Decibel Therapeutics to Participate in the 11th Annual SVB Leerink Global Healthcare Conference

On February 10, 2022 Decibel Therapeutics (Nasdaq: DBTX), a clinical-stage biotechnology company dedicated to discovering and developing transformative treatments to restore and improve hearing and balance, reported that Laurence Reid, Ph.D., Chief Executive Officer of Decibel, will participate in a fireside chat at the 11th Annual SVB Leerink Global Healthcare Conference on Thursday, February 17, 2022 at 3:00 p.m. ET (Press release, Decibel Therapeutics, FEB 10, 2022, View Source [SID1234607978]).

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A live webcast of the fireside chat may be accessed by visiting the Investors section of the Decibel Therapeutics website at View Source An archived replay of the webcast will be available on the Company’s website for approximately 90 days following the fireside chat.

TriSalus Life Sciences Expands Clinical Executive Team and Scientific Advisors in Support of Company’s Focus to Overcome Liver and Pancreatic Cancer Treatment Barriers and Enable More Patients to Benefit From Immunotherapy

On February 10, 2022 TriSalus Life Sciences, an immunotherapy company on a mission to improve the lives of patients living with liver and pancreatic tumors, reported the addition of three new members to its Scientific Advisory Boards and two new members of its clinical leadership team, Drs. Alexander Kim and John Hardaway, as director of interventional oncology clinical strategies and strategic immunotherapy advisor, respectively (Press release, TriSalus Life Sciences, FEB 10, 2022, View Source [SID1234607994]).

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Alexander Y. Kim, MD, FSIR, is a nationally recognized vascular and interventional radiologist. Throughout his career, Dr. Kim has led or participated in clinical trials related to the study of liver cancers, uterine fibroids and symptoms of benign prostate hypertrophy. Recognized for his expertise, Dr. Kim has served in leadership positions on professional associations including the Society of Interventional Radiology and the American Board of Radiology. Following his clinical training, which included a research fellowship at Memorial Sloan-Kettering Cancer Center, he served as Chief of the vascular and interventional radiology division at Georgetown University Hospital.

John Hardaway, MD, PhD, is a board-certified general surgeon and surgical oncologist focused on surgical management of gastrointestinal malignancies, including diseases of the liver and pancreas. In addition to his surgical practice, Dr. Hardaway is a trained cellular immunologist with research efforts focused on translational development of CAR-T therapies against solid tumors and regional delivery of immunotherapies to treat solid tumors. He currently serves as a cancer liaison physician on the American College of Surgeons’ Commission on Cancer.

In addition to these hires, Drs. Venu Pillarisetty, Divya Sridhar, and Jordan Tasse have joined TriSalus’ Scientific Advisory Boards. The three new appointments join 10 other preeminent experts—across medical, surgical and radiation oncology, interventional radiology and immunology—who guide and support the company as it aims to transform the way liver and pancreatic tumors are treated through its interventional immunotherapy platform.

"These additions come at a critical point in TriSalus’ growth as we advance work to enable more liver and pancreas tumor patients to benefit from checkpoint inhibitors and other immunotherapeutic agents," said Steven Katz, MD, FACS, chief medical officer at TriSalus and Scientific Advisory Board chairman. "Our advisors represent the integration of key leaders in the medical oncology, surgical oncology and interventional radiology fields who share our vision of overcoming current limitations in immunotherapy treatment success for liver and pancreatic cancers. This collective expertise enhances our focus on overcoming specific immunologic barriers in the liver or pancreas and physical limitations to drug delivery that result in treatment failure."

Venu G. Pillarisetty, MD, FACS, is a board-certified surgical oncologist, professor of surgery at the University of Washington Medical School and medical director for the Continuous Performance Improvement Department at Seattle Cancer Care Alliance. Dr. Pillarisetty specializes in treating pancreatic cancer and his expertise includes both open and minimally invasive surgical techniques. Throughout his career, Dr. Pillarisetty has authored and co-authored over 70 medical publications. His research focuses on the immune response to pancreatic cancer as well as other solid tumors. Dr. Pillarisetty received his medical degree from Columbia University and completed a surgical oncology fellowship at Memorial Sloan-Kettering Cancer Center. He is a fellow of the American College of Surgeons.

Divya Sridhar, MD, is an interventional radiologist and chief of vascular and interventional radiology at Harlem Hospital Center, a Level 1 Trauma Center affiliated with Columbia University Medical Center. Dr. Sridhar’s specialties include image-guided therapies for cancer and many other conditions. She received her medical degree from the University of Miami Medical School and is a board-certified in diagnostic radiology and interventional radiology by the American Board of Radiology.

Jordan C. Tasse, MD, is a vascular and interventional radiologist, an associate professor of radiology, and the director of interventional oncology at Rush University Medical Center. Dr. Tasse received his medical degree from the Chicago Medical School at Rosalind Franklin University of Medicine and Science.

TriSalus’ Scientific Advisory Boards reflect a unique blend of specialties, including clinical expertise on the barriers that prevent optimal delivery and performance of immunotherapeutics when treating liver and pancreatic tumors, as well as clinical research and evaluation of new therapeutics. Additional Scientific Advisory Board members include:

Oncology

Richard D. Carvajal, MD
Christopher Crane, MD
Marlana M. Orloff, MD
Sapna Patel, BA, MD
Vincent Picozzi, MD
Interventional Radiology

Terence Gade, MD, PhD​
Ripal Gandhi, MD​​
Sirish Kishore, MD ​
Rahul Sheth, MD​​
Particularly as the company continues its Pressure Enabled Regional Immuno-Oncology (PERIO)-01 clinical study evaluating the administration of SD-101, an investigational toll-like receptor 9 (TLR9) agonist, via the Pressure Enabled Drug DeliveryTM (PEDD) method, input from leading experts is instrumental. The ongoing study is the first program to evaluate TriSalus’ platform aimed at improving outcomes in liver and pancreatic cancer by delivering SD-101 to the site of disease via an intra-vascular approach through proprietary PEDD method of administration. TriSalus’ immunotherapy platform aims to solve two primary issues that limit the effectiveness of immunotherapy in the liver and pancreas: immunosuppressive pathways dominant in the liver or pancreas and physical barriers to delivery.​

PERIO-01 investigators include Sapna Patel, MD, associate professor of melanoma medical oncology at The University of Texas MD Anderson Cancer Center; Richard Carvajal, MD, director of the melanoma service at Columbia University Irving Medical Center; and Marlana Orloff, MD, associate professor at Thomas Jefferson University Hospital.

For more background, visit www.trisaluslifesci.com/scientific-boards.

Cytokinetics to Announce Fourth Quarter Results on February 24, 2022

On February 10, 2022 Cytokinetics, Incorporated (Nasdaq: CYTK) reported that it is scheduled to report fourth quarter results on February 24, 2022 at 4:00 PM Eastern Time (Press release, Cytokinetics, FEB 10, 2022, View Source,-February%2010%2C%202022&text=SOUTH%20SAN%20FRANCISCO%2C%20Calif.%2C,4%3A00%20PM%20Eastern%20Time. [SID1234608031]). Following the announcement, Cytokinetics’ senior management will host a conference call at 4:30 PM Eastern Time to discuss operational and financial results and the company’s outlook for the future.

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The conference call will be simultaneously webcast and can be accessed from the homepage and in the Investors & Media section of Cytokinetics’ website at www.cytokinetics.com. The live audio of the conference call can also be accessed by telephone by dialing either (866) 999-CYTK (2985) (United States and Canada) or (706) 679-3078 (international) and typing in the passcode 2895984.

An archived replay of the webcast will be available via Cytokinetics’ website until March 10, 2022. The replay will also be available via telephone by dialing (855) 859-2056 (United States and Canada) or (404) 537-3406 (international) and typing in the passcode 2895984 from February 24, 2022 at 8:00 PM Eastern Time until March 10, 2022.

Nkarta to Participate at Upcoming Investor Conferences

On February 10, 2022 Nkarta, Inc. (Nasdaq: NKTX), a biopharmaceutical company developing engineered natural killer (NK) cell therapies to treat cancer, reported its participation at these upcoming investor conferences (Press release, Nkarta, FEB 10, 2022, View Source [SID1234607963]):

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SVB Leerink 11TH Annual Global Healthcare Conference
February 17, 2022
1:40 p.m. ET – fireside chat presentation

Cowen 42ND Annual Health Care Conference
March 7, 2022
10:30 a.m. ET – leukemias panel discussion

Oppenheimer 32ND Annual Healthcare Conference
March 16, 2022
10:00 a.m. ET – presentation

A simultaneous webcast of the presentations will be available on the Investors section of Nkarta’s website, www.nkartatx.com, and a replay will be archived on the website for approximately four weeks.

Entry into a Material Definitive Agreement

On February 10, 2022, Bausch Health Companies Inc. (the "Company") reported that completed its offering of $1,000,000,000 aggregate principal amount of its 6.125% Senior Notes due 2027 (the "Notes") (Filing, 8-K, Bausch Health, FEB 10, 2022, View Source [SID1234607979]).

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The Notes were offered in the United States and sold to qualified institutional buyers pursuant to Rule 144A under the Securities Act of 1933, as amended (the "Securities Act"), and outside the United States to non-U.S. persons pursuant to Regulation S under the Securities Act. The Notes have not been and will not be registered under the Securities Act or any state securities law and may not be offered or sold in the United States absent registration or an applicable exemption from the registration requirements.

The net proceeds of the Notes offering, along with the proceeds from new term B loans expected to be borrowed in connection with the Company’s previously announced refinancing of its existing credit agreement (the "Credit Agreement" and such refinancing, the "Credit Agreement Refinancing"), the initial public offering ("IPO") of Bausch + Lomb Corporation ("Bausch + Lomb" and such offering, the "Bausch + Lomb IPO") and the repayment of an intercompany note owed to the Company by Bausch + Lomb (which repayment is expected to be funded by a related debt financing by Bausch + Lomb, are expected to be used to fund the Company’s previously announced conditional redemption in full of its outstanding 6.125% Senior Notes due 2025 (the "6.125% Notes due 2025"), refinance all of the existing term B loans, fund the Company’s previously announced conditional partial redemption of its outstanding 9.000% Senior Notes due 2025 (the "9.000% Notes due 2025" and, collectively with the 6.125% Senior Notes due 2025, the "Existing Notes") and to pay related fees, premiums and expenses.

The Notes Indenture

The Notes were issued pursuant to the indenture, dated as of February 10, 2022 (the "Indenture"), among the Company, the guarantors named therein, The Bank of New York Mellon, as trustee and the notes collateral agents party thereto.

Interest and Maturity

Pursuant to the Indenture, the Notes will mature on February 1, 2027. Interest on the Notes will be payable semi-annually in arrears on each February 1 and August 1, beginning on August 1, 2022.

Guarantees

The Notes will initially be jointly and severally guaranteed on a senior secured basis by each of the Company’s subsidiaries that is a guarantor under the Credit Agreement, the Company’s existing senior secured notes (the "Existing Senior Secured Notes") and the Company’s existing senior unsecured notes (the "Existing Senior Unsecured Notes" and, such guarantors, the "Note Guarantors"). The Notes and the guarantees related thereto will be senior obligations and will be secured, subject to permitted liens and certain other exceptions, by the same first priority liens that secure the obligations of the Company and the Notes Guarantors under the Credit Agreement and the Existing Senior Secured Notes. Effective on the closing date of the Bausch + Lomb IPO, we expect that Bausch + Lomb and its subsidiaries will cease to be guarantors under the Credit Agreement and, as a result, will cease to guarantee the Notes.

Ranking

The Notes and the guarantees related thereto will be:

general secured obligations, secured by a first-priority lien (subject to permitted liens and certain other exceptions) on the collateral;

pari passu in right of payment with all existing and future unsubordinated indebtedness of the Company and the Note Guarantors;

effectively pari passu with all existing and future indebtedness secured by a first-priority lien on the collateral (including the credit facilities and the Existing Secured Notes);


effectively senior to all existing and future indebtedness that is unsecured (including the Existing Senior Notes and the guarantees thereof) or that is secured by junior liens, in each case to the extent of the value of the collateral; and

structurally subordinated to (x) all existing and future indebtedness and other liabilities of any of the Company’s subsidiaries that do not guarantee the notes to the extent of the value of such subsidiaries’ assets and (y) any of the Company’s debt that is secured by assets that are not collateral to the extent of the value of such assets.

Optional Redemption

The Notes will be redeemable at the option of the Company, in whole or in part, at any time on or after February 1, 2024, at the redemption prices as set forth in the Indenture.

In addition, the Company may redeem some or all of the Notes prior to February 1, 2024 at a price equal to 100% of the principal amount thereof plus a "make-whole" premium. Prior to February 1, 2024, the Company may redeem up to 40% of the aggregate principal amount of the Notes using the net cash proceeds of certain equity offerings at the redemption price set forth in the Indenture.

Upon the occurrence of a change of control (as defined in the Indenture), unless the Company has exercised its right to redeem all of the Notes, as described above, holders of the Notes may require the Company to repurchase such holder’s Notes, in whole or in part, at a purchase price equal to 101% of the principal amount of such Notes plus accrued and unpaid interest to, but excluding, the purchase date applicable to such Notes.

Special Mandatory Redemption

The Notes will be subject to special mandatory redemption in the event (i) the Bausch + Lomb IPO has not occurred on or prior to August 15, 2022, or (ii) if, prior to such date, the Company notifies the trustee in writing that it will not pursue the Bausch + Lomb IPO. The special mandatory redemption price will be equal to 100% of the issue price of the Notes, plus accrued and unpaid interest, if any, from February 10, 2022 up to, but excluding, the date of such special mandatory redemption.

Certain Covenants

The Indenture contains covenants that limit the ability of the Company and any of its restricted subsidiaries (as such term is defined in the Indenture), to, among other things:

incur or guarantee additional indebtedness;

make certain investments and other restricted payments;

create liens;

enter into transactions with affiliates;

engage in mergers, consolidations or amalgamations; and

transfer and sell assets.

Bausch + Lomb and its subsidiaries will initially remain restricted subsidiaries subject to such restrictive covenants as of pricing of the Bausch + Lomb IPO. The Company expects to designate Bausch + Lomb and its subsidiaries (and any intermediate parent entity) as "unrestricted" subsidiaries upon the satisfaction of the conditions to such designation, including achieving a pro forma total net leverage ratio under the Credit Agreement of 7.6x and satisfying the restricted payments covenant in each of the indentures governing the Existing Senior Secured Notes and the Existing Senior Unsecured Notes, as well as under the indenture that governs the Notes. Such designation could take place at any time after the Bausch + Lomb IPO (including as soon as the closing of the Bausch + Lomb IPO).

Events of Default

The Indenture also provides for customary events of default.

The foregoing summary of the Indenture is not complete and is qualified in its entirety by reference to the full and complete text of the Indenture, a copy of which is attached as Exhibit 4.1 to this Current Report on Form 8-K and incorporated herein by reference.