On March 8, 2022 Blueprint Medicines Corporation (NASDAQ: BPMC) reported plans to present new clinical and preclinical data for multiple programs across its precision therapy portfolio at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2022 in New Orleans, April 8 to 13 (Press release, Blueprint Medicines, MAR 8, 2022, View Source [SID1234609727]). The presentations highlight Blueprint Medicines’ next wave of therapeutic candidates in its growing pipeline. These investigational treatments could bring the promise of precision medicine to broad patient populations with genomically defined cancers, including lung, ovarian and breast cancers.

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"At AACR (Free AACR Whitepaper), we plan to unveil a constellation of data highlighting our scientific leadership in precision therapy, and reflecting our commitment to rapidly translate research into transformative medicines for patients," said Fouad Namouni, M.D., President of Research and Development at Blueprint Medicines. "With multiple drug candidates entering clinical trials, our AACR (Free AACR Whitepaper) presentations feature initial results from the Phase 1/2 SYMPHONY study of BLU-945 in EGFR-driven non-small cell lung cancer, as well as data reinforcing our programs’ differentiated preclinical profiles and significant potential to advance patient care."

The accepted abstracts are listed below and available on the AACR (Free AACR Whitepaper) conference website: View Source

Clinical Trial and Late-Breaking Poster Presentations

Presentation Title: Emerging evidence of activity of BLU-945 in patients with advanced EGFR-mutant NSCLC utilizing circulating tumor DNA (ctDNA) in the phase 1/2 SYMPHONY study
Session Title: Phase I Clinical Trials 2
Session Date & Time: Tuesday, April 12, 2022 from 9:00 a.m. – 12:30 p.m. CT (10:00 a.m. – 1:30 p.m. ET)
Abstract Number: CT184
Location: New Orleans Convention Center, Exhibit Halls D-H, Poster Section 33

Presentation Title: Efficacy of a highly potent and selective KIT V654A inhibitor for treatment of imatinib resistant GIST
Session Title: Late-Breaking Research: Experimental and Molecular Therapeutics 2
Session Date & Time: Wednesday, April 13, 2022 from 9:00 a.m. – 12:30 p.m. CT (10:00 a.m. – 1:30 p.m. ET)
Abstract Number: LB205
Location: New Orleans Convention Center, Exhibit Halls D-H, Poster Section 16

Poster Presentations

Presentation Title: LNG-451,* a potent inhibitor of EGFR exon 20 insertion mutations with high CNS exposure
Session Title: Epigenetic Targets
Session Date & Time: Tuesday, April 12, 2022 from 1:30 p.m. – 5:00 p.m. CT (2:30 p.m. – 6:00 p.m. ET)
Abstract Number: 3261
Location: New Orleans Convention Center, Exhibit Halls D-H, Poster Section 23

Presentation Title: LNG-451* is a potent, CNS-penetrant, wild-type EGFR sparing inhibitor of EGFR exon 20 insertion mutations
Session Title: Tyrosine Kinase and Phosphatase Inhibitors
Session Date & Time: Tuesday, April 12, 2022 from 1:30 p.m. – 5:00 p.m. CT (2:30 p.m. – 6:00 p.m. ET)
Abstract Number: 3332
Location: New Orleans Convention Center, Exhibit Halls D-H, Poster Section 26

Presentation Title: BLU-222, an investigational, potent, and selective CDK2 inhibitor, demonstrated robust antitumor activity in CCNE1-amplified ovarian cancer models
Session Title: Cell Cycle Control and Cell Cycle Regulators as Therapeutic Targets
Session Date & Time: Tuesday, April 12, 2022 from 9:00 a.m. – 12:30 p.m. CT (10:00 a.m. – 1:30 p.m. ET)
Abstract Number: 2306
Location: New Orleans Convention Center, Exhibit Halls D-H, Poster Section 5

Presentation Title: Antitumor activity of BLU-945 and BLU-701 as single agents and in combination in EGFR L858R-driven models of NSCLC
Session Title: Tyrosine Kinase and Phosphatase Inhibitors
Session Date & Time: Tuesday, April 12, 2022 from 1:30 p.m. – 5:00 p.m. CT (2:30 p.m. – 6:00 p.m. ET)
Abstract Number: 3328
Location: New Orleans Convention Center, Exhibit Halls D-H, Poster Section 26

* LNG-451 is now known as BLU-451.

Investor Conference Call Information

Blueprint Medicines will host a live webcast on Friday, April 8, 2022 beginning at 2:00 p.m. ET to discuss the data reported at AACR (Free AACR Whitepaper). On the day of the webcast, poster presentations will be made available on the AACR (Free AACR Whitepaper) conference website at 1:00 p.m. ET. To access the live call, please dial 844-200-6205 (domestic) or 929-526-1599 (international), and refer to conference ID 084402. A webcast of the conference call will be available in the Investors & Media section of Blueprint Medicines’ website at View Source The archived webcast will be available on Blueprint Medicines’ website approximately two hours after the conference call and will be available for 30 days following the call.

On March 8, 2022 Affimed N.V. (Nasdaq: AFMD), a clinical-stage immuno-oncology company committed to giving patients back their innate ability to fight cancer, reported that two abstracts with clinical data of its innate cell engagers (ICE) have been accepted for presentation at the annual meeting of the American Association for Cancer Research (AACR) (Free AACR Whitepaper), taking place April 8-13, 2022 in New Orleans, Louisiana (Press release, Affimed, MAR 8, 2022, View Source [SID1234609801]).

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The two events include an oral presentation with an update of the study that evaluates AFM13 pre-complexed with NK cells in patients with CD30-positive lymphomas and a poster presentation with data of the dose-escalation phase of the AFM24 monotherapy study for solid tumor treatment.

Oral presentation details:

Title: Innate cell engager (ICE) AFM13 combined with preactivated and expanded cord blood (CB)-derived NK cells for patients with refractory/relapsed CD30+ lymphoma

Presentation: CT003

Authors: Yago Nieto, Pinaki Banerjee, Indreshpal Kaur, Roland Bassett, Lucila Kerbauy, Rafet Basar, Mecit Kaplan, Lori Griffin, Daniel Esqueda, Christina Ganesh, Melissa Barnett, Amin Alousi, Chitra Hosing, Jeremy Ramdial, Neeraj Saini, Samer Srour, Karenza Alexis, Andreas Harstrick, Elizabeth J Shpall, Katayoun Rezvani

Session: Clinical Trials of Cellular Immunotherapies, Sunday, April 10, 1:00 – 3:00 p.m. CDT

Poster details:

Title: A phase 1/2a first-in-human study of AFM24, a CD16A/epidermal growth factor (EGFR) bispecific Innate Cell Engager (ICE), in patients with locally advanced or metastatic EGFR-expressing solid tumors: Preliminary findings from the dose-escalation phase

Abstract number: CT149

Authors: Anthony El-Khoueiry, Juanita Lopez, Omar Saavedra, Mark Awad, Jacob Thomas, Crescens Tiu, Elena Garralda, Bettina Rehbein, Gabriele Hintzen, Kerstin Pietzko, Christa Raab, Erich Rajkovic, Paulien Ravenstijn, Michael Emig

Session: Phase I Clinical Trials 1, Monday, April 11, 1:30 p.m. – 5:00 p.m. CDT

Abstract release: The full abstract will become public at 1:00 p.m. ET on Friday, April 8

More details about the programs for the AACR (Free AACR Whitepaper) Virtual Annual Meetings are available online at www.aacr.org.

About AFM13

AFM13 is a first-in-class innate cell engager (ICE) that uniquely activates the innate immune system to destroy CD30-positive hematologic tumors. AFM13 induces specific and selective killing of CD30-positive tumor cells, leveraging the power of the innate immune system by engaging and activating natural killer (NK) cells and macrophages. AFM13 is Affimed’s most advanced ICE clinical program and is currently being evaluated as a monotherapy in a registration-directed trial in patients with relapsed/refractory peripheral T-cell lymphoma (REDIRECT, NCT04101331).

In addition, The University of Texas MD Anderson Cancer Center is studying AFM13 in an investigator-sponsored phase 1/2 trial in combination with cord blood-derived allogeneic NK cells in patients with relapsed/refractory CD30-positive lymphomas (NCT04074746).

About AFM24

AFM24 is a tetravalent, bispecific innate cell engager (ICE) that activates the innate immune system by binding to CD16A on innate immune cells and EGFR, a protein widely expressed on solid tumors, to kill cancer cells. Generated by Affimed’s fit-for-purpose ROCK platform, AFM24 represents a distinctive mechanism of action that uses EGFR as a docking site to engage innate immune cells for tumor cell killing through antibody-dependent cellular cytotoxicity and antibody-dependent cellular phagocytosis.

Affimed evaluates AFM24 as a monotherapy (AFM24-101) for patients with advanced EGFR-expressing solid malignancies whose disease has progressed after treatment with previous anticancer therapies. The first-in-human Phase 1/2a open-label, non-randomized, multi-center, multiple ascending dose escalation and expansion study and can be found at www.clinicaltrials.gov using the identifier NCT04259450. Furthermore, AFM24 is evaluated in a phase 1/2a study in combination with Roche’s anti-PD-L1 checkpoint inhibitor atezolizumab (AFM24-102, NCT05109442). Affimed and NKGen Biotech have initiated a Phase 1/2a study (AFM24-103), investigating AFM24 in combination with SNK01, NKGen Biotech’s NK cell product (NCT05099549).

On March 8, 2022 Lyell Immunopharma, Inc. (Lyell), (Nasdaq: LYEL), a T-cell reprogramming company dedicated to the mastery of T cells to cure patients with solid tumors, reported that an abstract has been accepted for poster presentation at the upcoming American Association for Cancer Research (AACR) (Free AACR Whitepaper) 2022 Annual Meeting, scheduled for April 8-13 in New Orleans (Press release, Lyell Immunopharma, MAR 8, 2022, View Source [SID1234609998]).

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The poster presentation being presented at AACR (Free AACR Whitepaper) will highlight the preclinical data characterizing LYL797, Lyell’s first therapeutic candidate incorporating T-cell reprogramming technologies for the treatment of solid tumors. LYL797 is an investigational chimeric antigen receptor (CAR) T-cell therapy for patients with receptor tyrosine kinase-like orphan receptor 1-positive (ROR1+) solid tumors. LYL797 incorporates two Lyell technologies designed to address major barriers to successful Adoptive Cell Therapy (ACT): Gen-R, a genetic reprogramming technology that endows T cells with the ability to resist exhaustion, and Epi-R, an epigenetic reprogramming technology that creates populations of T cells with the properties of durable stemness. T cells with properties of durable stemness are able to proliferate, persist, and self-renew with anti-tumor functionality.

"With LYL797 entering clinical development, we are excited to present the preclinical data evaluating our two T-cell reprogramming technologies which are designed to overcome the barriers we believe have impeded the development of more effective cell therapies for patients with solid tumor cancers," said Tina Albertson, MD, PhD, Chief Medical Officer and Head of Development of Lyell. "Reprogramming T cells to be able to resist exhaustion and demonstrate properties of durable stemness is key to our mission to develop cell therapies that can outlast and eradicate hard-to-kill solid tumors."

Details on the poster presentation are below:

Poster Title: LYL797, a ROR1 CAR T-cell therapy with genetic and epigenetic reprogramming for solid tumors
Session: Adoptive Cell Therapy
Abstract Number: 3808
Presentation Date, Time & Location: Tuesday, April 12, 9:00am – 12:30pm, Section 30
Presenter: Spencer Park, PhD, Lyell Immunopharma

The abstract has been posted to the AACR (Free AACR Whitepaper) online itinerary planner. Following the meeting, the abstract will be published in an online-only supplement to the AACR (Free AACR Whitepaper) journal Cancer Research.

Lyell announced U.S. Food and Drug Administration (FDA) clearance of its Investigational New Drug (IND) application to initiate a Phase 1 clinical trial for LYL797 in December 2021.

On March 8, 2022 Cothera Bioscience, the parent company of Percans Oncology, reported that it received approval from the National Medical Products Administration (NMPA) to conduct a Phase 2 clinical trial to test its targeted MYC mutation inhibitor PC-002 as a first-line or second-line treatment for drug-resistant or relapsed high-grade B-cell lymphoma (HGBCL) (Press release, Cothera Bioscience, MAR 8, 2022, View Source [SID1234618849]). The NMPA completed its review of the project in just 45 working days, demonstrating the strong support of regulatory authorities for innovative drugs.

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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PC-002, the core product of Cothera Bioscience, is a first-in-class small molecule drug targeting MYC-mutated tumors. With a unique mechanism of action (MOA), PC-002 selectively induces MYC protein degradation and cell apoptosis in MYC-dependent tumors. With more than 50% of human cancers showing increased expression, MYC is regarded as one of the most important yet "undruggable" cancer targets. Via its unique mechanism, PC-002 selectively kills tumor cells with MYC mutation and may potentially target multiple indications in cancers.

On March 8, 2022 Aptose Biosciences Inc. (Nasdaq: APTO; TSX: APS), a clinical stage precision oncology company developing highly differentiated oral kinase inhibitors to treat hematologic malignancies, will report financial results for the year and quarter ended December 31, 2021, on Tuesday, March 22, 2022 after the close of the market, and provide a corporate update (Press release, Aptose Biosciences, MAR 8, 2022, View Source [SID1234609624]).

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Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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Conference Call & Webcast:

The live conference call can also be accessed through a link on the Investor Relations section of Aptose’s website here. An archived version of the webcast along with a transcript will be available on the company’s website for 30 days.

The press release, the financial statements and the management’s discussion and analysis for the year and quarter ended December 31, 2021 will be available on SEDAR at www.sedar.com and EDGAR at www.sec.gov/edgar.shtml.