05/12/2022?Medical & Biological Laboratories and Crown Bioscience Enter Joint Venture ~Providing Advanced Preclinical Services in Japan~

On June 2, 2022 JSR Corporation reported that Medical & Biological Laboratories (MBL) and Crown Bioscience, JSR Life Sciences companies, have formed a joint venture to further extend their preclinical services to Japanese customers (Press release, JSR, JUN 2, 2022, View Source [SID1234615399]). The new company named "Crown Bioscience & MBL", provides preclinical and translational services to biopharmaceutical customers in Japan. MBL is currently a distributor for Crown Bioscience and the establishment of the joint venture marks a significant milestone in the long-standing relationship between the two founding companies.

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The company, established in April 2022, is expected to start service operation from September 2022. For details, please refer to the announcements from Crown Bioscience.

Sysmex Inostics & QIAGEN Highlight Cancer Companion Diagnostics Alliance at ASCO 2022

On June 2, 2022 Sysmex Inostics, Inc. and QIAGEN N.V. reported that it will co-exhibit at the 2022 ASCO (Free ASCO Whitepaper) Annual Meeting, the world’s largest clinical cancer research meeting, held June 3, 2022, through June 7, 2022, in Chicago (Press release, Sysmex Inostics, JUN 2, 2022, View Source [SID1234615415]).

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QIAGEN, the leading global provider of sample to insight solutions for molecular testing, and Sysmex Inostics combined forces in July 2021 to accelerate global companion diagnostic access. QIAGEN provides unparalleled global custom cancer companion diagnostics (CDx) development and commercialization capabilities utilizing Sysmex Inostics ultra-sensitive NGS liquid biopsy technology. The goal of the alliance is to promote early clinical implementation of Sysmex Inostics’ technology to expedite clinical trial timelines for pharmaceutical companies that develop molecularly targeted drugs for cancer.

"Sysmex Inostics is focused on developing tools to support the fight against cancer and other devastating diseases. By partnering with industry leaders like QIAGEN we can help accelerate the fight to help patients with these diseases," said Shinichi Sato, CEO of Sysmex Inostics, Inc. "We look forward to highlighting our partnership with QIAGEN at ASCO (Free ASCO Whitepaper) 2022."

"Through our partnership with Sysmex, we can develop ultrasensitive blood-based NGS panels to the specific requirements of our pharma partners for their clinical trials," stated Jonathan Arnold, Vice President, Head of Oncology and Precision Diagnostics of QIAGEN. Arnold added, "If and when a CDx is required, QIAGEN will lead IVD submission, manufacturing, and global commercialization as a kitted product."

Sysmex and QIAGEN will highlight their alliance at ASCO (Free ASCO Whitepaper) booth 8149, Saturday, June 4, 2022, through Monday, June 6, 2022, 9:00 AM – 5:00 PM CDT each day.

Poster Presentations Utilizing Sysmex Inostics’ Technology
Yoshinori Kagawa MD, PhD, Department of Gastroenterological Surgery, Osaka General Medical Center, Osaka, Japan, will present the poster "Plasma RAS dynamics and anti-EGFR rechallenge efficacy in patients with RAS/BRAF wild-type metastatic colorectal cancer: REMARRY and PURSUIT trials." Circulating tumor DNA (ctDNA) was analyzed and monitored using the Sysmex Inostics OncoBEAMTM RAS CRC Kit. Dr. Kagawa will present poster 3518 during the Gastrointestinal Cancer—Colorectal and Anal session on Saturday, June 4, 2022, 3:00 PM-4:30 PM CDT.

Linda (Yilin) Cao, MD, Department of Radiation Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, will present the poster "Dynamic cell free HPV DNA is an early measure of treatment responsiveness in patients receiving induction chemotherapy for HPV-related head and neck cancer." Findings add to the breadth of ongoing clinical studies using HPV-SEQ to investigate de-escalation of HPV-positive patients from unnecessary and potentially harmful head and neck squamous cell carcinomas (HNSCC) treatments. HPV-SEQ is an ultrasensitive test for the detection of HPV16/18 DNA from blood and is CLIA validated to detect as few as five HPV DNA molecules from two tubes of blood.1 See here for additional study information. Dr. Cao will present poster 6062 during the Head and Neck Cancer session on Monday, June 6, 2022, 1:15 PM- 4:15 PM CDT.

AnaptysBio to Participate at the 2022 Jefferies Healthcare Conference

On June 2, 2022 AnaptysBio, Inc. (Nasdaq: ANAB), a clinical-stage biotechnology company developing first-in-class antibodies focused on emerging immune control mechanisms applicable to inflammation and immuno-oncology indications, reported that Dan Faga, chief executive officer, and Paul Lizzul, chief medical officer of AnaptysBio, will represent the company in a fireside chat at the Jefferies Healthcare Conference on Wednesday, June 8, 2022, at 10:00 a.m. ET / 7:00 a.m. PT (Press release, AnaptysBio, JUN 2, 2022, View Source [SID1234615432]).

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A live audio webcast of the presentation will be available on the investor section of the AnaptysBio website at View Source A replay of the webcast will be available for 90 days following the event.

PACIRA BIOSCIENCES TO PARTICIPATE IN FIRESIDE CHAT AT THE JEFFERIES HEALTHCARE CONFERENCE

On June 2, 2022 Pacira BioSciences, Inc. (NASDAQ: PCRX) reported that it will participate in an analyst-led fireside chat at the Jefferies Healthcare Conference at 9:00 AM ET on Thursday, June 9, 2022 in New York (Press release, Pacira Pharmaceuticals, JUN 2, 2022, View Source [SID1234615449]). Live audio of the event can be accessed by visiting the "Events" page of the company’s website at investor.pacira.com. A replay of the webcast will also be available for two weeks following the event.

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Sarah Cannon to Present Latest Oncology Research Insights at 2022 ASCO® Annual Meeting

On June 2, 2022 Sarah Cannon Research Institute reported that it will highlight its latest cancer research insights through more than 140 abstracts and presentations at the 2022 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting, taking place in Chicago and online from June 3-7, 2022 (Press release, Sarah Cannon Research Institute, JUN 2, 2022, View Source [SID1234615465]). Experts from across Sarah Cannon Research Institute’s network will join oncology leaders from around the globe to discuss the latest research findings that are accelerating progress in the fight against cancer. As a leader in drug development, Sarah Cannon Research Institute is presenting data from 75 early-phase studies.

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"Collaboration is essential to how we accelerate progress in the fight against cancer, and we look forward to coming together with our colleagues in Chicago to discuss the latest advances in oncology research," said Howard A. "Skip" Burris III, MD, FACP, FACSO, President, Clinical Operations & Chief Medical Officer, Sarah Cannon Research Institute. "With the variety of novel molecularly-targeted agents, immunotherapies, and cellular therapies in development, we are seeing a remarkable number of possibilities to truly transform care and personalize treatments for patients."

Presentations will cover a wide range of topics including how targeted agents and immunotherapies are performing in an array of disease settings, how molecular profiling is expanding access to clinical trials, and how researchers are advancing clinical research despite pressures in a post-pandemic environment.

Below are several highlighted presentations that Sarah Cannon principal investigators will lead during the Annual Meeting:

Gerald Falchook, MD, MS, Director, Drug Development, Sarah Cannon Research Institute at HealthONE, will deliver "Phase 1 Trial of TIM-3 Inhibitor Cobolimab Monotherapy and in Combination with PD-1 Inhibitors Nivolumab or Dostarlimab (AMBER)" in an oral presentation on June 4 from 1:15-4:15 p.m. CDT (2:27 p.m. CDT) in Hall B1.
Erika Hamilton, MD, Director, Breast Cancer and Gynecologic Cancer Research, Sarah Cannon Research Institute at Tennessee Oncology, will give two oral presentations – "Trastuzumab Deruxtecan (T-DXd) vs Trastuzumab Emtansine (T-DM1) in Patients (pts) with HER2-Positive (HER2+) Unresectable and/or Metastatic Breast Cancer (mBC): Safety Follow-Up of the Randomized, Phase 3 Study DESTINY-Breast03" on June 4 from 1:15-4:15 p.m. CDT (1:15 p.m. CDT) in Hall D1 and "Phase I, Two-Part, Multicenter, First-In-Human (FIH) Study of DS-6000a in Subjects with Advanced Renal Cell Carcinoma (RCC) and Ovarian Tumors (OVC)" on June 7 from 9:45 a.m. – 12:45 p.m. CDT (10:09 a.m. CDT) in S406.
Melissa Johnson, MD, Director, Lung Cancer Research, Sarah Cannon Research Institute at Tennessee Oncology, will present "Resistance to KRAS Inhibition and Future Combinations" in the Education Session, Development of Novel Inhibitors of the RAS Pathway, on June 7 from 8-9:15 a.m. CDT in S406. Dr. Johnson will also present "Dose Escalation of a Phase 1b/2 Study of Modakafusp Alfa, an Immune-Targeting Attenuated Cytokine, in Patients (pts) with Metastatic Solid Tumors" in an oral presentation on June 4 from 1:15-4:15 p.m. CDT (1:51 p.m. CDT) in Hall B1.
Andrew McKenzie, PhD, Vice President, Personalized Medicine, Sarah Cannon Research Institute; Scientific Director, Genospace, will present "Expanding Access to Clinical Trials Through Molecular Profiling Review and Telehealth Consultations" during the Education Session, Rethinking Cancer Clinical Trial Conduct With Telemedicine, on June 6 from 4:45-6 p.m. CDT in S504.
Jeremy Pantin, MD, Senior Investigator, Sarah Cannon Transplant and Cellular Therapy Program at TriStar Centennial, will chair the Clinical Science Symposium, Beating Bad Blood: The Power of Immunotherapy in Hematologic Malignancies, as well as discuss "Refining the CAR-T’s Engine: How to Improve CD19-Directed CAR-T Performance" on June 6 from 8-9:30 a.m. CDT in S100bc.
David Spigel, MD, Chief Scientific Officer, Sarah Cannon Research Institute, is a speaker and panelist on the Education Session, The Business of Clinical Trials: The Impact of Funds Flow and the Shrinking Workforce on Trial Development, on June 5 from 8-9:15 a.m. CDT in S102.
Abstracts and presentations with Sarah Cannon experts as first authors will be presented by:

Dr. Howard Burris
Dr. Gerald Falchook
Lucio Gordan, MD, Chief Medical Officer, Sarah Cannon Research Institute at Florida Cancer Specialists
Dr. Erika Hamilton
Marilyn (Holt) Hammer, PhD, Program Specialist, Personalized Medicine, Sarah Cannon Research Institute
Lowell Hart, MD, FACP, Scientific Director, Clinical Research, Sarah Cannon Research Institute at Florida Cancer Specialists
Shekeab Jauhari, MD, Associate Director, Drug Development, Sarah Cannon Research Institute at Florida Cancer Specialists – Lake Mary
Dr. Melissa Johnson
William Kevin Kelly, DO, Senior Investigator, Drug Development, Sarah Cannon Research Institute at Sidney Kimmel Cancer Center
Meredith McKean, MD, MPH, Director, Melanoma & Skin Cancer Research, Sarah Cannon Research Institute at Tennessee Oncology
Dr. Andrew McKenzie (Chair)
Kathleen Moore, MD, Director, Drug Development, Sarah Cannon Research Institute at the Stephenson Cancer Center
Manish Patel, MD, Director, Drug Development, Sarah Cannon Research Institute at Florida Cancer Specialists – Sarasota
Meredith Pelster, MD, MSCI, Assistant Director, Gastrointestinal Research, Sarah Cannon Research Institute at Tennessee Oncology
Cesar Augusto Perez, MD, Director, Drug Development, Sarah Cannon Research Institute at Florida Cancer Specialists – Lake Nona
Russell Schilder, MD, Director, Drug Development, Sarah Cannon Research Institute at Sidney Kimmel Cancer Center
Emma Sturgill, PhD, Senior Program Specialist, Personalized Medicine, Sarah Cannon Research Institute
Susanna Ulahannan, MD, MMed, Associate Director, Phase 1 Program, Sarah Cannon Research Institute at The Stephenson Cancer Center (Co-Chair)