On April 2, 2025 Sensei Biotherapeutics, Inc. (Nasdaq: SNSE), a clinical stage biotechnology company focused on the discovery and development of next-generation therapeutics for cancer patients, reported that John Celebi, President and Chief Executive Officer, will participate in the New Radiotherapy and Targeted Therapy Approaches panel at the Canaccord Genuity Horizons in Oncology Virtual Conference on Monday, April 7 at 2:00 p.m. ET (Press release, Sensei Biotherapeutics, APR 2, 2025, View Source [SID1234651763]).

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On April 2, 2025 Alpha Tau Medical Ltd. (NASDAQ: DRTS, DRTSW), the developer of the innovative alpha-radiation cancer therapy Alpha DaRT, reported that the FDA has approved an Investigational Device Exemption (IDE) application to initiate a pilot study for the treatment of patients with recurrent glioblastoma (GBM) using the Alpha DaRT technology (Press release, Alpha Tau Medical, APR 2, 2025, View Source [SID1234651748]).

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"This is very exciting news for patients suffering from glioblastoma, a highly aggressive form of brain cancer with an extremely poor prognosis and survival rate. In this trial, we will introduce a completely novel approach, which is specifically designed to deliver Alpha DaRT sources into brain tumors that are not amenable to surgery," said Dr. Robert B. Den, Alpha Tau Chief Medical Officer. "According to the National Brain Tumor Society, glioblastoma is one of the most complex, deadly, and treatment-resistant cancers, with an estimated average survival rate of only 8 months."

The clinical trial is expected to enroll up to ten U.S. patients with recurrent glioblastoma not amenable for surgical resection who have undergone a prior course of central nervous system radiation. The primary objective of the study is to evaluate the feasibility and safety of the treatment following the Company’s promising results from pre-clinical studies.

"This IDE approval follows the FDA’s continued recognition of the huge promise that this technology holds for patients with recurrent glioblastoma; after having already received the FDA’s Breakthrough Device Designation, followed by acceptance into the FDA’s prestigious Total Product Life Cycle Advisory Program to accelerate the Alpha DaRT treatment to market and to the GBM patients who may stand to benefit greatly," added Alpha Tau Chief Executive Officer Uzi Sofer.

About Alpha DaRT

Alpha DaRT (Diffusing Alpha-emitters Radiation Therapy) is designed to enable highly potent and conformal alpha-irradiation of solid tumors by intratumoral delivery of radium-224 impregnated sources. When the radium decays, its short-lived daughters are released from the sources and disperse while emitting high-energy alpha particles with the goal of destroying the tumor. Since the alpha-emitting atoms diffuse only a short distance, Alpha DaRT aims to mainly affect the tumor, and to spare the healthy tissue around it.

On April 2, 2025 Syndax Pharmaceuticals (Nasdaq: SNDX), a commercial-stage biopharmaceutical company developing an innovative pipeline of cancer therapies, reported that Michael A. Metzger, Chief Executive Officer of Syndax, as well as members of the Syndax management team, will participate in a fireside chat at the Stifel 2025 Virtual Targeted Oncology Forum on Wednesday, April 9, 2025, at 10:30 a.m. ET (Press release, Syndax, APR 2, 2025, View Source [SID1234651764]).

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A live webcast of the fireside chat will be available in the Investor section of the Company’s website at www.syndax.com, where a replay will also be available for a limited time.

On April 2, 2025 Astellas Pharma Inc. (TSE: 4503, President and CEO: Naoki Okamura, "Astellas") and Japanese Foundation for Cancer Research (Chairman: Toshio Asano, Ph.D., "JFCR") reported they have entered into a strategic collaboration to accelerate translational and clinical oncology research (Press release, Astellas, APR 2, 2025, View Source [SID1234651749]).

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The collaboration leverages Astellas’ unique scientific, translational and clinical expertise and JFCR’s strength as a world-class comprehensive cancer research center to quickly advance the development of novel treatments for patients with cancers that are resistant to current therapies.

Under the agreement, projects will be selected jointly based on shared interest and expertise. Selected projects will generate new translational and clinical data for Astellas’ early-stage pipeline assets, which will be integrated with Astellas’ own data to accelerate and refine these programs.

Through this collaboration, Astellas is committed to strengthening translational science and clinical research in order to deliver innovative new medicines. For JFCR, the collaboration provides early access to Astellas’ pipeline, along with additional resources and expertise to bring these therapies to patients.

Tadaaki Taniguchi, M.D., Ph.D., Chief Research and Development Officer, Astellas
"Collaborations with leading academic centers are at the heart of Astellas’ strategy to deliver valuable medicines through scientific innovation. We are pleased to collaborate with JFCR, one of the largest and well-known cancer centers in Japan, to help advance our oncology pipeline. With a diverse set of early-stage oncology assets spanning multiple cutting-edge modalities, we are committed to delivering the next generation of therapies with outcomes that matter for patients. Through our partnerships, we can collectively enhance the insights and expertise that are critical for accelerating the development of new and innovative treatments for patients in need."

Toshio Asano, Ph.D., Chairman, Japanese Foundation for Cancer Research
"Bringing new treatments to patients is our mission, and we believe that partnership between industry and academia is essential to drive drug development. We are very pleased to partner with Astellas, which has an innovative pipeline, to accelerate translational research and development. Astellas, with its outstanding global pharmaceutical R&D capabilities, and JFCR, with its unique organization that integrates the hospital and research divisions to enhance drug discovery, will work together to fulfill our mission of "Achieving Better Cancer Control" and "Well-being of People Everywhere"

On April 2, 2025 Imugene Limited (ASX: IMU), a clinical-stage immuno oncology company, reported it has received clearance from the Cohort Review Committee (CRC) to escalate the dose level in the intravenous (IV) combination arm of its Phase 1 onCARlytics trial (Press release, Imugene, APR 2, 2025, View Source [SID1234651765]).

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With the successful completion of the safety observation period the IV combination arm will progress to a higher dose level.

Known as OASIS, the Phase 1 dose escalation onCARlytics clinical trial is targeting adult patients with advanced or metastatic solid tumours. The trial aims to evaluate the safety and efficacy of two routes of administration, intratumoural (IT) injection and intravenous (IV) infusion of either onCARlytics (a CD19-expressing oncolytic virus) alone, or in combination with CD19 targeting bispecific monoclonal antibody blinatumomab (Blincyto), which is a cancer immunotherapy.

OASIS is being conducted at seven sites in the U.S. including City of Hope, University of Cincinnati, MD Anderson Cancer Center, Emory, Roswell Park, University of Pittsburgh, Northwestern and University of Nebraska, with the potential to open a total of 10 sites to recruit approximately 40-50 patients with advanced solid cancers that have spread.

Imugene’s Managing Director and Chief Executive Officer, Leslie Chong, said:

"CD19 is a very significant target for blood cancers, but solid cancers like breast, lung or gastric do not have a common target on their cell surface, and therefore the aim with onCARlytics is to make available a target for CD19 therapies to treat these solid cancers. As the trial continues to progress and dose escalation is executed, we are eager to learn of the potential impact our treatment is having for patients in need."