On February 8, 2022 EdiGene, Inc., a global biotechnology company focused on translating gene-editing technologies into transformative therapies for patients with serious genetic diseases and cancer, reported a non-exclusive, worldwide license agreement with Arbor Biotechnologies, a biotechnology company discovering and developing the next generation of genetic medicines, to access Arbor’s proprietary CRISPR gene editing technology for certain ex vivo engineered cell therapy programs in the field of oncology (Press release, EdiGene, FEB 8, 2022, View Source [SID1234607865]).

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"Partnering with leading engineered cell therapy developers is a key component of Arbor’s strategy to broaden the potential of our CRISPR discovery engine beyond our wholly-owned in vivo genetic medicine approaches for the benefit of even more patients," said Devyn Smith, Ph.D., Chief Executive Officer of Arbor. "We look forward to expanding the global impact of Arbor’s proprietary gene editing technologies through our partnership with EdiGene."

The licensed technology is a part of Arbor’s proprietary CRISPR gene-editing portfolio, which is tailored to address the underlying pathology of genetic diseases.

"It has been great working with Arbor’s team in the past year to optimize ways of integrating Arbor’s proprietary CRISPR system into our ex vivo platforms," said Dong Wei, Ph.D., CEO of EdiGene. "This partnership will expand EdiGene’s gene-editing toolkit and strengthen our capabilities to advance ongoing ex vivo gene-editing cell therapy programs for multiple serious diseases. We look forward to collaborating with Arbor to achieve our shared commitment to developing innovative therapies to address unmet medical needs."

Under the agreement, EdiGene will pay Arbor certain upfront, milestone payments, commercial payments upon the achievement of certain development and sales milestones, and tiered royalties on net sales of royalty-bearing EdiGene products.

On February 8, 2022 Seagen Inc. (Nasdaq: SGEN) reported that management will participate in a virtual fireside chat at the 11th Annual SVB Leerink Global Healthcare Conference on Thursday, February 17, 2022 at 2:20 p.m. Eastern Time (Press release, Seagen, FEB 8, 2022, View Source [SID1234607834]). The presentation will be webcast live and available for replay from the investor section of Seagen’s website at investor.seagen.com.

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On February 8, 2022 ADC Therapeutics SA (NYSE: ADCT), a commercial-stage biotechnology company improving the lives of those affected by cancer with its next-generation, targeted antibody drug conjugates (ADCs) for patients with hematologic malignancies and solid tumors, reported that it will provide insight into its ADC platform and solid tumor pipeline during a live webcast from 9:00 to 11:00 a.m. EST (Press release, ADC Therapeutics, FEB 8, 2022, View Source [SID1234607850]).

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During the webcast, Chris Martin, PhD, Chief Executive Officer, Patrick van Berkel, PhD, Senior Vice President of Research & Development, and Joseph Camardo, MD, Chief Medical Officer, will discuss the broad applicability and flexibility of the Company’s novel ADC technology and provide a deep dive on its portfolio of solid tumor programs including three clinical-stage assets (Cami, ADCT-901, and ADCT-601); ADCT-701, which is approaching the clinic; and a newly disclosed program, ADCT-212, an ADC targeting PSMA with potential utility in metastatic castrate-resistant prostate cancer (mCRPC).

The live webcast will be available via the Events & Presentations page in the Investors section of ADC Therapeutics’ website, ir.adctherapeutics.com. A replay of the webcast will be available for approximately 30 days.

On February 8, 2022 Arrakis Therapeutics, a biopharmaceutical company pioneering the discovery of a new class of small molecule medicines that directly target RNA, reported that Michael Gilman, Ph.D., Chief Executive Officer, will present a corporate overview at the Guggenheim Healthcare Talks Oncology Conference on Friday, February 11, 2022 at 10:00 a.m. ET (Press release, Arrakis Therapeutics, FEB 8, 2022, View Source [SID1234607866]).

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On February 8, 2022 Nuformix plc (LSE: NFX), a pharmaceutical development company targeting unmet medical needs in fibrosis and oncology via drug repurposing, reported that following the Company’s signing of an exclusive global licensing agreement with Oxilio Ltd ("Oxilio") for NXP001 on 13 September 2021, Oxilio has progressed the product and signed a significant service contract with Quotient Sciences Ltd ("Quotient Sciences") to support the formulation development of NXP001 (Press release, Oxilio, FEB 8, 2022, https://www.londonstockexchange.com/news-article/NFX/oxilio-nxp-001-formulation-development-contract/15319186 [SID1234621609]). NXP001 is a proprietary new form of aprepitant which is currently marketed for cancer chemotherapy induced nausea and vomiting ("CINV").

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Under the contract Oxilio will work with Quotient Sciences, a drug development and manufacturing accelerator, to identify and evaluate the cocrystal formulation of aprepitant to deliver optimal bioavailability for the treatment of CINV.

Quotient has prior experience of working with the Nuformix NXP-001 co-crystal and previously developed a capsule and a powder for oral suspension formulation, evaluating its performance in a relative bioavailability study versus EMEND (a branded aprepitant).

Quotient will prepare for Oxilio CMC (chemistry, manufacturing and controls) batches and stability data to support a clinical trial application for the new formulation of NXP001.

The Company looks forward to providing further updates on Oxilio’s progress with NXP001 in due course.

Commenting, Alastair Riddell, Executive Chairman of Nuformix, said: "We are very pleased to see the progress Oxilio is making with NXP001. Under the exclusive licence we signed with Oxilio we received an upfront payment, expect to receive milestone payments when the product completes clinical trials and ultimately royalties on any sales. This arrangement is allowing Oxilio to progress NXP001 without cost to the Company whilst we focus on progressing our two lead assets, NXP002 and NXP004. In relation to NXP002 and NXP004 we continue to make significant progress and I look forward to making further announcements in due course."