On February 9, 2022 Poseida Therapeutics, Inc. (Nasdaq: PSTX), a clinical-stage biopharmaceutical company utilizing proprietary genetic engineering platform technologies to create cell and gene therapeutics with the capacity to cure, reported that it will host a virtual R&D Day at 10:00 am – 1:30 pm ET / 7:00 – 10:30 am PT on Wednesday, February 23, 2022 (Press release, Poseida Therapeutics, FEB 9, 2022, View Source [SID1234607916]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Poseida to host second annual Virtual R&D Day on February 23, 2022. $PSTX
Poseida’s second annual R&D Day will include presentations from the Company’s executive leadership, researchers, clinical team members, and key opinion leaders, followed by an interactive Q&A session. The event will focus on the Company’s differentiated genetic engineering platform technologies, novel approach to cell and gene therapy, and emerging discovery programs. Speakers will also discuss the Company’s R&D progress and its program and pipeline goals for 2022 in both cell and gene therapy, including its recently announced research collaboration with Takeda Pharmaceutical Company Limited ("Takeda") to develop non-viral in vivo gene therapies.

External speakers will include Susan F. Slovin, M.D., Ph.D., Associate Vice Chair of Academic Administration at Memorial Sloan Kettering Cancer Center and an investigator on a Phase 1 trial evaluating P-PSMA-101, the Company’s autologous CAR-T candidate for the treatment of metastatic castrate resistant prostate cancer (mCRPC); and Luca Gattinoni, M.D., Director of the Division of Functional Immune Cell Modulation, Leibniz Institute for Immunotherapy at the University of Regensburg in Germany. Dr. Gattinoni is a member of the Company’s Immuno-Oncology Scientific Advisory Board.

Registration for this virtual event and access to the live webcast will be available on the Investors & Media section of Poseida’s website, www.poseida.com. A replay of the webcast will be available for 30 days following the presentation.

On February 9, 2022 Johnson & Johnson (NYSE: JNJ) reported that it will participate in the Raymond James 43rd Annual Institutional Investors Conference on Tuesday, March 8th. Joseph J. Wolk, Executive Vice President and Chief Financial Officer, will represent the Company in a session scheduled at 1:05 p.m. (Eastern Time) (Press release, Johnson & Johnson, FEB 9, 2022, View Source;johnson-to-participate-in-the-raymond-james-43rd-annual-institutional-investors-conference-301479192.html [SID1234607931]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

This webcast will be available to investors and other interested parties by accessing the Johnson & Johnson website at www.investor.jnj.com.

A webcast replay will be available approximately 48-hrs after the live webcast.

On February 9 2022 Targovax ASA (OSE: TRVX) reported that it will announce its fourth quarter 2021 results on Thursday 17 February 2022 (Press release, Targovax, FEB 9, 2022, View Source [SID1234607880]). An online presentation by Targovax’s management to investors, analysts and the press will take place at 10:00 am CET.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

The results report and the presentation will be available at www.targovax.com in the Investors section from 07:00 am CET.

Presentation

There will be a virtual presentation of the results with a live webcast 17 February at 10.00 am CET. You can join the webcast here. It will be possible to ask questions during the presentation.

On February 9, 2022 Sonnet BioTherapeutics Holdings, Inc. (NASDAQ:SONN) ("Sonnet" or the "Company"), a biopharmaceutical company developing innovative targeted biologic drugs, reported that data from preclinical studies of the company’s proprietary Fully Human Albumin Binding candidates, SON-1010, SON-1210, and SON-1410, will be presented at the upcoming American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2022, to be held April 8-13, in New Orleans, Louisiana (Press release, Sonnet BioTherapeutics, FEB 9, 2022, View Source [SID1234607901]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Details of the abstract and poster presentation are as follows:

Title: An innovative human platform for targeted delivery of bispecific interleukins to tumors
Abstract Number: 4229
Session: Immunology
Presentation Type: Poster
Session Date and Time: Wednesday April 13, 2022; 9:00 AM – 12:30 PM EDT
Location: New Orleans Convention Center, Exhibit Halls D-H, Poster Section 38
Poster Board Number: 9

On February 9, 2022 Aptevo Therapeutics Inc. ("Aptevo" or the "Company") (NASDAQ:APVO), a clinical-stage biotechnology company focused on developing novel immuno-oncology therapeutics based on its proprietary ADAPTIR and ADAPTIR-FLEX platform technologies, reported that the Company has earned a $10 million non-dilutive milestone payment related to 2021 sales of RUXIENCE (Press release, Aptevo Therapeutics, FEB 9, 2022, View Source [SID1234607917]). Additionally, based on RUXIENCE 2021 fourth quarter and full-year sales results, the Company is optimistic about the possibility of earning additional non-dilutive milestones totaling $22.5 million over the next two years. The Company also announced that its Phase 1b trial evaluating lead drug candidate APVO436 for the treatment of acute myeloid leukemia (AML) continues to enroll new clinical trial sites and that the first complete remission patient, announced in 2021, is proceeding to transplant.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

RUXIENCE Milestones

Aptevo has earned a $10 million milestone payment related to sales of RUXIENCE under the terms of its royalty purchase agreement with HealthCare Royalty Management, LLC (HCR). The milestone will be used to pay down MidCap Financial debt, reducing outstanding principal on the debt to $5 million and strengthening the Company’s balance sheet. This, in combination with $46.3 million of cash-on-hand as of December 31, 2021, gives the Company cash runway through 1Q23, positioning Aptevo well to complete dosing in its ongoing APVO436 Phase 1b clinical trial and, in partnership with Alligator BioScience, to initiate a clinical trial for ALG.APV-527.

RUXIENCE, a Pfizer drug, is a biosimilar to RITUXAN. Pfizer reported 2021 revenue of $491 million from RUXIENCE, including $148 million in 4Q21, exceeding the $395 million threshold required for Aptevo to fully earn the 2021 $10 million milestone. Annualizing the $148 million Q4 revenue suggests 2022 full-year revenue could be approximately $592 million. Aptevo will earn $12.5 million of additional milestones in 2022 if revenue is at least $525 million. Similarly, an additional $10 million milestone can be earned in 2023 if revenue is at least $570 million. Given the above, Aptevo is optimistic about fully earning these additional future non-dilutive milestones totaling $22.5 million.

APVO436 Clinical Trial

The Company’s multi-site, multi-cohort Phase 1b clinical trial evaluating APVO436 for the treatment of acute myeloid leukemia (AML) continues to progress:

MD Anderson Cancer Center joins numerous other sites already enrolling and Aptevo plans to add additional sites this year
A patient with complete remission, announced in November 2021, is progressing to transplant
Initial data is expected mid-year 2022
"We are very pleased to announce meaningful progress in our clinical work and to reinforce the strength of our financial position, especially during such a challenging time in the market. From our inception, Aptevo has remained committed to a focused business strategy designed to deliver results that will ultimately benefit patients," said Marvin White, CEO. "On the clinical side, we are pleased to expand the number of trial sites as this increases the pool of patients potentially eligible to participate in the study. Further, we are happy to report that the patient we reported on in November, who achieved complete remission in the expansion trial, remains in remission and is proceeding to transplant. We wish them well."

"Adding to Marvin’s comments about a previously reported complete remission patient, it’s encouraging that they are proceeding to transplant after receiving a combination of chemotherapy plus APVO436. Complete remission and transplant in patients who have failed prior frontline therapy such as this one, are indicators that the patient is making positive clinical progress in fighting this difficult-to-treat disease." said Dirk Huebner, MD, Senior Medical Advisor.