On September 26, 2024 ChromaDex Corp. (NASDAQ:CDXC), the global authority on nicotinamide adenine dinucleotide (NAD+) with a focus on healthy-aging research, reported that Rob Fried, CEO of ChromaDex and Founder of Tru Niagen, will participate in a fireside chat moderated by Sean McGowan, Senior Analyst at Roth Capital Partners, at the Lytham Partners Fall 2024 Investor Conference (Press release, ChromaDex, SEP 26, 2024, View Source [SID1234646874]). Wesley Yu, Vice President of Finance at ChromaDex, and Mr. Fried will also host virtual one-on-one meetings with investors.

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Company Webcast

The webcasted fireside chat will take place at 1:15 PM ET on Tuesday, October 1, 2024. The webcast can be accessed at View Source or on the Company’s website at chromadex.com. The webcast will also be available for replay following the event.

1×1 Meetings

Mr. Fried and Mr. Yu will participate in virtual one-on-one meetings throughout the event. To arrange a meeting with management, please contact Lytham Partners at 1×[email protected] or register for the event at View Sourceinvreg" target="_blank" title="View Sourceinvreg" rel="nofollow">View Source .

Further information on the conference is available at View Source .

For additional information on ChromaDex, visit www.chromadex.com.

On September 26, 2024 Mission Bio, a leader in single-cell multiomics solutions for precision medicine, reported the launch of its Tapestri Genome Integrity CNV Solution (Press release, Mission Bio, SEP 26, 2024, View Source [SID1234646890]). This new product is the only single-cell high-throughput solution for measuring genome-wide copy number variants (CNVs) on the market and is designed to fulfill important needs in the critical areas of therapeutic development oncology research.

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While genome-editing and stem cell therapies continue to harbor tremendous promise for treating complex diseases but have encountered safety concerns associated with genomic instability. The latest FDA guidance suggests that assessment of genomic integrity should include chromosomal abnormalities like CNVs (i.e., duplications and deletions) as indicators of clinical safety. Conventional methods of assessing genomic instability such as g-banding fail to provide adequate answers due to their low throughput, as they may not analyze enough cells to detect aberrations. Oncology researchers have faced similar issues unlocking the potential of CNVs to serve as prognostic or therapeutic markers associated with tumor evolution, immune evasion, and therapeutic resistance. Existing bulk techniques provide only a limited view of CNV-based clonal architecture.

Mission Bio’s Tapestri Genome Integrity CNV Solution enables both CGT developers and oncology researchers with high-throughput, single-cell multiomic analysis of genome-wide CNVs, combined with automated reporting and multiplexing capabilities to ensure even more accessibility. Compared to current methods, the solution equips CGT developers with improved assay throughput to uncover potentially adverse chromosomal events, while simultaneously measuring genome editing outcomes. For oncology researchers, the solution enables the assessment of cell-to-cell aneuploidy and CNV events across the genome with the potential to co-measure SNVs and focal CNVs. Tapestri enables these researchers the rapid characterization of clonal heterogeneity behind tumorigenesis and therapy resistance.

"While working on a new way of investigating chromosomal instability and aneuploidy within tumors, we found that Mission Bio’s Tapestri Platform was able to provide the combination of high throughput and high sensitivity we needed," said Dr. Teresa Davoli of the NYU School of Medicine’s Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology. "Mission Bio’s Tapestri platform gave our team the flexibility and customizability necessary to push our understanding of aneuploidy across thousands of single cells simultaneously." For details of her study see "KaryoTap Enables Aneuploidy Detection in Thousands of Single Human Cells."

"The launch of the Tapestri Genome Integrity CNV Solution represents a significant advancement in therapeutic development and cancer research," said Vanee Pho-Conners PhD, Senior Director of Product Management at Mission Bio. "By offering genome-wide CNV analysis at the single-cell level, we’re bridging a critical safety gap for CGT developers, who require precise genomic stability measurements to ensure the safety and efficacy of their therapies. This innovation highlights our commitment to equipping researchers with the most comprehensive tools to drive transformative breakthroughs in treatment."

The assay will be a key focus of Mission Bio at the 31st annual European Society of Gene & Cell Therapy Meeting, taking place Oct. 22-25 in Rome. For more information, please visit booth B24 or View Source

On September 26, 2024 Epitopea, a transatlantic cancer immunotherapy company, and CQDM reported the launch of a collaborative research project between Epitopea and Université de Montréal (UdeM), a leading Canadian research institution renowned for scientific innovation and technology transfer (Press release, Epitopea, SEP 26, 2024, View Source [SID1234646875]). Together, they will examine the feasibility of developing new immunotherapies to effectively treat patients with lung and ovarian cancers. This collaborative program was made possible by a grant of Canadian $1,499,457 from the government of Quebec.

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CryptoMapTM is a platform resulting from the work of Professors Claude Perreault and Pierre Thibault at the Institute for Research in Immunology and Cancer (IRIC) of UdeM. This platform has already allowed identification of non-mutated tumor antigens, uniquely expressed by cancer cells present in patients with the same type of cancer, called Cryptigens. During this project, novel CryptigenTM sets will be identified from patients with diverse origins enabling the creation of universal RNA-coding cancer vaccines targeting this new class of antigens. Epitopea will validate this unique approach to stimulate the immune system to precisely recognize and destroy cancer cells more rapidly and effectively.

This project has the potential to ‘unveil’ an unprecedented collection of CryptigensTM, an approach that distinguishes Epitopea from other cancer vaccine companies. Based on these data, Epitopea will be positioned to develop new RNA-based immunotherapies from this vast collection of patients samples and advance these innovative products into clinical trials. Epitopea’s mission aligns perfectly with Quebec’s initiatives to develop expertise in the field of RNA vaccines, as was highlighted in the recent AReNA announcement, Quebec’s new RNA cluster, which aims to position Quebec as a leader in RNA-based therapies(1).

"Our government is pleased to support CQDM’s initiative to facilitate research into new RNA-targeting therapies for the treatment of various forms of cancer. Québec is a global centre for innovation in the life sciences, and we remain committed to pushing forward on behalf of all Quebecers who are affected by cancer in one way or another,"

said Christine Fréchette, Minister of the Economy, Innovation and Energy, Minister responsible for Regional Economic Development and Minister responsible for the Greater Montreal Area.

"We are very pleased to partner with CQDM, UdeM, and our scientific co-founders, Drs. Perreault and Thibault to further extend the patient population that could potentially benefit from Epitopea’s transformative approach to treating cancer,"

commented Epitopea’s CEO, Alan C. Rigby.

"Epitopea will initially deploy these CryptigensTM in an off-the-shelf cancer vaccine approach, which we believe offers significant competitive advantages over personalized cancer vaccines being developed by many other organizations in the RNA immunotherapy ecosystem. Thanks to its refined versatility, we believe that the CryptoMapTM platform developed at UdeM could be applied to a wide range of tumor types, positively impacting patient responses in Quebec and across the globe."

"CQDM is proud to support a project that could transform the lives of cancer patients by providing accessible and effective RNA therapeutic solutions for difficult-to-treat diseases. This innovative collaboration between the Université de Montréal and Epitopea illustrates Quebec’s dynamism as a world leader in immunotherapy research. Not only will this project strengthen our understanding of cancer treatments, it will also position Quebec as a key player in the global vaccine and RNA therapy industry,"

On September 26, 2024 Cue Biopharma, Inc. (Nasdaq: CUE), a clinical-stage biopharmaceutical company developing a novel class of therapeutic biologics to selectively engage and modulate disease-specific T cells, reported the pricing of an underwritten public offering of (i) 11,564,401 shares of its common stock and accompanying common stock warrants to purchase an aggregate of 2,891,100 shares of common stock and, (ii) to certain investors in lieu of common stock, pre-funded warrants to purchase 12,435,599 shares of common stock and accompanying common stock warrants to purchase an aggregate of 3,108,900 shares of common stock (Press release, Cue Biopharma, SEP 26, 2024, View Source [SID1234646893]). Each share of common stock and accompanying common stock warrant are being sold together at a combined public offering price of $0.50, and each pre-funded warrant and accompanying common stock warrant are being sold together at a combined public offering price of $0.499. The aggregate gross proceeds of the offering are expected to be approximately $12.0 million, before deducting underwriting discounts and commissions and other offering expenses. Each pre-funded warrant will have an exercise price of $0.001 per share, will be exercisable immediately and will be exercisable until all of the pre-funded warrants are exercised in full. Each common stock warrant will have an exercise price of $0.50 per share, will be exercisable immediately and will expire five years from the date of issuance. The offering is expected to close on or about September 30, 2024, subject to satisfaction of customary closing conditions. All of the securities are being offered by Cue Biopharma.

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Oppenheimer & Co. Inc. is acting as sole book-running manager for the offering. Newbridge Securities Corporation is acting as co-manager for the offering.

A shelf registration statement on Form S-3 (File No. 333-271786) relating to the securities to be offered in the public offering was filed with the Securities and Exchange Commission (the "SEC") on May 9, 2023 and declared effective on May 26, 2023. The offering was made only by means of a prospectus supplement and accompanying prospectus that form a part of the registration statement. A preliminary prospectus supplement relating to and describing the terms of the offering has been filed with the SEC and may be obtained for free by visiting the SEC’s website at www.sec.gov. A final prospectus supplement relating to the offering will be filed with the SEC. When available, copies of the preliminary prospectus supplement and final prospectus supplement relating to the offering may also be obtained by contacting: Oppenheimer & Co. Inc., Attention: Syndicate Prospectus Department, 85 Broad Street, 26th Floor, New York, New York 10004, by telephone at (212) 667-8055, or by email at [email protected].

This press release does not constitute an offer to sell, or a solicitation of an offer to buy these securities, nor shall there be any sale of, these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

On September 26, 2024 GT Biopharma, Inc. (the "Company") (NASDAQ: GTBP), a clinical stage immuno-oncology company focused on developing innovative therapeutics based on the Company’s proprietary natural killer (NK) cell engager TriKE platform, reported that Dr. Jeffrey Miller, MD1, from the University of Minnesota Medical School and GT Biopharma’s Consulting Senior Medical Director, will participate in a panel discussion on innovative therapies for acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) at the 3rd Annual ROTH Healthcare Opportunities Conference taking place October 9, 2024 in New York, NY (Press release, GT Biopharma, SEP 26, 2024, View Source [SID1234646876]). Company management will also be participating in 1×1 meetings during the event.

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3rd Annual ROTH Healthcare Opportunities Conference – October 9, 2024
Title: Panel 4 – Focus: Hematologic malignancies
Date: Wednesday, October 9, 2024
Time: 1:15-1:55 pm ET
Participant: Dr. Jeffrey Miller, MD, Deputy Director, Masonic Cancer Center, Co-Leader Immunology Program at the University of Minnesota Medical School & Consulting Senior Medical Director, GT Biopharma

If you are interested in arranging a 1×1 meeting request with management, please contact your ROTH representative.