Calidi Biotherapeutics Announces Closing of $6.9 Million Underwritten Public Offering and Full Exercise of Underwriters’ Over-Allotment Option

On August 21, 2025 Calidi Biotherapeutics, Inc. (NYSE AMERICAN: CLDI) ("Calidi" or the "Company"), a clinical-stage biotechnology company pioneering the development of targeted therapies with the potential to deliver genetic medicines to distal sites of disease, reported the closing of its previously announced underwritten public offering and the exercise in full of the underwriters’ over-allotment option for gross proceeds of $6.9 million, prior to deducting underwriting commissions and offering expenses (Press release, Calidi Biotherapeutics, AUG 21, 2025, View Source [SID1234655454]).

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In connection with the offering, the Company sold (i) 1,922,764 common stock units with each unit consisting of one share of common stock and one Series I warrant to purchase one share of common stock ("Common Stock Unit") and (ii) 1,528,000 pre-funded warrant units consisting of one pre-funded warrant to purchase one share of common stock and one Series I warrant to purchase one share of common stock ("Pre-Funded Unit"). The common stock units include 450,000 units that the underwriters elected to purchase pursuant to the over-allotment option. The price per Common Stock Unit is $2.00 and the price per Pre-Funded Unit is $1.999. The Series I warrant has an exercise price of $2.00 per share, is exercisable upon issuance, and has a term expiring five years from issuance. The warrants issued in this offering are fixed priced and do not contain any variable price features.

Ladenburg Thalmann & Co. Inc. acted as sole book-running manager for the offering. Laidlaw & Company (U.K.) Ltd. acted as a co-manager for the offering.

The securities described above were offered pursuant to a registration statement on Form S-1 (File No. 333-289670), which was declared effective by the United States Securities and Exchange Commission ("SEC") on August 20, 2025. A final prospectus was filed with the SEC on August 21, 2025, and is available on the SEC’s website at View Source Electronic copies of the final prospectus may also be obtained by contacting Ladenburg Thalmann & Co. Inc., Prospectus Department, 640 Fifth Avenue, 4th Floor, New York, New York 10019 or by email at [email protected].

This press release does not constitute an offer to sell or the solicitation of an offer to buy, nor will there be any sales of these securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of such jurisdiction.

Jazz Pharmaceuticals to Participate in the 2025 Wells Fargo Healthcare Conference

On August 21, 2025 Jazz Pharmaceuticals plc (Nasdaq: JAZZ) reported that the Company will participate in the 2025 Wells Fargo Healthcare Conference. Company management will participate in a fireside chat on Wednesday, September 3, 2025, at 6:30 a.m. PDT / 9:30 p.m. EDT / 2:30 p.m. IST (Press release, Jazz Pharmaceuticals, AUG 21, 2025, View Source [SID1234655434]).

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An audio webcast of the fireside chat will be available via the Investors section of the Jazz Pharmaceuticals website at View Source A replay of the webcasts will be archived on the website for 30 days.

Immunophotonics and Swiss Cancer Institute Complete SAKK 66/17 Phase 1b/2a Multicenter Clinical Trial for Treatment of Solid Tumors

On August 21, 2025 Immunophotonics, Inc., a clinical-stage biotech company focused on developing novel immune-stimulating drugs to augment routine tumor destruction techniques, reported the completion of its multicenter clinical trial (SAKK 66/17) conducted in collaboration with the Swiss Cancer Institute (formerly known as SAKK) (Press release, Immunophotonics, AUG 21, 2025, View Source [SID1234655435]). This milestone — along with completion of the Company’s INJECTABL-1 trial covering different indications, which the Company announced in July 2025 — marks a significant advancement in evaluating the immunologically mediated anticancer effects of intratumoral injection of IP-001 following thermal ablation in patients with advanced solid tumors.

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The SAKK 66/17 trial was designed to assess the safety and tolerability of IP-001 in combination with thermal ablation in patients with various types of advanced solid tumors, with a second phase assessing efficacy for melanoma and soft-tissue sarcoma. With treatment completed for all patients in both phases, data analysis is now underway.

Prof. Dr. Markus Joerger, Principal Investigator for the study at the Cantonal Hospital St. Gallen Clinic for Medical Oncology and Hematology commented: "This collaboration between Immunophotonics and Swiss Cancer Institute highlights the importance of partnerships in advancing cancer treatments. With the completion of this trial, we made the next important step in the development of a new treatment option for patients with advanced solid tumors. The results could have a meaningful impact in the fight against cancer."

The results of this trial provide further evidence regarding safety and efficacy of IP-001 in a broader patient population. Immunophotonics and Swiss Cancer Institute remain committed to advancing the development of this potential cancer treatment and bringing it to patients in need.

About IP-001

IP-001 is a proprietary glycan polymer that generates tumor antigen depots and acts as a potent, multimodal immune stimulant intended to induce immunological responses to eradicate cancer. IP-001 is designed to (1) prolong the availability of the targeted tumor antigens, (2) facilitate the recruitment and activation of innate immune cells such as antigen-presenting cells (APCs), (3) increase the uptake of the tumor antigens into the APCs, and (4) lead to a downstream adaptive immune response against the tumor cells. Activation of a systemic, adaptive immune response allows immune effector cells to seek out and eliminate tumor cells throughout the body.

Cerus Corporation to Participate in the Cantor Global Healthcare Conference 2025

On August 21, 2025 Cerus Corporation (Nasdaq: CERS) reported that company management will participate in a fireside chat at the Cantor Global Healthcare Conference 2025 on Wednesday, September 3, 2025, at 10:55 A.M. ET (Press release, Cerus, AUG 21, 2025, View Source [SID1234655420]).

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A live webcast of the fireside chat will be available on the Events and Presentations section of the company’s website at ir.cerus.com/events-and-presentations/events-and-webcasts/. A replay will be available for 30 days after the event.

Chemomab Therapeutics to Present at H.C. Wainwright 27th Annual Global Investor Conference

On August 21, 2025 Chemomab Therapeutics Ltd. (Nasdaq: CMMB) (Chemomab), a clinical stage biotechnology company developing innovative therapeutics for fibro-inflammatory diseases with high unmet need, reported that Chief Executive Officer Dr. Adi Mor will deliver a corporate presentation at the H.C. Wainwright 27th Annual Global Investment Conference (Press release, Chemomab, AUG 21, 2025, View Source [SID1234655421]). Dr. Mor’s prerecorded presentation will be webcast and will be available starting on September 5, 2025 at 7:00 am ET. The link to access the webcast is included below and is also available at the Events section of the Chemomab website. Chemomab management will also be hosting 1×1 investor meetings during the conference on September 8 and September 9, 2025.

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Chemomab Presentation at H.C. Wainwright 27th Annual Global Investment Conference

Date: September 5, 2025
Time: Available starting at 7:00 am ET for 90 days
Venue: Virtual
Format: Prerecorded webcast presentation
Webcast Link: View Source