On May 19, 2026 Incyte (Nasdaq:INCY) and Edison Scientific reported a strategic collaboration to employ Kosmos, Edison’s AI scientist, for Incyte’s discovery and development work.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Kosmos will be embedded across the Incyte discovery and development lifecycle, enabling continuous learning from translational and clinical data, real-time synthesis of evidence and predictive models of therapeutic performance.

The initial deployment will be focused on high-impact use cases in target discovery and validation and translational biology, centered on embedding Edison’s AI capabilities within Incyte’s research workflows to support more efficient exploration of experimental, clinical and biomarker data with the potential to expand across Incyte’s broader R&D organization. The companies will work together to measure impact on decision quality and long-term pipeline productivity as the system evolves.

"Our vision is for our data to become a learning system that enhances every decision," said Pablo J. Cagnoni, M.D., President and Global Head of Research and Development at Incyte. "This partnership aims to maximize our data’s value by integrating AI to guide experimental design and improve the quality and consistency of scientific and development decisions. Our goal is not just faster development, but better outcomes across our programs."

"By using systems that learn from our experimental and clinical data, we can enhance result interpretation, creating a feedback loop that boosts both speed and quality in future programs," added Patrick Mayes, Ph.D., Executive Vice President and Chief Scientific Officer at Incyte.

At the core of the collaboration is a new model for biopharma: one in which a company’s data is not just stored and analyzed, but becomes a compounding asset, used to train AI systems that improve over time and systematically enhance experimental and clinical outcomes.

"Most AI efforts in pharma treat data as something to analyze," said Sam Rodriques, Ph.D., Chief Executive Officer of Edison Scientific. "What we are building treats data as something to learn from continuously. The result is a system that compounds—where every experiment, every clinical readout and every decision improves the underlying models. That is how companies, like Incyte, will turn their data into a sustainable advantage over their competitors."

(Press release, Incyte, MAY 19, 2026, View Source [SID1234665885])

On May 19, 2026 Torqur AG, a subsidiary of Swiss Rockets AG, reported it will present new clinical and translational findings from its actinic keratosis (AK) program at the 7th Dermatology Drug Development Summit Europe, taking place in Amsterdam, the Netherlands, from May 19–21, 2026.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

During the summit, the Torqur team will deliver a scientific presentation, highlighting the company’s progress in the development of topical bimiralisib for actinic keratosis (AK), a common precancerous skin condition with significant unmet medical need.

The presentation will feature recent clinical and translational data supporting the continued development of bimiralisib, a dual pan PI3K/mTOR inhibitor designed to target a key oncogenic signaling pathway involved in the progression of actinic keratosis and cutaneous squamous cell carcinoma. Recent clinical findings demonstrated encouraging field-directed efficacy and favorable tolerability, supporting a differentiated mechanism-driven therapeutic approach.

Alongside the topical bimiralisib program, the oral bimiralisib program is informed by the broader oncology interest in targeting the PI3K/mTOR pathway, one of the most frequently dysregulated pathways in cancer. While many approaches have focused on isoform-selective inhibition, increasing scientific attention is being given to broader pathway inhibition to address pathway complexity and resistance mechanisms, positioning bimiralisib as a differentiated dual PI3K/mTOR inhibitory approach.

Torqur AG will be represented at the summit by Dr. Dana Novac, Chief Medical Officer; Dr. Petra Hillmann, Head of Translational Science; and Dr. Patrick Schnider, Head of Research & Development.

Dana Novac and Petra Hillmann will represent the company as featured speakers during the scientific program.
"Actinic keratosis remains a disease in which patients and physicians continue to need more effective and better-tolerated treatment options. We look forward to presenting the progress of our bimiralisib program and discussing the translational and clinical findings supporting its further development," said Dana Novac, Chief Medical Officer.

(Press release, Torqur, MAY 19, 2026, View Source [SID1234665870])

On May 19, 2026 BioLineRx Ltd. (NASDAQ: BLRX) (TASE: BLRX), a clinical development stage biopharmaceutical company pursuing life-changing therapies in oncology and rare diseases, and Hemispherian AS, a clinical-stage oncology company developing novel small molecule therapeutics, reported highly encouraging new preclinical data that further support the recently initiated Phase 1/2a clinical trial evaluating GLIX1 for the treatment of recurrent and progressive GBM and other high-grade gliomas.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

GBM remains one of the most aggressive and treatment-resistant cancers, urgently in need of breakthrough innovations and more effective treatment.

In a comprehensive pre-clinical program, orally administered GLIX1 demonstrated robust anti-tumor activity in orthotopic cell-derived xenograft (CDX) GBM models, as well as in a newly completed subcutaneous TMZ-resistant patient-derived xenograft (PDX) GBM model. In the three orthotopic CDX studies, significant tumor growth inhibition and survival benefit were observed following treatment with GLIX1 across all doses tested, with greater benefit at higher dose levels. In these models, mice treated with TMZ also showed significantly decreased tumor volume and survival benefit. Most notably, in the subcutaneous PDX model, GLIX1 demonstrated a robust anti-tumor effect while TMZ showed no effect.

"The compelling results from these studies, including the recently completed TMZ-resistant PDX model, are very exciting as they suggest that GLIX1 may bring hope to a broad range of patients with GBM," said Philip Serlin, Chief Executive Officer of BioLineRx. "In addition, the pre-clinical dose-response characterization adds important information for dose optimization in the Phase 2 part of the ongoing clinical study. We believe GLIX1 has the potential to offer a novel therapeutic approach in this cancer indication, as well as in multiple other cancer indications where DNA damage repair is critical for cancer survival."

BioLineRx and Hemispherian plan to present the data from these studies at one or more future medical conferences.

About Glioblastoma
Glioblastoma is the most common primary brain tumor and remains one of the most aggressive and treatment-resistant cancers, urgently in need of breakthrough innovations and more effective treatment. The standard of care for newly diagnosed GBM established since 2005 consists of surgery, followed by radiotherapy and treatment with temozolomide (TMZ), with no established standard of care for recurrent GBM. However, patients with unmethylated MGMT[1] promoter status (who represent more than half of all GBM patients) have demonstrated a limited response to TMZ.

About GLIX1
GLIX1 is a first-in-class, orally administered, brain penetrating, small molecule activator of the Ten-Eleven Translocation 2 (TET2) pathway that is commonly inhibited in cancer. Activating the novel TET2 pathway by GLIX1 overwhelms the DNA repair capacity of cancer cells, resulting in apoptotic cancer cell death.

About the Phase 1/2a Trial with GLIX1
The Phase 1/2a trial is an open-label, multicenter trial. Part 1 of the trial is a dose escalation study where patients receive GLIX1 daily as monotherapy. This part is expected to recruit up to 30 patients with recurrent and progressive GBM and other high-grade gliomas. The primary objective is to establish a maximum tolerated dose (MTD) and/or a recommended dose based on safety, PK/PD and preliminary efficacy. Updates to the Phase 1/2a trial are anticipated during H2 2026, with full results on the dose escalation part expected in 2027.

The Phase 2a expansion part of the trial is planned to include additional indications, including newly diagnosed GBM, as well as select cancers, with GLIX1 as monotherapy or in combination with standard of care (including in combination with PARP inhibitors). These cohorts are expected to identify preliminary efficacy, PD assessments and dose optimization data, serving as the basis for a rapid and effective advanced clinical development plan.

For more information on the Phase 1/2a trial, please visit NCT07464925.

[1] MGMT stands for O6-methylguanine-DNA methyltransferase, a DNA repair enzyme.

(Press release, BioLineRx, MAY 19, 2026, View Source [SID1234665855])

On May 19, 2026 Plus Therapeutics, Inc. (Nasdaq: PSTV) (the "Company"), a clinical-stage pharmaceutical company developing targeted radiotherapeutics for central nervous system (CNS) cancers, reported that it has signed an agreement to enter into a strategic partnership with Ephemeral Technologies ("Ephemeral") to deliver a unique AI execution platform for CNS oncology. The AI execution platform is designed to integrate, organize, and derive actionable intelligence from longitudinal therapeutic, diagnostic and bioinformatic data sets generated across Plus’ CNS oncology technology programs.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

"Plus is building a CNS oncology platform to integrate across our therapeutics, diagnostics and bioinformatics data sets," said Marc Hedrick, M.D., Plus Therapeutics President and Chief Executive Officer. "Our partnership with Ephemeral and its expertise in deploying artificial intelligence brings industry-proven engineering and advanced AI capabilities to the most challenging area of oncology. This partnership is intended to help further position Plus as a leader in CNS oncology and accomplish our mission of improving survival for patients with the most devastating cancers."

Ephemeral was founded by the former co-heads of Palantir Technologies’ U.S. healthcare business. Ephemeral was launched to bring AI solutions to life sciences to accelerate drug development.

Plus and Ephemeral believe the combination of multi-modal, longitudinal data with generative AI reasoning and agentic workflows will create both near- and long-term value for shareholders. Beginning in 2026, Plus anticipates tangible improvements in both laboratory and clinical operating efficiency and workflows. Beyond 2026, Plus intends to increasingly use artificial intelligence for fully integrated operational workflows, operational decision support, translational and treatment response analytics, patient stratification, precision oncology initiatives, pharmaceutical collaborations and real-world evidence initiatives.

"Ephemeral was founded to help companies like Plus align AI to real scientific and operational execution to more quickly deliver better medicines to patients," said Drew Goldstein, Ephemeral Co-Founder and Co-Chief Executive Officer. "Plus’ unique positioning and data sets in CNS oncology represents an ideal opportunity for Ephemeral, and we are proud to leverage our technology to support Plus’ mission to help patients with CNS cancers."

Under the agreement, Plus Therapeutics and Ephemeral will assess and implement AI-enabled data infrastructure to support the integration, organization, and analysis of complex CNS oncology data sets generated through the Company’s therapeutic and diagnostic workflows. No financial terms of the agreement were disclosed.

(Press release, Plus Therapeutics, MAY 19, 2026, View Source [SID1234665872])

On May 19, 2026 Black Diamond Therapeutics, Inc. (Nasdaq: BDTX), a clinical-stage oncology company developing MasterKey therapies that target families of oncogenic mutations in patients with cancer, reported it will host a webcast for investors to present updated results from its ongoing Phase 2 trial of silevertinib in frontline patients with EGFR mutated non-small cell lung cancer on Thursday, May 21, 2026, at 5:30 p.m. ET.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Webcast information

The webcast can be accessed under "Events and Presentations" on the Investors section of the Black Diamond website at www.blackdiamondtherapeutics.com. A replay of the webcast will be available following the completion of the event for a limited time.

(Press release, Black Diamond Therapeutics, MAY 19, 2026, View Source [SID1234665856])