On January 16, 2024 Carcell Biopharma ("Carcell") and CATUG Biotechnology ("CATUG") reported their collaboration to provide lipid nanoparticle (LNP) services worldwide (Press release, Carcell Biopharma, JAN 16, 2024, View Source [SID1234639240]).

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This partnership aims to deliver contract research and manufacturing services globally for clients developing LNP-based drugs. These services will utilize Carcell’s proprietary cationic lipids and unique high throughput in vivo lipid screening platform, coupled with CATUG’s advanced capabilities for large-scale manufacturing of LNP-based drugs. Under the terms of the agreement, CATUG will have non-exclusive rights to utilize Carcell’s LNP technology for servicing its clients.

Lanlin Wu, CEO of Carcell, shared Carcell’s privilege to have CATUG as a strategic partner. She commended CATUG as the embodiment of the high execution speed of Chinese companies and is emerging as an industrial benchmark for gene therapy and nucleic acid drug production. Leveraging a proprietary large lipid library and internally-developed high-throughput formulation technology, Carcell has identified lipids with global intellectual property rights. When compared to industry benchmarks, these novel LNPs have demonstrated superior potency in applications that include vaccines and gene editing. Ms Wu believes that the partnership with CATUG unlocks multiple opportunities in the global non-viral nucleic acid delivery space and will contribute to the dynamic growth of the cell and gene therapy field.

Dr. Xiao Wang, CEO of CATUG, expressed that CATUG is honored to be in a strategic partnership with Carcell, whom possesses a world-class LNP development team and technical capabilities. As CATUG is committed to providing a one-stop CRDMO (Contract Research, Development and Manufacturing Organization) solution to customers globally, she believes that this newly formed strategic partnership with Carcell will empower customers who are seeking unique and high quality LNPs for drug delivery, for instance extra-hepatic delivery to immune cells. Such a partnership presents many opportunities for both parties and greatly accelerates R&D of various gene therapies and nucleic acid drugs.

On January 16, 2024 Myriad genetics presented its corporate presentation (Presentation, Myriad Genetics, JAN 16, 2024, View Source [SID1234639262]).

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On January 16, 2024 Accurus Biosciences Inc. ("Accurus") reported that it has entered into a worldwide licensing agreement for its CLDN18.2 monoclonal antibody with ImmPACT Bio USA, Inc. ("ImmPACT Bio"), a clinical-stage company focusing on the development of next generation chimeric antigen receptor (CAR) T-cell therapies (Press release, Accurus Biosciences, JAN 16, 2024, View Source [SID1234639282]).

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"We are excited to announce that ImmPACT Bio chose to utilize our potential best-in-class CLDN18.2 antibody to develop next generation CAR T therapies," said Dr. Richard Zhang, chief executive officer of Accurus. "We believe ImmPACT’s programs have the potential to deliver differentiated and powerful therapies to benefit cancer patients."

Under the terms of the agreement, Accurus Biosciences has granted exclusive worldwide rights to ImmPACT Bio to develop and commercialize next generation cell therapies using a designated antibody from Accurus’ CLDN18.2 antibody portfolio. Accurus retains the rights to develop and commercialize its CLDN18.2 antibody portfolio for all non-cell based therapeutic applications. The financial terms were not disclosed

On January 16, 2024 Propanc Biopharma, Inc. (OTC Pink: PPCB) ("Propanc" or the "Company"), a biopharmaceutical company developing novel cancer treatments for patients suffering from recurring and metastatic cancer, reported that a certificate of grant for the Company’s foundation patent was received from the Canadian Intellectual Property Office (Press release, Propanc, JAN 16, 2024, View Source [SID1234639263]). The foundation patent covers composition claims for the Company’s lead product candidate, PRP. In further news, the PRP dosing and method to treat cancer stem cells (CSCs) patents were validated in countries across Europe, resulting in the Company’s IP portfolio growing to 87 patents filed in major global jurisdictions.

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The Canadian foundation patent is the final application to receive a certificate of grant in the Company’s foundation patent family (there are two divisional patents remaining citing additional inventions in the US and Mexico further dividing an original patent,). This means that grant status has been secured in every jurisdiction in which the Company has filed a foundation patent application. Propan has achieved grant status for the foundation patent in over 30 different countries across North America, Europe, Asia, the Middle East and Japan.

The PRP dosing patent is an important part of the IP portfolio covering possible future clinical dosage ranges for PRP as the Company advances into early stage clinical development. For the CSCs patent, the claims cover a method to minimize the progression of cancer in a patient who has already received a first line treatment by detecting the presence of CSCs, followed by administering PRP. The future potential clinical application describes when a patient experiences a relapse and the cancer returns after primary standard of care has been applied. Europe is considered a major global region and in 2022, the worldwide pharmaceutical market was valued at approximately $1.48 trillion by Statista.com and accounted for 23.4% of global pharmaceutical sales in 2021, according to the European Federation of Pharmaceutical Industries and Associations (EFPIA).

"The advancement of our growing IP portfolio in these major regions gives us confidence that we are leading a novel approach using proenzyme technology as a long-term therapy for the treatment and prevention of metastatic cancer from solid tumors by targeting and eradicating CSCs," said Mr. James Nathanielsz, Propanc’s Chief Executive Officer. "Our lead product candidate, PRP, is unique from other approaches as it targets CSCs, but leaves healthy cells alone, making it less toxic compared to standard treatment approaches. Furthermore, PRP is known as differentiation therapy, which means it does not directly kill CSCs, but enforces them to return to a less malignant state so they die naturally. This means a less aggressive and toxic approach, providing a better quality of life for the patient, but we hope effective over a prolonged period, because you can treat them for longer, minimizing the threat of recurrence. We look forward to advancing PRP into the clinic, and together with our growing IP portfolio, establishing the Company as a pioneer in the way we treat this killer disease."

On January 16, 2024 InnoCare Pharma (HKEX: 09969; SSE: 688428), a commercial-stage biotech company, reported that the U.S. Food and Drug Administration (FDA) has cleared the Investigational New Drug (IND) application for the Company’s B-cell lymphoma-2 (BCL2) inhibitor, ICP-248 (Press release, InnoCare Pharma, JAN 16, 2024, View Source [SID1234639283]). This is InnoCare’s fifth innovative drug to enter the clinical stage in the U.S.

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This is a Phase I study to evaluate the safety, tolerability, pharmacokinetics and preliminary efficacy of ICP-248 in hematologic malignancy patients.

ICP-248 is a novel, orally bioavailable BCL2-selective inhibitor, which aims to treat hematologic malignancies as a monotherapy or in combination with other therapies. The Phase I dose escalation trial of ICP-248 is ongoing in China, and the preliminary results demonstrated good efficacy and safety profiles.

BCL2 is an important regulatory protein of the apoptosis pathway, and its abnormal expression is related to the development of various hematologic malignancies. ICP-248 exhibits its anti-tumor effects by selectively inhibiting BCL2 and restoring the mechanism of programmed cell death.

Dr. Jasmine Cui, the Co-founder, Chairwoman and CEO of InnoCare said, "ICP-248 would become an important asset for the Company’s globalization after orelabrutinib. The current study results will support ICP-248 to treat hematologic malignancies as a monotherapy or in combination with other therapies. Meanwhile, InnoCare is dedicated to building a leading franchise in hemato-oncology, and we have developed multiple drugs that cover a variety of important hemato-oncology targets such as BTK, CD19, CD20xCD3, BCL2 and E-3 ligase to address unmet medical needs."