Hamilton, EP

Trastuzumab deruxtecan (T-DXd) vs trastuzumab emtansine (T-DM1) in patients (pts) with HER2+ metastatic breast cancer (mBC): Updated survival results of DESTINY-Breast03.

Abstract #1025

Poster Session

2 June 2024

9:00am

Gastrointestinal Cancers

Zhang, Q

Phase I study of C-CAR031, a GPC3-specific TGFβRIIDN armored autologous CAR-T, in patients with advanced hepatocellular carcinoma (HCC).

Abstract #4019

Rapid Oral Abstract Session

3 June 2024

10:51am

Xu, RH

Updates on Abstract 434420: A Phase 1 Trial of Claudin 18.2-Specific Antibody-Drug Conjugate CMG901 in Patients with Advanced Gastric/Gastroesophageal Junction Cancer

Education Session

1 June 2024

12:42pm

Chan, SL

Safety analysis by treatment periods from EMERALD-1: A phase 3, randomized, placebo-controlled study of transarterial chemoembolization with durvalumab with/without bevacizumab in participants with embolization-eligible unresectable hepatocellular carcinoma.

Abstract #4122

Poster Session

1 June 2024

1:30pm

Kelley, RK

T cell receptor and immune gene expression pharmacodynamics for durvalumab monotherapy and in combination with tremelimumab or bevacizumab in unresectable hepatocellular carcinoma (uHCC).

Abstract #4022

Poster Session

1 June 2024

1:30pm

Hamilton, A

ATHENA: A phase 1/2 study of AZD5851, a chimeric antigen receptor (CAR) T-cell therapy directed against GPC3 in adult patients with advanced/recurrent hepatocellular carcinoma (HCC).

Abstract #TPS2675

Poster Session

1 June 2024

9:00am

Shen, L

GEMINI-Gastric: A phase 2 study of novel treatment combinations in patients with locally advanced unresectable or metastatic gastric cancers.

Abstract #TPS4182

Poster Session

1 June 2024

1:30pm

Zhou, J

GEMINI-Hepatobiliary: A phase 2 study of novel first-line immuno-oncology-based treatments in patients with advanced hepatobiliary cancers.

Abstract #TPS4187

Poster Session

1 June 2024

1:30pm

Gynaecological Cancers

Simpkins, F

Combination ATR and PARP Inhibitor (CAPRI): A phase 2 study of ceralasertib plus olaparib in patients with recurrent, platinum-sensitive epithelial ovarian cancer (cohort A).

Abstract #5510

Clinical Science Symposium

1 June 2024

1:39pm

Pan-Tumour

Raufi, AG

CLARITY-PanTumor01: A phase 2 trial of the claudin 18.2-specific antibody-drug conjugate AZD0901 (CMG901) in patients with CLDN18.2-expressing advanced solid tumors.

Abstract #TPS3163

Poster Session

1 June 2024

9:00am

Punekar, SR

An open-label, phase 1, multicenter study to evaluate the safety and preliminary anti-tumor activity of NT‑112 in human leukocyte antigen-C*08:02–positive adult patients with unresectable, advanced, and/or metastatic solid tumors that are positive for the KRAS G12D mutation.

Abstract #TPS2677

Poster Session

1 June 2024

9:00am

Spira, AI

PRIMROSE: A modular phase 1/2a study of AZD3470, an MTA-cooperative PRMT5 inhibitor, in patients with MTAP deficient advanced solid tumors.

Abstract #TPS3179e

Poster Session

1 June 2024

9:00am

Perez, A

Non-clinical evaluation of NT-175, an autologous T cell product engineered to express an HLA-A*02:01-restricted TCR targeting TP53 R175H and resistant to TGF-b inhibition.

Abstract #2560

Poster Session

1 June 2024

9:00am

On May 22, 2024 CytomX Therapeutics, Inc. (Nasdaq: CTMX), a leader in the field of masked, conditionally activated biologic therapeutics, reported that Sean McCarthy, D.Phil., chief executive officer and chairman, will present at the Jefferies Global Healthcare Conference on Thursday, June 6, 2024, at 8:30 a.m. ET (Press release, CytomX Therapeutics, MAY 22, 2024, View Source [SID1234643542]).

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A live webcast of the presentation will be available on the Events and Presentations page of CytomX’s website at www.cytomx.com. In addition, management will be available for one-on-one meetings with investors who are registered to attend the conference.

On May 22, 2024 Xcell Biosciences Inc. (Xcellbio), an innovative technology company focused on cell and gene therapy manufacturing applications, reported its speaker lineup and activities for the upcoming ISCT 2024, the annual meeting of the International Society for Cell & Gene Therapy, taking place May 29 – June 1 in Vancouver, British Columbia (Press release, Xcell Biosciences, MAY 22, 2024, View Source [SID1234643558]). Along with AmplifyBio and the University of Virginia, Xcellbio will offer poster presentations of its AVATAR technology in T cell manufacturing and analytical applications.

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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"ISCT is the leading organization dedicated to cell and gene therapies, and we look forward to this conference every year to meet with customers, collaborators, and anyone else whose cell therapy development efforts can be accelerated by our unique approach to conditioning cells for more potent and persistent cancer-killing abilities," said Brian Feth, co-founder and CEO at Xcellbio.

Building upon the success of the AVATAR system previously launched for cell and gene therapy research and development, the cGMP AVATAR Foundry system represents the latest platform advancement to deliver novel capabilities for improving expansion and potency of cell therapies. The AVATAR product family now covers small-scale research and process development capabilities, as well as scale-up bioreactor manufacturing platforms for metabolically reprogramming therapeutic cells to improve their expansion, potency, and persistence in the tumor microenvironment.

Booth Activities

Xcellbio can be found at booth #704 in the ISCT exhibit hall. Conference attendees may visit the booth to see the AVATAR Foundry system and experience a live demonstration of the instrument. In addition, information about participating in the expanded beta access program for the AVATAR Foundry system will be available.

Poster Presentations

The following posters will include data generated with the AVATAR system:

Poster #933: Adapting T cells for the Tumor Microenvironment (TME) During Manufacturing for Improved Anti-Tumor Potency
Presenter: Craig Fett, AmplifyBio

Poster #1009: Acclimation of Effector T Cells to Tumor Microenvironment Induces Enhanced Proliferation and Anti-tumor Activity Against Breast Cancer Cell Lines
Presenter: Archana Thakur, University of Virginia

Poster #912: Modulating Environmental Conditions to Enhance Production of Potent Cell Therapies for the Solid Tumor Microenvironment
Presenter: Yelena Bronevetsky, Hadia Lemar, Evan Massi, Candy Garcia, Xcellbio

More information about the beta access program is available at View Source