On February 3, 2025 Kazia therapeutics presented its corporate presentation (Presentation, Kazia Therapeutics, FEB 3, 2025, View Source [SID1234649997]).

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On February 3, 2025 Olema Pharmaceuticals, Inc. ("Olema" or "Olema Oncology", Nasdaq: OLMA), a clinical-stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted therapies for breast cancer and beyond, reported that management will participate in the following investor conferences (Press release, Olema Oncology, FEB 3, 2025, View Source [SID1234649998]):

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Oppenheimer 35th Annual Healthcare Life Sciences Conference
Date: Wednesday, February 12, 2025 at 9:20 a.m. ET
Format: Virtual Presentation

Citi’s 2025 Virtual Oncology Leadership Summit
Date: Thursday, February 20, 2025 at 10 a.m. ET
Format: Virtual Fireside Chat

Live webcasts of these presentations will be available in the Events and Presentations section of Olema’s investor relations website at ir.olema.com. The webcasts will be archived for at least 30 days.

On February 3, 2025 Orum Therapeutics ("Orum" or the "Company") (KRX: 475830), a clinical-stage biotechnology company pioneering the field of degrader-antibody conjugates (DACs), reported the pricing of its initial public offering of 2,500,000 shares of common stock at a public offering price of KRW 20,000 per share (Press release, Orum Therapeutics, FEB 3, 2025, View Source [SID1234649999]). All of the shares are being offered by Orum Therapeutics. The shares are expected to begin trading on the Korean Securities Dealers Automated Quotations (KOSDAQ) on February 14, 2025, under the stock code KRX: 475830. The gross proceeds of the offering, before deducting underwriting discounts and commissions and other offering expenses payable by Orum, are expected to be approximately KRW 50 billion.

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The offering is expected to close on February 5, 2025, subject to the satisfaction of customary closing conditions.

Korea Investment Securities acted as underwriter for the offering.

A registration statement relating to the offering has been filed with the Financial Supervisory Service and was declared effective on January 16, 2025. The offering is being made only by means of a prospectus. Copies of the final prospectus relating to the offering, when available, may be obtained for free by visiting DART on the Financial Supervisory Service website at View Source Alternatively, copies of the final prospectus, when available, may be obtained from Korea Investment Securities, Attention: https://securities.koreainvestment.com, by telephone at +82-2-3276-5783, +82-2-3276-5783-4528, or by email at [email protected].

This press release does not constitute an offer to sell or the solicitation of an offer to buy these securities, nor will there be any sale of these securities in any state or jurisdiction in which such an offer, solicitation, or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction. Any offers, solicitations or offers to buy, or any sales of securities will be made in accordance with the registration requirements of the Korean Securities and Exchange Act, as amended, and otherwise in accordance with applicable securities laws in any other jurisdiction.

On February 3, 2025 Purple Biotech Ltd. ("Purple Biotech" or "the Company") (NASDAQ/TASE: PPBT), a clinical-stage company developing first-in-class therapies that overcome tumor immune evasion and drug resistance, reported that it has entered into a Research Collaboration Agreement with the Icahn School of Medicine at Mount Sinai ("Icahn School of Medicine") in New York, NY, to explore the immunoregulation of NK and T cells within the TME by Purple’s CAPTN-3 multi-specific engagers with the purpose of enhancing tumor-specific immunity against various cancer types (Press release, Purple Biotech, FEB 3, 2025, View Source [SID1234650000]).

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"Partnering on this important preclinical work with the Marc and Jennifer Lipschultz Precision Immunology Institute and The Tisch Cancer Institute at the Icahn School of Medicine is expected to deepen our understanding of the mechanisms of action for our innovative tri-specific platform in preparation for human clinical studies," said Gil Efron, Purple Biotech CEO. "We have recently observed a growing interest in multi-specific engagers, and we look forward to advancing CAPTN-3 development as we prepare for first-in-human clinical studies."

The Principal Investigator of the study is Amir Horowitz, PhD, Associate Professor of Immunology & Immunotherapy and Oncological Sciences and a member of the Lipschultz Precision Immunology Institute and The Tisch Cancer Institute. Dr. Horowitz, an expert in the immunoregulation of the TME in cancer patients, has demonstrated a novel immunotherapeutic target axis involving the interaction between HLA-E expressing tumor cells and NKG2A-positive NK and CD8 T cells, which suppresses immune responses in treatment-resistant patients. He and others have shown the HLA-E/NKG2A axis to be a dominant inhibitory checkpoint pathway in solid tumors.

Dr. Horowitz commented, "CAPTN-3’s dual potential mechanisms of action appear to be a promising indicator of the platform’s potential safety and efficacy to treat cancer through its synergistic regulation of both T cells and NK cells at the tumor microenvironment. In this collaboration, we plan to map how CAPTN-3 antibodies alter T and NK cell activation within the TME, specifically focusing on the modulation of HLA-E/NKG2A interactions and enhancing features of innate immunity."

"The opportunity to deepen our understanding of the tumor immune evasion mechanisms that CAPTN-3 uniquely addresses is exciting, and we hope it will pave the way for effective treatments for many challenging tumor indications. We are looking forward to working with Dr. Horowitz and his team at Mount Sinai to validate the unique aspects of CAPTN-3 design in a wide screen of patient-derived tumors, potentially bringing new insights for overcoming resistance to standard frontline immunotherapies," stated Purple Biotech’s VP Research and Development, Dr. Hadas Reuveni.

On January 31, 2025 Immunome, Inc. ("Immunome") (Nasdaq: IMNM), a biotechnology company focused on developing first-in-class and best-in-class targeted cancer therapies, reported the closing of its underwritten public offering of 22,258,064 shares of its common stock, including the exercise in full by the underwriters of their option to purchase an additional 2,903,225 shares, at a price to the public of $7.75 per share (Press release, Immunome, JAN 31, 2025, View Source [SID1234649984]). The gross proceeds to Immunome from the offering, before deducting underwriting discounts and commissions and offering expenses, were $172.5 million. All of the shares in the offering were sold by Immunome.

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J.P. Morgan, TD Cowen, Leerink Partners and Guggenheim Securities acted as joint book-running managers for the offering. Wedbush PacGrow acted as lead manager for the offering.

The offering was made pursuant to a shelf registration statement on Form S-3 that was filed with the U.S. Securities and Exchange Commission (the "SEC") on February 13, 2024 and automatically became effective upon filing. A preliminary prospectus supplement and accompanying prospectus relating to the offering were filed with the SEC and are available for free on the SEC’s website located at View Source A final prospectus supplement and accompanying prospectus relating to the offering were filed with the SEC and are available for free on the SEC’s website located at View Source Copies of the final prospectus supplement and the accompanying prospectus relating to the offering may be obtained from: J.P. Morgan Securities LLC, Attention: Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY 11717, or by telephone at (866) 803-9204, or by email at [email protected]; TD Securities (USA) LLC, 1 Vanderbilt Avenue, New York, NY 10017, by telephone at (855) 495-9846 or by email at [email protected]; Leerink Partners LLC, Syndicate Department, 53 State Street, 40th Floor, Boston, MA 02109, or by telephone at (800) 808-7525 ext. 6105, or by email at [email protected]; or Guggenheim Securities, LLC Attention: Equity Syndicate Department, 330 Madison Avenue, New York, NY 10017 or by telephone at (212) 518-9544, or by email at [email protected].

This press release shall not constitute an offer to sell or a solicitation of an offer to buy, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.