On April 15, 2026 Arima Genomics, Inc., a company leveraging whole-genome sequence and structure information to advance cancer therapy selection, reported that it will present new data at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2026, taking place April 17-22, 2026, in San Diego, California. The five presentations will highlight the power of Arima’s Hi-C sequencing-based approach to detect clinically relevant structural variants and uncover important drivers of cancer across solid tumors. Together, they reflect Arima’s vision for expanding cancer genomics beyond sequence alone.

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"Structural variants are an important driver of cancer biology, and Arima is focused on bringing that dimension into cancer genomics," said Anthony Schmitt, PhD, Senior Vice President of Science at Arima Genomics. "The data we will present at AACR (Free AACR Whitepaper) reflect the breadth of that opportunity across solid tumors."

The presentations include data demonstrating Arima’s ability to detect structural variants in lung and gastrointestinal tumors, showing concordance with traditional methods while also identifying variants those methods may miss. That capability, demonstrated across multiple studies, underpins Arima’s Aventa FusionPlus clinical assay. Additional presentations demonstrate the ability to detect and predict the functional impact of enhancer hijacking rearrangements and extrachromosomal DNA (ecDNA) amplifications in non-small cell lung cancer (NSCLC). A fifth presentation extends Arima’s work in fusion and rearrangement detection into gynecologic carcinosarcoma through analysis of aberrations involving genes potentially linked to homologous recombination deficiency (HRD). Together, the AACR (Free AACR Whitepaper) data show the range of biological and clinical questions that a structural variant-focused approach can address.

"These studies show how Arima’s technology provides a new lens with which to view the cancer genome in a way that no other technology can," said Tom Willis, PhD, Chief Executive Officer of Arima Genomics. "We are already putting this approach to work for patients through our Aventa clinical tests, while continuing to build the evidence and applications that support a more complete view of cancer."

List of Poster Presentations

April 20, 2026, 2:00-5:00 PM

Detection and functional assessment of extrachromosomal DNA amplifications in FFPE lung tumor specimens using Hi-C sequencing

Poster Number: 3259
Location: Section 22
Discovery and functional characterization of enhancer hijacking oncogene rearrangements in NSCLC using Hi-C sequencing of FFPE tumors

Poster Number: 3747
Location: Section 41
Fusions and rearrangement detection in gastrointestinal and lung tumors leveraging low-pass whole-genome sequencing based Hi-C chemistry

Poster Number: 3817
Location: Section 44
Genome wide testing of archived ovarian and uterine carcinosarcoma FFPE tissue using FusionPlus Hi-C to determine HRD status

Poster Number: 3970
Location: Section 49
April 21, 2026, 2:00-5:00 PM

Actionable fusions and rearrangements can be efficiently identified by Hi-C whole genome sequencing in lung tumors

Poster Number: 6521
Location: Section 43

(Press release, Arima Genomics, APR 15, 2026, View Source [SID1234664423])

On April 15, 2026 Kazia Therapeutics (NASDAQ: KZIA), a clinical-stage oncology company developing differentiated therapies for cancers with high unmet need, reported the appointment of Dr. Sudha Rao as Chief Scientific Officer (CSO).

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Dr. Rao is the scientific originator of the epigenetic framework underlying paxalisib and a pioneer in next-generation therapeutic platforms, including PD-L1 protein degradation and SETDB1-targeted chromatin modulation. Her appointment brings deep expertise in translational epigenetics, AI-guided epi-drug discovery capability, liquid and spatial epigenetic clinical biomarker precision medicine platforms, and early clinical development into Kazia’s executive leadership as the Company advances its integrated oncology platform strategy.

Dr. Rao is a highly accomplished translational scientist and biotech executive with more than 20 years of experience spanning pharmaceutical R&D, biotechnology, and early clinical development. She currently holds a professorial appointment and leads the Gene Regulation and Translational Medicine Laboratory at QIMR Berghofer Medical Research Institute and previously held senior scientific roles at Sanofi/Rhône-Poulenc in the UK, where she contributed to one of the earliest clinical genomics platforms.

She is the founder and former Chief Scientific Officer of EpiAxis Therapeutics and has advanced first-in-class epigenetic therapeutics from discovery through IND-enabling studies and into early clinical trials, including the first Phase 1b study of an LSD1 inhibitor in metastatic breast cancer. Dr. Rao is lead inventor on 39 international patents and has authored numerous high-impact publications in journals including Science, Nature, and Immunity.

At Kazia, Dr. Rao will lead all research and development activities, advancing the Company’s pipeline and expanding its next-generation platform capabilities, including:

Paxalisib, a brain-penetrant dual PI3K/mTOR inhibitor being developed across oncology indications, including advanced breast cancer;
NDL2, a novel PD-L1 protein degrader platform designed to target intracellular and nuclear PD-L1 biology; and
MSETC, a first-in-class SETDB1-targeted epigenetic program aimed at reversing immune evasion at the chromatin level.
Her scientific work has been central to advancing the concept of PI3K/mTOR inhibition as a driver of epigenetic reprogramming, forming the foundation of Kazia’s strategy to move beyond pathway inhibition toward therapeutic control of cancer’s regulatory drivers.

Dr. John Friend, CEO of Kazia Therapeutics, commented: "Dr. Rao is a leading translational epigenetics scientist, a breast cancer researcher, and the lead inventor behind the intellectual property linking PI3K/mTOR inhibition to epigenetic regulation. As the architect of much of our platform, including paxalisib, NDL2, and MSETC, her appointment allows us to immediately strengthen execution while advancing a more integrated, platform-driven oncology strategy."

"I am excited by the opportunity to advance a next-generation oncology platform at Kazia. PI3K/mTOR is a key driver of tumour growth and a master regulator of epigenetic programs that shape tumour behaviour, the tumour microenvironment (TME), and immune evasion," stated Dr. Rao. "We are building a platform focused on precision targeting and precision medicine, integrating spatial and liquid epigenomics and AI-driven drug discovery to accelerate novel therapies. This includes paxalisib alongside emerging programs such as the PD-L1 degrader and SETDB1-targeting approaches. We aim to enable patient selection, real-time target engagement, and a scalable pipeline with clear clinical translation."

Dr. Rao will also play a key role in advancing Kazia’s biomarker strategy, external collaborations, scientific publications, and strategic partnerships, while continuing to expand the Company’s platform and pipeline.

For investor and media, please contact Mike Moyer, Managing Director LifeSci Advisors LLC, mmoyer@lifesciadvisors, +1-617-308-4306.

(Press release, Kazia Therapeutics, APR 15, 2026, View Source [SID1234664408])

On April 15, 2026 Calidi Biotherapeutics, Inc. (NYSE American: CLDI) ("Calidi" or the "Company"), a biotechnology company pioneering the development of targeted genetic medicines, reported it will participate in RedChip’s upcoming virtual investor conference, "Biotech Resurgence: Platforms and Pipelines of Today’s Innovators," taking place April 16, 2026, from 9:30 a.m. to 4:00 p.m. E.T.

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The full-day event will spotlight publicly traded companies advancing innovation across biotechnology, therapeutics, medical devices, diagnostics, and digital health. The conference will provide investors with direct access to executive leadership teams developing next-generation healthcare platforms, advancing clinical pipelines, and scaling commercial healthcare solutions.

Registration is free and open to the public: View Source

RedTail is Calidi’s systemically delivered virotherapy platform designed to selectively target tumors, remodel the tumor microenvironment (TME), and enable high-level expression of therapeutic genetic payloads directly at the tumor site while limiting peripheral exposure. CLD-401, the lead candidate derived from the RedTail platform, is engineered to express high levels of IL-15 superagonist (IL-15 SA), a known T and NK-cell activator, in the TME. The Company expects to file an IND for CLD-401 by the end of 2026. Additionally, Calidi is expanding the RedTail platform to enable in situ expression of T-cell engagers (TCEs) in solid tumors, including in combination with T-cell activating payloads such as IL15 SA. This strategy is intended to support localized T-cell engagement within the TME following systemic administration. The Company is developing CLD-501, a RedTail virus that expresses high levels of a TROP2-targeting TCE and IL-15SA in the TME.

"I look forward to discussing the advances we’ve made with the RedTail platform and the path to IND filing expected this year for CLD-401" said Eric Poma, PhD, Chief Executive Officer of Calidi. "We continue to expand what the RedTail platform can do with new payload, a novel approach to in situ T-cell engagers, and ongoing lead discovery in indications outside of oncology."

The Company continues to expand the functionality of the RedTail platform and is also actively pursuing strategic partnerships to accelerate clinical development and broaden the impact of its RedTail platform.

(Press release, Calidi Biotherapeutics, APR 15, 2026, View Source [SID1234664424])

On April 15, 2026 ImmunoGenesis, a clinical-stage biotech company developing innovative, science-driven immunotherapies, reported that it will present a poster at the upcoming American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2026, which is being held from April 17–22, 2026, in San Diego, CA.

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The poster presentation will include details around the IND-enabling activities for the company’s potent STING Agonist, IMGS-203, for the treatment of GBM. This therapy is designed for intratumoral delivery, enabling localized immune activation with minimal systemic exposure. In orthotopic GBM models, IMGS-203 demonstrated robust anti-tumor activity and significant survival benefit. The data support a clear translational path, with pharmacologic activity confirmed across multiple species and pilot toxicology studies informing dose and delivery parameters for the GLP toxicology study and eventual clinical trial.

"IMGS-203 combines potent STING activation with a localized delivery approach designed to overcome the immunosuppressive tumor microenvironment in GBM," said Dr. Federica Pericle, Chief Scientific Officer of ImmunoGenesis. "These data support the advancement of IMGS-203 toward clinical development."

IMGS-203 Presentation Details:
GBM is a lethal malignancy with a highly immunosuppressive tumor microenvironment (TME) enriched in myeloid-derived suppressor cells, tumor-associated macrophages, and tumor-associated neutrophils. IMGS-203 is a potent STING agonist developed for intratumoral (IT) delivery, a route of administration (ROA) particularly suited for GBM, a tumor that rarely metastasizes and is readily accessible for local delivery during standard procedures such as biopsy. In vitro assays and preclinical murine studies, including a humanized model with epigenetically silenced STING, demonstrated the antitumor efficacy, specificity, and mechanism of action of IMGS-203. These studies also provided pharmacokinetic data and supported its translational potential for local delivery.

Title:

IND-enabling development of a novel STING agonist, IMGS-203, for the treatment of glioblastoma

Abstract Number:

4300

Date and Time:

Tuesday, April 21, 2026, 9:00 AM – 12:00 PM PT

Session:

Immunomodulatory Agents

Location:

Poster Section 8, Poster Board Number 4

For more information and to view the Company’s abstract, visit the AACR (Free AACR Whitepaper) Annual Meeting website.

(Press release, ImmunoGenesis, APR 15, 2026, View Source [SID1234664409])

On April 15, 2026 Boehringer Ingelheim and Zai Lab (NASDAQ: ZLAB; HKEX: 9688) reported a clinical collaboration focused on pioneering a dual DLL3-targeting combination. The Phase Ib/II study will assess the safety, tolerability, and initial clinical activity of combining obrixtamig, Boehringer Ingelheim’s DLL3/CD3 T-cell engager, with zocilurtatug pelitecan (zoci; formerly ZL‑1310), Zai Lab’s DLL3-targeting ADC. The study will enroll patients with poorly differentiated NECs and extensive stage SCLC (ES-SCLC); diseases where patients urgently need more effective treatment options.

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"The strategy to engage the immune system with a specific T‑cell engager and deliver a potent cytotoxic payload with a DLL3‑targeting ADC, aligns with our immuno‑oncology strategy and our drive to advance smart combinations for hard‑to‑treat cancers," said Itziar Canamasas, Ph.D., Global Head of Oncology at Boehringer Ingelheim. "It’s another step in our mission to expand effective options for people with DLL3‑expressing cancers."

"Zoci has shown encouraging activity and good tolerability in SCLC," said Rafael G. Amado, M.D., President, Head of Global Research and Development at Zai Lab. "We have rapidly advanced zoci into pivotal stage and are pursuing opportunities to explore multiple combination approaches in SCLC and other NECs. This collaboration with Boehringer Ingelheim offers a compelling DLL3‑targeting strategy with the potential to benefit patients who urgently need better treatments."

Obrixtamig is Boehringer Ingelheim’s investigational bispecific DLL3/CD3 T‑cell engager, designed to direct the body’s own immune cells to attack DLL3‑expressing cancer cells, a hallmark of SCLC and certain NECs. In the global Phase I first‑line ES‑SCLC study DAREON‑8, in combination with chemotherapy and atezolizumab, obrixtamig showed encouraging signs of early clinical efficacy and a manageable safety profile1. Obrixtamig is being evaluated across multiple global studies and is advancing into a global Phase III trial (DAREON‑Lung‑1, NCT07472517). The molecule has received FDA Fast Track Designation and Orphan Drug Designation from both the FDA and the European Commission for neuroendocrine carcinomas.

Zocilurtatug pelitecan is Zai Lab’s DLL3targeting ADC engineered to deliver a potent cytotoxic payload to DLL3positive tumor cells in ES-SCLC. Updated global Phase I results in previously treated ES-SCLC show strong and durable responses, including in patients with brain metastases, along with a favorable safety profile. On this basis, the program has advanced into a global Phase III registrational study. In addition to SCLC, zoci is being evaluated in NECs. Zoci has received FDA Orphan Drug Designation and FDA Fast Track Designation for the treatment of SCLC.

Under the terms of the agreement, Zai Lab will supply its DLL3‑targeting ADC for the study, while Boehringer Ingelheim will sponsor and oversee day‑to‑day clinical operations. Each company retains the rights to its respective assets.

(Press release, Boehringer Ingelheim, APR 15, 2026, View Source [SID1234664425])