On July 6, 2026 Cancer Research UK, Cytovation and the Norwegian Cancer Society reported a new multi-national Phase 2 clinical trial (CLARITY; ISRCTN15479264) for people with advanced adrenocortical carcinoma (ACC), a rare and aggressive cancer affecting the adrenal glands. The trial currently has multiple sites open in the UK, with further sites planned across the UK and Europe.

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Around 350 people in the UK are diagnosed with ACC every year*. Treatment options are limited, with around 130 people dying from adrenal gland cancer every year in the UK**, underlining an urgent need for new therapies.

For rare cancers, like ACC, where patient populations are smaller, recruitment for clinical trials in a single country can be challenging. Running studies with international partners helps clinical teams to move faster and give more patients with rare cancers access to cutting-edge therapies.

CY-101 (getacatetide), developed by biotech company Cytovation, is a novel intratumoral peptide immunotherapy designed to convert immune-resistant "cold" tumours (such as ACC) into immune-active "hot" tumours. It does this by stimulating local immune activation directly within the tumour microenvironment, while simultaneously inhibiting the Wnt/β-catenin signalling pathway, a key driver of immunotherapy resistance in cancers such as ACC.

Dr Lars Erwig, Director of the Centre for Drug Development at Cancer Research UK, said:
"People living with ACC deserve better treatment options and we are pleased the CLARITY study has reached this exciting stage. We thank our partners, Cytovation and the Norwegian Cancer Society for their ongoing collaboration to help bring us closer to a world where people with rare cancers live longer, better lives, free from the fear of cancer."

Professor Debashis Sarker, Professor of Experimental Oncology at King’s College London, Consultant Medical Oncologist at Guy’s, St Thomas’ and King’s College Hospitals, and Chief Investigator of the study, said:
"Advanced ACC is a rare and highly challenging cancer with very limited treatment options and clinical trials available for patients, leading to poor outcomes. This makes opening a new clinical trial for advanced ACC a very important milestone. We are excited by the scientific rationale and potential of CY-101 and deeply grateful to the patients and clinical research teams participating in this trial."

CY-101’s development builds on Cytovation’s Phase 1 CICILIA trial, which demonstrated encouraging outcomes in people with solid tumours, including ACC. These results highlight CY-101’s potential to address the specific mechanisms of ACC.

Dr Lars Prestegarden, CEO of Cytovation, said:
"Reaching this milestone is an important step for patients with ACC, where treatment options remain very limited. The activity we observed in the patients with ACC enrolled in our Phase 1 CICILIA trial gave us strong reason to advance into a dedicated Phase 2 study in this disease. We are grateful to Cancer Research UK and the Norwegian Cancer Society for their commitment to bringing new options to people with rare cancers, and to the patients, families and clinical teams making the CLARITY trial possible."

Cancer treatments are becoming increasingly more targeted which, while increasing efficacy and reducing side effects, narrows the eligibility criteria for taking part in a clinical trial. Cancer Research UK and the Norwegian Cancer Society have worked together since 2023 to broaden access to cutting-edge clinical trials across Europe, with this study being the latest collaboration.

Ingrid Stenstadvold Ross, CEO of the Norwegian Cancer Society, said:
"We are excited that our first joint project with Cancer Research UK’s Centre for Drug Development involves a Norwegian innovation, focused on patients with a rare cancer and a substantial unmet need. With the opening of this trial, the treatment is finally reaching patients in the UK and soon also in Norway and other European countries. We are proud to work alongside our partners to develop a new therapy that could offer hope to patients facing aggressive disease."

Cancer Research UK’s Centre for Drug Development has sponsored, designed and is delivering the Phase 2 CLARITY trial. Cytovation is licensing the use of CY-101 for the clinical trial. The Norwegian Cancer Society’s support provides access to the additional resources, patients and sites required for trials in rare diseases. Cancer Research Horizons, Cancer Research UK’s innovation arm, continues to manage the commercial relationship between the three parties.

(Press release, Cytovation, JUL 6, 2026, View Source;utm_medium=rss&utm_campaign=cancer-research-uk-and-partners-announce-new-global-phase-2-trial-in-rare-adrenal-gland-cancer [SID1234669070])

On July 6, 2026 Moleculin Biotech, Inc., (Nasdaq: MBRX) ("Moleculin" or the "Company"), reported that Walter Klemp, Chairman and Chief Executive Officer of Moleculin, participated in a Virtual Investor "What This Means" segment.

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For the segment, Chairman and CEO Wally Klemp discusses the positive preliminary unblinded efficacy results from the first 45 patients enrolled in Part A of the pivotal Phase 2/3 MIRACLE trial evaluating Annamycin in relapsed or refractory acute myeloid leukemia (R/R AML). During the conversation, Mr. Klemp provides his perspective on the significance of the early efficacy trends observed across both Annamycin treatment arms, summarizes the key data, and discusses the commercial opportunity, including insights from the Company’s recent market research assessing the potential addressable market for Annamycin if approved.

(Press release, Moleculin, JUL 6, 2026, View Source [SID1234669071])

On July 6, 2026 Novartis reported that it has entered into an agreement to acquire Myricx Bio ("Myricx"), a privately held UK-based biotechnology company developing a new class of antibody-drug conjugates (ADCs), using N-myristoyltransferase inhibitor (NMTi) payloads.

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The proposed acquisition would strengthen the Novartis oncology pipeline and advance next-generation targeted drug conjugates with novel payload mechanisms. Myricx’s approach is designed to deliver a differentiated cancer-killing payload directly to tumor cells, with the potential to address limitations of commonly used ADC payload classes such as TOPO-1 inhibitors. Myricx is developing two lead assets directed towards the targets B7-H3 and HER2, with potential across multiple solid tumor settings.

"ADCs have become an important part of cancer treatment, but there remains a clear need for new payload mechanisms to overcome resistance and expand their impact for patients," said Fiona Marshall, President of Biomedical Research at Novartis. "Myricx Bio has developed a promising NMTi payload platform with a differentiated mechanism that could broaden the use of ADCs across multiple tumor settings. This proposed acquisition reflects our strategy to scale innovative platforms, as we have with radioligand therapies, to deliver more durable, transformative treatments for patients."

NMT is an enzyme that helps important proteins function inside cells, which is essential for how cancer cells grow and survive. By inhibiting NMT, Myricx’s payload is designed to disrupt critical processes that cancer cells rely on. Preclinical data suggest this novel NMTi payload may have broad activity across solid tumors, including TOPO-1 resistant models, and may enable more effective use of ADCs in settings where existing payload classes have limitations.

More broadly, this agreement would give Novartis the opportunity to help establish NMTi, if clinically validated, as a new class of ADC payloads that could be applied across additional targets and platforms.

Transaction Details
Under the terms of the agreement, Novartis will pay USD 1.1bn upfront, with up to USD 400m in potential milestone payments to acquire Myricx Bio. The transaction is expected to close in H2 2026, subject to the satisfaction or waiver of customary closing conditions, including regulatory approvals.

(Press release, Novartis, JUL 6, 2026, View Source [SID1234669072])

On July 06, 2026 NOMAD Power Solutions, Inc. ("NOMAD" or the "Company"), reported that it has completed its name change from LIXTE Biotechnology Holdings, Inc. (Nasdaq: LIXT) to NOMAD Power Solutions, Inc (Nasdaq: NMAD).

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The Company’s common stock will begin trading today under its new ticker, NMAD on the Nasdaq Stock Market. Shares under the symbol LIXT ceased trading at the close of market on Thursday, July 2, 2026.

The new corporate name reflects the next chapter for the Company in the AI energy infrastructure equipment and services sector, following the recent acquisition of NOMAD Transportable Power Systems, a pioneer in the meeting the rapidly growing power demands of AI and hyperscale data centers. Nomad introduced the first mobile, utility-grade truck-transportable battery energy storage system.

The company’s innovative mobile products provide instantaneous power to an electrical grid or facility, bypassing months of construction typically required for traditional fixed installations. NOMAD’s patented platforms are deployed on semi-trailers, and serve emerging AI-driven applications, along with utilities, industrial operators, government agencies, and critical infrastructure providers through equipment sales, rentals and Energy-as-a-Service offerings. The Company no longer plans to operate in its legacy life sciences market and is exploring options for a sale or merger of those assets.

"Our new corporate name marks an important milestone in the Company’s transformation, reflecting who we are today and where we are headed," said Geordan Pursglove Chief Executive Officer. "We believe the broad AI energy sector offers significant, scalable growth opportunities and tangible long-term shareholder value, as we address a multi-billion dollar rapidly growing marketplace."

(Press release, Nomad Power Solutions, JUL 6, 2026, View Source [SID1234670432])

On July 6, 2026 FORUS Therapeutics Inc ("FORUS"), a wholly owned subsidiary of PharmaEssentia Corp, reported that it has received a Notice of Compliance (NOC) authorizing BESREMI (ropeginterferon alfa-2b) for the treatment of adults with polycythemia vera (PV). BESREMI is expected to become commercially available in Canada in the coming weeks.

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Polycythemia vera is a rare, chronic blood cancer characterized by overproduction of red blood cells, which increases blood viscosity and can lead to serious complications, including thrombosis, stroke, myocardial infarction, and progression to myelofibrosis or acute myeloid leukemia.

"We are very pleased that Health Canada has approved BESREMI for the treatment of adults with polycythemia vera," said Ko-Chung Lin, Ph.D., Founder and CEO of PharmaEssentia. BESREMI is a next-generation interferon demonstrated to provide durable hematologic and molecular responses, reduced symptom burden, and a favorable safety and tolerability profile. We look forward to working closely with Canadian hematologists and other key stakeholders to make BESREMI available to patients living with PV across Canada.

"Polycythemia vera is a chronic myeloproliferative neoplasm that requires long-term management to reduce the risk of complications and control symptoms. The approval of BESREMI in Canada is an important and welcome development for patients living with PV and for the physicians who care for them," said Dr. Shireen Sirhan, President, Canadian Myeloproliferative Neoplasms Group; Vice-President (Research) , Quebec Research Group for Chronic Myeloid Leukemia and Myeloproliferative Neoplasms (GQR-LMC-NMP); Hematologist, Jewish General Hospital, McGill University Montreal. The availability of an interferon therapy specifically approved for PV has been long anticipated within the Canadian MPN community and represents a meaningful expansion of the treatment options available to patients. This approval reflects continued progress in the field and supports a more individualized approach to the management of PV.

(Press release, FORUS Therapeutics, JUL 6, 2026, View Source;utm_medium=rss&utm_campaign=forus-therapeutics-announces-health-canada-approval-of-besremi [SID1234669073])