On May 2, 2022 Poseida Therapeutics, Inc. (Nasdaq: PSTX), a clinical-stage biopharmaceutical company utilizing proprietary genetic engineering platform technologies to create cell and gene therapeutics with the capacity to cure, reported that preclinical data highlighting the use of anti-c-kit CAR-T cells, P-ckit-ALLO1 as a preconditioning agent to enable hematopoietic stem cell (HSC) transplants, will be presented at the American Society of Gene and Cell Therapy (ASGCT) (Free ASGCT Whitepaper) 25th Annual Meeting, being held in Washington, D.C. and virtually on May 16-19, 2022 (Press release, Poseida Therapeutics, MAY 2, 2022, View Source [SID1234613412]).

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The Company’s anti-c-kit CAR-T program leverages its proprietary piggyBac Gene Delivery System and Cas-CLOVER Site-specific Gene Editing System to develop fully allogeneic CAR-T cells targeting human c-kit which is highly expressed on HSCs, as well as on myeloid malignancies such as acute myeloid leukemia (AML), meaning the treatment can be used for either HSC transplant conditioning or as a treatment for AML. In addition to the CAR gene, the piggyBac transposon includes a selection marker for generation of a pure CAR+ product and a proprietary fast-acting safety switch enabling rapid clearance of the reactive CAR-T cells prior to donor HSC transplant.

Presentation details:

Poster Presentation: Anti-c-kit CAR-T Cells Enable HSC Engraftment in a Humanized Model of Stem Cell Transplant Conditioning
Session Title: Cell Therapies II
Session Date/Time: Tuesday, May 17, 2022, 5:30 – 6:30 PM ET
Poster Board Number: Tu-239
Location: Walter E. Washington Convention Center, Hall D
Abstract Number: 734

On April 30, 2022 Genome Insight, a global leader in Whole Genome Sequence analysis and interpretation, reported $23 million in Series B funding (Press release, Genome Insight, APR 30, 2022, View Source [SID1234613261]).

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Dunamu & Partners led the financing with participation from InterVest, Signite Partners, KC, and VNTG Corporation, as well as existing investors DSC Investment, Paratus Investment, and Schmidt. The funding will be allocated towards advancing Genome Insight’s data production and curation pipelines that enable scalable investigation of whole-genome sequences (WGS), the most comprehensive technique for understanding the molecular origin of human diseases. These efforts will bring WGS in real-world clinics for clinicians and patients for next-generation medical practice, in particular, for cancer and rare diseases.

Genome Insight is a start-up company with expertise in the biomedical curation of WGS data. WGS examines the entire genomic sequence of diseased tissues, providing the most comprehensive characterization of tens of thousands of genomic mutations carried on it as a whole. While historically confined as a research tool, due to its massive data size and high cost for data curation, WGS is a leading driver for opening up an ultimate era of personalized medicine with entire genomic information. Making biomedical sense of the vast amount of WGS data at an affordable cost, predictable timeline, and standardized procedure has been the main barrier to the widespread use of WGS.

"With the falling cost of genome data production, we are at the tipping point of a whole-genome based transformation in treating genetically driven illnesses such as cancer and rare diseases. We plan to bring the analysis and interpretation technologies to make whole-genome sequences meaningful," said Young Seok Ju, founder of Genome Insight. "We are excited to have as our new investors, not only those in bio-tech but also those in digital-tech. This investment is a clear signal that the field is at the forefront of bio-tech and digital-tech convergence."

Genome Insight was founded in 2020 in South Korea by co-founders Young Seok Ju and Jeong Seok Lee, who are both physician-scientists and professors at KAIST (Korea Advanced Institute of Science and Technology). Earlier this year, the Company announced its incorporation as a US company and is now headquartered in San Diego, at the heart of the genomics hotbed of the west coast.

On April 30, 2022 Yiling Pharmaceutical reported its 2021 Annual Report Friday and disclosed the main development statistics (Press release, Yiling Pharmaceutical, APR 30, 2022, View Source;301536781.html [SID1234613262]). According to the report, its annual revenue reached USD 1.53 billion, an increase of 15.19% from last year, besides, net profit attributable to equity holders reached USD 203.75 million, achieving a 10.27% growth YoY.

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The annual revenue of Tongxinluo Capsules, Shensong Yangxin Capsules, and Qili Qiangxin Capsules, Yiling’s 3 main products for cardio-cerebrovascular diseases, reached USD 687.4 million, accounting for 44.82% of the overall revenue, achieving a 31.56% YoY growth despite the Covid-19 hit. Notably, in 2021, the annual revenue of Lianhua Qingwen Capsules reached USD 622.8 billion. It also ranked No.1 in the sales of patented traditional Chinese medicine for cold in China’s public medical market in 2021H1, according to statistics.

Public information indicates that Lianhua Qingwen Capsules was developed in the SARS period, it is the only herbal medicine for cold and flu that has won the Second Prize of China’s National Progress Award in Science and Technology.

In 2020, a clinical study Efficacy and safety of Lianhuaqingwen capsules, a repurposed Chinese herb, in patients with coronavirus disease 2019: A multicenter, prospective, randomized controlled trial published in Phytomedicine, shows that along with routine treatment, oral administration of Lianhua Qingwen Capsules for 14 days, COVID-19’s clinical symptoms such as fever, fatigue, and cough can be alleviated significantly, and the pulmonary imaging lesions can be improved dramatically, the duration of symptoms was obviously shortened and the clinical cure rate was obviously elevated.

Lianhua Qingwen has been granted for sale in nearly 30 countries and regions. Furthermore, it has been approved for COVID-19 indications in Kuwait and Mongolia, and selected to be listed on the whitelist of anti-epidemic drugs issued by the Ministry of Health of Uzbekistan. In July 2021, it has been adopted as a treatment in the COVID-19 patients’ self-care protocol at home by the Cambodian Ministry of Health.

On April 29, 2022 Avecho (ASX:AVE) reported its Quarterly Activities Report and 4C Quarterly Cash Flow Report, for the period ended 31 March 2022 (Press release, Phosphagenics, APR 29, 2022, View Source [SID1234613211]).

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Key highlights from this period include:

Completion of Phase II Clinical Trial examining its proprietary topical cannabidiol (CBD) gel for the management of pain associated with arthritis of the hand;
First licensing and supply agreement for the use of TPM in the US recreational cannabis space;
TGA feedback on Phase III CBD soft-gel program and completion of initial Phase III Clinical Trial design;
Avecho’s cash balance on 31 March was $3.265m.

Throughout the Quarter, the Company has remained heavily focused on advancing its CBD soft-gel product, whilst also pursuing large, untapped licensing opportunities in the US cannabis space.

Avecho CEO, Dr Paul Gavin, said:

"The data we have generated across our expanded cannabinoid program is beginning to pay dividends. Our deep biotechnology expertise and experience in non-cannabinoid drug development is seen as a major differentiator to medicinal cannabis companies for potential licensees. We are focused on expanding our business development activities with the aim of closing further deals in the various cannabinoid markets"

On April 29, 2022 GENFIT (Nasdaq and Euronext: GNFT), a late-stage biopharmaceutical company dedicated to improving the lives of patients with severe chronic liver diseases, reported the filing of its 2021 Universal Registration Document with the Autorité des marchés financiers (AMF) and its Annual Report on Form 20-F for the year ended December 31, 2021 with the U.S. Securities and Exchange Commission (SEC), as well as the availability of preparatory documents for its annual shareholders meeting on Wednesday May 25, 2022 (Press release, Genfit, APR 29, 2022, https://ir.genfit.com/news-releases/news-release-details/genfit-announces-publication-2021-universal-registration [SID1234613255]).

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These annual reports are available to the public free of charge in accordance with applicable regulations and may be viewed at and downloaded from GENFIT’s website at ir.genfit.com. The 2021 Registration Document is also available on the AMF’s website: www.amf-france.org and the Annual Report on Form 20-F is available on the website of the SEC (www.sec.gov).

GENFIT’s 2021 Universal Registration Document includes, in particular, the annual financial report, the annual Board of Directors’ management report, the Board of Directors’ report on corporate governance, the Statutory Auditors’ reports on the annual and consolidated financial statements and related-party agreements, and the table summarizing the fees paid to the Statutory Auditors.

Documents for the Annual Combined Shareholders Meeting on May 25, 2022 are available to shareholders in accordance with existing regulations, and can be found on the Company’s website, in the Investors and Media section (https://ir.genfit.com/financial-information/shareholders-meeting).