On October 18, 2017 Corvus Pharmaceuticals, Inc. (Nasdaq:CRVS), a clinical-stage biopharmaceutical company focused on the development and commercialization of novel immuno-oncology therapies, reported that it will present data on lead checkpoint inhibitor CPI-444 from its ongoing Phase 1/1b study in an oral session at the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) 32ND Annual Meeting, which is taking place November 8-12 in National Harbor, Maryland. Following are the details for the oral presentation (Press release, Corvus Pharmaceuticals, OCT 18, 2017, View Source;p=RssLanding&cat=news&id=2309621 [SID1234521012]).

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ORAL PRESENTATION

TITLE: Clinical Activity of Adenosine A2a Receptor (A2aR) Inhibitor CPI-444 is Associated with Tumor Expression of Adenosine Pathway Genes and Tumor Immune Modulation
PRESENTER: Jason J. Luke, M.D., FACP, Assistant Professor of Medicine, University of Chicago Medicine
SESSION: Clinical Trials: Novel Combinations
PRESENTATION DATE AND TIME: November 11, 2017, 5:45 – 6:00 p.m. EST

On October 18, 2017 Exelixis, Inc. (NASDAQ:EXEL) reported that its third quarter 2017 financial results will be released on Wednesday, November 1, 2017 after the markets close. At 5:00 p.m. EDT / 2:00 p.m. PDT, Exelixis management will host a conference call to discuss the results and provide a general business update (Press release, Exelixis, OCT 18, 2017, View Source;p=RssLanding&cat=news&id=2309609 [SID1234521013]). The conference call will be accessible via the Internet from the company’s website.

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To access the webcast link, log onto www.exelixis.com and proceed to the News & Events / Event Calendar page under the Investors & Media heading. Please connect to the company’s website at least 15 minutes prior to the conference call to ensure adequate time for any software download that may be required to listen to the webcast. Alternatively, please call (855) 793-2457 (domestic) or (631) 485-4921 (international) and provide the conference call passcode 96645455 to join by phone.

A telephone replay will be available until 8:00 p.m. EDT on November 3, 2017. Access numbers for the telephone replay are: 855-859-2056 (domestic) and 404-537-3406 (international); the passcode is 96645455. A webcast replay will also be archived on www.exelixis.com for one year.

On October 18, 2017 Five Prime Therapeutics, Inc. (Nasdaq:FPRX), a clinical-stage biotechnology company focused on discovering and developing innovative immuno-oncology protein therapeutics, reported that it will feature new preclinical data on FPT155, its novel therapeutic CD80-Fc fusion protein, in a poster presentation at the 2017 AACR (Free AACR Whitepaper)-NCI-EORTC AACR-NCI-EORTC (Free AACR-NCI-EORTC Whitepaper) International Conference on Molecular Targets and Cancer Therapeutics (EORTC-NCI-AACR) (Free ASGCT Whitepaper) (Free EORTC-NCI-AACR Whitepaper) (Press release, Five Prime Therapeutics, OCT 18, 2017, View Source [SID1234521014]). The conference is scheduled to take place October 26-30, 2017, in Philadelphia, and abstracts may now be viewed online through the itinerary planner.

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Abstract Number and Title: B005 – "FPT155, a novel therapeutic CD80-Fc fusion protein, with potent anti-tumor activity in preclinical models"
Session Title: Session PO.B01 – Immune Modulators
Session Date and Time: Sunday, October 29, 2017, 12:30 – 4:00 PM
Location: Hall E, Philadelphia Convention Center

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On October 17, 2017 Can-Fite BioPharma Ltd. (NYSE American: CANF) (TASE:CFBI), a biotechnology company advancing a pipeline of proprietary small molecule drugs that address cancer, liver and inflammatory diseases, reported the Korean Intellectual Property Office has issued patent No. 10-1741281 titled, "Pharmaceutical Composition Comprising A3 Adenosine Receptor Agonist (IB-MECA/CF-101) For Treatment of Psoriasis" for the Company’s lead drug candidate Piclidenoson (CF101) in its psoriasis indication (Press release, Can-Fite BioPharma, OCT 17, 2017, View Source [SID1234520971]).

Can-Fite has two distribution agreements in Korea including one with Kwang Dong Pharmaceutical for Piclidenoson in the treatment of rheumatoid arthritis and another with Chong Kun Dang for Namodenoson in the treatment of liver cancer.

"Korea is an important market for us, as evidenced by the two distribution agreements we already have there. This patent may increase the value of a potential distribution deal in Korea for Piclidenoson in the treatment of psoriasis," stated Can-Fite CEO Dr. Pnina Fishman. "We believe Piclidenoson is a strong candidate for the treatment of moderate to severe psoriasis due to its excellent safety profile for long-term use and its favorable comparison with Otezla, the leading oral therapy currently on the market."

In an upcoming Phase III trial expected to commence in 2018, Piclidenoson, administered orally, will be investigated compared to placebo as its primary endpoint and as compared to apremilast (Otezla) as its secondary endpoint in approximately 400 patients with moderate-to-severe plaque psoriasis. The psoriasis market is forecast to be $8.9 billion in 2018 and Otezla sales are estimated to be $2.35 billion by 2020.

About Piclidenoson (CF101)

Piclidenoson is a novel, first-in-class, A3 adenosine receptor agonist (A3AR) small molecule, orally bioavailable drug with a favorable therapeutic index demonstrated in Phase II clinical studies. Piclidenoson is currently under development for the treatment of autoimmune inflammatory diseases including rheumatoid arthritis (completed Phase II) and psoriasis (completed Phase II/III).

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