Xynomic Pharma has acquired Greater China rights to a novel ACAT-1 inhibitor for cancer indications

On March 8, 2017 Xynomic Pharmaceuticals has acquired Greater China rights to a novel ACAT-1 inhibitor for cancer indications from Resarci Therapeutics of West Lafayette, Indiana (Press release, Xynomic Pharmaceuticals, MAR 8, 2017, View Source [SID1234535672]). It will be tested as a treatment for prostate, pancreatic and other solid tumors. Xynomic will pay $1.2 million in upfront and milestone payments, plus royalties that could total $59 million.

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20-F – Annual and transition report of foreign private issuers [Sections 13 or 15(d)]

(Filing, Annual, AstraZeneca, 2016, MAR 7, 2017, View Source [SID1234518031])

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Daiichi Sankyo Announces New Oxycodone Extended Release Tablets "Daiichi Sankyo" for Sustained Cancer Pain Treatment

On March 8, 2017 Daiichi Sankyo Company, Limited (hereafter, Daiichi Sankyo) reported that it has launched new generic oxycodone extended release formulations to treat sustained cancer pain: Oxycodone Extended Release 5 mg, 10 mg, 20 mg and 40 mg "Daiichi Sankyo" (date of approval: August 15, 2016; date of listing in the NHI reimbursement price list in Japan: December 9, 2016) (Press release, Daiichi Sankyo, MAR 7, 2017, View Source [SID1234518076]).

This oxycodone extended release tablet is an opioid analgesic providing the degree of analgesia prescribed for various cancers with moderate to severe pain, and the first tablet generic for an oxycodone extended release formulation. Our domestic subsidiary, Daiichi Sankyo Propharma Co., Ltd. (manufacturing and marketing) manufactures from drug substance to formulation using our GWATab technology*.

Daiichi Sankyo expects this drug to be able to contribute to all patients and medical staff by offering a new therapeutic option.

Product summary
Product name
Therapeutic Category
Original brand name
Oxycodone Extended Release tablets 5mg "Daiichi Sankyo"
Oxycodone Extended Release tablets 10mg "Daiichi Sankyo"
Oxycodone Extended Release tablets 20mg "Daiichi Sankyo"
Oxycodone Extended Release tablets 40mg "Daiichi Sankyo"
Sustained cancer pain treatment
OxyContinⓇTablets 5mg
OxyContinⓇTablets 10mg
OxyContinⓇTablets 20mg
OxyContinⓇTablets 40mg

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*GWATab (Gelling WAter soluble polymer matrix Tablet) technology is proprietary technology that combines a drug substance with a water-soluble polymer, releasing medication along a wide range of the gastrointestinal tract after dosing, for sustained drug efficacy.

Cyclenium Pharma announces a Research Collaboration with The Hospital for Sick Children to Identify Novel Macrocyclic Modulators for Pharmacological Targets in Multiple Therapeutic Areas

On March 07, 2017 Cyclenium Pharma Inc., an emerging pharmaceutical company specializing in the discovery and development of novel drug candidates based on proprietary macrocyclic chemistry and The Hospital for Sick Children (SickKids), one of the world’s premier biomedical research and treatment centres, reported they have entered into a research agreement designed to discover novel modulators for multiple new and existing biological targets of pharmacological interest across a variety of disease areas, including cardiovascular, immunology and oncology (Press release, Cyclenium, MAR 7, 2017, View Source [SID1234635927]). This collaboration will provide SickKids researchers with immediate access to Cyclenium’s proprietary QUEST Library of next generation macrocyclic molecules and associated chemical hit and lead optimization capabilities. The initial objective of these exploratory efforts is to identify compounds capable of interacting with specific therapeutic targets being studied at SickKids, thereby providing tools to improve the understanding of their involvement in the pathophysiology of specific diseases, with the ultimate goal of discovering novel therapeutic or diagnostic agents.

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"We are delighted that a distinguished institution like SickKids is interested in the power and capabilities of our small molecule macrocyclic technology to contribute to their cutting-edge research efforts," stated Helmut Thomas, Ph.D., President, Chief Scientific Officer & Chief Executive Officer of Cyclenium. "The combination of their internationally renowned investigators and translational expertise with our CMRT Technology and past development success in the macrocycle space provides unique opportunities for the ground-breaking discovery and development of new therapies and diagnostics."

The library will be made available to researchers through the SickKids Proteomics, Analytics, Robotics & Chemical Biology Centre (SPARC BioCentre). The SPARC BioCentre is a high-throughput drug screening facility at SickKids. One of the first studies to be initiated involves targets implicated for the treatment of cancer and immune disorders.

For Cyclenium, this is the latest in an extensive series of international discovery collaborations established with prominent companies and research institutions to explore the exciting potential of its unique macrocycle chemistry technology, including Astellas Pharma, Haplogen GmbH, Fundación MEDINA, German Cancer Research Center (DKFZ), McGill University/Goodman Cancer Research Centre, Institute for Research in Immunology and Cancer (IRIC)/Université de Montréal, and Southern Research Institute.

Virogin Biotech Ltd. Announces $5 Million in Series A+ Financing

On March 6, 2017 Virogin Biotech Ltd. ("Virogin") reported the completion of its Series A+ round of financing for a total of $5 million USD on February 28th, 2017 (Press release, Virogin Biotech, MAR 6, 2017, View Source [SID1234518865]). Virogin Biotech Ltd. specializes in cancertherapeutics research and discovery with a strong focus on innovative oncolyticvirotherapy.

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The financing was led by Sangel Capital and co-funded by bothexisting investors – Purity Star Ltd., Dahua Investment Corp. and Top FortuneVentures Ltd., and new strategic investor, FuRong Capital. FuRong Capital isthe industrial investment and commercialization arm of Shanghai FudanUniversity. The continued financial support from existing investors, alongsidethe endorsement by FuRong Capital, reflect investor confidence in Virogin’songoing development and further success.

The proceeds from this round offinancing will be used towards three areas: completion of pre-clinical research and IND enabling studies for VG161 – Virogin’s firstoncolytic virus product to enter clinical stage, continued expansion andoptimization of the research team with emphasis on clinical development andregulatory approval, and further development of the company’s product andproject pipelines.

"We are very grateful for the level of supportand dedication demonstrated by our existing investors during this round of financing,and we delightedly welcome FuRong Capital to the Virogin family." said Mr. Chris Huang, co-founder and CEO of Virogin, "Combinationtherapy will be the future direction of cancer immunotherapy, and oncolyticvirotherapy is inherently advantageous in achieving combination therapy;therefore, we expect it to be at the center of attention in the near future. Asone of the pioneers in the field of oncolytic virotherapy, Virogin possessesthe necessary technical expertise, proprietary technology and innovativeproduct design concept to be at the leading edge of this field. With thecapital infusion from this round of financing, we will be able to ensureprogress of our clinical and product development plans."

Dr. William Jia, co-founder and CSO of Virogin, also expressed hisexcitement, "We really appreciate the confidence and encouragement from theinvestors. In the past 20 months, Virogin has been growing at an incrediblepace, and has established its unique product pipeline with proprietarytechnology and innovative product design. Our first product VG161 showedexcellent pre-clinical results and we are looking forward to initiating clinicaltrials soon. The successful completion of this round of financing will fuel ourfast running engine to achieve higher speed and reach new heights. "

Dr. NanxingHe, Managing Partner at Sangel Capital, added, "As one of the earliestinvestors of Virogin, we have witnessed the level of progress the companyachieved in less than 2 years, and we sincerely admire their dedication and entrepreneurship.Dr. Jia and his research team are both knowledgeable and trustworthy. As aprofessional investment institution in the field of biomedicine, we willcontinue to be a strong supporter of Virogin, and we look forward to a brightfuture for the company."

"Weare delighted to participate in Virogin’s Series A+ round of financing," statedDr. Pengjun Sun, General Manager of FuRong Capital, "Better yet, Virogin isco-founded by a distinguished scientist and a seasoned entrepreneur, both ofwhom are alumni of Shanghai Fudan University. They have demonstrated strongexpertise and experience in their respective fields, thus we are confident inVirogin’s market competitiveness and growth potential in the biotech andpharmaceutical industry. We look forward to further collaboration betweenVirogin and Shanghai Fudan University in the areas of research and discovery,human capital, and clinical development. Collectively, we will be able tofurther promote the growth and development of Virogin."