On May 12, 2022 Lantern Pharma Inc. (NASDAQ: LTRN), a clinical stage biopharmaceutical company using its proprietary RADR artificial intelligence ("A.I.") and machine learning (ML) platform to transform the cost, pace, and timeline of oncology drug discovery and development, reported that it will host a virtual key opinion leader (KOL) webinar on May 26th, 2022 at 12:00 p.m. ET (Press release, Lantern Pharma, MAY 12, 2022, View Source [SID1234614382]). The webinar will focus on glioblastoma multiforme (GBM) and the potential of Lantern’s drug candidate LP-184 for GBM as well as other brain cancers.

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The webcast will feature discussions by two leading experts in GBM and brain cancer treatment and research: John Laterra, M.D., Ph.D. and Matthias Holdhoff, M.D., Ph.D. They will be accompanied by Lantern’s Chief Scientific Officer, Kishor Bhatia, Ph.D. who will describe the clinical development plans for LP-184 as well as the mechanisms targeted by LP-184 in GBM and other brain cancers. Following their discussion, there will be a live question and answer session with Dr. Bhatia.

Virtual KOL Webinar Details:

Thursday, May 26th, 2022 at 12:00 p.m. – 1:00 p.m. ET
To register for the webinar, please use the link below:
View Source
A replay of the webinar will be available on Lantern’s website beginning on May 27th: www.lanternpharma.com
About Brain Cancer Awareness Month:
This KOL webinar will be hosted during Brain Tumor Awareness Month, which is also known as "Gray May". This month is meant to bring support and awareness to the estimated 700,000 people in the US living with primary brain tumors and to their families and caregivers. Patients with primary brain tumors have a low 5-year survival rate of only 35.6% and have limited treatment options due to the lack of effective drugs that can cross the blood brain barrier. For more information, please visit the Brain Tumor Awareness month website.

GBM is one of the most common types of primary brain tumors with an estimated 13,000 people in the US diagnosed each year. Patients with GBM have a very poor prognosis with a median overall survival of 24 months. The low survival rate of patients with GBM is in part due to the lack of effective new therapies that can cross the blood brain barrier (BBB) and there is an urgent and unmet clinical need for new therapies. In preclinical studies, Lantern’s drug candidate, LP-184, has shown potency against unmethylated and methylated types of GBM as well as the ability to cross the BBB.

About Dr. John Laterra
Dr. Laterra is an internationally recognized researcher in neurology, oncology, and neuroscience. He serves as the Director of the Brain Cancer Program and the Director of the Division of Neuro-Oncology at Johns Hopkins School of Medicine where he specializes in investigating mechanisms of brain tumor malignancy, tumor vascular biology, and identification of new therapeutic targets in gliomas. Dr. Laterra received his Ph.D. in microbiology and M.D. from Case Western Reserve University. He served as a resident and chief resident in neurology at the University of Michigan at Ann Arbor. Dr. Latera joined Johns Hopkins and the Kennedy Krieger Institute in 1988.

About Dr. Mattias Holdhoff:
Dr. Holdhoff is a medical neuro-oncologist in the Brain Cancer Program at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, as well as an associate professor of oncology and neurological surgery at Johns Hopkins University School of Medicine. Dr. Holdhoff’s clinical and research expertise is in primary brain cancers, malignant gliomas, and central nervous system lymphomas. He received his Ph.D. at Charité University Medicine Berlin and his M.D. from Freie Universität Berlin. Dr. Holdhoff completed his residency in internal medicine at Johns Hopkins Bayview Medical Center, followed by a fellowship in medical oncology at Johns Hopkins Hospital.

On May 12, 2022 GENFIT (Nasdaq and Euronext: GNFT), a late-stage biopharmaceutical company dedicated to improving the lives of patients with severe chronic liver diseases, reported its cash position as of March 31, 2022 and revenues for the first three months of 2022 (Press release, Genfit, MAY 12, 2022, https://ir.genfit.com/news-releases/news-release-details/genfit-reports-first-quarter-2022-financial-information [SID1234614401]).

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Cash position

As of March 31, 2022, the Company’s cash and cash equivalents amounted to €222.2 million compared with €108.9 million as of March 31, 2021 and €258.8 million as of December 31, 2021.

The increase in cash and cash equivalents between March 31, 2021 and March 31, 2022 takes into account the collaboration and license agreement signed with Ipsen in December 2021 which granted Ipsen an exclusive worldwide license to develop, manufacture and commercialize GENFIT’s investigational treatment elafibranor.1 As part of this licensing agreement, GENFIT received a non-refundable upfront payment of €120.0 million euros in December 2021, as well as €24.0 million in VAT collected on that amount. Furthermore, to underscore the long-term commitment represented by this partnership, Ipsen purchased newly issued GENFIT equity representing 8% post-issuance through a €28.0 million investment in GENFIT.

This increase also comprises three non-dilutive loans, which include two State-Guaranteed Loans from a pool of partner banks and Bpifrance respectively, as well as a subsidized loan from Bpifrance for an amount totaling €15.2 million euros.

The decrease in cash and cash equivalents between December 31, 2021 and March 31, 2022 notably includes the payment in January 2022 of the amount of €24.0 million representing the VAT collected on the initial upfront payment received from Ipsen in December 2021.

Revenues

Revenues for the first three months of 2022 amounted to €3. 895 million compared to €1 thousand for the same period in 2021.

The initial upfront payment from Ipsen in December 2021 was partially recognized as deferred revenue, amounting to €40.0 million as at the end of 2021, to be gradually recognized as revenue following the completion of the ELATIVE double-blind study, in accordance with the IFRS 15 norms. Revenues for the first three months of 2022 mainly came from the partial recognition of this amount corresponding to this period.

On May 12, 2022 BeiGene (NASDAQ: BGNE; HKEX: 06160; SSE: 688235), a global, science-driven biotechnology company focused on developing innovative and affordable medicines to improve treatment outcomes and access for patients worldwide, reported 20 presentations from the Company’s global clinical development programs in hematologic malignancies at the European Hematology Association (EHA) (Free EHA Whitepaper) 2022 Hybrid Congress being held June 9 – 12, 2022 in Vienna, Austria (Press release, BeiGene, MAY 12, 2022, View Source [SID1234614420]).

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"With an oral presentation for the ROSEWOOD trial of zanubrutinib in follicular lymphoma and 19 poster presentations describing clinical data and patient-focused endpoints, our scientific presence at EHA (Free EHA Whitepaper) demonstrates BeiGene’s commitment to improving patient-care through innovative research"

"With an oral presentation for the ROSEWOOD trial of zanubrutinib in follicular lymphoma and 19 poster presentations describing clinical data and patient-focused endpoints, our scientific presence at EHA (Free EHA Whitepaper) demonstrates BeiGene’s commitment to improving patient-care through innovative research," said Lai Wang, Ph.D., Global Head of Research & Development at BeiGene. "We look forward to sharing data pointing to the promise of our pipeline in areas of high unmet need for people with hematologic malignancies."

BeiGene presentation highlights

Zanubrutinib

ROSEWOOD: Zanubrutinib plus obinutuzumab versus obinutuzumab monotherapy in patients with relapsed or refractory follicular lymphoma: primary analysis of the Phase 2 randomized ROSEWOOD trial
ASPEN: Long-term follow-up results of a Phase 3 randomized trial of zanubrutinib versus ibrutinib in patients with Waldenström macroglobulinemia
SEQUOIA: Patient-reported outcomes from a Phase 3 randomized study of zanubrutinib versus bendamustine plus rituximab (br) in patients with treatment-naïve (tn) chronic lymphoctic leukemia (CLL)/ small lymphocytic lymphoma (SLL)
ALPINE: Health-related quality of life outcomes associated with zanubrutinib vs ibrutinib monotherapy in patients with relapsed/refractory (rr) CLL/SLL: results from the randomized Phase 3 ALPINE trial
Early-stage pipeline

Two poster presentations for BCL-2 inhibitor BGB-11417
Monotherapy and combination with zanubrutinib: Phase 1 data in CLL, non-Hodgkin’s lymphoma and acute myeloid leukemia (AML)
Monotherapy: preliminary safety and efficacy in AML
Presentation details

Abstract Title and Number

Session/Location

Date and Time
(all times CEST)

Presenting Author

BeiGene Hematologic Malignancies Clinical Data at EHA (Free EHA Whitepaper)2022 Hybrid Congress

Zanubrutinib plus obinutuzumab versus obinutuzumab monotherapy in patients with relapsed or refractory follicular lymphoma: primary analysis of the Phase 2 randomized ROSEWOOD trial

Abstract Number: S205

Session Title: Indolent and mantle cell lymphoma;

Session room: Hall C1

Saturday, June 11

11:30 AM – 12:45 PM

Pier L. Zinzani, M.D., Ph,D.

ASPEN: Long-term follow-up results of a Phase 3 randomized trial of zanubrutinib vs ibrutinib in patients with Waldenström macroglobulinemia (WM)

Abstract Number: P1161

Friday, June 10

16:30 – 17:45 PM

Alessandra Tedeschi, M.D.

Results of a Phase 2 expanded access study of zanubrutinib in patients with Waldenström macroglobulinemia

Abstract Number: P1160

Friday, June 10

16:30 – 17:45 PM

Jorge J. Castillo, M.D.

Zanubrutinib in older patients (pts) with relapsed/refractory marginal zone lymphoma: subgroup analysis of the Magnolia study

Abstract Number: P1162

Friday, June 10

16:30 – 17:45 PM

Prof. Stephen Opat

Tislelizumab, a PD-1 inhibitor for relapsed/refractory mature T/NK-cell neoplasms: results from a Phase 2 study

Abstract Number: P1239

Friday, June 10

16:30 – 17:45 PM

Emmanuel Bachy. M.D., Ph.D.

A Phase 1 study with the novel B-cell lymphoma 2 inhibitor BGB-11417 as monotherapy or in combination with zanubrutinib in patients with B-cell malignancies: preliminary data

Abstract Number: P687

Friday, June 10

16:30 – 17:45 PM

Prof. Stephen Opat

Preliminary safety and efficacy of BGB-11417, a potent and selective B-cell lymphoma 2 (BCL2) inhibitor, in patients with acute myeloid leukemia

Abstract Number: P590

Friday, June 10

16:30 – 17:45 PM

Prof. Jake Shortt

A Phase 1 first in-human study of BGB-16673, a Bruton tyrosine kinase protein degrader, in patients with B-cell malignancies (trial in progress)

Abstract Number: P686

Friday, June 10

16:30 – 17:45 PM

Constantine S. Tam, M.B.B.S., M.D., F.R.A.C.P., F.R.C.P.A.

Zandelisib on intermittent dosing as a single agent or in combination with rituximab or zanubrutinib in relapsed/refractory follicular lymphoma: results from a multi-arm Phase 1b study

Abstract Number: P1114

Friday, June 10

16:30 – 17:45 PM

Felipe Samaniego, M.D.

BeiGene Patient-Reported Outcomes (PRO), Real-World Evidence (RWE) and Health Economics & Outcomes Research at EHA (Free EHA Whitepaper)2022 Hybrid Congress

Patient-Reported Outcomes from a Phase 3 Randomized Study of Zanubrutinib versus Bendamustine Plus Rituximab (BR) in Patients with Treatment-Naïve (TN) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)

Abstract Number: P662

Friday, June 10

16:30 – 17:45 PM

Paolo Ghia, M.D., Ph.D.

Health-Related Quality of Life Outcomes Associated With Zanubrutinib Versus Ibrutinib Monotherapy In Patients With Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (RR CLL/SLL): Results from the Randomized Phase 3 ALPINE Trial

Abstract Number: P663

Friday, June 10

16:30 – 17:45 PM

Peter Hillmen, M.B., Ch.B., Ph.D.

Population-Wide Patterns of Care in Chronic Lymphocytic Leukemia in Australia: An Analysis of the Pharmaceutical Benefits Scheme Dataset

Abstract Number: P661

Friday, June 10

16:30 – 17:45 PM

Constantine Tam, M.B.B.S., M.D., F.R.A.C.P., F.R.C.P.A.

Real world evidence of impact of atrial fibrillation (AF) on clinical and economic outcomes in patients (pts) with chronic lymphocytic leukemia (CLL)

Abstract Number: P685

Friday, June 10

16:30 – 17:45 PM

Asher Chanan-Khan, M.B.B.S., M.D.

Real-world treatment patterns and comparative effectiveness of Bruton tyrosine kinase inhibitors (BTKi) in patients (pts) with mantle cell lymphoma (MCL)

Abstract Number: P1157

Friday, June 10

16:30 – 17:45 PM

Bijal D. Shah, M.D.

Real-world treatment (tx) patterns and economic burden of patients (pts) with Marginal Zone Lymphoma (MZL)

Abstract Number: P1158

Friday, June 10

16:30 – 17:45 PM

Bijal D. Shah, M.D.

BeiGene Online Only Abstracts at EHA (Free EHA Whitepaper)2022 Hybrid Congress

Zanubrutinib in acalabrutinib-intolerant patients with B-cell malignancies

Abstract Number: PB1890

Online Only

Mazyar Shadman, M.D., M.P.H.

Efficacy of First-Line Treatment for Chronic Lymphocytic Leukemia: A Bayesian Network Meta-Analysis

Abstract Number: PB1888

Online Only

Asher Chanan-Khan, M.B.B.S., M.D.

Network Meta-Analysis of Progression Free Survival in the Treatment of Relapsed/Refractory Chronic Lymphocytic Leukemia

Abstract Number: PB1887

Online Only

Asher Chanan-Khan, M.B.B.S., M.D.

Population-Wide Patterns of Care in Mantle Cell Lymphoma in Australia: An Analysis of the Pharmaceutical Benefits Scheme Dataset

Abstract Number: PB2082

Online Only

Constantine Tam, M.B.B.S., M.D., F.R.A.C.P., F.R.C.P.A.

Treatment persistence and adherence to ibrutinib in patients with WM: a German claims data analysis

Abstract Number: PB2081

Online Only

Prof. Christian Buske

About BRUKINSA
BRUKINSA (zanubrutinib) is a small molecule inhibitor of Bruton’s tyrosine kinase (BTK) discovered by BeiGene scientists that is currently being evaluated globally in a broad clinical program as a monotherapy and in combination with other therapies to treat various B-cell malignancies. Because new BTK is continuously synthesized, BRUKINSA was specifically designed to deliver complete and sustained inhibition of the BTK protein by optimizing bioavailability, half-life, and selectivity. With differentiated pharmacokinetics compared to other approved BTK inhibitors, BRUKINSA has been demonstrated to inhibit the proliferation of malignant B cells within a number of disease relevant tissues.

BRUKINSA is supported by a broad clinical program which includes more than 3,900 subjects in 35 trials across 28 markets. To date, BRUKINSA has received more than 20 approvals covering more than 45 countries and regions, including the United States, China, the EU, and Great Britain, Canada, Australia and additional international markets. Currently, more than 40 additional regulatory submissions are in review around the world.

BeiGene Oncology
BeiGene is committed to advancing best- and first-in-class clinical candidates internally or with like-minded partners to develop impactful and affordable medicines for patients across the globe. We have a growing R&D and medical affairs team of approximately 2,900 colleagues dedicated to advancing more than 100 clinical trials that have involved more than 14,500 subjects. Our expansive portfolio is directed predominantly by our internal colleagues supporting clinical trials in more than 45 countries and regions. Hematology-oncology and solid tumor targeted therapies and immuno-oncology are key focus areas for the Company, with both mono- and combination therapies prioritized in our research and development. BeiGene currently has three approved medicines discovered and developed in our own labs: BTK inhibitor BRUKINSA in the U.S., China, the European Union, Great Britain, Canada, Australia and additional international markets; and the non-FC-gamma receptor binding anti-PD-1 antibody tislelizumab as well as the PARP inhibitor pamiparib in China.

BeiGene also partners with innovative companies who share our goal of developing therapies to address global health needs. We commercialize a range of oncology medicines in China licensed from Amgen, Bristol Myers Squibb, EUSA Pharma and Bio-Thera. We also plan to address greater areas of unmet need globally through our other collaborations including with Mirati Therapeutics, Seagen, and Zymeworks.

In January 2021 BeiGene and Novartis announced a collaboration granting Novartis rights to co-develop, manufacture, and commercialize BeiGene’s anti-PD1 antibody tislelizumab in North America, Europe, and Japan. Building upon this productive collaboration, including a biologics license application (BLA) under U.S. Food and Drug Administration (FDA) review, BeiGene and Novartis announced an option, collaboration and license agreement in December 2021 for BeiGene’s TIGIT inhibitor ociperlimab that is in Phase 3 development. Novartis and BeiGene also entered into a strategic commercial agreement through which BeiGene will promote five approved Novartis Oncology products across designated regions of China.

On May 12, 2022 Jerome Canady Research Institute for Advanced and Biological Technological Sciences (JCRI-ABTS) and US Medical Innovations, LLC (USMI) reported that Jerome Canady MD, Chief Science Officer at JCRI-ABTS and a Surgical Oncologist at Holy Cross Hospitals Silver Spring/Germantown, MD will present the results of a Two-year follow up, "Phase I Clinical Trial of Canady Helios Cold Atmospheric Plasma (CHCP) Treatment for Patients with Advanced Stage IV Metastatic and Recurrent Solid Tumors: A Novel Potential 4th Treatment Arm for Cancer" at The Biannual Conference of the Israeli Society of Surgical Oncology (ISSO), May 11-13, 2022 in Haifa, Israel (Press release, JCRI-ABTS, MAY 12, 2022, View Source;ABTS-and-USMI-to-Present-a-Two-year-Follow-up-of-Phase-I-Clinical-Trial-Using-Cold-Atmospheric-Plasma-for-the-Treatment-of-Solid-Tumors-at-Israeli-Society-of-Surgical-Oncology [SID1234614439]).

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Dr. Canady stated, "Metastatic and recurrent Stage IV solid tumors have a poor overall survival (OS) despite the advancement of surgery, chemotherapy, radiation, and immunotherapy. The CHCP Trial was a Phase I, multiple-center, open labelled, prospective controlled trial which enrolled eligible subjects undergoing surgery and intra-operative CHCP treatment. Between March 2020 to April 2021, twenty (20) patients were recruited from Rush University Medical Center Chicago, Illinois and Sheba Medical Center Tel HaShomer, Israel. Patients received intra-operative CHCP treatment at the operative site after the tumor was removed. The primary end point was safety, and the secondary end point was to demonstrate ablation and slowing down tumor growth in cancer patients without damaging surrounding normal biological tissue."

Patients from 26 to 85 years of age (mean age 59) were enrolled in the study. Physiological data was recorded throughout surgery (i.e. blood pressure, pulse, body temperature, End Tidal CO2, and oxygen saturation which demonstrated no significant changes (p > 0.05) during the intra-operative CHCP treatment period). There were no adverse events related to CHCP.

As of May 12, 2022, four patients died of their disease at 3, 4, 8 and 10 months. Kaplan-Meier survival analysis showed that interim OS rate at 26 months was 80.0% (95% confidence interval [CI], 64.3 – 99.6%). Median survival was 14.5 months. Histology of the surgical margins revealed cancer cell death and no damage to normal tissue. Ex vivo culture confirmed reduction of cancer cell growth.

CHCP treatment in combination with surgery for high-risk stage IV solid tumors is safe, induces tumor death and slows down tumor growth in vitro, ex vivo and in cancer patients without damaging non-cancerous tissue. CHCP is potentially a 4th Treatment Arm for Solid Tumor Cancers. (ClinicalTrials.gov identifier: NCT04267575.)

The FDA Phase One Clinical trial was completed April 15, 2021, at Rush University Medical Center (Chicago, IL) and Sheba Medical Center-Tel HaShomer (Ramat Gan, Israel). The Principal Investigators were Professor Steven Gitelis, M.D., and Professor Aviram Nissan, M.D. respectively.

On May 12, 2022 IN8bio, Inc. (Nasdaq: INAB), a clinical-stage biopharmaceutical company focused on the discovery and development of innovative gamma-delta T cell therapies utilizing its DeltEx platform, reported financial results and operational highlights for the quarter ended March 31, 2022 (Press release, In8bio, MAY 12, 2022, View Source [SID1234614483]). In addition, the Company provided an overview of recent corporate developments.

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"Our team continues to execute and advance our programs on multiple fronts despite these challenging times in biotech," said William Ho, CEO and co-founder of IN8bio. "Our Phase I clinical trials for both DeltEx gamma-delta product candidates, INB-200 in GBM and INB-100 in leukemia patients, continue to progress with encouraging early data. We added key clinical and regulatory expertise to our senior management team and we will be introducing our iPSC derived gamma-delta T cell platform at ASGCT (Free ASGCT Whitepaper) next week. The IN8bio team will continue to be disciplined with our capital and we will use our resources to continue to accelerate the growth and momentum in our Company."

Business Highlights & Updates

In January 2022, IN8bio provided a clinical update from the Phase 1 clinical trial of its genetically modified gamma-delta T cell therapy candidate, INB-200, in newly diagnosed GBM. In the single ascending dose cohort 1 (n=3), all three
patients showed no dose limiting toxicities (DLTs), no cytokine release syndrome (CRS) or neurotoxicity and demonstrated a manageable safety profile. Cohort 2, which will receive three repeat doses of INB-200, includes one patient who has already received all three doses without any DLTs or significant cell therapy related adverse events. All of the patients treated have exceeded their expected progression-free survival (PFS) interval based on age and MGMT status and exceeded median expected PFS of up to seven months with encouraging trends in overall survival.

IN8bio presented a clinical update from the ongoing Phase 1 clinical trial of INB-100, an allogeneic gamma-delta T cell therapeutic candidate in leukemia patients undergoing hematopoietic stem cell transplantation. All three patients treated remain in morphologic CR with durable remissions ranging from nine to 23 months through March 2022. We observed robust immune reconstitution in the patients including T cells, B cells and gamma-delta T cells. INB-100’s safety profile continues to be manageable with no DLTs, no grade 3 or greater graft vs. host disease (GvHD), no CRS and no neurotoxicity. The data were presented at the EBMT 48th Annual Meeting. These are encouraging results given up to 51% are expected to relapse within a year with standard of care treatment.

In April 2022, IN8bio announced the continued expansion of its clinical and regulatory teams with the appointments of Urvashi Patel, Ph.D., Vice President, Regulatory Affairs, and Stacey Bilinski, Vice President, Clinical Operations. They bring deep clinical and regulatory experience to the IN8bio team, from early to late-stage development across the biotechnology and pharmaceutical industry with more than 45 years of combined experience. Dr. Patel has provided regulatory guidance to biopharmaceutical companies, including WindMIL Therapeutics, Precision for Medicine, Janssen, Elan Pharmaceuticals and Genentech. Ms. Bilinski has initiated numerous first in-human and early-phase clinical development programs at biopharmaceutical companies, including Taiho Oncology, Onconova, Insmed, Amicus Therapeutics and Covance.

Upcoming Milestones and Events

In May 2022, IN8bio unveiled a new preclinical program focused on developing iPSC derived gamma-delta T cells to be presented at the ASGCT (Free ASGCT Whitepaper) Annual Meeting, which will be held from May 16-19, 2022. Scalable iPSC-based cellular manufacturing is designed to create for a uniform and renewable therapeutic product available "off-the-shelf" for patients. IN8bio will be holding an investor event via webcast at the conference to introduce the program to the investment community on May 17, 2022, at 6:00 p.m. EDT. A link to the webcast will be available on the Events & Presentations page of the Company’s website.

IN8bio plans to submit an investigational new drug (IND) application for a Phase 1b/2 clinical trial of INB-400 in GBM during the second half of 2022.

Expected Upcoming Presentations

ASGCT 25th Annual Meeting, Washington, D.C., May 2022: introducing a new program on "The Development of Off-the-Shelf" Manufacturing Strategies for iPSC-Based Gamma-Delta T Cells" along with an oral presentation by Dr. Lamb, "Off the Shelf Cell Therapies – Beyond T Cells (Education Session) and The Next Generation of γδ T Cell-based Therapies" by Dr. Lamb.

Advanced Therapies Congress Live, London, May 2022: presenting "New Directions in the Treatment of Solid Tumors with gdT Cells" by Dr. Lamb.

Cambridge Healthcare Immuno-Oncology Therapeutic Development,
London, May 2022: presenting "Genetically Modified gamma delta T cells in
combination with chemotherapy: now in the clinic" by Dr. Lamb

Cell Engager summit, Boston, May 2022: presenting "Gamma-Delta T-cells: Novel approaches to genetic engineering and cell-type specific therapeutic applications" by Dr. Rochlin.

H.C. Wainwright Global Investment Conference, May 2022: Mr. Ho will participate in a fireside chat on May 25, 2022, at 2 p.m. EDT.

American Society for Clinical Oncology (ASCO) (Free ASCO Whitepaper), June 2022: presenting "Phase 1 study of drug-resistant immunotherapy (DRI) with gene-modified autologous γδ T cells in patients with newly diagnosed glioblastoma multiforme (GBM) receiving maintenance temozolomide (TMZ)" by Louis B. Nabors, M.D.

Jefferies Healthcare Conference, June 2022: Mr. Ho will present at 1:30 p.m. EDT on Wednesday, June 8, 2022.

First Quarter 2022 Financial Highlights

Cash position: As of March 31, 2022, the Company had cash of $32.1 million, compared to $37.0 million as of December 31, 2021. The decrease in cash was primarily due to cash used by the Company in research and development and continued operations to advance its programs.

Research and Development (R&D) expenses: R&D expenses were $2.4 million for the three months ended March 31, 2022, compared to $1.2 million for the comparable prior year period. The increase in R&D expenses were primarily due to (i) increased third-party clinical trial and IND-related activities, (ii) contract manufacturing costs for the ongoing INB-200 clinical trial and (iii) increased personnel-related costs, including salaries, benefits and stock-based compensation due to increased headcount.

General and administrative expenses: General and administrative expenses were $3.8 million for the three months ended March 31, 2022, compared to $1.1 million for the comparable prior year period. The increase was primarily
due to increased legal expenses, insurance costs and expenses associated with operating as a public company.

Net loss: The Company reported a net loss attributable to common stockholders of $6.1 million, or $0.33 per basic and diluted common share, for the three months ended March 31, 2022, compared to a net loss attributable to common stockholders of $3.1 million, or $0.82 per basic and diluted common share, for the comparable prior year period.