Theratechnologies to Announce Second Quarter 2022 Financial Results and Provide Business Update

On July 7, 2022 Theratechnologies Inc. (TSX: TH) (NASDAQ: THTX) (Theratechnologies), a biopharmaceutical company focused on the development and commercialization of innovative therapies, reported that it will report financial results for its second quarter of fiscal 2022 ended May 31 on Thursday, July 14, 2022 (Press release, Theratechnologies, JUL 7, 2022, View Source [SID1234616524]).

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The conference call will be held on July 14, 2022 at 8:30 a.m. (ET) to discuss the results and recent business updates. The call will be hosted by Paul Lévesque, President and Chief Executive Officer. Joining Mr. Lévesque on the call will be other members of the management team, including Chief Financial Officer Philippe Dubuc and Chief Medical Officer Christian Marsolais, who will be available to answer questions from participants following prepared remarks.

Participants are encouraged to join the call ten minutes in advance to secure access.

The live conference call will be accessible via webcast at: View Source

Biogen to Report Second Quarter 2022 Financial Results July 20, 2022

On July 7, 2022 Biogen Inc. (Nasdaq:BIIB) reported it will report second quarter 2022 financial results Wednesday, July 20, 2022, before the financial markets open (Press release, Biogen, JUL 7, 2022, View Source [SID1234616544]).

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Following the release of the financials, the Company will host a live webcast with Biogen management at 8:00 a.m. ET. To access the live webcast, please go to the investors section of Biogen’s website at investors.biogen.com. Following the live webcast, an archived version of the call will be available on the website.

Horizon Therapeutics plc to Release Second-Quarter 2022 Financial Results and Host Webcast on Aug. 3, 2022

On July 7, 2022 Horizon Therapeutics plc (Nasdaq: HZNP) reported that it will release its second-quarter 2022 financial results on Wednesday, Aug. 3, 2022 (Press release, Horizon Therapeutics, JUL 7, 2022, View Source [SID1234616545]). Following the announcement, Horizon’s management will host a live webcast at 8 a.m. Eastern Time to review the Company’s financial and operating results.

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The live webcast may be accessed at View Source Please connect to the Company’s website at least 15 minutes prior to the live webcast to ensure adequate time for any software download that may be needed to access the webcast. A replay will be available approximately two hours after the live webcast.

Mercy St. Louis Begins Treatment With Mevion Compact Proton Therapy System

On July 7, 2022 Mevion Medical Systems, the leading provider of compact proton therapy systems for use in radiation treatment for cancer patients, reported that the first patient was treated at the David C. Pratt Cancer Center at Mercy Hospital St. Louis on July 5th with the MEVION S250i Proton Therapy System (Press release, Mevion Medical Systems, JUL 7, 2022, View Source [SID1234616546]).

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The new Mercy Proton Therapy Center is one of only 40 treating centers in the U.S. Thanks to the compact size of the MEVION S250i, Mercy was able to integrate the addition into the existing radiation oncology department, enabling the hospital to share existing resources and maintain a full continuum of care for patients.

A ribbon-cutting event was held on June 30 with members from Mercy and Mevion Medical Systems.

"We know patients have choices when it comes to cancer care and when they choose Mercy, we want them to know they have access to all the options for care," said Dr. Robert Frazier, division chief of radiation oncology at Mercy Hospital St. Louis. "Each patient is unique so no two treatment plans will be the same. At the David C. Pratt Cancer Center, we now have all the most advanced radiation therapy technologies, both Cyberknife and proton therapy, making sure we offer what’s best for each individual during their cancer therapy."

The center features Mevion’s industry-leading HYPERSCAN pencil beam scanning technology and Adaptive Aperture pMLC. The powerful duo delivers faster and more precise, therapeutic doses of radiation to tumors while preserving surrounding healthy tissue and organs at risk, making proton therapy an ideal treatment choice for tumors near sensitive parts of the body such as the head and neck, spinal cord, breasts, esophagus, prostate, lung, bone, gastrointestinal, stomach, colon, and bladder.

The MEVION S250i system at Mercy also integrates the CBCT imaging system and the C-RAD Catalyst PT surface-guided tracking system, enabling a cutting-edge Image-Guided Proton Therapy configuration for high-precision patient positioning and intra-fraction motion management.

"We congratulate Mercy for starting treatment with the Mevion proton therapy system," said Tina Yu, chief executive officer and president of Mevion Medical Systems. "Mevion is proud to be a part of Mercy’s dedication to offering this state-of-the-art cancer treatment in St. Louis and the surrounding area."

Mevion is the system provider for 60% of the clinical single-room proton centers in the U.S. and has treated over 7,000 patients worldwide.

SELLAS Life Sciences Adds Once-a-Week Dose Cohort in Ongoing Phase 1 Clinical Trial with its Highly Selective CDK9 Inhibitor GFH009

On July 7, 2022 SELLAS Life Sciences Group, Inc. (NASDAQ: SLS) ("SELLAS" or the "Company"), a late-stage clinical biopharmaceutical company focused on the development of novel therapies for a broad range of cancer indications, reported that the Company has added a second, once-a-week dose cohort in its ongoing global Phase 1 clinical trial in both the United States and China with the highly selective CDK9 inhibitor GFH009 for patients suffering from advanced relapsed or refractory lymphoma and acute myeloid leukemia (AML) (Press release, Sellas Life Sciences, JUL 7, 2022, View Source [SID1234616529]).

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SELLAS previously reported that AML patients treated twice-a-week at the 22.5mg dose level experienced no dose-limiting toxicities, including no Grade 3/4 neutropenia (an abnormally low count of neutrophils, a type of white blood cell). The patients in the AML arm of the clinical trial have entered the last twice-a-week 30mg planned dose level. Additionally, enrollment for lymphoma patients at the twice-a-week 15mg dose level cohort has been completed and safety assessments are underway. The twice-a-week dose regimens for both groups will proceed as planned and are on target for completion this year.

Given that both AML and lymphoma patients tolerated all dose levels studied to date with the twice-a-week administration as well as the efficacy signals seen with both AML and lymphoma patients, SELLAS has amended its protocol to introduce an additional single-dose cohort to study GFH009 once-a-week administration starting at the higher dose level of 30 mg.

The new, weekly single-dose cohort regimen is as follows:

Dose levels are 30mg, 45mg and 60mg once per week.
The amended protocol allows SELLAS to further escalate the doses if each level is determined safe for patients.
The new cohort is expected to take approximately one month to enroll patients and another 21 days to complete the safety assessment for each dose level.
"As we continue to evaluate GFH009 with its unique mechanism of action, increasing the dose administered and extending the administration of the dose will allow us to expand our knowledge of the drug’s safety and efficacy profile, including potentially seeing whether there are further increases in efficacy beyond the already observed efficacy for these patients," said Dragan Cicic, MD, Senior Vice President, Clinical Development, SELLAS. "With this additional valuable data on the new dose levels and regimen, SELLAS will be one step closer to discovering the optimal dosage for patients in preparation for the Phase 2 study."