On February 3, 2022 Amgen (NASDAQ:AMGN) reported that it will host a virtual Business Review Meeting at 8:00 a.m. ET on Tuesday, Feb. 8, 2022 (Press release, Amgen, FEB 3, 2022, View Source [SID1234607682]). Robert A. Bradway, chairman and chief executive officer, along with other members of Amgen’s management team, will present a comprehensive review of the company’s strategy, operations, pipeline, research capabilities and growth outlook. The Business Review Meeting will be broadcast over the internet simultaneously and will be available to members of the news media, investors and the general public.

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The webcast, as with other selected webcasts and presentations regarding developments in Amgen’s business given at certain investor and medical conferences, can be accessed on Amgen’s website, www.amgen.com, under the Investors tab.

Information regarding presentation times, webcast availability and webcast links are noted on Amgen’s Investor Relations Events Calendar. The webcast will be archived and available for replay for at least 90 days after the event.

On February 3, 2022 Kintara Therapeutics, Inc. (Nasdaq: KTRA) ("Kintara" or the "Company"), a biopharmaceutical company focused on the development of new solid tumor cancer therapies, reported that the U.S. Patent and Trademark Office has issued to Kintara United States Patent No. 11,234,955 covering a method of treating brain tumors including glioblastoma (GBM), medulloblastoma, and cancer brain tumor stem cells that has O6-methylguanine-DNA methyltransferase (MGMT)-driven drug resistance (Press release, Kintara Therapeutics, FEB 3, 2022, View Source [SID1234607699]).

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The patent allows for claims recognizing the unique anti-neoplastic activity of VAL-083 on malignant brain tumor cells, in particular those cells that express the DNA repair enzyme MGMT. The MGMT repair enzyme is the principal resistance mechanism that limits significant therapeutic benefit for GBM patients receiving temozolomide (TMZ), the current first line therapy. VAL-083’s activity is independent of MGMT and provides clinical treatment opportunities for newly-diagnosed patients who express the enzyme as well as recurrent patients who fail TMZ treatment. Moreover, MGMT is a biomarker used in the diagnosis of a patient’s brain tumor and helps clinicians to understand the patient’s prognosis.

In addition to the antiproliferative activity in GBM, the patent covers the significant activity of VAL-083 for medulloblastoma, another deadly form of brain tumor, as well as the opportunity to target brain tumor stem cells, perhaps the ultimate cause of brain tumor therapy resistance. Medulloblastomas are invasive, rapidly growing, and are a common type of brain tumor in children.

"The effect of VAL-083 on brain tumor stem cells represents a unique advance," Dennis Brown, Ph.D., Kintara’s Chief Scientific Officer said. "These undifferentiated stem cells are resistant to radiation and chemotherapy and are thought to represent the source of most brain tumor recurrences. We believe the ability to target these stem cells with VAL-083 may offer clinicians additional approaches to improve patient treatment outcomes."

On February 3, 2022 Sierra Oncology, Inc. (Nasdaq: SRRA), a late-stage biopharmaceutical company dedicated to delivering targeted therapies for rare cancers, reported that the underwriters of its previously announced underwritten public offering exercised in full their option to purchase 750,000 additional shares of common stock at a price of $27.00 per share, before deducting underwriting discounts and commissions (Press release, Sierra Oncology, FEB 3, 2022, View Source [SID1234607719]). With this exercise, the aggregate gross proceeds to Sierra Oncology from the offering were approximately $155.3 million, before deducting underwriting discounts and commissions and other offering expenses. The offering of the additional 750,000 shares closed on February 3, 2022. Sierra Oncology intends to use the net proceeds of the offering to prepare for potential commercialization of momelotinib, clinical development of its other product candidates, research, clinical and process development and manufacturing of its product candidates, working capital, and capital expenditures and other general corporate purposes.

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Jefferies and Cantor acted as the joint book-running managers and representatives of the underwriters for the offering. LifeSci Capital, Oppenheimer & Co. and H.C. Wainwright & Co. acted as lead managers for the offering.

A shelf registration statement on Form S-3 relating to the securities offered in the public offering described above was filed with the Securities and Exchange Commission (SEC) on November 5, 2021 and declared effective by the SEC on November 12, 2021. A final prospectus supplement and accompanying prospectus relating to the offering have been filed with the SEC and are available on the SEC’s website at www.sec.gov. Copies of the final prospectus supplement and accompanying prospectus may also be obtained by contacting Jefferies LLC, Attention: Equity Syndicate Prospectus Department, 520 Madison Avenue, 2nd Floor, New York, NY 10022, by telephone at (877) 821-7388, or by email at [email protected]; or Cantor Fitzgerald & Co., Attention: Capital Markets, 499 Park Avenue, New York, New York 10022, or by e-mail at [email protected].

This press release shall not constitute an offer to sell or the solicitation of an offer to buy the securities being offered, nor shall there be any sale of the securities being offered in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or other jurisdiction.

On February 3, 2022 Galapagos NV (Euronext & NASDAQ: GLPG) reported that it received a new transparency notification from EcoR1 Capital, LLC (Press release, Galapagos, FEB 3, 2022, View Source [SID1234607790]).

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Pursuant to Belgian transparency legislation1, Galapagos received a transparency notification on 2 February 2022 from EcoR1 Capital LLC, who notified that it holds 3,407,246 of Galapagos’ voting rights, consisting of 211,622 ordinary shares and 3,195,624 American Depository Receipts. EcoR1 Capital LLC, controlled by Mr. Nodelman, controls investment funds EcoR1 Capital Fund Qualified LP and EcoR1 Capital Fund LP, which all together hold 3,407,246 of Galapagos’ voting rights. This represents 5.2% of Galapagos’ currently outstanding 65,552,721 shares. EcoR1 Capital LLC thus crossed above the 5% threshold of Galapagos’ voting rights by acquisition of voting securities on 27 January 2022. The full transparency notice is available on the Galapagos website.

On February 3, 2022 Revolution Medicines, Inc. (Nasdaq: RVMD), a clinical-stage oncology company developing novel targeted therapies for RAS-addicted cancers, reported that the company will participate in the Guggenheim Healthcare Talks 2022 Oncology Conference (Press release, Revolution Medicines, FEB 3, 2022, View Source [SID1234607665]). Mark A. Goldsmith, M.D., Ph.D., chief executive officer and chairman of Revolution Medicines, will be the featured participant in a fireside chat at the event.

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Details of the company’s participation are as follows:

Guggenheim Healthcare Talks 2022 Oncology Conference
Conference Date: February 9-11, 2022
Fireside Chat Time/Date: 12:30 p.m. Pacific on Thursday, February 10, 2022
Format: Virtual conference; webcast available
To access the live webcast of the fireside chat, please visit the "Events & Presentations" page of Revolution Medicines’ website at View Source Additionally, a replay of the webcast will be available on the "Events & Presentations" page of the Revolution Medicines website for at least 14 days following the conference.