On July 27, 2022 Alkermes plc (Nasdaq: ALKS) reported financial results for the second quarter of 2022 and provided updated financial expectations for full-year 2022 (Press release, Alkermes, JUL 27, 2022, View Source [SID1234616995]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

"In the second quarter, Alkermes continued to execute successfully across the business. VIVITROL and ARISTADA both grew year-over-year and sequentially, and LYBALVI continued on a strong launch trajectory," commented Iain Brown, Chief Financial Officer of Alkermes. "Today, we are pleased to be raising our financial expectations for full-year 2022, primarily due to LYBALVI’s launch performance and updated assumptions related to continued royalty revenues on sales of long-acting INVEGA products outside of the U.S. We believe that we are well positioned to continue to make meaningful progress against our strategic priorities and to drive shareholder value."

Quarter Ended June 30, 2022 Financial Results

Revenues

– Total revenues for the quarter were $276.2 million, compared to $303.7 million for the same period in the prior year.

– Net sales of proprietary products for the quarter were $190.8 million, compared to $160.8 million for the same period in the prior year.

Net sales of VIVITROL were $96.1 million, compared to $88.4 million for the same period in the prior year, representing an increase of approximately 9%.
Net sales of ARISTADAi were $74.6 million, compared to $72.4 million for the same period in the prior year, representing an increase of approximately 3%.
Net sales of LYBALVI were $20.1 million, following its commercial launch in October 2021.
– Manufacturing and royalty revenues for the quarter were $85.3 million, compared to $142.3 million for the same period in the prior year.

Royalty revenues from INVEGA SUSTENNA/XEPLION, INVEGA TRINZA/TREVICTA and INVEGA HAFYERA/BYANNLI (the long-acting INVEGA products) were $26.6 million, compared to $81.1 million for the same period in the prior year. This decrease was driven primarily by Janssen Pharmaceutica N.V.’s (Janssen) partial termination of the license agreement related to sales of the long-acting INVEGA products in the United States (U.S.).
Manufacturing and royalty revenues from VUMERITY were $26.2 million, compared to $20.3 million for the same period in the prior year.
Costs and Expenses

– Total operating expenses for the quarter were $310.7 million, compared to $299.3 million for the same period in the prior year, primarily reflecting increased investment to support the commercial launch of LYBALVI.

Cost of Goods Manufactured and Sold were $58.4 million, compared to $53.1 million for the same period in the prior year.
Research and Development (R&D) expenses were $92.9 million, compared to $97.5 million for the same period in the prior year.
Selling, General and Administrative (SG&A) expenses were $150.4 million, compared to $139.2 million for the same period in the prior year.
Profitability

– Net loss according to generally accepted accounting principles in the U.S. (GAAP) was $30.1 million for the quarter, or a basic and diluted GAAP loss per share of $0.18. This compared to GAAP net income of $2.4 million, or a basic and diluted GAAP earnings per share of $0.01, for the same period in the prior year.

– Non-GAAP net income was $10.5 million for the quarter, or a non-GAAP basic and diluted earnings per share of $0.06. This compared to non-GAAP net income of $49.2 million for the quarter, or a non-GAAP basic earnings per share of $0.31 and a diluted earnings per share of $0.30, for the same period in the prior year.

Balance Sheet

– At June 30, 2022, the company recorded cash, cash equivalents and total investments of $760.0 million, compared to $758.7 million at March 31, 2022. The company’s total debt outstanding as of June 30, 2022 was $294.5 million.

"Our second quarter results reflect revenue growth from our proprietary commercial portfolio, highlighted by our continued progress in the launch of LYBALVI, a new oral treatment for schizophrenia and bipolar I disorder," said Richard Pops, Chief Executive Officer of Alkermes. "At the same time, we continued to make progress in our development pipeline, highlighted by the presentation of nemvaleukin ARTISTRY-1 data at the 2022 ASCO (Free ASCO Whitepaper) annual meeting. As we strive to make a meaningful impact on the lives of patients and families, we will continue to focus on execution against our strategic priorities and our commitment to deliver value for our shareholders."

Financial Expectations for 2022

The following updated financial expectations for 2022 primarily reflect LYBALVI’s launch performance to date and the company’s current assumption that it will continue to receive royalty payments related to sales of the long-acting INVEGA products outside the U.S. through at least October 2022. All line items are according to GAAP, except as otherwise noted.

Recent Events:

Oncology

In June 2022, the company presented data from its phase 1/2 ARTISTRY-1 clinical trial for nemvaleukin alfa (nemvaleukin), the company’s novel, investigational, engineered interleukin-2 (IL-2) variant immunotherapy, at the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting. Trial-in-progress posters from the ongoing ARTISTRY-3 trial and the potential registration-enabling ARTISTRY-6 and ARTISTRY-7 trials were also presented at the ASCO (Free ASCO Whitepaper) meeting.
Psychiatry

In May 2022, the company presented research related to its psychiatry portfolio at four scientific conferences. The meetings included: American Telemedicine Association (ATA) Annual Conference, International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Annual Meeting, American Psychiatric Association (APA) Annual Meeting, and American Society of Clinical Psychopharmacology (ASCP) Annual Conference.
Other

In May 2022, the company announced a series of actions as part of its ongoing commitment to strong corporate governance and regular board refreshment, including the appointment to the company’s Board of Directors (the Board) of Christopher I. Wright, M.D., Ph.D., a new, independent director with neuroscience and drug development expertise and the seventh independent director to join the Board in the last three years; the appointment of Nancy J. Wysenski as Lead Independent Director of the Board; and the retirement from the Board of two longer-serving directors, David W. Anstice AO and Wendy L. Dixon, Ph.D.
Conference Call

Alkermes will host a conference call and webcast presentation with accompanying slides at 8:00 a.m. ET (1:00 p.m. BST) on Wednesday, July 27, 2022, to discuss these financial results and provide an update on the company. The webcast may be accessed on the Investors section of Alkermes’ website at www.alkermes.com. The conference call may be accessed by dialing +1 877 407 2988 for U.S. callers and +1 201 389 0923 for international callers. In addition, a replay of the conference call will be available from 11:00 a.m. ET (4:00 p.m. BST) on Wednesday, July 27, 2022, through Wednesday, August 3, 2022, and may be accessed by visiting Alkermes’ website or by dialing +1 877 660 6853 for U.S. callers and +1 201 612 7415 for international callers. The replay conference ID is 13731319.

On July 27, 2022 Myovant Sciences (NYSE: MYOV), a biopharmaceutical company that aspires to redefine care for women and for men through purpose-driven science, empowering medicines, and transformative advocacy, reported financial results for the first quarter of fiscal year 2022 and provided other corporate updates (Press release, Myovant Sciences, JUL 27, 2022, https://investors.myovant.com/news-releases/news-release-details/myovant-sciences-announces-corporate-updates-and-financial-4 [SID1234617011]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

"We’re excited to start fiscal year 2022 with solid performance across both brands," said David Marek, Chief Executive Officer of Myovant Sciences, Inc. "ORGOVYX delivered double digit volume growth across treatment settings and MYFEMBREE is now the market leader in new and total prescriptions while continuing to grow the class." Mr. Marek added, "despite the challenging macro-economic environment, we remain well capitalized to build on our commercial momentum and advance our pipeline in women’s health and hormone-sensitive oncology."

First Fiscal Quarter 2022 and Recent Corporate Updates

ORGOVYX (relugolix 120 mg)

First fiscal quarter 2022 net product revenues for ORGOVYX in the U.S. were $36.0 million, reflecting 22% sequential growth compared to fourth fiscal quarter 2021. ORGOVYX commercial demand volume grew 26% quarter-over-quarter driven by broad adoption and strong growth across all treatment settings.
Approximately 3,500 new patients started treatment on ORGOVYX in the first fiscal quarter of 2022, reaching approximately 18,000 cumulative patients since launch.
A $50.0 million upfront payment was received from Accord Healthcare, Ltd. (Accord), pursuant to the exclusive license agreement Myovant entered into with Accord in May 2022 to commercialize ORGOVYX for the treatment of advanced hormone-sensitive prostate cancer in Europe.
On April 29, 2022, the European Commission (EC), and on June 17, 2022, the United Kingdom (U.K.) Medicines and Healthcare products Regulatory Agency (MHRA), approved ORGOVYX as the first and only oral androgen deprivation therapy for advanced hormone-sensitive prostate cancer in the European Union (EU) and U.K., respectively. We expect our commercialization partner, Accord, to commence the launch of ORGOVYX for the treatment of advanced hormone-sensitive prostate cancer in Europe in the second half of calendar year 2022.
MYFEMBREE (relugolix 40 mg, estradiol 1.0 mg, and norethindrone acetate 0.5 mg)

First fiscal quarter 2022 net product revenues for MYFEMBREE in the U.S. were $4.0 million.
MYFEMBREE maintains market leadership in new-to-brand prescription (NBRx) share among GnRH antagonist therapies approved by the U.S. Food and Drug Administration (FDA) for the treatment of uterine fibroids and is now the number one prescribed GnRH antagonist therapy for uterine fibroids with 51% total prescription (TRx) share in June 2022. Data provided by Symphony Health.
Approximately 2,400 new patients started treatment on MYFEMBREE in first fiscal quarter 2022, resulting in 71% sequential quarterly growth in the number of patients treated since launch.
MYFEMBREE continues to drive total prescription growth of the GnRH antagonist for uterine fibroids class, which has grown 180% since its launch in June 2021, with 61% of MYFEMBREE prescribers being first time prescribers of a GnRH antagonist FDA-approved for the treatment of uterine fibroids.
FDA provided labeling comments with respect to the MYFEMBREE sNDA for the management of moderate to severe pain associated with endometriosis. FDA’s decision is expected by the extended Prescription Drug User Fee Act (PDUFA) goal date of August 6, 2022. An approval would trigger a $100.0 million milestone payment from Pfizer. If approved by the PDUFA goal date, Myovant and Pfizer expect to launch MYFEMBREE in the U.S. for this indication in August 2022.
In June 2022, the FDA accepted for review an sNDA that proposes updates to MYFEMBREE’s U.S. Prescribing Information (USPI) based on 2-year safety and efficacy data from the Phase 3 LIBERTY randomized withdrawal study (RWS) of MYFEMBREE in premenopausal women with heavy menstrual bleeding associated with uterine fibroids. The FDA set a target action date of January 29, 2023 for this sNDA.
In June 2022, Myovant and Pfizer announced that the results of the Phase 3 SPIRIT 1 and SPIRIT 2 studies of once-daily relugolix combination therapy (relugolix 40 mg, estradiol 1.0 mg, and norethindrone acetate 0.5 mg) in women with endometriosis-associated pain were published in The Lancet.
Additional data from the SPIRIT 2-year extension study in women with endometriosis were presented at the European Society of Human Reproduction and Embryology (ESHRE) 2022 Annual Meeting in July 2022. The Society recognized the presentation as the best oral presentation of a clinical topic at the ESHRE 2022 Annual Meeting.
Expected Upcoming Milestones

Myovant expects the FDA decision for the MYFEMBREE sNDA seeking approval for the management of moderate to severe pain associated with endometriosis by its extended PDUFA goal date of August 6, 2022. Approval would trigger a $100.0 million milestone payment from Pfizer. If approved by the PDUFA goal date, Myovant and Pfizer expect to launch MYFEMBREE in the U.S. for this indication in August 2022.
European Medicines Agency regulatory submission for RYEQO for the treatment of women with endometriosis-associated pain is expected in the second half of calendar year 2022. Gedeon Richter Plc. (Richter) will be the sponsor.
Myovant expects to submit New Drug Submissions to Health Canada seeking marketing approval for ORGOVYX for advanced prostate cancer, MYFEMBREE for heavy menstrual bleeding associated with uterine fibroids, and MYFEMBREE for the treatment of endometriosis-associated pain in Canada in the second half of calendar year 2022.
Accord is expected to commence the launch of ORGOVYX for the treatment of advanced hormone-sensitive prostate cancer in Europe in the second half of calendar year 2022.
Myovant expects the FDA decision for the MYFEMBREE sNDA proposing updates to MYFEMBREE’s USPI based on the safety and efficacy data from the Phase 3 LIBERTY RWS of MYFEMBREE in premenopausal women with heavy menstrual bleeding associated with uterine fibroids for up to two years by the January 29, 2023 PDUFA goal date.
First Fiscal Quarter 2022 Financial Summary

Total revenues for the three months ended June 30, 2022, and 2021 were $116.5 million and $41.1 million, respectively.

Product revenue, net for the three months ended June 30, 2022 and 2021 were $41.4 million and $11.6 million, respectively. Product revenue, net consisted of the following:
Product revenue, net from sales of ORGOVYX in the U.S. for the three months ended June 30, 2022 was $36.0 million compared to $10.5 million for the three months ended June 30, 2021.
Product revenue, net from sales of MYFEMBREE in the U.S. for the three months ended June 30, 2022 was $4.0 million compared to $1.1 million for the three months ended June 30, 2021. MYFEMBREE was launched in the U.S in June 2021.
Product revenue, net related to product supply to Richter for the three months ended June 30, 2022 was $1.1 million. Product revenue, net related to royalties on net sales of RYEQO in Richter’s Territory for the three months ended June 30, 2022 was $0.2 million. There were no such revenues in the year ago period.
Pfizer collaboration revenue for the three months ended June 30, 2022 and 2021 was $25.1 million and $29.5 million, respectively, reflecting the partial recognition of the upfront payment Myovant received from Pfizer upon entering into the Pfizer Collaboration and License Agreement in December 2020 and of the regulatory milestone payment from Pfizer that was triggered upon the FDA approval of MYFEMBREE for the management of heavy menstrual bleeding associated with uterine fibroids in May 2021.
Accord license revenue for the three months ended June 30, 2022 was $50.0 million, reflecting the recognition of the upfront payment received from Accord in May 2022 pursuant to the Accord License Agreement. There was no Accord license revenue in the year ago period.
Cost of product revenue for the three months ended June 30, 2022 was $4.9 million, compared to $1.0 million for the three months ended June 30, 2021 related to the cost of goods sold and royalty expense payable to Takeda pursuant to the Takeda License Agreement. The increase in cost of product revenue in the three months ended June 30, 2022 was primarily due to an increase in cost of goods sold and royalty expense payable to Takeda as a result of higher sales of ORGOVYX and MYFEMBREE in the U.S., as compared to the year ago period.

Collaboration expense to Pfizer for the three months ended June 30, 2022, was $18.0 million, compared to $5.3 million for the three months ended June 30, 2021, reflecting Pfizer’s 50% share of net profits from sales of ORGOVYX and MYFEMBREE in the U.S., pursuant to the Pfizer Collaboration and License Agreement. The increase in collaboration expense to Pfizer in the three months ended June 30, 2022 was due to an increase in net profits generated from sales of ORGOVYX and MYFEMBREE in the U.S., as compared to the year ago period.

Selling, general and administrative (SG&A) expenses for the three months ended June 30, 2022, and 2021 were $79.0 million and $61.2 million, respectively. The increase in SG&A expenses primarily reflects higher expenses to support the ORGOVYX and MYFEMBREE commercialization activities in the U.S, including higher personnel-related costs, patient activation costs particularly for MYFEMBREE, as well as a banker fee associated with the Accord License Agreement.

Research and development (R&D) expenses for the three months ended June 30, 2022, and 2021 were $23.9 million and $30.9 million, respectively. The decrease in R&D expenses primarily reflects a reduction in clinical study costs due to the completion and wind down of Myovant’s Phase 3 LIBERTY, HERO, and SPIRIT studies.

Interest expense for the three months ended June 30, 2022, and 2021 was $4.2 million and $3.5 million, respectively, and was primarily related to the Sumitomo Pharma Loan Agreement. Interest expense related to the Sumitomo Pharma Loan Agreement increased $0.7 million, as a result of an increase in 3-month LIBOR as compared to the year ago period. Interest expense includes $0.6 million of accretion of the financing component of the cost share advance from Pfizer for both the three months ended June 30, 2022, and 2021.

Income tax expense for the three months ended June 30, 2022, and 2021 was $8.2 million and $0.9 million, respectively. The increase in income tax expense was driven principally by the changed requirement under Internal Revenue Code Section 174, effective for years beginning after December 31, 2021, to capitalize and subsequently amortize R&D expenditures, pursuant to changes enacted in the Tax Cuts and Jobs Act 2017. For periods beginning prior to December 31, 2021, R&D expenses were allowed to be expensed as incurred.

Net loss for the three months ended June 30, 2022 was $21.2 million compared to $61.7 million for the year ago period. On a per common share basis, net loss was $0.22 and $0.67 for the three months ended June 30, 2022 and 2021, respectively.

Capital resources: Cash, cash equivalents, marketable securities, and amounts available under the Sumitomo Pharma Loan Agreement totaled $400.0 million as of June 30, 2022, and consisted of $358.7 million of cash, cash equivalents, and marketable securities and $41.3 million of available borrowing capacity under the Sumitomo Pharma Loan Agreement.

Conference Call
As previously announced, Myovant will hold a webcast and conference call to discuss corporate updates and financial results for its first fiscal quarter, ended June 30, 2022. The webcast and conference call will be held at 5:00 p.m. Eastern Time / 2:00 p.m. Pacific Time on July 27, 2022. Investors and the general public may access the live webcast: View Source The live webcast can also be accessed by visiting the investor relations page of Myovant’s website at: https://investors.myovant.com/. A replay of the webcast, along with the earnings press release and presentation materials, can be found on Myovant’s investor relations website for a period of one year.

About Relugolix

Relugolix is a once-daily, oral gonadotropin-releasing hormone (GnRH) receptor antagonist that reduces testicular testosterone, a hormone known to stimulate the growth of prostate cancer, and ovarian estradiol, a hormone known to stimulate the growth of uterine fibroids and endometriosis. ORGOVYX (relugolix, 120 mg) was approved in the U.S. by the FDA in December 2020 as the first and only oral GnRH receptor antagonist for the treatment of adult patients with advanced prostate cancer. In April and June 2022, respectively, the European Commission and the United Kingdom (U.K.) Medicines and Healthcare products Regulatory Agency (MHRA) approved ORGOVYX (relugolix, 120 mg) as the first and only oral GnRH receptor antagonist for the treatment of adult patients with advanced hormone-sensitive prostate cancer in Europe and the U.K. MYFEMBREE (relugolix 40 mg, estradiol 1.0 mg, and norethindrone acetate 0.5 mg) was approved in the U.S. by the FDA in May 2021 as the first and only once-daily oral treatment for the management of heavy menstrual bleeding associated with uterine fibroids in premenopausal women, with a treatment duration of up to 24 months. In July 2021, the European Commission, and in August 2021, the U.K. MHRA, approved RYEQO (relugolix 40 mg, estradiol 1.0 mg, and norethindrone acetate 0.5 mg) for the treatment of moderate to severe symptoms of uterine fibroids in adult women of reproductive age, with no limitation for duration of use. In September 2021, the FDA accepted to review Myovant’s supplemental New Drug Application (sNDA) for MYFEMBREE for the management of moderate to severe pain associated with endometriosis. On May 6, 2022, Myovant and Pfizer announced that the FDA extended the Prescription Drug User Fee Act (PDUFA) goal date for this sNDA to August 6, 2022. In June 2022, the FDA accepted to review Myovant’s sNDA for updates to the United States Prescribing Information (USPI) based on safety and efficacy data from the Phase 3 LIBERTY randomized withdrawal study (RWS) of MYFEMBREE in premenopausal women with heavy menstrual bleeding due to uterine fibroids for up to two years. The FDA set a PDUFA goal date of January 29, 2023 for this sNDA. MYFEMBREE is also being assessed for contraceptive efficacy in women with endometriosis or uterine fibroids who are 18 to 50 years of age and at risk for pregnancy.

On July 27, 2022 The Parker Institute for Cancer Immunotherapy (PICI) is helping to forge a future without cancer, reported by investing in top talent to train and empower the research leaders of tomorrow (Press release, Parker Institute for Cancer Immunotherapy, JUL 27, 2022, View Source [SID1234617027]). This year, PICI recognized its largest Early Career Researcher class yet, nine exceptional graduate and postdoctoral researchers from leading academic institutions. They will share a total of up to $4.5 million in fellowship and scholarship awards.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Marking the Early Career Researcher program’s sixth anniversary, previous awardees recently presented their work to the PICI Network of world-renowned innovators in cancer immunotherapy research at the organization’s biannual scientific retreat.

As a part of this ongoing program, PICI is furthering its commitment to addressing disparities in the field of cancer research through diversity, equity, inclusion and belonging initiatives. Those include the creation of its Representation In SciencE (RISE) Scholar program, which awards a Black, Indigenous or Person of Color (BIPOC) graduate or rising postdoctoral student who has an outstanding scientific background and conducts research at a PICI Network institution.

"The 2022 awardees, like those who have come before them, are among the best and brightest minds anywhere," said John Connolly, Ph.D., chief scientific officer at PICI. "We are proud to support these researchers, who are dedicated to innovating our approach to cancer to improve patient outcomes."

This year, PICI also is proud to partner with the V Foundation for Cancer Research to fund four of the nine class of 2022 awardees. Known as Parker Bridge Fellows, the four recipients are senior postdoctoral investigators working to answer the most critical questions in cancer immunotherapy as they transition into faculty positions following mentorship by PICI’s network of leaders.

The 2022 Parker Bridge Fellows are:

Katie Campbell, Ph.D., University of California, Los Angeles (UCLA)
Kenneth Hu, Ph.D., University of California, San Francisco (UCSF)
Derek Oldridge, M.D., Ph.D., University of Pennsylvania (Penn)
Bingfei Yu, Ph.D., Stanford Medicine
"Our mission is to support cutting-edge cancer research, so as many patients as possible can benefit from the extraordinary breakthroughs that researchers are making today," said Susanna Greer, Ph.D., chief scientific officer at the V Foundation. "PICI helps us further the V Foundation’s mission to fund accomplished young researchers bringing new techniques to combat cancer that warrant further exploration. We’re thrilled to support this work and to get to know these rising stars."

This year, an anonymous donor has committed substantial funding to create the Parker RISE Scholar award. The inaugural RISE Scholar is Gabriel Abril Rodriguez, Ph.D., a postdoctoral researcher at UCLA.

"The scholarship is a validation of my project idea, which is a very ambitious, high-impact project," said Abril Rodriguez, who is developing new tools to study T-cell biology. "As part of the PICI Network, I will interact and share my ideas with some of the brightest minds in the field. Learning from them will help me push this project forward."

The other award categories are:

Parker Senior Fellow – a senior researcher who recently has earned an M.D. or Ph.D. degree and is ready to establish a laboratory or independent program in cancer immunotherapy. The 2022 Parker Senior Fellow is Ya-Ting (Emma) Wang, Ph.D., of Memorial Sloan Kettering Cancer Center (MSK).
Parker Scholars – graduate students and researchers focused on high-impact projects who are entering their first postdoctoral appointments. The 2022 Parker Scholars are Inaki Etxeberria, Ph.D., of MSK, Louai Labanieh, Ph.D., of Stanford and Darwin Ye, a doctoral candidate at Penn.
"My project involves learning how cells become resistant to immunotherapy so we can design more effective clinical trials, and this is something that requires an interdisciplinary approach," Ye said. "The PICI Network lets me explore that approach with leading cancer researchers in the field."

With this year’s class, PICI has recognized 37 Early Career Researchers since 2016, awarding over $19 million in total funding and welcoming them into the PICI Network. They are working to advance cancer research on cell and gene therapies, CAR T cells, immune checkpoint blockade therapy and other critical scientific projects.

Awardees pursue bold research through support from PICI’s world-class network of immunotherapy experts and research institutions, as well as individual mentorship by PICI members and researchers from affiliated institutions. They also are given access to leading-edge technology, informatics and clinical data needed for their research.

"This fellowship allows me to collaborate and communicate with experts from very different fields, including cancer biologists, computational biologists and clinical scientists," said Yu, a Stanford immunologist and postdoctoral scientist who is doing research on the targeting mechanisms that T cells and other immune cells use to kill cancer. "Being able to learn from these leaders while also operating my own lab is an incredible opportunity."

On July 27, 2022 Allogene Therapeutics, Inc. (Nasdaq: ALLO), a clinical-stage biotechnology company pioneering the development of allogeneic CAR T (AlloCAR T) products for cancer, reported that it will report second quarter 2022 financial results on Tuesday, August 9, 2022, after the close of the market (Press release, Allogene, JUL 27, 2022, View Source [SID1234616996]). The announcement will be followed by a live audio webcast and conference call at 2:00 PM Pacific Time/5:00 PM Eastern Time.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Audio Webcast
The webcast will be made available on the Company’s website at www.allogene.com under the Investors tab in the News and Events section. Following the live audio webcast, a replay will be available on the Company’s website for approximately 30 days.

On July 27, 2022 Neoleukin Therapeutics, Inc., "Neoleukin" (NASDAQ:NLTX), reported it will report second quarter 2022 financial results on Tuesday, August 9, 2022 after the close of financial markets and then host a conference call and live audio webcast to discuss these results and provide a corporate update (Press release, Neoleukin Therapeutics, JUL 27, 2022, View Source [SID1234617012]). Details of the event are as follows:

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

The archived audio webcast will be available on the Investor Relations section of the Neoleukin website approximately two hours after the event and will be available for replay for at least 30 days after the event.