On June 9, 2022 SOPHiA GENETICS (Nasdaq: SOPH), the Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) of Barcelona, and the Spanish Diagnóstica Longwood reported from the European Hematology Association (EHA) (Free EHA Whitepaper) Congress in Vienna that they have combined their expertise to develop a new Chronic Lymphocytic Leukemia (CLL) solution to advance CLL care (Press release, Sophia Genetics, JUN 9, 2022, View Source [SID1234615846]). This collaboration will unify the wide variety of current guideline recommendations into one single application aiming to improve CLL characterization and CLL research practices in Iberia.

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SOPHiA GENETICS has already facilitated the analysis of one million genomic profiles through the SOPHiA DDM Platform, including a significant amount of onco-hematological-related diseases such as acute myeloid leukemia and lymphomas. The Platform computes a wide array of genomic variants needed to continually hone machine learning algorithms designed to accurately detect rare and challenging cases. The growing number of users of the SOPHiA DDM community can share and access insights by pulling the relevant signals detected from the noise, ultimately saving time and helping to make better-informed decisions.

The new CLL solution allows for progress of Chronic Lymphocytic Leukemia research using genomic analysis. This could lead to better detection of the disease, which accounts for 25-30% of all leukemia cases in Western countries and affects yearly more than 100,000 people globally[1], and ultimately improve patient care. Thanks to the SOPHiA DDM Platform and IDIBAPS, hematopathologists can now access guidelines for the mutational status of TP53, immunoglobulin (IG) gene rearrangements and their somatic hypermutation status, while benefitting from the identification of 23 CLL-specific genes for SNVs, InDels and CNVs including NOTCH1, SF3B1, ATM, IGLV3-21, BTK, PLCG2, BCL2, del13q14, and trisomy 12, all in one single NGS workflow.

The new CLL solution has already been used in routine in Spain, with further opportunities throughout the country, and in Latin America through Diagnóstica Longwood’s distribution channels.

"We are proud to work together with some of the most renowned experts in the field of Chronic Lymphocytic Leukemia research around the world. This partnership is a great example of how combining advanced data analytics with emerging CLL strategies can move the possibilities of data-driven medicine forward," said Lara Hashimoto, Chief Business Officer at SOPHiA GENETICS.

"It is a great satisfaction to see how thanks to the partnership with SOPHiA GENETICS and Diagnóstica Longwood we will be able to transfer into clinical practice the relevant information generated for so many years in the research of CLL using a simple and robust assay," said Elías Campo, principal investigator and director of IDIBAPS.

On June 9, 2022 Shanghai I-Mab reported that it will alter its collaboration with Switzerland’s Ferring Pharma to develop olamkicept, a potential therapy for inflammatory bowel disease (Press release, I-Mab Biopharma, JUN 9, 2022, View Source [SID1234615863]). In 2016, I-Mab acquired rights to develop olamkicept. a selective interleukin-6 inhibitor, in Greater China and Korea. Now, Ferring will invest in the global development of olamkicept, while I-Mab will have an option to collaborate with Ferring in olamkicept’s global development at a pre-defined milestone. No details were given, though Ferring mal underwrite a China Phase III trial of olamkicept, and I-Mab will opt into global development later.

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On June 9, 2022 Chemomab Therapeutics Ltd. (Nasdaq: CMMB), (Chemomab), a clinical-stage biotechnology company focused on the discovery and development of innovative therapeutics for fibrotic and inflammatory diseases with high unmet need, reported that the company will participate in a number of investor and scientific conferences in June 2022 (Press release, Chemomab, JUN 9, 2022, View Source [SID1234615815]).

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JMP Securities Life Sciences Conference:

Date: Thursday, June 16, 2022
Venue: Lotte Palace Hotel, New York, NY USA
Format: In-person live and webcast presentation; One-on-one meetings on June 16
Time: 11:00 a.m. ET
Link: View Source
Information: View Source

A replay of the webcast will be available at the Investor section of Chemomab’s website for at least 30 days.

The Extracellular Matrix Pharmacology Congress

Date: June 23-25, 2022
Venue: Tivoli Congress Center, Copenhagen, Denmark
Format: Poster presentation: CCL24 Inhibition by CM-101 Attenuates Extracellular Matrix and Fibrotic Biomarkers in Both Patients and Experimental Murine Models, Abstract ID:155
Time: Poster Session 1, June 23 from 13:00 – 14:15 CET
Presenter: Udi Gluschnaider, PhD, Chemomab Project Lead
Information: ECM Congress (ecm-congress.org)

A copy of the poster will be available at the R&D section of Chemomab’s website starting on June 23, 2022.

EASL: The International Liver Congress 2022

Date: June 22-26, 2022
Venue: ExCeL London, London, UK, and virtual
Format: Oral poster presentation: Combination of whole liver single cell RNA sequencing and spatial transcriptomics reveals specific cell sub-populations and pathways regulated by CCL24, Abstract Identifier: OS02
Presenter: Raanan Greenman, PhD, Chemomab Project Lead
Time: June 23, 2022, 16:45 CET
Session: Immune-mediated and cholestatic: Experimental and pathophysiology
Information: View Source

The presentation will be available at the R&D section of Chemomab’s website starting on June 24, 2022

In addition, Chemomab’s business development team members will be in San Diego, California June 13-16, 2022, participating in the BIO International Convention’s One-on-One Partnering event. Registered attendees can click here to log in and schedule a meeting with Chemomab.

On June 9, 2022 Aeterna Zentaris Inc. (NASDAQ: AEZS) (TSX: AEZS) ("Aeterna" or the "Company"), a specialty biopharmaceutical company developing and commercializing a diversified portfolio of pharmaceutical and diagnostic products, reported Dr. Klaus Paulini, Chief Executive Officer of Aeterna Zentaris, will present at the JMP Securities Life Sciences Conference on Wednesday, June 15, 2022 at 12:30 PM ET being held in New York, New York (Press release, AEterna Zentaris, JUN 9, 2022, View Source;id=233641&p=2232418&I=1206939-c7Z3G6f3m8 [SID1234615831]).

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In addition to the presentation, management will be available to participate in one-on-one meetings with qualified members of the investor community who are registered to attend the conference. For more information, please visit the conference website.

A live video webcast of the presentation will be available on the Company’s website on the Events page in the Investors section of the Company’s website (zentaris.com). The webcast replay will be archived for 90 days following the event.

On June 9, 2022 IceCure Medical Ltd. (NASDAQ: ICCM) (TASE: ICCM) ("IceCure" or the "Company"), developer of minimally-invasive cryoablation technology, the ProSense System, that destroys tumors by freezing as an alternative to surgical tumor removal ("ProSense"), reported that KTRFIOS IMPORTACAO E EXPORTACAO LTDA., IceCure’s distributor in Brazil ("KTRFIOS"), has submitted a regulatory filing to the Brazilian Health Regulatory Agency ("ANVISA") for the approval of ProSense for several indications (Press release, IceCure Medical, JUN 9, 2022, View Source [SID1234615847]). KTRFIOS has submitted this regulatory filing as part of an agreement signed with IceCure which includes KTRFIOS’ guarantee of at least $6.6 million in total sales for five years following such regulatory approval and a down payment of $344,000 for 50% of the initial order.

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The indications for use included in the ANVISA application are for oncology, including ablation of benign and malignant tissues in breast, prostate, kidney, lung, liver, musculoskeletal, and skin tissues, as well as for palliative intervention and other indications.

According to the World Health Organization’s (WHO) Cancer Tomorrow | IARC project, Brazil had a population of over 200 million with an estimated 592,000 cancer cases in 2020, 88,500 of which were breast cancer. The WHO expects the number of breast cancer cases in Brazil to rise to 99,800 by 2025. Therefore, IceCure believes there is a clear need for minimally-invasive cancer treatments, such as ProSense, in the Brazilian market.

"We are very pleased to be working with KTRFIOS in Brazil, a significant healthcare market in Latin America, and to achieve this major milestone. This regulatory application reflects the broad number of indications for which our ProSense system can provide a highly effective, minimally invasive, and safe method of treatment for cancer patients," stated IceCure CEO Eyal Shamir. "Regulatory approvals in Brazil would add to our global regulatory landscape which now encompasses various indications across 14 countries including the U.S. and Europe."