On September 8, 2015 Boehringer Ingelheim reported that the Global Lung Cancer Coalition (GLCC) presented, at the 16th World Conference on Lung Cancer (WCLC) in Denver, USA, results of Lung Cancer: We’re Listening, a global campaign, supported by Boehringer Ingelheim (Press release, Boehringer Ingelheim, SEP 7, 2015, View Source [SID:1234507407]). The global survey intended to increase knowledge and understanding of real world challenges facing lung cancer patients and their carers. The data showed 64% of lung cancer patients and 55% of carers identified that daily life challenges, such as emotional and social issues, were more significant than medical care challenges such as diagnosis and treatment planning.1 The findings of the survey highlight the need for a more holistic approach to lung cancer care.

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Aoife McNamara, a specialist oncology nurse with the Irish Cancer Society said, "Lung cancer is the world’s biggest cancer killer, sadly the majority of patients are diagnosed at an advanced stage so addressing the medical challenges faced by patients can often be the focus of care. However the Lung Cancer: We’re Listening survey highlighted that challenges related to everyday life were often the biggest burden and as advancements in medical care continue it is paramount that there is an equal emphasis on helping patients cope with the day-to-day struggles of lung cancer. Daily life challenges need to be routinely identified and alleviated to ensure those affected by lung cancer receive the necessary spectrum of support and information to help improve patient’s lives."

The GLCC and Boehringer Ingelheim collaborated in 2013 to launch Lung Cancer: We’re Listening, a global online survey to identify the priorities and variety of challenges faced by lung cancer patients and their caregivers. Respondents included 725 patients and carers who identified their most significant challenge related to lung cancer from 200 specific challenges. The specific challenges, which had been identified by GLCC lung cancer experts, were grouped into categories and illustrated with a short text descriptor.

Daily life challenges in the category of ‘emotional and social needs’ were deemed to be the most significant with 19% of respondents affected by challenges such as expressing and sharing feelings, dealing with stigma and developing coping strategies.1 Medical care challenges in the category of ‘diagnosis’ were the most significant with 20.5% of respondents affected by challenges such as molecular tumour testing, getting a second opinion and misdiagnosis.1

More than half of patients and carers indicated their lack of ability to cope with the challenges they face, with 50.8% stating they were either unable to cope or could only cope sometimes; 56.2% of respondents stated they needed information related to the specified challenge and over a quarter (25.5%) needed a lot of help or support from either a professional or caregiver.1

Dr Jörg Barth, Corporate Senior Vice President, Therapy Area Head Oncology, Boehringer Ingelheim said, "Boehringer Ingelheim is committed to improving the treatment and the lives of patients who suffer from lung cancer as demonstrated by this important initiative. We would like to extend our thanks to the GLCC for the Lung Cancer: We’re Listening initiative and are proud to have supported it.The results deepen our understanding of the importance of supporting lung cancer patients and their carers. We will continue to support the ongoing work of the GLCC to improve the lives of patients with lung cancer, ensuring their needs are at the heart of a holistic approach to care which shifts the current paradigm beyond medical treatment."

About ‘Lung Cancer: We’re Listening’
In 2013, The Global Lung Cancer Coalition (GLCC) and Boehringer Ingelheim collaborated to create a global online survey to identify the priorities and variances in challenges faced by the lung cancer patient and carer community.

Lung cancer experts from the GLCC identified 200 challenges faced by lung cancer patients and carers, which were related to either medical care or daily life, grouped into sub-categories and illustrated with a short text descriptor. At survey entry, respondents identified their greatest challenge as relevant to either daily life or medical care and chose subsequent sub-categories of challenges, until one distinctive challenge was identified as being the most significant.

For more information on the survey methodology and results please visit:

On September 8, 2015 Roche (SIX: RO, ROG; OTCQX: RHHBY) reported that data from 138 abstracts will be presented at this year’s European Cancer Congress (ECC) from 25–29 September in Vienna, Austria (Press release, Hoffmann-La Roche , SEP 7, 2015, View Source [SID:1234507408]). Results will be presented from several clinical studies that are supporting ongoing regulatory discussions for three investigational medicines across specific types of lung, bladder and skin cancer (alectinib, atezolizumab and cobimetinib, which recently received its first approval in Switzerland where it is marketed as Cotellic). Building on its large portfolio of approved cancer medicines, these regulatory discussions represent significant progress for Roche’s pipeline in the fields of cancer immunotherapy and targeted medicines.

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"With our targeted medicines, cancer immunotherapies and the combination potential in our portfolio, we are committed to setting new standards for treating people with cancer," said Sandra Horning, M.D., Roche’s Chief Medical Officer and Head of Global Product Development. "At the 2015 European Cancer Congress, new data will be presented for three investigational medicines that we hope will be approved within the next year, including atezolizumab for people with PD-L1 expressing lung and bladder cancers."

In addition to data for alectinib, atezolizumab and cobimetinib, results will be presented across multiple tumour types from Roche’s cancer immunotherapy and targeted medicines pipeline including CEA-IL2v (RG7813), IDO Inhibitor (GDC-0919) and vanucizumab (anti-Ang2/VEGF, RG7221). The table below contains key abstracts featuring Roche medicines, including late breaking abstracts that will be presented during the Congress.

Follow Roche on Twitter via @Roche and keep up to date with the 2015 European Cancer Congress news and updates by using the hashtag #ECC2015.

On September 7, 2015 Genentech, a member of the Roche Group (SIX: RO, ROG; OTCQX: RHHBY), reported that data from 138 abstracts will be presented at this year’s European Cancer Congress (ECC) from Sept. 25 – 29 in Vienna, Austria (Press release, Genentech, SEP 7, 2015, View Source [SID:1234507412]). Results will be presented from several clinical studies that are supporting ongoing regulatory discussions for three investigational medicines across specific types of lung, bladder and skin cancer (alectinib, atezolizumab and cobimetinib, which recently received its first approval in Switzerland where it is marketed as Cotellic). Building on its large portfolio of approved cancer medicines, these regulatory discussions represent significant progress for Genentech’s pipeline in the fields of cancer immunotherapy and targeted medicines.

"With our targeted medicines, cancer immunotherapies and the combination potential in our portfolio, we are committed to setting new standards for treating people with cancer," said Sandra Horning, M.D., chief medical officer and head of Global Product Development. "At the 2015 European Cancer Congress, new data will be presented for three investigational medicines that we hope will be approved within the next year, including atezolizumab for people with PD-L1 expressing lung and bladder cancers."

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In addition to data for alectinib, atezolizumab and cobimetinib, results will be presented across multiple tumor types from Genentech’s cancer immunotherapy and targeted medicines pipeline including CEA-IL2v (RG7813), IDO Inhibitor (GDC-0919) and vanucizumab (anti-Ang2/VEGF, RG7221). The table below contains key abstracts featuring Genentech medicines, including late breaking abstracts that will be presented during the Congress.

Follow Genentech on Twitter via @Genentech and keep up to date with the 2015 European Cancer Congress news and updates by using the hashtag #ECC2015.

On September 7, 2015 Innate Pharma SA (the "Company" – Euronext Paris: FR0010331421 – IPH) reported that Professor Martine Bagot, Head of the Dermatology Department at the Saint-Louis Hospital in Paris and co-discoverer of the target KIR3DL2, will present the rationale of IPH4102, a first-in-class anti-KIR3DL2 monoclonal antibody for the treatment of CTCL, as well as the protocol of the upcoming Phase I trial at the EORTC cutaneous lymphoma task force meeting (September 25-27, 2015 in Turin, Italy) (Press release, Innate Pharma, SEP 5, 2015, http://innate-pharma.com/en/news-events/presentation-iph4102-rationale-and-phase-i-protocol-be-presented-upcoming-eortc-cutaneous-lymphoma-task-force-meeting [SID:1234507402]).

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Presentation title: "A novel targeted immunotherapy for CTCL: anti-KIR3DL2 mAb IPH4102 is potent and safe in non-clinical studies"

Session Name: Neil-Smith memorial lecture

Date: Saturday, September 26, 2015

Presentation Time: 12:30 AM – 1:00 PM

On September 4, 2015 DelMar Pharmaceuticals, Inc. (OTCQX: DMPI) ("DelMar" and the "Company"), a biopharmaceutical company focused on the development and commercialization of new cancer therapies, reported its financial results for the fiscal year ending June 30, 2015 and provided an overview of recent Company highlights and expected near-term milestones (Press release, DelMar Pharmaceuticals, SEP 4, 2015, View Source [SID:1234507397]).

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RECENT HIGHLIGHTS

VAL-083 (dianhydrogalactitol), for the treatment of refractory glioblastoma multiforme (GBM)

Completed Phase I dose-escalation in the clinical trial in refractory GBM and presented data supporting a dose response trend.
Patients receiving a dose >/= 30mg/m2 had a median survival of nine (9) months vs. five (5) months at doses up to 5mg/m2.
Initiated a Phase II expansion cohort for the GBM study at a dose of 40mg/m2. We anticipate enrolling approximately 14 patients in the Phase II expansion cohort.

To date, 19 patients have been screened and six (6) patients have initiated treatment with VAL-083 at the 40mg/m2 dose.
To further explore the therapeutic window, three (3) patients have also initiated treatment at an interim dose of 45mg/m2. The Phase II expansion cohort may be continued at this higher dose if warranted by safety data.

Continued preparation for advancement into registration-directed Phase II/III clinical trials.

Presented additional data on the activity of VAL-083 against temozolomide-resistant GBM and its potential as a therapeutic option for patients who fail or are unlikely to respond to current front-line therapy.

Added the fourth and fifth Phase I/II clinical trial sites at Mayo Clinic Cancer Center in Rochester, MN and Sarah Cannon Cancer Research Center at HealthOne in Denver, CO.

Expanding our drug development pipeline: Lung and Ovarian Cancer

Non-small cell lung cancer (NSCLC)

Presented preclinical data in lung cancer models supporting differentiation of VAL-083 versus platinum-based chemotherapy in treatment of drug-resistant NSCLC.
Announced plans to initiate clinical research in NSCLC in collaboration with Guangxi Wuzhou Pharmaceutical Group (Co) Ltd.
Ovarian Cancer

Announced the upcoming presentation of new non-clinical data supporting the activity of VAL-083 in treatment-resistant ovarian cancer.

Corporate

Raised $2.6 million gross proceeds in a registered direct offering.

Announced an additional non-dilutive funding increase of up to CDN$287,000 from the National Research Council of Canada Industrial Research Assistance Program for continued support of our non-clinical research programs.

Continued to take steps toward listing our common shares on a national stock exchange including reducing the derivative liability component of our balance sheet, appointing new independent directors and establishing required corporate governance structures and policies.

"We have made tremendous progress during this fiscal year in executing our clinical development strategy and driving value into our lead product candidate VAL-083. The promising results of the Phase I dose-escalation study were instrumental in advancing the program in GBM. We anticipate reporting additional data from the Phase II expansion cohort at upcoming peer reviewed scientific meetings and are implementing our plan to advance VAL-083 into a Phase II/III registration-directed clinical program in refractory GBM," stated Jeffrey Bacha, president & CEO of DelMar Pharmaceuticals.

"Based on promising results of grant-funded research, we are also preparing to expand the VAL-083 clinical research portfolio into non-small cell lung cancer (NSCLC), which will be funded through our collaboration with Guangxi Wuzhou Pharmaceutical (Group) Co., Ltd.," added Mr. Bacha. "We believe our VAL-083 program in NSCLC has significant future potential for partnering opportunities."

Mr. Bacha concluded, "We believe that the unique mechanism of action of VAL-083 provides a basis to address unmet medical needs in a range of cancers."

FY2016 MILESTONES

Complete enrollment of the Phase II expansion study in refractory GBM;
Advance VAL-083 into registration-directed Phase II/III clinical trials;
Expand our clinical development activities through new trials supported by our collaboration with Guangxi Wuzhou Pharmaceutical (Group) Co. Ltd.;
Continue to actively communicate our progress to the investment and medical communities through presentations at peer-reviewed scientific meetings;
Continue to build our intellectual property portfolio; and
Implement strategies to enable DelMar to meet qualifications to list its shares on a national stock exchange.

CONFERENCE CALL DETAILS
The DelMar business update conference call and live webcast is scheduled to begin today at 11:00 a.m. Eastern Time / 8:00 a.m. Pacific Time. For both "listen-only" participants and those who wish to take part in the question and answer portion of the call, the telephone Dial-in Number is (866) 394-9399 (toll-free) with Conference ID 22042321. A link to the webcast and slides will be available on the IR Calendar of the Investors section of the Company’s website at www.delmarpharma.com, and will be archived for 30 days.

SUMMARY OF FINANCIAL RESULTS FOR THE FISCAL YEAR ENDED JUNE 30, 2015
For the twelve months ended June 30, 2015 the Company reported a net loss of $4,796,030, or a net loss per share of $0.13, compared to a net income of $3,129,348, or a net income per share of $0.10 for the twelve months ended June 30, 2014. The income from 2014 was due to the revaluation of our derivative liability. During the twelve months ended June 30, 2015 the Company has reduced its derivative liability from approximately $3.3 million at June 30, 2014 to approximately $1.0 million at June 30, 2015 through warrant exercises and exchanges.

The Company ended the 2015 fiscal year with approximately $1.75 million of cash and cash equivalents. Subsequent to the 2015 fiscal year end, the company announced the closing of a registered direct placement with $2.6 million in gross proceeds received from the offering.

Based on management’s current projections, the Company has enough capital to fund its operations into the third quarter of 2016.