On April 22, 2026 Altimmune, Inc. (Nasdaq: ALT), a late clinical-stage biopharmaceutical company developing pemvidutide to address serious liver diseases, reported the pricing of its previously announced underwritten public offering consisting of (i) 64,250,000 shares of its common stock and accompanying common stock warrants to purchase an aggregate of 64,250,000 shares of common stock (or pre-funded warrants in lieu thereof) and (ii) in lieu of common stock, to certain investors that so choose, pre-funded warrants to purchase an aggregate of up to 10,750,000 shares of its common stock and accompanying common stock warrants to purchase an aggregate of 10,750,000 shares of common stock (or pre-funded warrants in lieu thereof), at an exercise price of $0.001 per pre-funded warrant. The common stock and pre-funded warrants are being sold in combination with an accompanying common stock warrant to purchase one share of common stock (or pre-funded warrant in lieu thereof) issued for each share of common stock or pre-funded warrant sold. The accompanying common stock warrant has an exercise price of $3.00 per share, is immediately exercisable from the date of issuance and will expire upon the earlier of (i) the fifth anniversary of the original issuance date and (ii) forty-five days following the Company’s public announcement of a successful data readout of its Phase 3 trial of pemvidutide in metabolic dysfunction-associated steatohepatitis ("MASH"). The combined offering price of each share of common stock and accompany common stock warrant is $3.00. The combined offering price of each pre-funded warrant and accompanying common stock warrant is $2.999. The offering is expected to close on or about April 24, 2026, subject to satisfaction of customary closing conditions.

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All of the shares, pre-funded warrants and accompanying common stock warrants in the offering are being sold by Altimmune. The gross proceeds from the offering before deducting underwriting discounts and commissions and other offering expenses, are expected to be approximately $225 million. The public offering is subject to market and other conditions, and there can be no assurance as to whether or when the public offering may be completed.

Altimmune intends to use the net proceeds from this offering to fund its upcoming Phase 3 trial in MASH, as well as for working capital and general corporate purposes.

Leerink Partners and Barclays are acting as joint bookrunning managers for the offering. Titan Partners is acting as co-bookrunning manager for the offering.

The shares of common stock, pre-funded warrants, common stock warrants and shares of common stock issuable upon the exercise of the pre-funded warrants and common stock warrants are being offered by Altimmune pursuant to two effective shelf registration statements on Form S-3 that were previously filed with the U.S. Securities and Exchange Commission (SEC) and declared effective by the SEC on December 5, 2025 and March 13, 2025, respectively, and a related registration statement that was filed with the SEC on April 22, 2026 pursuant to Rule 462(b) under the Securities Act of 1933, as amended (and became automatically effective upon filing). The preliminary prospectus supplement and accompanying prospectuses relating to and describing the terms of the offering were filed with the SEC on April 22, 2026 and are available on the SEC’s website located at www.sec.gov. Electronic copies of the final prospectus supplement may be obtained, when available, by contacting Leerink Partners LLC, Syndicate Department, 53 State Street, 40th Floor, Boston, MA 02109, or by telephone at (800) 808-7525 ext. 6105, or by email at [email protected]; Barclays Capital Inc., c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY 11717, by telephone at (888) 603-5847, or by email at [email protected]; or by accessing the SEC’s website at www.sec.gov. Before you invest, you should read the preliminary prospectus supplement and accompanying prospectuses and other documents Altimmune has filed with the SEC that are incorporated by reference into the preliminary prospectus supplement and accompanying prospectuses for more complete information about Altimmune and the offering.

This press release shall not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

(Press release, Altimmune, APR 22, 2026, View Source [SID1234664698])

On April 22, 2026 The US Food and Drug Administration (FDA) reported that it has extended by up to three months the target action date for its review of the biologics license application for Sarclisa (isatuximab-irfc) subcutaneous (SC) in combination with approved standard-of-care regimens for the treatment of patients with multiple myeloma (MM) across all currently approved US indications of Sarclisa intravenous (IV) formulation. The revised target action date for the FDA decision is July 23, 2026.

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Sanofi is committed to working closely with the FDA to bring this new advancement to patients and providers as quickly as possible. If approved, Sarclisa would be the first anticancer treatment to be administered through an on-body injector (OBI).

On March 26, 2026, the European Medicine Agency Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion recommending the approval of Sarclisa SC administered via both an OBI and manual injection for the treatment of MM patients across all currently approved indications and combinations for Sarclisa IV formulation in the EU. A final decision is expected in the coming months.

About Sarclisa
Sarclisa (isatuximab-irfc) has been approved in almost 60 countries across four indications for certain patients with newly diagnosed MM and relapsed or refractory MM. Sarclisa-based regimens have been prescribed to treat more than 60,000 patients worldwide.

At Sanofi, we are building on a long-standing commitment to oncology as we continue to chase the miracles of science to improve the lives of those living with cancer. We are committed to transforming cancer care by developing innovative, first and best-in-class immunological and targeted therapies for rare and difficult-to-treat cancers with high unmet need.

For more information on Sarclisa clinical studies, please visit www.clinicaltrials.gov.

(Press release, Sanofi, APR 22, 2026, View Source [SID1234664714])

On April 22, 2026 NETRIS Pharma, a clinical-stage oncology company targeting the netrin-1 / epithelial-to-mesenchymal transition (EMT) axis, reported that positive results from « LAPNET-01 » its phase 1b trial (NCT05546853) of NP137, were published in Nature (DOI: 10.1038/s41586-026-10436-4) :

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The data show that in patients with pancreatic ductal adenocarcinoma (PDAC) with locally advanced PDAC (LAPC), treatment with NP137, the first-in-class anti-netrin1 monoclonal antibody, in combination with modified FOLFIRINOX (mFOLFIRINOX) as a first-line therapy achieved a median progression free survival (PFS) of 10.85 months, median overall survival (OS) of 16.43 months and a 23% conversion-to-surgery rate. In addition, a subset of patients with high tumor netrin-1 receptor neogenin expression showed a median PFS of 15.65 months, a 40% conversion-to-surgery rate and a 12-months OS rate of 100%.

« Achieving this early clinical efficacy in pancreatic ductal adenocarcinoma is very promising for patients who have limited options. The group of neogenin-high patients, where we saw dramatically extended PFS and OS is unprecedented and opens a path for personalized and potentially more effective treatments of this group of pancreatic cancer patients » said Gael Roth, MD, PhD, Professor in GI Oncology at Grenoble Alpes University Hospital, LAPNET-01 lead investigator and first author of the paper in Nature. « The LAPNET-01 data amply justify further development in pancreatic ductal adenocarcinoma ».

Patrick Mehlen, PhD, Chief Executive Officer of NETRIS Pharma, said :

While this is only a Phase 1b trial, we are thrilled to observe the strong PFS and OS being achieved in the neogenin-high PDAC patients in LAPNET-01; we are eager to confirm these results in a larger study. This marks the third Nature publication outlining the compelling scientific and mechanistic rationale for our anti-netrin1 strategy. LAPNET-01 data strongly support the clinically meaningful potential of targeting the netrin-1 / EMT axis to overcome the development of treatment resistance by PDAC, especially in neogenin-high patients. These exciting positive data will accelerate further development of NP137, the first-in-class anti-netrin1 monoclonal antibody. We are engaging with US and EU regulatory authorities as we design the development pathway for NP137 to treat PDAC and other solid tumors.

The next steps for NETRIS include initiation of a randomized, potentially registrational, phase 2 trial of NP137 in first-line metastatic PDAC, incorporating a neogenin IHC assay to help validate this test as a potential companion diagnostic. The development of NP137 is advancing in several other oncology indications including HCC and HNSCC.

About LAPNET-01
LAPNET-01 (NCT05546853) was a multicenter, open-label, phase 1b study promoted by Grenoble Alpes University Hospital and conducted across nine centers in France. Between March 2023 and June 2024, 43 patients with LAPC were enrolled to receive 14 mg/kg of NP137 administered every two weeks in combination with mFOLFIRINOX, for up to 12 cycles. The study population was representative of LAPC. At baseline, all patients were considered unresectable, including 2 with metastatic disease.

The LAPNET-01 trial was designed around the specific hypothesis that mFOLFIRINOX drives EMT-mediated resistance in LAPC and that concurrent netrin1 blockade with NP137 could mitigate this effect, thereby augmenting the depth and durability of response to chemotherapy.

Response and Disease Control
Among 41 evaluable patients assessed by RECIST 1.1, 12 achieved a confirmed partial response (ORR 29%; 95% CI 0.16–0.46), with a median duration of response of 9.02 months (95% CI 5.84–NR). 88% of patients experienced tumor shrinking.

Progression-Free and Overall Survival
Median PFS was 10.85 months at a median follow-up of 13.1 months (95% CI 10.03–15.61), with 6-month and 12-month PFS rates of 88% and 45%, respectively. Notably, patients with high tumor neogenin expression treated with mFOLFIRINOX+NP137 achieved a markedly superior median PFS of 15.65 months versus 10.22 months in the neogenin-low group (p=0.003).

Median OS was 16.43 months (95% CI 12.75–NR), with 6-month and 12-month OS rates of 91% and 62%, and 21 patients still alive at the data cut-off. Median OS was not yet reached in the neogenin-high group with a 12-months OS rate of 100% at the time of data cut-off.

These outcomes compare favorably to benchmark data from the NEOPAN trial, which reported median PFS of approximately 9.7 months and median OS of approximately 15.7 months with FOLFIRINOX alone in LAPC.

Conversion to Surgery
Ten of 43 intention-to-treat patients (23%) and four of 10 (40%) of neogenin-high patients underwent post-therapy R0 resection — a rate that is substantially higher than benchmark conversion rates from prospective LAPC trials.

Neogenin, Candidate Companion Diagnostic

Pre-planned exploratory analyses examined components of the netrin1 signaling pathway for associations with outcomes in LAPNET-01. NEO1, encoding neogenin — a netrin1 receptor previously shown to mediate the netrin1-driven epithelial-to-mesenchymal transition (EMT) and tumor progression in pancreatic cancer preclinical models — emerged as the most strongly correlated gene with improved efficacy outcomes in the non-refractory patient subset (n=21) with available transcriptomic data.

Clinical Safety

Safety was assessed in all 43 patients who received at least one dose of NP137 plus mFOLFIRINOX. While 100% of patients experienced at least one adverse event (AE) with a grade 3 and above adverse event rate of 37%, this profile was comparable to what is anticipated with the chemotherapy backbone alone.

Full details of the LAPNET-01 data are available in the Nature paper :

The aggregated body of evidence — spanning two prior Nature publications (Cassier et al. and Lengrand et al., see links below), the NETRIS AACR (Free AACR Whitepaper) 2026 posters (Poster #2445, #7489 and #0822, presented this week, on April 20), and today’s Nature 2026 manuscript — supports a coherent mechanistic hypothesis : netrin1, re-expressed by cancer cells as a survival mechanism, is a master upstream regulator of epithelial-to-mesenchymal transition (EMT), a central mechanism for the development of acquired resistance in many tumor types.

The absence of a pharmacological EMT inhibitor in the approved oncology arsenal — a gap explicitly noted by the Nature editors in the clinical briefing accompanying the 2023 publications — positions NP137 as a potential first-in-class agent addressing a mechanism of resistance that is orthogonal to debulking agents such as checkpoint inhibition, KRAS targeting, and antibody-drug conjugate strategies.

About LAPC
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, ranking as the fourth leading cause of cancer-related death globally, with a five-year survival rate below 5%. LAPC — a subset representing roughly 30% of PDAC cases at diagnosis — occupies a particularly difficult clinical niche because tumors at this stage are predominantly unresectable, yet lack distant metastases, rendering patients ineligible for both metastatic and curative-intent surgical protocols.

The current standard of care, FOLFIRINOX or gemcitabine-based combinations, yields a median PFS of 6–10 months and a median OS of approximately 12–17 months in LAPC (LAP-07, NEOPAN trials). Conversion-to-surgery rates under these regimens are low: prospective data from the NEOPAN and CONKO-007 trials report R0 resection rates of 6% and 18%, respectively, while PANOVA-3 reported 10.8% under gemcitabine/nab-paclitaxel.

(Press release, Netris Pharma, APR 22, 2026, View Source [SID1234664683])

On April 22, 2026 Phanes Therapeutics, Inc. (Phanes), a clinical stage biotech company focused on innovative drug discovery and development in oncology, reported that they will present updated Phase 2 results of spevatamig (PT886) in combination with chemotherapy in frontline (1L) treatment of metastatic pancreatic ductal adenocarcinoma (mPDAC) at the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting held on May 29 – June 2, 2026 in Chicago. Details of the presentation are below:

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Title: Spevatamig (PT886), a claudin 18.2 (CLDN18.2)/CD47 bispecific antibody, in combination with gemcitabine plus nab-paclitaxel (GnP) in frontline (1L) treatment of metastatic pancreatic ductal adenocarcinoma (mPDAC)

Date/Time: May 30, 2026, 9:00 AM-12:00 PM CDT

Session: Gastrointestinal Cancer – Gastroesophageal, Pancreatic, and Hepatobiliary

Abstract #: 4192

Poster #: 175

First Author: Anwaar Saeed, MD, University of Pittsburgh Medical Center

ABOUT SPEVATAMIG

Spevatamig is a first-in-class native IgG-like bispecific antibody (bsAb) targeting claudin 18.2 and CD47. It was granted orphan drug designation (ODD) for the treatment of pancreatic cancer by the FDA in 2022 and was granted Fast Track designation for the treatment of patients with metastatic claudin 18.2-positive pancreatic adenocarcinoma in 2024. In 2023, Phanes entered into a clinical collaboration agreement with Merck (known as MSD outside the US and Canada) to study spevatamig in combination with pembrolizumab.

Phanes is conducting clinical trials with spevatamig in multiple cancer indications, including a Phase 2 study evaluating the efficacy of spevatamig in combination with chemotherapy in first-line PDAC patients. As of April 2026, 180 patients globally have been dosed with spevatamig collectively in monotherapy and combination therapy settings.

(Press release, Phanes Therapeutics, APR 22, 2026, View Source [SID1234664699])

On April 22, 2026 BeyondSpring Inc. (NASDAQ: BYSI) reported new preclinical data at the 2026 Annual Meeting of the American Association for Cancer Research (AACR) (Free AACR Whitepaper) demonstrating that Plinabulin has the potential to enhance both the efficacy and tolerability of ADC therapy — potentially boosting anticancer responses while keeping patients on treatment long enough to benefit.

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Antibody-drug conjugates — a form of targeted chemotherapy that delivers cancer-killing agents directly to tumor cells, known as ADCs — have emerged as one of oncology’s most important new treatment classes. But two persistent clinical barriers limit their full potential: they do not always produce durable responses, and neutropenia (a dangerous drop in white blood cell counts) can force dose reductions or treatment delays that cut treatment short. New AACR (Free AACR Whitepaper) data show that Plinabulin directly and simultaneously addresses both.

Three Key Findings from AACR (Free AACR Whitepaper) 2026

The data show why the combination works. Plinabulin, when added to two leading approved ADCs — T-DXd (trastuzumab deruxtecan) and Dato-DXd (datopotamab deruxtecan) — produced three significant results that neither drug achieved alone:

Stronger anticancer activity: Complete tumor regressions were more frequent and animals survived significantly longer — in both two-drug (ADC+ Plinabulin) and three-drug (ADC+ Plinabulin + PD-1 inhibitor) combinations (PD-1 inhibitors are immunotherapies that activate the body’s own immune system to fight cancer).
Better tolerability to potentially keep patients on therapy: Plinabulin reduced animal death in both two-drug and three-drug combinations. In 6 prior clinical studies, Plinabulin measurably reduced chemotherapy-induced neutropenia, the white blood cell toxicity that commonly forces ADC dose reductions or treatment delays — potentially allowing patients to remain on treatment long enough to benefit from the drug’s anticancer activity.
Immune system activation: Analysis showed that Plinabulin enhanced the body’s own cancer-fighting T-cells, significantly increasing CD8+ T cell/Treg ratio — providing a biological explanation for why the combination outperforms either drug alone.

Plinabulin is Mechanistically Complementary, Not Merely Additive

Plinabulin activates a protein called GEF-H1 that simultaneously matures immune cells (dendritic cells) to attack tumors, signals the body to replenish cancer-fighting blood cells, and disrupts the blood supply feeding tumors. These are precisely the biological pathways that ADCs do not activate — which is why the two work better together than either does alone.

In BeyondSpring’s pivotal Phase 3 DUBLIN-3 study (The Lancet Respiratory Medicine, 2024), Plinabulin combined with docetaxel chemotherapy doubled two- and three-year survival rates in second- and third-line EGFR wild-type NSCLC patients — and simultaneously reduced docetaxel-limiting grade 4 neutropenia from 33% to 5%, keeping patients on therapy longer for the drug to work. The new AACR (Free AACR Whitepaper) data extend that same combination logic into the ADC setting, broadening Plinabulin’s reach across the treatment landscape.

BeyondSpring’s planned DUBLIN-4 program — a 442-patient FDA-aligned confirmatory Phase 3 trial building directly on the DUBLIN-3 results — is the defined next clinical step. Today’s AACR (Free AACR Whitepaper) data further strengthen the scientific rationale for Plinabulin’s combination potential and point toward future ADC combination studies beyond the confirmatory program.

Plinabulin as a Potential Backbone Drug Across Multiple ADC Combinations

ADCs are increasingly being tested in earlier lines of cancer treatment and in combination with immunotherapy. However, recent large Phase 3 studies — TROPION-Lung01 and EVOKE-01 — showed that leading ADCs failed to outperform older chemotherapy, such as docetaxel, in certain lung cancer settings, underscoring the need for an agent that can improve the efficacy and tolerability of ADC-based combinations.

Plinabulin’s ability to simultaneously boost efficacy and reduce toxicity positions it as a potential backbone agent across the ADC landscape — a role no other drug currently fills. Today’s AACR (Free AACR Whitepaper) data open the door to ADC combination studies as a natural next chapter in Plinabulin’s clinical development, alongside the ongoing DUBLIN-4 confirmatory program.

"Plinabulin has the potential to enable ADC therapy to deliver on its full promise — producing more complete responses, extending survival, and keeping patients on treatment. These AACR (Free AACR Whitepaper) data further strengthen our conviction in Plinabulin’s combination potential, as we advance the DUBLIN-4 confirmatory Phase 3 program in NSCLC post immune checkpoint inhibitors and explore the broader opportunity in ADC-based regimens."
— Dr. Lan Huang, Co-Founder, Chairman, and CEO, BeyondSpring Inc.

BeyondSpring’s China operations have been a strategic engine in building the ADC partnerships that support Plinabulin’s global development.

"China’s ADC research ecosystem is among the most active in the world, and BeyondSpring is well-positioned to leverage those capabilities. Our collaboration with Shanghai Chest Hospital demonstrated the value of strategic partnerships in advancing Plinabulin’s preclinical and clinical development in ADC combination, and we see continued opportunity to build on that model as the ADC combination landscape evolves."
— Min Qiu, Deputy General Manager, BeyondSpring China

BeyondSpring’s AACR (Free AACR Whitepaper) 2026 Presentation

Title: Plinabulin Boosts Antitumor Efficacy of Topoisomerase Inhibitor-Based Antibody-Drug Conjugates Without or With Immune Checkpoint Inhibitor

Presenters: Yingjuan June Lu, Xiaoyan He, Weiwei Cheng, Zhengyan Zhang, James Tonra, Lan Huang

Session: T Cell Engagers 2 / Antibody-Drug Conjugates 1 (Immunology Track)

Poster Number: 5597

About Plinabulin

Plinabulin is a late-stage Phase 3 anticancer agent and first-in-class GEF-H1 (guanine nucleotide exchange factor H1) agonist. Its multifunctional mechanism — encompassing dendritic cell maturation, tumor microenvironment modulation, anti-angiogenesis, and chemotherapy-induced neutropenia (CIN) mitigation — activates biological pathways that standard chemotherapy and ADCs do not. Over 700 cancer patients have been treated with good tolerability and durable anticancer benefit in rational combination settings. DUBLIN-3 Phase 3 results in NSCLC were published in The Lancet Respiratory Medicine in 2024.

About DUBLIN-3 and the Path to DUBLIN-4

In the DUBLIN-3 Phase 3 study of 2L/3L EGFR wild-type NSCLC (Lancet Respiratory Medicine, 2024), Plinabulin plus docetaxel significantly outperformed docetaxel monotherapy (n=559, 1:1 randomization), with improvements in OS, PFS, and ORR; doubling of 2- and 3-year survival rates; and reduction of docetaxel-induced grade 4 neutropenia from 33% to 5% (p<0.0001).

DUBLIN-4 is BeyondSpring’s planned FDA-aligned confirmatory Phase 3 program (n=442, 1:1 randomization), designed to validate the DUBLIN-3 results in a prospective confirmatory setting in a patient population selected based on Plinabulin’s mechanism of action: non-squamous NSCLC patients who have progressed on PD-1/L1 inhibitors. The ADC preclinical data presented at AACR (Free AACR Whitepaper) 2026 broaden the scientific case for Plinabulin’s combination potential.

(Press release, BeyondSpring Pharmaceuticals, APR 22, 2026, View Source [SID1234664715])