On February 1, 2022 Chimeric Therapeutics (ASX:CHM, "Chimeric"), a clinical-stage cell therapy company and the ASX leader in cell therapy, reported that it has signed a Sponsored Research Agreement with the University of Pennsylvania ("Penn") to support the continued research and development of CHM 2101, a novel 3rd generation CDH17 CAR T cell therapy.

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The research will be led by one of the inventors of CHM 2101, Xianxin Hua, MD, PhD. Dr Hua is a professor of Cancer Biology in Penn’s Perelman School of Medicine, and an investigator at the Abramson Family Cancer Research Institute.

The research will focus on furthering the development of CHM 2101 with preclinical studies in gastrointestinal cancers, enhancing the understanding of CHM 2101 through correlative studies and investigating CDH17 directed follow on candidates.

As part of the agreement, Chimeric has the first right of negotiation to license Penn intellectual property arising from the conduct of the sponsored research. "We are pleased to announce this research agreement as it reflects our shared commitment to the further research and development of CHM 2101 with Dr. Hua and the University of Pennsylvania," said Jennifer Chow, Chief Executive Officer of Chimeric Therapeutics.

"We are also thrilled with the progress we have made on driving this important therapy to clinic and are excited as the execution of this agreement will enhance our ability to move forward with that goal."

Authorised on behalf of the Chimeric Therapeutics board of directors by Chairman Paul Hopper

On February 1, 2022 Eagle Pharmaceuticals, Inc. (Nasdaq: EGRX) ("Eagle" or the "Company") reported the commercial availability of its novel product PEMFEXY (pemetrexed for injection) (Press release, Eagle Pharmaceuticals, FEB 1, 2022, View Source [SID1234607563]). A branded alternative to ALIMTA, Eagle’s PEMFEXY is a ready-to-use liquid with a unique J-code approved to treat nonsquamous non-small cell lung cancer and mesothelioma.

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"We’ve spent the past several months building our inventory and are pleased that PEMFEXY will now be available to the many patients who need it. Together with our recent launch of vasopressin and now PEMFEXY, these products represent significant opportunities for Eagle," stated Scott Tarriff, President and Chief Executive Officer.

In February 2020, Eagle received final approval from the U.S. Food and Drug Administration of its New Drug Application for PEMFEXY, following the settlement agreement of patent litigation with Eli Lilly and Company (NYSE: LLY) in December 2019. The agreement provided for a release of all claims by the parties and allows for an initial entry of PEMFEXY into the market (equivalent to approximately a three-week supply of current ALIMTA utilization) on February 1, 2022 and a subsequent uncapped entry on April 1, 2022.

On October 1, 2020, PEMFEXY’s Healthcare Common Procedure Coding System code, or J-code, became effective.

About PEMFEXY

PEMFEXY is a pemetrexed injection ready-to-dilute formulation for locally advanced or metastatic nonsquamous non-small cell lung cancer in combination with cisplatin; locally advanced or metastatic nonsquamous non-small cell lung cancer whose disease has not progressed after four cycles of platinum-based first-line chemotherapy, as maintenance treatment; locally advanced or metastatic nonsquamous non-small cell lung cancer after prior chemotherapy as a single agent; and malignant pleural mesothelioma whose disease is unresectable or who are otherwise not candidates for curative surgery in combination with cisplatin.

On February 1, 2022 Orion Corporation reported that 38,220 A shares have been converted into 38,220 B shares (Press release, Orion , FEB 1, 2022, View Source,Register%20on%201%20February%202022. [SID1234607579]). The conversion has been entered into the Trade Register on 1 February 2022 .

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The total number of shares in Orion Corporation is 141,134,278 which, after the conversion, consists of 34,774,986 A shares and 106,359,292 B shares. The number of votes of the company’s shares is after the conversion 801,859,012.

On February 1, 2022 DiscoveryBioMed, Inc. and collaborators reported that they are humbled and honored to receive a 2-year grant from the Michael J. Fox Foundation for Parkinson’s Research (MJFF) (Press release, DiscoveryBioMed, FEB 1, 2022, View Source [SID1234607596]). MJFF is a premier private foundation driving cutting-edge research that will yield viable therapeutics for Parkinson’s disease.

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The monies are awarded to develop, validate, select and progress hit-to-lead Stimulator of Interferon Genes (STING) inhibitors for Parkinson’s disease. DiscoveryBioMed, Inc. and our collaborator, Nitor Therapeutics led by Dr. Shanta Bantia, are performing in vitro assays currently to determine which hit-to-lead STING inhibitors bind STING directly and which inhibit the STING-associated signal transduction pathway in human immune-relevant cells. Then, we will identify STING inhibitors that are both blood-brain barrier permeant and that are also potent and effective at inhibiting STING and the STING-based signaling pathway in innate immunity-relevant human cells in vitro. This therapeutic approach may quell chronic neuroinflammation in Parkinson’s disease. MJFF funded the program and has already provided sage advice in the beginnings of the project. Later term, bioavailability of our lead STING inhibitors in the central nervous system (CNS) will be determined, and critical proof-of-concept efficacy testing in a mutant alpha-synuclein over-expression model of Parkinson’s disease in the brain of mice will be performed with a lead STING inhibitor. In addition to Dr. Bantia as a paid consultant, Dr. David G. Standaert, MD, PhD, John N. Whitaker Professor and Chair of the Department of Neurology at the UAB Heersink School of Medicine is also advising DBM on this project as a world expert on Parkinson’s disease and other neurological disorders that affect movement.

"We are honored to be funded and working with MJFF. The experience working with MJFF has already been helpful, and we are excited to identify a lead STING inhibitor as a potential Parkinson’s disease therapeutic," declared Dr. Erik Schwiebert, DBM’s CEO and Chief Scientific Officer, and Dr. John Streiff, DBM’s Chief Chemistry Officer. "Our chemical series are distinct from nucleosides and nucleotides that have been classical STING ligands in past efforts."

The discovery of multiple hit-to-lead chemical classes of STING inhibitors was funded by a successful Phase 1 SBIR award from the National Institutes of Health (NIH) and its National Institute of Allergy and Infectious Disease (NIAID). A potential Phase 2 SBIR award is pending possible funding.

On February 1, 2022 Eli Lilly and Company (NYSE: LLY) reported that it will participate in the Guggenheim Oncology Conference on Wednesday, Feb. 9, 2022 (Press release, Eli Lilly, FEB 1, 2022, View Source [SID1234607564]). Jake Van Naarden, CEO of Loxo Oncology at Lilly and president, Lilly Oncology and David Hyman, M.D., chief medical officer, Lilly Oncology, will participate in a virtual fireside chat at 12 p.m., Eastern time .

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A live audio webcast will be available on the "Webcasts & Presentations" section of Lilly’s Investor website at View Source A replay of the presentation will be available on this same website for approximately 90 days.