On August 25, 2022 Elevar Therapeutics, Inc., a fully integrated biopharmaceutical company dedicated to elevating treatment experiences and outcomes for patients who have limited or inadequate therapeutic options, reported that initial data from the Phase 3 study of its drug candidate rivoceranib combined with camrelizumab versus sorafenib as a first-line therapy for unresectable hepatocellular carcinoma(uHCC) was accepted for a late-breaking proffered paper presentation at the annual Congress of the European Society for Medical Oncology (ESMO) (Free ESMO Whitepaper) on September 10, 2022 in Paris (Press release, Elevar Therapeutics, AUG 25, 2022, View Source [SID1234618654]).

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Details of the presentation are as follows:

Title: Camrelizumab (C) plus rivoceranib (R) vs. sorafenib (S) as first-line therapy for unresectable hepatocellular carcinoma (uHCC): a randomized, phase Ⅲ trial

Presenter: Shukui Qin, M.D., Ph.D., professor and chief physician of the Cancer Center of Jinling Hospital, Nanjing University of Chinese Medicine

Event, Date, Time and Location: ESMO (Free ESMO Whitepaper),Saturday, Sept. 10, 8:40 a.m. – 8:50 a.m. CEST, 7.1.C – Cannes Auditorium

Session: Proffered Paper Session 1: GI, upper digestive

Presentation Number: LBA35

About Rivoceranib

Rivoceranib is the first small-molecule tyrosine kinase inhibitor (TKI) to be approved in gastric cancer in China (December 2014). Rivoceranib is a highly potent inhibitor of vascular endothelial growth factor receptor 2 (VEGFR-2), a primary pathway for tumor angiogenesis. VEGFR-2 inhibition is a clinically validated approach to limit tumor growth and disease progression. Rivoceranib is co-developed by Jiangsu Hengrui Pharmaceuticals Co., Ltd. (JHP) in China and by Elevar Therapeutics, Inc. globally (excluding China). It has been studied in more than 6,000 patients worldwide and was well tolerated in clinical trials with a comparable safety profile to other TKIs and VEGF inhibitors. Rivoceranib is currently being studied as a monotherapy and in combination with chemotherapy and immunotherapy in various solid tumor indications. Clinical studies are ongoing in multiple solid tumor types including gastric cancer (as a monotherapy and in combination with paclitaxel), hepatocellular carcinoma (HCC) (in combination with camrelizumab), adenoid cystic carcinoma (as monotherapy) and colorectal cancer (in combination with Lonsurf). Orphan drug designations have been granted in gastric cancer (U.S., EU and South Korea), in adenoid cystic carcinoma (U.S.) and in HCC (U.S.). Elevar holds the global rights (excluding China) and has partnered for the development and marketing of rivoceranib with HLB-LS in South Korea. Rivoceranib, under the name apatinib, is currently approved in China for advanced gastric cancer and in second-line advanced HCC by the Chinese-territory license-holder, JHP, under the brand name Aitan.

On August 25, 2022 Kriya Therapeutics, Inc., a fully integrated gene therapy company advancing a broad portfolio of innovative therapeutics, reported that it has appointed Curt Herberts, M.B.S., as President and Chief Operating Officer (Press release, Kriya Therapeutics, AUG 25, 2022, View Source [SID1234618674]). Herberts will oversee all general and administrative functions at Kriya .

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"Curt’s extensive experience building successful biotech companies will be a great asset for Kriya, as we expand our operations and capabilities for developing gene therapies to treat patients in need," said Shankar Ramaswamy, M.D., Co-Founder and Chief Executive Officer of Kriya. "Curt and I will be working in close partnership to build value for patients, investors, and employees."

Herberts joins Kriya from Senti Biosciences, Inc., where he was Chief Financial Officer and Chief Business Officer from 2018 to 2021, and Chief Operating Officer from 2021 to 2022. Prior to joining Senti, Herberts held various positions at Sangamo Therapeutics including as the company’s Chief Business Officer, as well as at Campbell Alliance Group, a leading management consulting firm specializing in the life science industry. Herberts earned his B.A. from Stanford University in human biology, and his Master of Business and Science from the Keck Graduate Institute of Applied Life Sciences.

"I am excited to join a company with a fully-integrated gene therapy engine that has the potential to develop a robust pipeline of therapies to treat a wide range of diseases," Herberts said. "I’m looking forward to helping the company lead the industry in ushering in a new era of innovative gene therapies for a broad range of therapeutic areas."

On August 25, 2022 BioInvent reported an interim report Q2 2022 (Presentation, BioInvent, AUG 25, 2022, https://www.bioinvent.com/media/1936/2022-bioinvent-interim-report-q2.pdf [SID1234618930]).

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On August 25, 2022 Eli Lilly and Company (NYSE: LLY) reported that it will attend Citi’s 17th Annual BioPharma Conference on Wednesday, Sept. 7, 2022 (Press release, Eli Lilly, AUG 25, 2022, View Source [SID1234618655]). Daniel Skovronsky, M.D., Ph.D., Lilly’s chief scientific and medical officer, and president of Lilly Research Laboratories, will participate in a fireside chat at 3:30 p.m., Eastern time.

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A live audio webcast will be available on the "Webcasts & Presentations" section of Lilly’s Investor website at View Source A replay of the presentation will be available on this same website for approximately 90 days.

On August 24, 2022 ImmuPharma plc (LSE : IMM), the specialist drug discovery and development company, reported that L1 Capital Global Opportunities Master Fund ("L1") has exercised Options over 1,000,000 new ordinary shares of 1p each ("Ordinary Shares") at an exercise price of 5p per share, for a consideration of £50,000 (Press release, ImmuPharma, AUG 24, 2022, View Source [SID1234618603]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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New Ordinary Shares and Admission

The New Ordinary Shares have been allotted today and are issued credited as fully paid and will rank pari passu in all respects with the Company’s existing issued Ordinary Shares.

An application will be made for the New Ordinary Shares to be admitted to trading on the AIM market ("Admission") of the London Stock Exchange. It is anticipated that Admission will occur on or around Tuesday 30 August 2022.

The New Ordinary Shares represent 0.30% of the Company’s enlarged issued share capital.

Total Shares in Issue

For the purposes of the Disclosure Guidance and Transparency Rules of the Financial Conduct Authority ("DTR"), the Board of ImmuPharma hereby notifies the market that following Admission, the Company’s total issued share capital will consist of 328,403,115 Ordinary Shares with a nominal value of 1p each.

This figure may be used by Shareholders as the denominator for the calculations by which they may determine if they are required to notify their interest in, or a change to their interest in, the Company under the DTR.