IMMUTEP LIMITED ANNOUNCES MILESTONE PAYMENT FROM CHINESE PARTNER EOC PHARMA

On February 1, 2018 Immutep Limited (ASX: IMM; NASDAQ: IMMP) reported that it has received a milestone payment from the Company’s Chinese partner for eftilagimod alpha (IMP321), EOC Pharma, an oncology focused affiliate of Eddingpharm (Press release, Immutep, FEB 1, 2018, View Source [SID1234523710]).

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The milestone payment of US$1 million relates to the clinical development of eftilagimod alpha in China and follows the granting of EOC Pharma’s Investigational New Drug (IND) application in China, as outlined in Immutep’s December 12, 2017 Operational Update.

Immutep CEO, Marc Voigt, commented, "We are very pleased with the recent progress EOC Pharma has made in China. Given the recent regulatory reform, we are optimistic about eftilagimod’s navigation of the Chinese Food and Drug Administration’s regulatory pathway and its clinical development. We look forward to supporting our partner EOC Pharma."

EOC’s CEO Xiaoming Zou, added, "We have been encouraged by the CFDA approval of the IND. Eftilagimod alpha showed impressive activity in a European Phase 1 clinical trial as well as in the safety run in phase of AIPAC in metastatic breast cancer, and we are confident Chinese patients will experience similar clinical benefit. We also look forward to entering a new phase of collaboration with our partner Immutep."

In May 2013, Immutep and Eddingpharm entered into a licensing agreement whereby Immutep granted Eddingpharm exclusive development rights for eftilagimod in China, including Hong Kong, Macau, and Taiwan. In January 2015, the license was transferred from Eddingpharm to EOC Pharma upon the consent of Immutep. In exchange for these rights, EOC Pharma agreed to pay for the manufacturing of certain drug supply for Immutep and will be required to make milestone payments to Immutep if eftilagimod achieves specified development milestones. EOC Pharma will also pay Immutep a royalty on net sales of eftilagimod in China, if approved.

OncoBioPharm Ltd is rebranded as aTen Therapeutics Ltd

On February 1, 2018 Scottish biotechnology company OncoBioPharm has reported that from this date it will operate as aTen Therapeutics Ltd (Press release, OncoBioPharm, FEB 1, 2018, View Source [SID1234526010]).

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aTen (pronounced ‘atten’) refers to the angiotensin pathway, which plays a key role in several major diseases, and is the target of the company’s lead antibody candidate, Tensinomab.

The new name reflects the company’s commitment to exploring the full potential of its innovative technology platform, not only within oncology but across other major disease areas.

Whilst the company’s main development programme continues to explore Tensinomab’s potential to treat primary cancers and protect against developing metastases, in parallel the development team is researching angiotensin pathway modulation in the context of other serious conditions.

Managing Director, Dr Tina Flatau, said: "Although the vast therapeutic potential of Tensinomab was first demonstrated in cancer models, there is mounting evidence to suggest that angiotensin pathway-modulation could also have major benefits in the treatment of other diseases, beyond oncology. The new aTen Therapeutics brand reflects our commitment to exploring the potential of our technology fully, not just for the treatment of cancer but also within the context of other serious and life-limiting diseases."

aTen Therapeutics Ltd (registered in Scotland no 547221) is a wholly-owned subsidiary of OncoBioPharm Limited (registered in Scotland 29/7/05 no. SC288225).

Integra LifeSciences to Host Fourth Quarter 2017 Earnings Results Conference Call on February 27, 2018

On February 1, 2018 Integra LifeSciences Holdings Corporation (NASDAQ:IART), a leading global medical technology company, reported that it will release fourth quarter and full year 2017 financial results on Tuesday, February 27, 2018, prior to market open (Press release, IsoTis, FEB 1, 2018, View Source [SID1234523685]). In conjunction with the earnings release, Integra will host a conference call at 8:30 a.m. ET.

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Peter J. Arduini, president and chief executive officer, and Glenn G. Coleman, chief financial officer and corporate vice-president of International, will review fourth quarter and full year 2017 results during the call.

The live call is accessible by dialing (323) 794-2093 and using the passcode 7668138. A simultaneous webcast of the call will be available via the Company’s website at www.integralife.com.

A webcast replay of the call can be accessed through the Investor Relations homepage of Integra’s website at www.integralife.com. A replay of the call will be available through March 3, 2018 by dialing (719) 457-0820 and using the passcode 7668138.

Oncolytics Biotech® to Host Conference all Outlining the Treatment Paradigm of Metastatic Breast Cancer Subtypes and Provide Topline Information on its Phase 3 Registration Study with REOLYSIN®

On February 1, 2018 Oncolytics Biotech Inc. (TSX: ONC) (OTCQX: ONCYF), a biotech company developing REOLYSIN, also known as pelareorep, an intravenously delivered immuno-oncolytic virus that activates the innate and adaptive immune systems to turn "cold" tumors "hot", reported that it will host a conference call to discuss the current treatment paradigm of metastatic breast cancer (mBC) subtypes (Press release, Oncolytics Biotech, FEB 1, 2018, View Source [SID1234523714]). The purpose of the call is to highlight the definitive unmet medical need to improve the overall survival of women with advanced or recurrent hormone receptor positive, HER2 receptor negative metastatic breast cancer, and will also discuss certain preliminary details of the Company’s planned phase 3 registration study in mBC. The conference call will take place on Wednesday, February 7, 2018 at 8:30 a.m. ET.

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"In recent years, we’ve seen meaningful advances in clinical studies targeting the HR+/HER2- patient population in the adjuvant setting, but only minor advancements for patients who have failed one or two prior chemotherapy regimens in the metastatic setting," said Andres Gutierrez, Chief Medical Officer of Oncolytics Biotech. "This is a significant patient population that many seem to perceive as having alternatives due to advancements in adjuvant chemotherapy and endocrine therapy, but these advancements have delivered only marginal effects in these HR+/HER2- metastatic breast cancer patients whose current options are merely palliative single-agent regimens that add no survival advantage."

Dr. Matt Coffey, President and CEO, and Dr. Andres Gutierrez, Chief Medical Officer, will discuss the planned phase 3 study design and timeline, followed by comments from Key Opinion Leader Dr. Aleix Prat. Dr. Prat will highlight why the results from Oncolytics’ phase 2 IND 213 in mBC are so meaningful, what the current treatment paradigm is for these patients receiving second and third line chemotherapy and why REOLYSIN could be an important advancement in providing an overall survival benefit to these patients. Following the call, all three speakers will field questions from Research Analysts and Institutional Investors.

Dr. Aleix Prat is the Head of the Medical Oncology of Hospital Clínic of Barcelona, Associate Professor of the University of Barcelona and the Head of the Translational Genomics and Targeted Therapeutics in Solid Tumors Group at August Pi i Sunyer Biomedical Research Institute (IDIBAPS). Dr. Prat designs and leads clinical trials of novel drugs and approaches, and is currently the scientific coordinator of SOLTI, a Spanish breast cancer cooperative group. He has recently been named as a Member of Executive Committee of The Breast International Group (BIG), an international non-profit organisation that includes more than 56 cooperative groups from around the world, more than 10,000 experts and it is linked to more than 3,000 hospitals. Dr. Prat received the International Prize for Breast Cancer Research (Padova, Italy) for his scientific discoveries regarding the characterization and clinical value of the intrinsic subtypes.

Webcast and Conference Call
Oncolytics management will host a conference call with a question and answer session for Analysts and Institutional Investors on Wednesday, February 7, 2018 at 8:30 am ET. The live call may be accessed by dialing 877-407-0839 for callers in North America and overseas callers can access by dialing 201-689-8863. A replay of this call will be available approximately two hours after the call is ended at 877-660-6853 for

North American callers and 201-612-7415 for overseas callers using the replay code 13675935 and will be available for two weeks.

A live audio webcast of the call will be accessible on the Investor Relations page of Oncolytics’ website at www.oncolyticsbiotech.com and will be archived for six months.

Cascadian Therapeutics reported merger with Seattle Genetics

On January 31, 2018, Cascadian Therapeutics, Inc., a Delaware corporation (the " Company "), reported that it has issued a press release announcing the entry into an Agreement and Plan of Merger (the " Merger Agreement "), by and among the Company, Seattle Genetics, Inc., a Delaware corporation (" Parent "), and Valley Acquisition Sub, Inc., a Delaware corporation and a wholly-owned subsidiary of Parent (" Purchaser "), pursuant to which Purchaser will commence a tender offer (the " Offer ") to purchase all of the issued and outstanding shares (the " Shares ") of common stock, par value $0.0001 per share, of the Company at a price of $10.00 per Share in cash, net to the seller, without interest and subject to any required withholding of taxes (Press release, Cascadian Therapeutics, JAN 31, 2018, View Source [SID1234523652]). If successful, the Offer will be followed by the merger of the Company with and into the Purchaser pursuant to Section 251(h) of the General Corporation Law of the State of Delaware, with the Company being the surviving corporation (the " Merger "), and becoming a wholly-owned subsidiary of Parent.

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This Schedule 14D-9 filing consists of the following documents related to the proposed Offer and Merger:

(i) Company email to employees

(ii) Company employee presentation

(iii) Letter to HER2CLIMB clinical investigators

(iv) Letter to partners and vendors

(v) Letter to vendors and suppliers

(vi) Email to temporary workers and contractors
The information set forth under Items 1.01, 8.01 and 9.01 of the Current Report on Form 8-K filed by the Company on January 31, 2018 (including Exhibit 2.1 and Exhibit 99.1 attached thereto) is incorporated herein by reference.

Additional Information and Where to Find It

The tender offer described in this communication (the "Offer") has not yet commenced, and this communication is neither an offer to purchase nor a solicitation of an offer to sell any shares of the common stock of Cascadian Therapeutics or any other securities. On the commencement date of the Offer, a tender offer statement on Schedule TO, including an offer to purchase, a letter of transmittal and related documents, will be filed with the United States Securities and Exchange Commission (the "SEC") and Cascadian Therapeutics will file a Solicitation/Recommendation Statement on Schedule 14D-9 relating to the Offer with the SEC. The offer to purchase shares of Cascadian Therapeutics common stock will only be made pursuant to the offer to purchase, the letter of transmittal and related documents filed with such Schedule TO. INVESTORS AND SECURITY HOLDERS ARE URGED TO READ BOTH THE TENDER OFFER STATEMENT AND THE SOLICITATION/RECOMMENDATION STATEMENT REGARDING THE OFFER, AS THEY MAY BE AMENDED FROM TIME TO TIME, WHEN THEY BECOME AVAILABLE BECAUSE THEY WILL CONTAIN IMPORTANT INFORMATION. The tender offer statement will be filed with the SEC by Valley Acquisition Sub, Inc. and Seattle Genetics, Inc., and the solicitation/recommendation statement will be filed with the SEC by Cascadian Therapeutics. Investors and security holders may obtain a free copy of these statements (when available) and other documents filed with the SEC at the website maintained by the SEC at www.sec.gov or by directing such requests to Innisfree M&A Incorporated toll-free at (888) 750-5834.

Cautionary Statement Regarding Forward-Looking Statements

This communication may contain, in addition to historical information, certain forward-looking statements, including, without limitation, statements regarding the pending acquisition of Cascadian Therapeutics, Inc. by Seattle Genetics, Inc. and its affiliates, including Valley Acquisition Sub, Inc. (the Offer, the merger and other related transactions are collectively referred to as the "Transactions"). Often, but not always, forward-looking statements can be identified by the use of words such as "believes," "anticipates," "plans," "expects," "expected," "will," "intends," "potential," "project," "possible," "scheduled," "estimates," "intends," "continue," "ongoing," "goal" and similar expressions or variations of such words and phrases or statements that certain actions, events, conditions, circumstances or results "may," "could," "would," "might" or "will" be taken, occur or be achieved. Forward-looking statements involve risks and uncertainties related to Cascadian Therapeutics’ business and the general economic environment, many of which are beyond Cascadian Therapeutics’ control. Such uncertainties and risks include, without limitation: uncertainties as to the timing of the Offer and merger; uncertainties as to how many of the Cascadian Therapeutics’ stockholders will tender their stock in the Offer; the possibility that various closing conditions for the Transactions may not be satisfied or waived, including that a governmental entity may prohibit, delay or refuse to grant approval for the consummation of the Transactions; the occurrence of any event, change or

other circumstance that could give rise to the termination of the Merger Agreement; the effects of the Transactions (or the announcement thereof) on relationships with employees, customers, other business partners or governmental entities; transaction costs; the risk that the Transactions will divert management’s attention from Cascadian Therapeutics’ ongoing business operations; and other risks and uncertainties detailed from time to time in documents filed by the Company with the securities regulators in the United States on EDGAR and in Canada on SEDAR, including current reports on Form 8-K, quarterly reports on Form 10-Q and annual reports on Form 10-K, as well as the Schedule 14D-9 to be filed by the Company. These risks, uncertainties and other factors could cause Cascadian Therapeutics’ actual results to differ materially from those projected in forward-looking statements. Although Cascadian Therapeutics believes that the forward-looking statements contained in this communication are reasonable as of the date hereof, it can give no assurance that its expectations are correct. All forward-looking statements are expressly qualified in their entirety by this cautionary statement. Cascadian Therapeutics disclaims any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events, conditions, circumstances or otherwise, except as required by applicable law.