Cellular Biomedicine Group Announces $30.6 million Investment from Sailing Capital Overseas Investment Ltd.

On February 5, 2018 Cellular Biomedicine Group Inc. (NASDAQ: CBMG) ("CBMG" or the "Company"), a biopharmaceutical firm engaged in the development of immunotherapies for cancer, reported the receipt of a $30.6 million investment from Sailing Capital Overseas Investment Ltd. and its affiliates (collectively "Sailing"), a global private equity firm focused on China cross-border investments in disruptive global companies in the healthcare, technology and consumer sectors (Press release, Cellular Biomedicine Group, FEB 7, 2018, View Source [SID1234523793]). As part of the transaction, Sailing will appoint a representative to the Company’s Board of Directors.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

"Sailing is a highly-regarded growth equity investor which leverages its unique commercial and government relationships to enhance its portfolio companies’ businesses in China and internationally. Sailing’s investment in the Company further validates our proprietary technology platform and independently affirms our prospects for CFDA approval and commercialization in China. We are proud of the demonstrated clinical proof-of-concept of our Chimeric Antigen Receptor ("CAR") T-cell immuno-oncology platform, and Sailing’s investment will enable further clinical development by funding our multiple clinical programs for progressive malignant lymphoma, Acute B lymphocytic leukemia and Hodgkin’s lymphoma, as well as development in novel T Cell Receptor (TCR) therapies to redirect T cells for solid tumors," said Tony (Bizuo) Liu, Chief Executive Officer of CBMG.

"With the recent regulatory approvals and commercialization of CAR-T in the US and the CFDA’s issuance of final guidance for the approval of CAR-T in China, we believe an investment in CBMG is timely as the China market opportunity for cell and gene therapy is substantial. We have conducted a deep dive on the cell and gene therapy industry and found CBMG to be not only a leader in China, but also globally, of vertically integrated cell and gene therapy manufacturing know-how, as evidenced by the Company’s strategic and joint development partnerships with both GE and Thermo Fisher. GMP quality manufacturing, market leading capacity (for 10,000 patients) and a focus on GCP standards in China are critical success factors in developing cutting-edge cancer immunotherapies for the global markets. Further, we have found CBMG to have strong innovation and translation medicine sophistication, which is reflected in a strong pipeline of multiple CAR-T and TCR constructs. We also see tremendous opportunity for leading cell and gene therapy companies based outside of China to partner with CBMG, leveraging the Company’s manufacturing expertise and the favorable regulatory environment in China, to rapidly advance development programs into the clinic. We look forward to supporting CBMG’s continued clinical success and believe the Company will emerge as a leader in the cancer medicine fields," said James Xiaodong Liu, Chairman of Sailing Capital.

Cellectar Receives USPTO Notice of Allowance for Patent Covering Use of CLR 131 in Multiple Myeloma

On February 7, 2018 Cellectar Biosciences (Nasdaq: CLRB), a clinical stage biopharmaceutical company focused on the discovery, development and commercialization of drugs for the treatment of cancer, reported that the United States Patent and Trademark Office has issued a notice of allowance for U.S. Patent Application No. 15/095,641, entitled "Alkylphosphocholine Analogs for Multiple Myeloma Imaging and Therapy," which covers a method of use for CLR 131, the company’s lead radiotherapeutic Phospholipid Drug Conjugate (PDC) in multiple myeloma (MM) (Press release, Cellectar Biosciences, FEB 7, 2018, View Source [SID1234523792]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

CLR 131 is Cellectar’s investigational compound under development for a range of orphan designated cancers. CLR 131 utilizes the company’s patented PDC tumor targeting delivery platform to deliver the cytotoxic radioisotope iodine-131 directly to tumor cells. CLR 131 is currently being evaluated in a Phase 1 clinical trial in patients with relapse or refractory MM, as well as in a Phase 2 clinical trial for relapsed or refractory MM and select relapsed or refractory lymphomas. The U.S. Food and Drug Administration has granted orphan drug designation for CLR 131 in the treatment of MM.

"This patent allowance enhances our intellectual property estate and underscores the novelty of CLR 131 for the treatment of multiple myeloma, a life-threatening disease with high unmet medical need," said James Caruso, chief executive officer of Cellectar Biosciences. "Importantly, upon issuance, this patent will extend our coverage into the mid-2030s."

About Phospholipid Drug Conjugates

Cellectar’s product candidates are built upon a patented delivery and retention platform that utilizes optimized phospholipid ether-drug conjugates (PDCs) to target cancer cells. The PDC platform selectively delivers diverse oncologic payloads to cancerous cells and cancer stem cells, including hematologic cancers and solid tumors. This selective delivery allows the payloads’ therapeutic window to be modified, which may maintain or enhance drug potency while reducing the number and severity of adverse events. This platform takes advantage of a metabolic pathway utilized by all tumor cell types in all cell cycle stages. Compared with other targeted delivery platforms, the PDC platform’s mechanism of entry does not rely upon specific cell surface epitopes or antigens. In addition, PDCs can be conjugated to molecules in numerous ways, thereby increasing the types of molecules selectively delivered. Cellectar believes the PDC platform holds potential for the discovery and development of the next generation of cancer-targeting agents.

BioLineRx to Present at 2018 BIO CEO & Investor Conference in New York on February 13

On February 6, 2018 BioLineRx Ltd. (NASDAQ: BLRX) (TASE: BLRX), a clinical-stage biopharmaceutical company focused on oncology and immunology, reported that its Chief Executive Officer, Philip Serlin, will present a company update at the 2018 BIO CEO & Investor Conference on Tuesday, February 13, 2018 at 9:30 am EST (Press release, BioLineRx, FEB 6, 2018, View Source;p=RssLanding&cat=news&id=2330476 [SID1234523741]). The conference will be held at the New York Marriott Marquis.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

A live webcast of the presentation will be available on BioLineRx’s website. A replay will be available one hour after the presentation ends and will be accessible for three months following the presentation.

Investors or potential partners attending the conference who wish to meet with BioLineRx management should contact the BIO Partnering Team at [email protected].

Leap Therapeutics to Present at the 20th Annual BIO CEO & Investor Conference

On February 6, 2018 Leap Therapeutics, Inc. (NASDAQ:LPTX), a biotechnology company developing targeted and immuno-oncology therapeutics, reported that Douglas E. Onsi, Chief Financial Officer, will present a corporate overview at the 20TH Annual BIO CEO & Investor Conference being held at the New York Marriott Marquis in New York City on February 12-13, 2018 (Press release, Leap Therapeutics, FEB 6, 2018, View Source;p=RssLanding&cat=news&id=2330482 [SID1234523761]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

20TH Annual BIO CEO & Investor Conference – Leap Presentation Details:
Date: Tuesday, February 13, 2018
Time: 1:45 P.M. Eastern Time

The presentation will be webcast live and may be accessed on the Investors page of the company’s website at www.investors.leaptx.com, where a replay of the event will also be available for a limited time.

Cyclacel Pharmaceuticals to Present at the 2018 BIO CEO & Investor Conference

On February 6, 2018 Cyclacel Pharmaceuticals, Inc. (NASDAQ:CYCC) (NASDAQ:CYCCP) (Cyclacel or the Company), a clinical-stage biopharmaceutical company using cell cycle, transcriptional regulation and DNA damage response biology to develop innovative, targeted medicines for cancer and other proliferative diseases, reported that the Company will present at the 2018 BIO CEO Investor Conference being held February 12 & 13, 2018 at the New York Marriott Marquis, New York (Press release, Cyclacel, FEB 6, 2018, View Source [SID1234523742]). Spiro Rombotis, President & Chief Executive Officer will provide an overview of the Company and its progress in key programs.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Information on the presentation is as follows:

Event: 2018 BIO CEO Investor Conference
Date: Monday, February 12, 2018
Time: 10:45 am ET
Location: Odets Room, New York Marriott Marquis
A live webcast of the presentation will be available through the Company’s website: www.cyclacel.com. The webcast will be archived for 90 days.