On August 19, 2026 Monteris Medical, the leader in minimally invasive neurosurgery with its NeuroBlate System for magnetic resonance-guided laser interstitial thermal therapy (LITT), reported the publication of the largest prospective dataset to date of patients undergoing LITT from its LAANTERN* study. Published in the distinguished Journal of Clinical Oncology (JCO), this ninth manuscript from LAANTERN analyzes outcomes from 787 tumor patients treated exclusively with NeuroBlate across 25 U.S. centers, establishing a new benchmark for clinical evidence in minimally invasive neurosurgery and highlighting key factors linked to increased survival.

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This LAANTERN analysis demonstrates that extent of ablation (EOA) is a critical determinant of survival, particularly in newly diagnosed glioblastoma and recurrent metastatic tumors. Patients who achieved ≥91% tumor ablation experienced significantly longer progression-free and overall survival, establishing EOA as a central driver of post-LITT outcomes in newly diagnosed glioblastoma brain tumors.

"LAANTERN advances how LITT is understood and applied in neuro-oncology," said Dr. Eric C. Leuthardt, principal investigator of LAANTERN, lead author of the study and a professor of neurological surgery at Washington University School of Medicine in St. Louis. "I was an early investigator of this technology, and long-term outcomes from this large cohort will help us identify the patients who are most likely to benefit from this therapeutic option." Leuthardt treats patients at Siteman Cancer Center, based at Barnes-Jewish Hospital and WashU Medicine, and is a research member of Siteman.

LAANTERN is the first – and remains the only – prospective multicenter study of this magnitude dedicated to LITT, with more than 1,000 patients enrolled and followed for up to five years. This latest publication from the LAANTERN study underscores Monteris’ sustained leadership and long-term commitment to generating rigorous, high-quality clinical evidence, culminating in outcomes data of unprecedented scale and significance for the field of minimally invasive neurosurgery.

NeuroBlate’s advanced engineering, including cooled laser probes that enable larger ablation volumes and the SideFire directional probe, which is specifically designed to address irregularly shaped lesions, optimizes the likelihood of achieving high EOA in real-world clinical practice.

For metastatic brain tumors, the study observed that earlier intervention, while lesions remain smaller, confers a survival advantage. This insight is particularly impactful for patients and providers as they make treatment decisions.

"These data show that timing matters," added Dr. Leuthardt. "Treating metastatic lesions earlier, before volume becomes prohibitive, improves patient outcomes and strengthens the role of LITT as a proactive cytoreductive option rather than a treatment of last resort."

Consistent with other publications from the LAANTERN study, patients undergoing NeuroBlate LITT experienced short hospital stays and rapid postoperative recovery, with the vast majority avoiding intensive care. Functional status and quality of life were largely preserved over time, with a favorable safety profile characterized by low complication and infection rates and few readmissions. Additional benefits included reductions in seizure burden and decreased reliance on steroids and anticonvulsant medications, supporting NeuroBlate as a minimally invasive option that promotes fast recovery while maintaining quality of life – areas of great importance to patients with brain tumors.

"Prior to the LAANTERN study, there was a lack of real-world evidence to support broad care team adoption, payer confidence and guideline inclusion," said Christa Seligman, senior director of clinical sciences at Monteris Medical. "It has been incredibly rewarding to lead a field that once did not have this foundation and to see that effort result in a publication of this caliber. Because of the dedicated LAANTERN clinical investigators and their patients, we are proud and humbled to continue leading with high-quality evidence that advances patient care."

*About LAANTERN

LAANTERN (Laser Ablation of Abnormal Neurological Tissue Using Robotic NeuroBlate System, NCT02392078) is a post-market study designed to evaluate the performance and utilization of the NeuroBlate System to generate real-world evidence and guide standard of care practice. This is the first prospective multicenter laser ablation study. All sites operated under an IRB-approved protocol and received rigorous data monitoring to ensure quality and consistency. LAANTERN enrolled over 1,000 patients in the United States and followed them up to five years. Outcomes included safety, quality of life, health economics, procedural outcomes, seizure freedom, and survival.

About the NeuroBlate System

Monteris Medical develops and markets innovative MR‑guided laser ablation systems that enable minimally invasive, robotically controlled brain surgery – often referred to as laser ablation, LITT (laser interstitial thermal therapy) or SLA (stereotactic laser ablation). The company’s NeuroBlate System is designed for adults and children aged two and older and uses laser technology to precisely destroy abnormal brain tissue, including certain brain tumors and specific areas of the brain that cause seizures due to epilepsy. NeuroBlate is the only LITT platform with a robotic interface that supports the targeted, safe delivery of laser energy and is studied prospectively. Multicenter publications on NeuroBlate show that patients typically experience short hospital stays, low rates of complications, improved quality of life and outcomes comparable to open surgical resection.

(Press release, Monteris Medical, AUG 19, 2026, View Source [SID1234670231])

On August 18, 2026 Antengene Corporation Limited ("Antengene", SEHK: 6996.HK), a leading innovative, commercial-stage global biotech company dedicated to discovering, developing and commercializing first-in-class and/or best-in-class medicines for autoimmune diseases, solid tumors and hematological malignancies, reported that the Company has been invited to participate in the Evercore 2nd China Biotech Summit, where it presented multiple key R&D highlights during a fireside chat. At the event, the Company presented updated clinical data for ATG–022 (CLDN18.2 antibody–drug conjugate [ADC]). Regarding T–cell engager (TCE) technologies, beyond its previously disclosed proprietary AnTenGager TCE platform, the Company showcased the TriGager TCE platform and multiple TCE functional modules for the first time. This further demonstrates the Company’s complete TCE engineering technology toolbox and illustrates the technical principles behind the TriGager TCE platform. In addition, the Company also introduced ATG–207, a first–in–class αCD3-TGF-β bifunctional fusion protein.

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1. ATG-022（CLDN18.2 ADC）

Latest data from the Phase II CLINCH study: As of June 26, 2026, among patients with moderate to high CLDN18.2 expression (IHC 2+ ≥ 20%) in the 2.4 mg/kg dose cohort, the objective response rate (ORR) was 42.4% (14/33) and the disease control rate (DCR) was 90.9% (30/33), with a median overall survival (mOS) of 12.85 months. In the 1.8 mg/kg dose cohort, the ORR was 46.7% (14/30), the DCR was 86.7% (26/30), and the mOS was not yet reached, with a median follow–up of 14.03 months. One patient in each of the two dose groups achieved a complete response (CR).

Favorable safety profile: Compared with the data cutoff of December 25, 2025, the incidence of Grade ≥3 treatment–related adverse events (TRAEs) in the 1.8 mg/kg dose cohort increased slightly from 19.4% to 21.0%, with only 9.7% of patients experiencing dose reduction due to TRAEs. These data demonstrate that despite more than six months of ongoing treatment follow–up and potential toxin accumulation in vivo, the incidence of Grade ≥3 TRAEs remained stable in the 1.8 mg/kg dose cohort. This favorable safety profile supports the combination of ATG–022 with chemotherapy and anti-PD-1 antibodies in the first–line setting, enabling the full therapeutic potential of ATG–022.

mOS not yet reached in the 1.8 mg/kg dose cohort: With a median follow–up of 14.03 months, mOS was not yet reached for the 1.8 mg/kg dose cohort, which further validates that ATG–022 can deliver durable long–term survival benefits for patients across all levels of CLDN18.2 expression.

Advancing clinical development across 1L to 3L gastric cancer: Antengene is currently conducting the Phase II CLINCH study, the Ib/II CLINCH–2 study, and the pivotal Phase III CLINCH–3 study of ATG–022 in Mainland of China and Australia. The Company continues to advance the clinical development of ATG-022 across different lines of gastric cancer treatment, including first-line therapy in combination with anti-PD-1 antibodies and chemotherapy (CAPOX/FOLFOX); second-line therapy in combination with anti-PD-1 antibodies; and third-line therapy as monotherapy. In addition, the CLINCH study of ATG-022 includes a basket trial cohort evaluating multiple tumor types, with the majority of patients continuing to receive treatment.
2. AnTenGager & TriGager TCE Platform

There is no universal template for designing TCE molecules across diverse targets and indications. Therapeutic potential can only be unlocked by striking a precise balance between efficacy and safety. To this end, the Company has built a comprehensive TCE engineering technology system, including proprietary platforms such as AnTenGager and TriGager, along with multiple functional modules, forming a flexible and customizable "technology toolbox". Leveraging this system, the R&D team can perform modular assembly and customized design of molecular structures based on the biological characteristics of different targets. This approach improves development efficiency while providing robust technical support for differentiated clinical strategies.

AnTenGager TCE platform: AnTenGager is Antengene’s proprietary, second-generation TCE platform featuring "2+1" bivalent binding for low-expressing targets, steric hindrance masking, and proprietary CD3 sequences with fast on/off kinetics to minimize cytokine release syndrome (CRS) and enhance efficacy. These characteristics support the platform’s broad applicability across autoimmune diseases, solid tumors and hematological malignancies indications. Leveraging this platform, Antengene has built a pipeline of multiple drug candidates, two of which have been out-licensed under exclusive license agreements:
ATG-201 (CD19 x CD3 TCE)：A global exclusive license agreement has been entered into with UCB. The Company has received USD 60 million upfront payment from UCB to date and is eligible to receive an additional USD 20 million near–term milestone payment, up to approximately USD 1.1 billion in additional milestone payments, as well as tiered royalties on future net sales.

ATG-106（CDH6×CD3 TCE）：An exclusive license agreement has been entered into with K2 Therapeutics, which was established by MPM BioImpact. Subject to satisfaction of certain near–term conditions, Antengene is entitled to upfront and near-term considerations of approximately USD 20 million, up to USD 960.5 million in additional milestone payments, as well as tiered royalties on future net sales.
TriGager TCE platform: TriGager is Antengene’s proprietary tri–specific TCE platform with steric hindrance masking technology, enabling the construction of diverse logic–gate molecules including AND–Gate, True AND–Gate and OR–Gate. AND–Gate and True AND–Gate molecules require target cells to co–express two disease–associated antigens before T–cell–mediated cytotoxicity can be triggered. This mechanism improves target specificity, reduces off–target toxicity, and expands the pool of druggable targets for TCE modalities. By contrast, OR–Gate molecules trigger T–cell–mediated killing upon recognition of either one of the disease–associated antigens, better addressing target–expression heterogeneity. Meanwhile, the platform supports incorporation of an engineered CD2 co–stimulatory moiety, which optimizes molecular developability, enhances TCE potency, and mitigates the risk of CRS, balancing efficacy and safety.
The Company also presented ATG–207, a globally first-in-class αCD3-TGF-β bifunctional fusion protein being developed for the treatment of T cell–mediated autoimmune diseases, and first disclosed its preclinical data at the 2026 European Congress of Rheumatology (EULAR 2026).

(Press release, Antengene, AUG 18, 2026, View Source [SID1234670214])

On August 18, 2026 Anixa Biosciences, Inc. ("Anixa" or the "Company") (NASDAQ: ANIX), a biotechnology company focused on the treatment and prevention of cancer, reported that management will participate in the H.C. Wainwright 28th Annual Global Investment Conference being held September 14 – 16, 2026.

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Dr. Amit Kumar, Chairman and CEO of Anixa, will deliver a presentation that will be available to view beginning at 7:00 AM ET, Friday, September 11, 2026. Dr. Kumar’s presentation will highlight Anixa’s breast cancer vaccine, being developed in collaboration with Cleveland Clinic, which completed a Phase 1 clinical trial that was funded by the U.S. Department of Defense. The trial met all primary endpoints, including safety, and protocol-defined immune responses were generated in 74% of participants. Preparations are underway for a Phase 2 trial.

Dr. Kumar will also discuss Anixa’s ovarian cancer CAR-T therapy, liraltagene-autoleucel, or lira-cel, which is being evaluated in an ongoing Phase 1 clinical trial in collaboration with Moffitt Cancer Center. Participants in this trial are highly pre-treated, recurrent and resistant ovarian cancer patients, who have failed conventional therapies and are progressing. In the lira-cel trial, dosing has advanced to the fifth and highest cohort evaluated to date, which incorporates lymphodepletion for the first time. No dose-limiting toxicities have been observed in the study to date, and four patients have surpassed one year of survival following treatment, with the longest at approximately 28 months.

"This is an exciting time for Anixa, with our ovarian cancer CAR-T program now dosing at the highest level evaluated in the trial and our breast cancer vaccine advancing toward Phase 2," said Dr. Kumar. "We look forward to sharing our progress in the coming weeks."

Details to view the presentation are as follows:

Event: H.C. Wainwright 28th Annual Global Investment Conference
Date & time: Beginning at 7:00 AM ET, September 11, 2026, and will remain available for 90 days
Webcast: View Source

Management will be available for one-on-one meetings during the conference.

On August 18, 2026 858 Therapeutics, a clinical-stage biotechnology company, reported that the U.S. Food and Drug Administration (FDA) has granted Fast Track designation to ETX-19477, the company’s internally discovered PARG inhibitor. The designation has been granted for the treatment of adult patients with BRCA-mutated, hormone receptor positive ("HR+"), human epidermal growth factor receptor 2 negative ("HER2-"), unresectable or metastatic breast cancer.

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"For patients with advanced HR+/HER2- breast cancer, there is an urgent need for new treatment options that can delay disease progression," said Jeffrey Stafford, Ph.D., CEO of 858 Therapeutics. "We are pleased that the FDA has granted Fast Track designation to ETX-19477 and are committed to working closely with the agency to accelerate its development. The designation was supported by preclinical findings and emerging clinical data from our ongoing Phase 1/2 trial, including evidence of antitumor activity."

FDA Fast Track status is designed to facilitate the development and expedite the review of new therapies that are intended to treat serious conditions with unmet medical need. Under the Fast Track designation, the ETX-19477 development program will have access to more frequent interactions with the FDA and may be eligible for accelerated approval and/or priority review if certain criteria are met.

ETX-19477 is being evaluated in an ongoing Phase 1/2, open-label, multicenter study in patients with advanced solid tumors, designed to assess safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary anti-tumor activity. The trial is currently enrolling patients in Phase 2 monotherapy cohorts in BRCA-mutated ovarian cancer and BRCA-mutated HR+/HER2- breast cancer.

About ETX-19477

Poly(ADP-ribose) glycohydrolase (PARG) is an enzyme that catalyzes the removal of poly-ADP-ribose (PAR) chains from proteins during the DNA damage response. PARG inhibition leads to selective cell death in tumors with underlying replication fork defects, including BRCAm tumors, through a mechanism distinct from PARP inhibition. ETX-19477 is an oral, potent, and selective PARG inhibitor that shows robust preclinical activity in mouse models of ovarian, breast, and gastric cancers. 858 Therapeutics is evaluating ETX-19477 in a Phase 1/2 study in patients with advanced solid tumors at multiple sites in the U.S. For more information on the Phase 1/2 study, please visit: View Source

(Press release, 858 Therapeutics, AUG 18, 2026, View Source;Unresectable-or-Metastatic-Breast-Cancer [SID1234670216])

On August 18, 2026 Eikon Therapeutics, Inc. (Nasdaq: EIKN) ("Eikon"), a late-stage clinical biopharmaceutical company dedicated to developing innovative medicines to address serious unmet medical needs, reported that its Chairman and Chief Executive Officer, Roger M. Perlmutter, M.D., Ph.D., will participate in a key opinion leader (KOL) event on Thursday, August 20, 2026, at 9:00 AM ET, hosted by Cantor Fitzgerald and featuring Dr. Timothy A. Yap, MBBS, PhD, FRCP, medical oncologist and physician scientist from the University of Texas MD Anderson Cancer Center.

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Dr. Timothy A. Yap currently serves as Vice President and Head of Clinical Development in the Therapeutics Discovery Division at the University of Texas MD Anderson Cancer Center, and is a Professor in the Department for Investigational Cancer Therapeutics (Phase I Program) and in the Department of Thoracic/Head and Neck Medical Oncology. Dr. Yap is and/or has been Principal Investigator for multiple clinical trials and translational studies evaluating novel strategies for targeting the DNA damage response in cancer and is an expert in the use of PARP inhibitors in oncology. Dr. Yap receives compensation as an advisor to Eikon, and this financial relationship has been disclosed to UT MD Anderson’s Conflict of Interest Committee in accordance with its institutional policy. Dr. Yap will discuss the current therapeutic landscape of PARP inhibition in breast, ovarian, prostate and pancreatic cancer, including usage of approved agents, therapeutic outcomes and limitations of currently available agents targeting PARP and parylation in oncology.

The event will be hosted by Imogen Mansfield at Cantor Fitzgerald. To access the archived webcast, please visit View Source A replay will be available on the Eikon website for 30 days following the event.

(Press release, Eikon Therapeutics, AUG 18, 2026, View Source [SID1234670217])