On January 5, 2026 Nurix Therapeutics, Inc. (Nasdaq: NRIX), a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of targeted protein degradation medicines in oncology and autoimmune diseases, reported that Arthur T. Sands, M.D., Ph.D., president and chief executive officer of Nurix, will present a corporate update at the 44th Annual J.P. Morgan Healthcare Conference on Monday, January 12, 2026, at 4:30 p.m. PT in San Francisco.

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The presentation will be webcast live and can be accessed via a link in the Investors section of the Nurix website. The archived webcast will be available for 30 days after the event.

(Press release, Nurix Therapeutics, JAN 5, 2026, View Source [SID1234661717])

On January 5, 2026 Natera, Inc. (NASDAQ: NTRA), a global leader in cell-free DNA and precision medicine, reported that new data from the ALTAIR trial will be presented at the 2026 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Gastrointestinal Cancers Symposium (ASCO GI), taking place January 8-10, 2026.

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A new analysis will be presented from the randomized, double-blind, phase III ALTAIR clinical trial (NCT04457297). ALTAIR examined treatment on molecular recurrence (TOMR) with Trifluridine/Tipiracil (FTD/TPI) in Signatera-positive patients with stage I-IV colorectal cancer (CRC). This investigator-initiated analysis, based on a post-hoc blinded central radiographic review that resulted in the reclassification of a subset of cases, showed a statistically significant DFS benefit of FTD/TPI vs. placebo in all patients (median DFS 9.23 vs 5.55 months; HR: 0.75, 95% CI: 0.55-0.98; P=0.0406). Importantly, these findings represent a substantial update from the previously reported overall ALTAIR analysis, which showed a numerical DFS improvement that did not reach statistical significance in the full study population.

In addition to ALTAIR, Natera’s ASCO (Free ASCO Whitepaper) GI presentations include a large-scale study on Signatera velocity as a prognostic marker for relapse risk stratification. In the study, CRC patients whose Signatera levels doubled in one month or less experienced ~40% shorter recurrence free survival (RFS) vs patients with slower doubling time. The prognostic association between the rate of circulating tumor DNA (ctDNA) increase and recurrence risk remained significant for patients who received adjuvant chemotherapy, as well as those who did not. This data is specific to Natera’s quantification method, which uses mean tumor molecules (MTM) per mL of plasma.

"Natera’s unmatched scale of evidence across tumor types uniquely positions the company to define ctDNA dynamics and translate them into meaningful biological insight and clinical action," said Adham Jurdi, M.D., senior medical director of GI oncology at Natera. "We believe these capabilities, including TOMR approaches, can ultimately support more precise risk stratification and cancer management."

The full list of 14 presentations at ASCO (Free ASCO Whitepaper) GI includes:

January 8, 11:30 AM PT | Abstract # 440
Presenter: Sahar Forootan Sedigh
Tumor-informed ctDNA monitoring during surveillance for early detection of recurrence in patients with stage II/III esophageal cancer treated with chemoradiation

January 8, 11:30 AM PT | Abstract # 843
Presenter: Axel Grothey, M.D.
AI-assisted automated abstraction for enhanced patient insights in gastrointestinal cancers

January 8, 11:30 AM PT | Abstract # 814
Presenter: Gladys Magaly Rodriguez, M.D., MS
Characterization of DPYD variants across ancestries in a large real-world cohort of cancer patients

January 9, 11:30 AM PT | Abstract # 778
Presenter: Elishama Kanu, M.D., MA
Prognostic value of ctDNA monitoring in patients with resectable pancreatic ductal adenocarcinoma during surveillance

January 10, 7:00 AM PT | Abstract # 163
Presenter: George Q. Zhang, M.D., MPH
Physical activity and molecular residual disease (MRD) in stage III colon cancer: Findings from CALGB (Alliance)/SWOG 80702

January 10, 7:00 AM PT | Abstract # 216
Presenter: Saori Mishima, M.D., Ph.D.
Assessing adjuvant chemotherapy benefit in younger and older molecular residual disease-positive patients with stage II/III colorectal cancer

January 10, 7:00 AM PT | Abstract # 221
Presenter: Naoya Akazawa, M.D.
Prognostic value of presurgical circulating tumor DNA (ctDNA) levels and other clinical factors in colon cancer

January 10, 7:00 AM PT | Abstract # 220
Presenter: Koji Ando
Correlation between the timing of recurrence and circulating tumor DNA (ctDNA) doubling time in patients (pts) with resected colon cancer

January 10, 7:00 AM PT | Abstract # 153
Presenter: Kozo Kataoka, M.D., Ph.D.
Adjuvant mFOLFOXFIRI after curative-intent resection of oligometastatic colorectal cancer: Phase II FANTASTIC trial

January 10, 7:00 AM PT | Abstract # TPS268
Presenter: Anwaar Saeed, M.D.
NSABP FC-13 (EMPIRE): A phase II platform study of cemiplimab monotherapy or cemiplimab-based combinations in patients with colorectal cancer and minimal residual disease (MRD) after definitive therapy

January 10, 7:00 AM PT | Abstract # 138
Presenter: Jun Watanabe, M.D., Ph.D.
Post-hoc central radiological review of the ALTAIR study in patients with molecular residual disease (MRD) following curative resection of colorectal cancer (CRC)

January 10, 7:00 AM PT | Abstract # TPS245
Presenter: Sarah Sawyer, Ph.D.
Design of a hybrid site and decentralized clinical research study of an early detection blood test for colorectal cancer

January 10, 7:00 AM PT | Abstract # 217
Presenter: Yoshiaki Nakamura, M.D., Ph.D.
Quantification of circulating tumor DNA (ctDNA) using a methylation-based, tissue-free colorectal cancer (CRC) test for the detection of molecular residual disease (MRD)

January 10, 11:30 AM PT | Abstract # 12 (Oral Presentation)
Presenter: Hideaki Bando, M.D., Ph.D.
Impact of postoperative ctDNA dynamics on eligibility for the ALTAIR randomized trial in patients with colorectal cancer: Implications for clinical trial enrollment

(Press release, Natera, JAN 5, 2026, View Source [SID1234661733])

On January 5, 2026 Olema Pharmaceuticals, Inc. ("Olema" or "Olema Oncology", Nasdaq: OLMA), a clinical-stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted therapies for breast cancer and beyond, reported that Sean P. Bohen, M.D., Ph.D., President and Chief Executive Officer, will present at the 44th Annual J.P. Morgan Healthcare Conference in San Francisco, California, on Tuesday, January 13, 2025 at 11:15 a.m. PT (2:15 p.m. ET).

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A live webcast of the presentation and any accompanying materials will be available in the Events and Presentations section of Olema’s Investor Relations website at ir.olema.com. A recording of the presentation will be made available in the same location.

(Press release, Olema Oncology, JAN 5, 2026, View Source [SID1234661718])

On January 5, 2026 Zai Lab Limited (NASDAQ: ZLAB; HKEX: 9688) reported that members of the Company’s senior management team will participate in the 44th Annual J.P. Morgan Healthcare Conference on Tuesday, January 13th, 2026, at 3:00 p.m. PST / 6:00 p.m. EST.

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A live webcast of the presentation will be available on the Investor Relations page of Zai Lab’s website at ir.zailaboratory.com/webcasts-presentations, and an archived replay will be available for up to 30 days following the completion of the event.

(Press release, Zai Laboratory, JAN 5, 2026, View Source [SID1234661734])

On January 05, 2026 Crescent Biopharma, Inc. ("Crescent" or the "Company") (Nasdaq: CBIO), a clinical-stage biotechnology company dedicated to rapidly advancing the next wave of therapies for cancer patients, reported regulatory clearances of Investigational New Drug (IND) applications for CR-001, a PD-1 x VEGF bispecific antibody, and CR-003, an integrin beta-6 (ITGB6)-targeted antibody drug-conjugate (ADC), both being developed for the treatment of advanced solid tumors.

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The U.S. Food and Drug Administration (FDA) has cleared Crescent’s IND for CR-001, and Crescent’s partner Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. ("Kelun-Biotech") has received IND approval for CR-003 (also known as SKB105) from the Center for Drug Evaluation (CDE) of the National Medical Products Administration (NMPA) of China.

"With regulatory clearances for CR-001 and CR-003, we are excited to begin 2026 with strong momentum as we work to deliver next generation therapies for people living with cancer," said Ellie Im, M.D., chief medical officer of Crescent. "We are on track to have four clinical trials initiate across our portfolio in 2026, starting with the ASCEND trial of CR-001 planned for this quarter. Based on its intentional design replicating a clinically validated approach and robust preclinical profile demonstrating cooperative pharmacology and anti-tumor activity, we believe CR-001 has the potential to be a best-in-class therapy and immuno-oncology backbone."

The Phase 1/2 ASCEND global clinical trial plans to enroll both treatment-naïve and previously treated patients with multiple solid tumor types, including non-small cell lung cancer (NSCLC) and various gastrointestinal and gynecological tumors. The trial is expected to enroll up to 290 participants in the dose-escalation, back-fill and dose-optimization cohorts designed to enable robust assessment of the clinical profile of CR-001. Crescent anticipates reporting proof-of-concept clinical data from the ASCEND trial in the first quarter of 2027, including safety, pharmacokinetic, pharmacodynamic and early anti-tumor activity in first-line and previously treated patients.

In December 2025, Crescent announced a strategic collaboration with Kelun-Biotech for CR-001 and CR-003 (SKB105). Under the terms of the strategic collaboration, Kelun-Biotech granted Crescent exclusive rights to research, develop, and commercialize CR-003 (SKB105) in the United States, Europe and all markets outside of Greater China (including mainland China, Hong Kong, Macau and Taiwan). In addition, Crescent granted Kelun-Biotech exclusive rights to research, develop, and commercialize CR-001 (also known as SKB118) in Greater China.

About CR-001 (also known as SKB118)

CR-001 (SKB118) is a tetravalent bispecific antibody being developed for the treatment of solid tumors that combines two complementary, validated mechanisms in oncology via a blockade of PD-1 and VEGF. PD-1 checkpoint inhibition is aimed at restoring T cells’ ability to recognize and destroy tumor cells, and blocking VEGF is intended for reducing blood supply to tumor cells and inhibiting tumor growth. In preclinical studies, CR-001 demonstrated cooperative pharmacology with increased binding to PD-1 and signal blockade in the presence of VEGF as well as robust anti-tumor activity. ASCEND, a global Phase 1/2 trial of CR-001 in patients with solid tumors, is anticipated to commence in the first quarter of 2026. CR-001’s anti-VEGF activity may also normalize the vasculature at the tumor site, which has the potential to improve the localization and effectiveness of combination therapies, such as the administration of CR-001 with Crescent’s antibody-drug conjugates (ADCs) in development. The first Phase 1/2 ADC combination trial with CR-001 is expected to initiate in the second half of 2026.

About CR-003 (also known as SKB105)

CR-003 (SKB105) is a differentiated ADC targeting integrin beta-6 (ITGB6) with a topoisomerase 1 inhibitor payload. ITGB6 is overexpressed in many solid tumors, but shows minimal to no expression in most normal tissues, thereby potentially reducing the risk of systemic toxicity and off-target effects. CR-003 (SKB105) incorporates proprietary Kthiol irreversible conjugation technology, linking anti-ITGB6 fully human IgG1 monoclonal antibody to a clinically validated cleavable linker. The design aims to enhance stability and tumor-specific payload delivery while reducing adverse effects. In preclinical models, CR-003 (SKB105) demonstrated a favorable efficacy, safety, and pharmacokinetic (PK) profile.

(Press release, Crescent Biopharma, JAN 5, 2026, View Source [SID1234663675])