On July 1, 2022 ADC Therapeutics SA (NYSE: ADCT) reported the appointment of veteran oncology drug developer Jean-Pierre Bizzari, MD, to its Board of Directors (Press release, ADC Therapeutics, JUL 1, 2022, View Source [SID1234616444]). Additionally, Ameet Mallik, who was appointed as the Company’s Chief Executive Officer in May 2022, will join the Board.

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"Jean-Pierre is an exceptional addition to our Board," said Ron Squarer, Chairman of ADC Therapeutics’ Board of Directors. "His integral role in the development and approval of leading cancer treatments across global markets will bring valuable perspective to ADC Therapeutics as we advance a robust pipeline of ADCs for the treatment of hematological cancers and solid tumors."

Dr. Jean-Pierre Bizzari is an internationally renowned oncologist with over 35 years of experience in oncology drug development. He was Executive Vice President and Group Head of Clinical Oncology Development at Celgene Corporation where he was responsible for clinical development and operations across the United States, Europe and Asia/Japan. During his tenure at Celgene, he oversaw the development and approval of leading oncology products including REVLIMID (lenalidomide), VIDAZA (azacytidine), and ABRAXANE (nab-paclitaxel). Dr. Bizzari also served as Vice President, Clinical Oncology Development for Sanofi-Aventis (formerly Rhône-Poulenc, Rhône-Poulenc Rorer and Aventis) where he oversaw the approval of ELOXATIN (oxaliplatin), TAXOTERE (docetaxel) and ELITEK (rasburicase).

Dr. Bizzari currently serves on the scientific advisory boards of France’s National Cancer Institute and the European Organisation for Research and Treatment of Cancer. He also serves on the scientific advisory boards and board of directors at numerous global pharmaceutical companies. Dr. Bizzari has received various industry honors and has authored hundreds of scientific articles and publications.

Dr. Bizzari received his medical degree from the University of Nice and has trained at the Pitié-Salpêtrière Hospital in Paris, the Ontario Institute for Cancer Research, and the McGill Rosalind and Morris Goodman Cancer Research Centre (formerly the McGill Cancer Center) in Montreal, Canada.

"With a proprietary ADC platform validated by the FDA approval of ZYNLONTA, a robust pipeline of solid tumor targets and a global team committed to transforming patients’ lives, ADC Therapeutics is poised to build on its success," said Dr. Bizzari. "I look forward to working with the Board to continue ADC Therapeutics’ positive momentum and make a meaningful difference for patients with difficult-to-treat cancers."

On July 1, 2022 RS Research, a clinical-stage biotechnology start-up developing smart nanomedicines for targeted chemotherapy, reported the progress of its leading candidate RS-0139’s Phase I trial (RS-001) on NSCLC (Press release, RS Research, JUL 1, 2022, View Source [SID1234616793]). Designing drug candidates with improved safety profile and superior therapeutic index based on its proprietary SagittaTM drug delivery technology, RS Research will advance to the next dose cohort following the positive review of the safety data from the dosing of the first cohort by the Independent Data Monitoring Committee (IDMC).

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Esteemed medical experts of IDMC recommended that the clinical trial continues as planned and escalates from the first dose of 75 mg/m2 to the next dose of 100 mg/m2. RS-0139 was designed for the treatment of various cancer indications, with the initial phase I ongoing with NSCLC patients. SagittaTM technology enables nanomedicine to target the receptors on the tumor cell surface, reducing side effects sparing the healthy cells from its harmful effects.

Five drug candidates in RS Research pipeline address the unmet needs of over 6 million newly diagnosed oncology patients. According to World Health Organization, in 2020 lung cancer patients alone constituted 2.2 million of this population. RS Research was founded in 2015 by Prof. Rana Sanyal and Sena Nomak as an academic spin-off from Boğaziçi University to take the necessary R&D and commercialization steps for bringing innovative therapies to patients. The company raised funds from national and international funding agencies along with over 14 million USD from investors including GEN Pharmaceuticals, Eczacıbaşı Momentum, Istanbul Asset Management and ACT Venture Partners.

On July 1, 2022 Novocure (NASDAQ: NVCR) reported that it will report financial results for the second quarter 2022 on Thursday, July 28, 2022, before the U.S. financial markets open (Press release, NovoCure, JUL 1, 2022, View Source [SID1234616445]). Novocure’s management will host a conference call and webcast to discuss the company’s financial results for the three and six months ended June 30, 2022, at 8 a.m. EDT on Thursday, July 28, 2022. To access the conference call by phone, use the following registration link, and dial-in details will be provided.

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The webcast, earnings slides presented during the webcast and the corporate presentation can be accessed live from the Investor Relations page of Novocure’s website, www.novocure.com/investor-relations, and will be available for at least 14 days following the call. Novocure has used, and intends to continue to use, its investor relations website as a means of disclosing material non-public information and for complying with its disclosure obligations under Regulation FD.

On July 1, 2022 (the "Closing Date"), Vertex Pharmaceuticals Incorporated, a Massachusetts corporation (the "Company" or "we"), reported that entered into a Credit Agreement (the "2022 Credit Agreement"), with Vertex Pharmaceuticals (Europe) Limited, a private limited company incorporated in England and Wales and a wholly-owned subsidiary of the Company, as a co-borrower, Vertex Pharmaceuticals (Ireland) Limited, a private company limited by shares incorporated in Ireland and a wholly-owned subsidiary of the Company, as a co-borrower, certain other wholly-owned subsidiaries of the Company party thereto as subsidiary guarantors, the lenders and issuing banks party thereto and Bank of America, N.A., as administrative agent, which provides for a $500 million senior unsecured revolving facility. Up to $100 million of the senior unsecured revolving facility may be allocated for loans and letters of credit in certain non-U.S. Dollar currencies (the "Alternative Currencies") (Filing, 8-K, Vertex Pharmaceuticals, JUL 1, 2022, View Source [SID1234616477]). The 2022 Credit Agreement also provides that, subject to satisfaction of certain conditions, we may request that the borrowing capacity under the 2022 Credit Agreement be increased by an additional $500 million. Proceeds of borrowings under the 2022 Credit Agreement will be used for general corporate purposes. The outstanding loans under the 2022 Credit Agreement mature, and the unused commitments thereunder terminate, on July 1, 2027.

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U.S. Dollar-denominated loans made under the 2022 Credit Agreement will bear interest, at our option, at a rate per annum equal to either a base rate or a SOFR-based rate, in each case, plus an applicable margin. Under the 2022 Credit Agreement, the applicable margin on base rate loans ranges from 0.000% to 0.500% and the applicable margin on SOFR-based loans ranges from 1.000% to 1.500% (such margin, the "Applicable Benchmark Margin"), in each case, depending upon, either (x) the Company’s consolidated funded indebtedness to consolidated EBITDA ratio for the most recently completed four fiscal quarter period (the "Consolidated Leverage Ratio") or (y) to the extent available, the Company’s credit rating. Alternative Currency-denominated loans will bear interest at a rate per annum equal to the applicable benchmark rate for such Alternative Currency plus the Applicable Benchmark Margin. Loans made under the 2022 Credit Agreement may be prepaid at par and commitments under the 2022 Credit Agreement may be reduced at any time, in whole or in part, without premium or penalty (except for customary SOFR breakage costs).

Loans made under the 2022 Credit Agreement will be guaranteed by certain of our existing and future domestic subsidiaries, subject to certain customary exceptions and limitations.

The 2022 Credit Agreement contains customary representations and warranties and affirmative and negative covenants, which include a financial covenant to maintain a Consolidated Leverage Ratio of 3.50 to 1.00, subject to an increase to 4.00 to 1.00 following a material acquisition.

The 2022 Credit Agreement also contains customary events of default. In the case of a continuing event of default, the administrative agent would be entitled to exercise various remedies, including the acceleration of amounts due under any outstanding loan.

The foregoing summary of the 2022 Credit Agreement is not complete and is qualified in its entirety by reference to the full and complete 2022 Credit Agreement, a copy of which will be filed with our Quarterly Report on Form 10-Q for the fiscal quarter ended June 30, 2022.

On June 5, 2022 Jacobio Pharma (1167.HK) announced the phase I clinical data of KRAS G12C inhibitor JAB-21822 at the 2022 annual meeting of American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) (Press release, Jacobio Pharmaceuticals, JUN , 2022, View Source [SID1234615590]).

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As of April 1, 2022, the Phase I clinical data of non-small cell lung cancer patients with KRAS G12C mutation shows that the overall response rate (ORR) is 56.3% (18/32) and the disease control rate (DCR) is 90.6% (29/32). In 400mg QD and 800mg QD cohorts, the ORR is 66.7% (8/12) and the DCR is 100% (12/12).

JAB-21822 was well tolerated with no dose limited toxicity (DLTs) in the dose escalation phase. The study of the clinical trial is still ongoing and remains open to enrollment.

The e-poster presentation materials has been available at 8:00 a.m. (Central Time) on June 5, 2022 at www.asco.org.

Conference Call Information
Jacobio will host JAB-21822 data discussion and business update call on June 6 9:00am-10:00am (HKT).
Registration link: View Source

About JAB-21822
JAB-21822 is a KRAS G12C inhibitor independently developed by Jacobio. Jacobio has initiated a number of Phase I/II clinical trials in China, the United States and Europe for patients with advanced solid tumors, including monotherapy for STK11 co-mutated non-small cell lung cancer in a front-line setting; combination therapy with SHP2 inhibitor, PD-1 monoclonal antibody and Cetuximab.