On April 27, 2026 Evaxion A/S (NASDAQ: EVAX) ("Evaxion"), a clinical-stage TechBio company developing novel vaccines with its pioneering AI-Immunology platform, that Birgitte Rønø, its Chief Scientific Officer (CSO), reported it will take on the dual responsibilities of CSO and Chief Operating Officer (COO).

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The promotion follows an internal management review of the optimal way of working to continue to deliver Evaxion’s strategy through broader external visibility of the power of the AI-Immunology platform with partners and investors. It also reflects the recognition of Dr Rønø’s long and extensive contribution to the internal operation of Evaxion over many years.

"I am delighted to announce the promotion of Dr Rønø to the dual role of CSO and COO, reflecting her long contribution to the efficient operation of the company coupled with her deep scientific expertise. Alongside the considerable expertise of the other members of the Evaxion management team, this change leaves us very well placed to continue building and broadening awareness of Evaxion’s unique AI capabilities in immune target discovery, vaccine and other drug product candidate design through to early preclinical and clinical validation," says Helen Tayton-Martin, CEO of Evaxion.

Following the promotion, Evaxion’s management team remains composed of the following members:

Helen Tayton-Martin, CEO
Birgitte Rønø, CSO and COO
Thomas Schmidt, CFO
Andreas Mattsson, Chief AI Officer

(Press release, Evaxion, APR 27, 2026, View Source [SID1234664791])

On April 27, 2026 QIAGEN N.V. (NYSE: QGEN; Frankfurt Prime Standard: QIA) reported preliminary results for the first quarter of 2026, continuing to deliver strong profitability as adjusted diluted earnings per share (EPS) achieved the outlook. Sales trends were mixed, as lower QuantiFERON sales and cautious U.S. Life Sciences customer demand offset solid growth in other areas of the portfolio.

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For Q1 2026, preliminary net sales were $492 million, up 2% on a reported basis and down 1% at constant exchange rates (CER) compared with the outlook for at least 1% CER growth. Adjusted diluted EPS are expected to be $0.54 on a reported basis and $0.54 CER, in line with the outlook.

QIAGEN’s growth pillars together grew 4% CER compared to Q1 2025. Sample technologies delivered 9% CER growth compared with Q1 2025, and 3% CER growth excluding the Parse acquisition, supported by demand for automated consumables and instrument placements. QIAcuity digital PCR delivered double-digit CER sales growth on higher consumables and instrument sales over the year-ago period. QIAGEN Digital Insights (QDI) posted solid single-digit gains led by clinical bioinformatics. QIAstat-Dx sales declined 1% CER as expected against tough prior-year results. Consumables sales rose despite a weaker respiratory season on double-digit CER growth from recently launched Gastrointestinal and Meningitis panels in the U.S., while instrument placements continued at a good level.

QuantiFERON sales declined 5% CER from Q1 2025, mainly due to a significant decline in immigration testing demand in the United States and the Middle East. Trends remained solid in other patient testing groups. QIAGEN now expects QuantiFERON full-year 2026 sales to be unchanged at CER compared with 2025 sales of $503 million.

QIAGEN has updated its full-year 2026 outlook for net sales growth of about 1-2% CER (previously at least 5% CER growth). Key factors include headwinds from reduced QuantiFERON immigration testing demand, sustained caution among U.S. Life Sciences customers and increased geopolitical uncertainty. Adjusted diluted EPS are now expected to be at least $2.43 CER (previously at least $2.50 CER). QIAGEN expects stronger growth trends in the second half of 2026, supported by the end of headwinds from the discontinuation of NeuMoDx and Dialunox, benefits from recent and planned product launches, sequential improvement in QuantiFERON sales and contributions from the Parse acquisition tracking ahead of the original target for 2026.

For Q2 2026, QIAGEN expects net sales to decline approximately 2% CER from $534 million in Q2 2025. Adjusted diluted EPS are expected to be at least $0.60 CER compared with $0.60 in Q2 2025.

"QIAGEN made important progress across many areas of the portfolio in the first quarter, led by solid sales growth in Sample technologies, QIAcuity and QIAGEN Digital Insights," said Thierry Bernard, Chief Executive Officer of QIAGEN. "QuantiFERON was affected by the significant decline in immigration testing demand, but we view this as a rebasing of demand within this testing group during 2026 and not a change in the overall long-term opportunity for latent TB testing. We are focused on executing against our updated 2026 targets and positioning QIAGEN for faster growth in the second half of 2026."

"Our profitability for the first quarter reflected disciplined execution in a challenging environment, as we managed the impact of supporting portfolio investments, as well as headwinds from tariffs, currency movements and measures to ensure reliable product supply," said Roland Sackers, Chief Financial Officer of QIAGEN. "We are focused on delivering solid profitable growth through efficiency gains combined with disciplined capital allocation and targeted investments that strengthen QIAGEN’s long-term growth potential and create value for shareholders."

Preliminary sales by product groups

In $ millions

Q1

2026

sales

2025

sales

Change

CER change

Sample technologies

170

150

+13 %

+9 %

Diagnostic solutions

185

187

-1 %

-4 %

Of which QuantiFERON

113

116

-3 %

-5 %

Of which QIAstat-Dx

36

34

+4 %

-1 %

Of which NeuMoDx

—

6

-100 %

-100 %

Of which Other

36

31

+19 %

+15 %

PCR/Nucleic acid amplification

69

76

-9 %

-13 %

Genomics/NGS

57

53

+6 %

+4 %

Other

12

18

-31 %

-31 %

Total net sales

492

483

+2 %

-1 %

Tables may have rounding differences. Percentage changes are to prior-year periods.

Preliminary Q1 2026 results conference call on Tuesday, April 28, 2026

A conference call to discuss the preliminary Q1 2026 results and updated full-year 2026 outlook is scheduled for Tuesday, April 28, 2026, at 15:30 Frankfurt Time / 14:30 London Time / 9:30 New York Time. A live audio webcast will be available in the Investor Relations section of the QIAGEN website (www.qiagen.com), with a recording accessible after the event. The accompanying presentation will be published at the same time as this press release under "Events and Presentations" in the same section.

Full Q1 2026 results publication on May 6, 2026

QIAGEN plans to publish full Q1 2026 results on May 6, 2026, shortly after 22:05 Frankfurt Time / 21:05 London Time / 16:05 New York Time.

QuantiFERON Spotlight Session on May 7, 2026

As previously announced, QIAGEN plans to hold a virtual Spotlight Session to provide insights into our strategic priorities for QuantiFERON and an update on the latest product enhancements. The online event, which is a new format that builds on the recent Deep Dives series, is scheduled for Thursday, May 7, 2026, at 15:30 Frankfurt Time / 14:30 London Time / 9:30 New York Time. Registration details and further information about the webcast are available in the Investor Relations section of the QIAGEN website (www.qiagen.com), under Events and Presentations (View Source), with a recording accessible after the event.

(Press release, Qiagen, APR 27, 2026, View Source [SID1234664808])

On April 27, 2026 Asgard Therapeutics, a privately held biotech company pioneering in vivo direct cell reprogramming for cancer immunotherapy, reported it will present advanced preclinical data on its lead asset AT-108, a first-in-class, off-the-shelf cancer immunotherapy, in an oral presentation at the ASGCT (Free ASGCT Whitepaper) Annual Meeting, held from 11-15 May, 2026, in Boston, Massachusetts, US.

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Fábio Rosa, Co-founder and VP and Head of Research at Asgard Therapeutics, who will give the oral presentation, said: "These data demonstrate the ability of AT-108 to reprogram tumor cells in situ into antigen-presenting cells with high efficiency, systematically driving activation of tumor-specific immune responses within the tumor microenvironment. This work provides clear preclinical evidence supporting our in vivo cell reprogramming platform and represents another milestone for Asgard as we advance AT-108 toward the clinic."

Shane Olwill, Chief Development Officer at Asgard Therapeutics, said: "We are delighted to have been selected for an oral presentation at ASGCT (Free ASGCT Whitepaper), which will highlight the progress we have made advancing AT-108 – our first-in-class, off-the-shelf gene-based immunotherapy designed to trigger powerful, personalized anti-cancer responses. Our pioneering approach to tackling cancer is potentially transformative and we are excited by AT-108’s broad potential across multiple cancer types."

Asgard had previously demonstrated that intratumoral delivery of AT-018 reprograms tumor cells into cDC1-like antigen-presenting cells and works synergistically with immune checkpoint blockade (ICB) to elicit powerful anti-tumor activity.

This new study, being presented at ASGCT (Free ASGCT Whitepaper) 2026, advances AT-108 across four key dimensions. It demonstrates AT-108’s ability to induce systemic anti-tumor immunity in mouse models leading to abscopal effect and regression on non-treated tumors in the same animals; it establishes AT-108 as the optimized clinical candidate following screening of >25 cassette variants; it defines dosing and treatment parameters required for durable responses; and it identifies pharmacodynamic biomarkers associated with reprogramming and immune activation.

Further highlights of the study include that:

In combination with ICB, Asgard’s approach induced abscopal effects and long-term tumor-free survival in the B16 mouse syngeneic model. These results were associated with increased T cells and NK cells, and reduced regulatory T cells, in both injected and non-injected tumors.
When used as a monotherapy, AT-108 doubled median survival in B16 and YUMM1.7 mouse models, and induced regression in ID8 ascites mouse model.
When used in combination with ICB, AT-108 achieved 50% complete response (CR) in B16, and extended survival in the PANC02 immunosuppressed mouse model.
Cell transduction peaked 1-2 days post injection and persisted for up to 9-15 days, supporting re-dosing every two days to sustain transduction. A three-dose lead cycle was required to achieve CRs, with maintenance dosing improving durability.
Regarding biomarkers, tumor and peripheral blood analyses identified pharmacodynamic signatures associated with AT-108 activity, including increased cytotoxic T cells, expansion of follicular helper T cells and enrichment of dendritic cells.

The abstract is available to view via the ASGCT (Free ASGCT Whitepaper) interactive program here.

The positive study results come as Asgard progresses AT-108 toward clinical development with a focus on solid tumors, by advancing IND-enabling studies and CMC development.

Details of the oral presentation are as follows:

Presentation title: Optimized in situ tumor-to-dendritic cell reprogramming by AT-108 adenoviral vector drives local and systemic antitumor immunity
Presenter: Fabio Rosa, Asgard Therapeutics
Presentation session: Cancer vaccines and oncolytic viruses I
Session date and time: 13 May 2026, 03:30 PM – 05:00 PM EDT
Location: MCEC Room 162AB (Level 1)
Presentation Time: 04:30 PM – 04:45 PM EDT

(Press release, Asgard Therapeutics, APR 27, 2026, View Source [SID1234664823])

On April 24, 2026 Oncotelic Therapeutics, Inc. ("Oncotelic" or the "Company"), a clinical-stage biopharmaceutical company focused on oncology and rare diseases, reported a corporate update on its partnership-driven strategy to advance its pipeline and enhance shareholder value.

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Following the success of its joint venture with GMP Biotechnology, which contributed to a $249.0 million increase in the Company’s balance sheet for the most recent fiscal year through an independent third-party valuation, the Company is continuing to pursue additional partnerships that provide financial and commercialization support.

The Company believes this strategy enables the advancement of multiple drug candidates in parallel while maintaining a capital-efficient operating model, and represents an effective approach to unlocking the value of its robust intellectual property portfolio.

CEO Commentary

"Our joint venture strategy has demonstrated the ability to unlock value through strategic partnerships," said Dr. Vuong Trieu, Chairman and Chief Executive Officer of Oncotelic. "We believe this is the right strategy to unlock our robust portfolio of intellectual property at scale. We are currently in discussions with potential partners and are working to establish additional collaborations in the near term."

(Press release, Oncotelic, APR 24, 2026, View Source [SID1234664764])

On April 24, 2026 Novartis reported it has withdrawn a European Medical Agency type II variation application for Pluvicto to treat adult patients with prostate-specific membrane antigen (PSMA)-positive metastatic castration-resistant prostate cancer (mCRPC)1 pre-chemotherapy, following CHMP feedback. The CHMP indicated that they would not support the application based on the control arm used in the PSMAfore study. The withdrawal is not related to the quality, efficacy or safety of Pluvicto and does not impact ongoing clinical trials, approved indications or pending regulatory submissions inside or outside the EU.

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Importantly, the PSMAfore study that supported the application, was the basis for successful approval of Pluvicto in pre-chemotherapy mCRPC patients in the United States, Japan, and China. The value of Pluvicto in this population is also reflected in evidence-based recommendations from leading professional guidelines, including ESMO (Free ESMO Whitepaper), EAU, ASCO (Free ASCO Whitepaper) and NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines)2.

We are disappointed by this outcome and remain committed to advancing treatment options for people with prostate cancer.

(Press release, Novartis, APR 24, 2026, View Source [SID1234664748])