On May 24, 2022 MaaT Pharma (EURONEXT: MAAT – the "Company"), a French clinical-stage biotech and a pioneer in the development of Microbiome Ecosystem Therapies dedicated to improving survival outcomes for patients with cancer reported that it will host its first R&D Day for analysts and investors to be held virtually on Tuesday, June 7th, 2022 from 4:00 pm CEST (10:00 am EST) to 6:00 pm CEST (12:00 pm EST) (Press release, MaaT Pharma, MAY 24, 2022, View Source [SID1234614981]).

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MaaT Pharma’s speakers will discuss the microbiome potential in cancer therapy and the latest clinical results of MaaT013 and MaaT033. They will also present the Company’s innovative proprietary drug discovery platform, the next generation of products MaaT03X and the construction of Europe’s largest cGMP manufacturing facility for Microbiome Ecosystem Therapies.

In addition to the presentations by MaaT Pharma’s senior team, the R&D Day will feature talks from world renowned scientists and physicians including:

Joël Doré – Research Director, Director of INRAE and Scientific Advisor at MaaT Pharma, France
Ernst Holler, M.D. – Senior Professor on Clinical and Experimental Allo-HSCT, Department of Internal Medicine, University Hospital Center Regensburg, Germany
Florent Malard, M.D. – Professor of Hematology, Saint Antoine Hospital (AP-HP) and Sorbonne University
Mohamad Mohty, M.D. – Professor, Sorbonne University and Head of the Clinical Hematology and Cellular Therapy Department, Saint-Antoine Hospital (AP-HP), France
Hassane Zarour, M.D. – Professor of Medicine, Immunology and Dermatology, University of Pittsburg, James and Frances McGlothlin Chair in Melanoma Immunotherapy Research
"MaaT Pharma’s inaugural R&D Day is an opportunity to bring together world-renowned scientists and our talented internal team to share MaaT Pharma’s innovative research and highlight our unique positioning in the microbiome space," said Hervé Affagard, Chief Executive Officer and Co-Founder of MaaT Pharma. "Since our successful IPO in November 2021, we have delivered on the key milestones we had defined and we continue to progress, with the ambition to leverage the microbiome for the benefit of millions of patients fighting cancer."

A question-and-answer session will follow the presentations. Please note that all the presentations are in English with French subtitles. The webcast will be made available on the Company’s website after the event.

On May 24, 2022 Shasqi, a clinical-stage biotechnology company developing click chemistry-activated oncology therapeutics, reported the additions of Steve Abella, M.D., as Chief Medical Officer and Scott Wieland, Ph.D., MBA, as Senior Vice President of Clinical Development (Press release, Shasqi, MAY 24, 2022, View Source [SID1234615000]).

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"To maximize the potential of our novel, click chemistry-based platform and continue expanding our portfolio of programs, clinical experience and leadership are critical," said José M. Mejía Oneto, M.D., Ph.D., Founder and CEO of Shasqi. "As we reach the end of dose escalation of SQ3370, we will initiate Phase 2 studies in advanced sarcomas and other solid tumors. In addition, we are rapidly advancing our second program toward the clinic, which activates high doses of monomethyl auristatin E, a commonly used antibody-drug conjugate payload, at the tumor. Now is the perfect time to add the deep expertise in clinical strategy and execution that both Steve and Scott bring to the team. We look forward to their contributions and working with them."

"Shasqi has made tremendous progress advancing SQ3370 into and through the clinic and building a robust pipeline of click chemistry-activated therapeutics to harness potent payloads and target them precisely to the tumor," said Dr. Abella. "I’m excited to join the company’s mission and help expand the reach of their platform."

"A click chemistry-based approach has enormous potential to dramatically improve the efficacy of powerful therapies that can be localized at the tumor site using a variety of delivery methods such as direct injection or biomarker targeting," said Dr. Wieland. "I look forward to seeing where we can take this technology and what the next iterations of Shasqi’s approach can achieve in improving the cancer therapeutic landscape and the lives of patients."

Dr. Steve Abella

Dr. Abella has been working in oncology clinical research for nearly 35 years, including more than 12 years in the pharmaceutical industry. Before joining Shasqi, he served as Chief Medical Officer at Vida Development Sciences. Prior to Vida, Steve served as Chief Medical Officer at BioClin Therapeutics. Prior to that, he served as Senior Director at Gilead Sciences where he led the non-Hodgkin’s lymphoma and leukemia drug development efforts and served as a core member of the oncology senior leadership team. Prior to Gilead, he served as Executive Director at Amgen, predominately responsible for the white cell franchise (Neulasta/Nepogen) and led global development efforts across clinical research and medical affairs. Before he joined the biopharmaceutical industry, he spent 15 years in academic oncology, serving as a Professor of Pediatric, Oncology, and Medicine at the Barbara Ann Karmanos Cancer Institute where he focused on stem cell transplantation and oncology clinical trials. Steve completed his fellowship and residency training at Wayne State University School of Medicine after graduating with a degree in medicine from the Universidad Central del Este. He attended the University of Pennsylvania for undergraduate studies.

Dr. Scott Wieland

Dr. Wieland is a biopharmaceutical veteran with over 30 years of experience in the biopharmaceutical industry. Over the course of his career, Scott has served in a variety of roles and responsibilities, most recently as Executive Vice President of Development at Nanobiotix, a nanomedicine company based in Paris, France. Scott started his career leading the Behavioral Pharmacology lab at CoCensys, then moved into a variety of positions across several small biopharmaceutical companies. Scott has been responsible for drug discovery, safety pharmacology, toxicology, bioanalytical development, manufacturing, formulation, clinical supply and distribution, regulatory affairs, and all aspects of clinical trials and development during his career. Scott received a bachelor’s degree in Physiological Psychology from UC Santa Barbara, CA. He received his master’s and Ph.D. in Psychology/Biopsychology with a minor in Neuropharmacology from the University of Arizona, Tucson, AZ, and an MBA in Management from Webster University, St. Louis, MO.

About CAPACTM and SQ3370

SQ3370 is the first click chemistry-based treatment to be tested in humans. It utilizes Shasqi’s proprietary CAPAC platform, an approach that activates cancer drugs at a tumor with decreased systemic toxicity. Shasqi is validating its platform with SQ3370, which is designed to activate a powerful chemotherapeutic, doxorubicin, at the tumor site. The investigational product is based on the chemical reaction between a drug protected through a trans-cyclooctene modification (a protodrug) and a tetrazine-modified biopolymer. The biopolymer is injected into the target tumor lesion, where it precisely activates an intravenously infused protodrug. Shasqi believes its click-chemistry approach can improve the efficacy and safety of many existing therapeutics across various modalities with a limited therapeutic window.

On May 24, 2022 PeLeMed reported that it will present the preclinical study results of the FLT3/RET dual inhibitor candidate ‘PLM-102’ at the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) 2022 (ASCO 2022) (Press release, PeLeMed, MAY 24, 2022, View Source [SID1234615603]).

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PLM-102, a target anticancer drug candidate of Pelemed, targets even FLT3-resistant mutations (D835Y, F691L) that develop resistance after treatment with existing drugs such as ‘Xospata, gilteritinib’, an FLT3 inhibitor for the treatment of acute myeloid leukemia (AML). do. Pelemed is aiming to submit an IND to the Korean and US Food and Drug Administration (FDA) next year.

At this ASCO (Free ASCO Whitepaper), Pelemed will present △in vitro biochemical, cellular △ in vitro efficacy, △mode of action, etc. of PLM-102 along with the existing drug Zosphata. .

Specifically, PLM-102 showed an excellent Kd value for binding even at a lower dose compared to the FLT3/AXL inhibitor Zosphata in the binding affinity test. The Kd value of PLM-102 was 0.019 nM (vs 1.4 nM) for normal FLT3 and 0.01 to 1.1 nM (vs 0.16 to 19 nM) for TKD mutant, which showed a lower Kd value than that of Zosphata.

Pelemed’s PLM-102 resulted in effective cell growth inhibition at a lower dose than Zosphata in acute myeloid leukemia cell lines (MV4-11, MOLM-13, MOLM-14) and Ba/F3 cell lines with FLT3 mutations. showed

A tumor mouse model administered with a dose of 5 mg/kg or more of PLM-102 showed complete remission with tumor growth inhibition when administered orally once a day. In addition, Pelemed explained that the anticancer effect was also confirmed in drug-resistant double mutation models (ITD/F691L, ITD/D835Y) administered with PLM-102.

Pelemed confirmed the RET inhibitory effect of PLM-102 and the decomposition effect of RET and FLT3 proteins. This proteolysis phenomenon did not appear in Zosphata and another approved RET inhibitor, Roche’s ‘Gavreto, pralsetinib’, indicating a differentiated mechanism of RLM-102, the company explained.

Acute myeloid leukemia (AML) is a type of blood cancer in which tumor cells appear in the blood or bone marrow. FLT3 mutations are observed in about 30% of acute myeloid leukemia patients. It is known that 50% of patients with acute myeloid leukemia who have achieved complete remission with high-intensity chemotherapy experience recurrence, and patients with FLT3 mutations are known to have a higher risk of recurrence and a lower survival rate than those who do not.

An official from Pelemed said, "PLM-102, which has a differentiated mechanism, is under non-clinical research this year.

On May 24, 2022 Merck (NYSE: MRK), known as MSD outside the United States and Canada, reported that the Board of Directors has declared a quarterly dividend of $0.69 per share of the company’s common stock for the third quarter of 2022 (Press release, Merck & Co, MAY 24, 2022, View Source [SID1234614982]). Payment will be made on July 8, 2022 to shareholders of record at the close of business on June 15, 2022.

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On May 24, 2022 Ikonisys SA (Code ISIN: FR00140048X2 / Mnémonique: ALIKO), a company specializing in the early and accurate detection of cancer with a unique fully-automated solution for medical diagnostic labs and the Department of Electronics, Information and Bioengineering (DEIB) of Politecnico di Milano (POLIMI), a world-class scientific institution engaged in cutting-edge research, training and technology transfer, reported the signing of a research contract and the initiation of a project to bear on the challenging problem of identifying specific cells in complex tissues through designing, training and deployment of a deep learning model able to detect them.

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Prof. Giacomo Boracchi of the DEIB will lead the research bringing his expertise in image processing and machine learning. In particular, the approach will aim to recognize clinically relevant cells of specific types in darkfield images of lung tissue acquired from the Ikoniscope20. Segmentation of single cell nuclei is a frequent challenge of microscopy image processing, often being the first step of many quantitative data analysis pipelines.

The ongoing collaboration will allow Ikonisys to further enhance its advanced image analysis capabilities and to accelerate the development of the Ikoniscope AI project with the implementation of deep learning models and novel state-of-art techniques into the instrument’s workflow, leading to the development of new applications or enhancement of the existing ones, especially in the most challenging fields such as Circulating Tumor Cells.