On March 23, 2026 Amplia Therapeutics Limited (ASX:ATX; OTCQB:INNMF), ("Amplia" or the "Company"), reported mature data from the ongoing ACCENT clinical trial in advanced pancreatic cancer in which the Company’s lead drug narmafotinib is combined with chemotherapy showing a median overall survival of 11.1 months, and five complete responses recorded to date.

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Expert central reading of the clinical data by a contracted independent laboratory has reclassified some of the response data, identifying an additional four (4) confirmed complete responses (CRs). This brings the total CR’s for all patients in the ACCENT trial receiving a 400 mg dose of narmafotinib to five (5), resulting in a CR rate of 7.8% (5/64) which is unprecedented in this indication. Notably, this does not include the pathological complete response (pCR) recorded in the ACCENT trial, announced in June 2025. A confirmed CR means that CT scans have confirmed the disappearance of measurable tumours and metastases for two months or more, without the appearance of new lesions.

An additional confirmed partial response (PR) has also been identified, resulting in an updated Objective Response Rate (ORR) of 35.9% (23/64) for all patients in both stages of the 1b/2a ACCENT trial on a 400 mg dose of narmafotinib. As of 15 March 2026, four (4) patients remain on study, with one patient approaching 24 months on trial.

Up until the independent analysis, all clinical response data reported to the market has been based on analysis by the clinical investigator at each trial site. The Company has always planned for an independent data analysis to occur toward the conclusion of the trial, and with the anticipated completion in Q3 2026 this analysis was recently initiated. The expert and independent ‘central read’ laboratory has used the standardized and internationally recognized RECIST 1.1 criteria for measuring how a patient’s cancer responds to treatment.

(Press release, Amplia Therapeutics, MAR 23, 2026, View Source [SID1234663804])

On March 23, 2026 Outlook Therapeutics, Inc. (Nasdaq: OTLK), a biopharmaceutical company focused on enhancing the standard of care for bevacizumab for the treatment of retina diseases, reported that it has commenced a best-efforts public offering of its common stock (or pre-funded warrants in lieu thereof) and accompanying warrants exercisable for shares of its common stock. The offering is subject to market and other conditions and there can be no assurance as to whether or when the offering may be completed, or as to the actual size or terms of the offering.

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H.C. Wainwright & Co. is acting as the exclusive placement agent for the offering.

Outlook Therapeutics intends to use the net proceeds from the offering primarily for working capital and general corporate purposes.

The securities described above are being offered by Outlook Therapeutics pursuant to a "shelf" registration statement on Form S-3 (File No. 333-278340) that was originally filed with the Securities and Exchange Commission (the "SEC") on March 28, 2024, and became effective on April 5, 2024. This proposed public offering is being made only by means of a prospectus supplement and an accompanying prospectus that form a part of the effective registration statement. A preliminary prospectus supplement and an accompanying prospectus related to the proposed public offering will be filed with the SEC and will be available on the SEC’s website at www.sec.gov. Copies of the preliminary prospectus supplement and the accompanying prospectus relating to this proposed public offering may also be obtained, when available, by contacting H.C. Wainwright & Co., LLC at 430 Park Avenue, 3rd Floor, New York, NY 10022, by phone at (212) 856-5711 or e-mail at [email protected].

This press release shall not constitute an offer to sell or a solicitation of an offer to buy any of the securities described herein, nor shall there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or other jurisdiction.

(Press release, Outlook Therapeutics, MAR 23, 2026, View Source [SID1234663826])

On March 23, 2026 BostonGene, developer of the leading AI foundation model for tumor and immune biology, reported an oral presentation at the United States and Canadian Academy of Pathology (USCAP) 115th Annual Meeting. The session highlights new clinical data generated in collaboration with leading academic investigators, including Weill Cornell Medicine.

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The event, held from March 21-26 at the Henry B. González Convention Center in San Antonio, TX, is the world’s premier gathering for pathology professionals serving as a critical global platform for clinicians and researchers to exchange cutting-edge research and educational insights across pathology subspecialties, with a particular focus on the integration of AI and molecular advancements into clinical practice.

The study, which demonstrates a multimodal AI framework trained on approximately 20,000 tumors, will be presented by Juan Miguel Mosquera, MD, MSc. Dr Mosquera is a Professor of Pathology and Laboratory Medicine at Weill Cornell Medicine and Director of Research Pathology at the Englander Institute for Precision Medicine, and is widely recognized for his contributions to cancer genomics and biomarker development with more than 130 peer-reviewed publications.

The research integrated whole exome and transcriptomic data to address cancers of unknown primary (CUP). In real-world cases, the framework accurately identified tumor origin while uncovering actionable therapeutic targets in more than 65% of patients, including FDA-approved options.

The results reflect a broader shift from traditional tumor classification toward AI-driven disease modeling, enabling deeper biological understanding, more precise patient stratification, and improved treatment selection.

Details of the oral presentation are below:

Abstract: 942
Title: Cancer of Unknown Primary (CUP): Beyond the Identification of the Tumor of Origin by an Integrative Whole Exome (WES) and Transcriptome Sequencing (RNAseq) Approach
Date & Time: Tuesday, March 24 | 8:30 AM – 8:45 AM
Location: Room 303B
Presenter: Juan Miguel Mosquera, MD, MSc, Weill Cornell Medicine

Research done in collaboration with Weill Cornell Medicine

(Press release, BostonGene, MAR 23, 2026, View Source [SID1234663846])

On March 23, 2026 PharmaMar (MSE:PHM) a Spanish biopharmaceutical company with 40 years of experience, reported that its treatment Zepzelca (lurbinectedin), in combination with atezolizumab (Tecentriq), has been approved by the Taiwan Food and Drug Administration (TFDA) as a first-line maintenance treatment for adult patients with advanced small cell lung cancer (SCLC).

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This approval as a first-line maintenance therapy means that the drug is administered after the initial induction treatment for those patients who achieve stable disease or better, in order to maintain the response achieved. In addition to Taiwan, this first-line maintenance combination has recently been approved for the same indication in the United Arab Emirates, Oman, Israel, Uruguay, Ecuador, Paraguay and Peru joining the United States and Switzerland, the first countries to have approved it for this indication. The Marketing Authorization Application (MAA) is currently under review by the European Medicines Agency (EMA), as well as in other countries worldwide.

PharmaMar commercializes its products outside Europe through agreements with strategic partners, with the aim of facilitating patient access worldwide to its innovative oncology therapies. Specifically, the Company collaborates with Lotus Pharmaceutical in Taiwan; Immedica in Oman and the United Arab Emirates; in Israel with Megapharm and Adium Pharma in Uruguay, Paraguay, Peru and Ecuador.

Furthermore, lurbinectedin as a monotherapy is approved as a second-line treatment, that is, after disease progression during or following platinum-based chemotherapy, in 22 countries.

Small cell lung cancer accounts for about 15% of lung cancer cases and is characterized by its aggressive behavior, and an early tendency to spread.

(Press release, PharmaMar, MAR 23, 2026, View Source [SID1234663827])

On March 23, 2026 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. (Biocytogen, SSE: 688796; HKEX: 02315), a global biotechnology company that drives the research and development of novel antibody-based drugs with innovative technologies, reported a strategic collaboration with Moonlight Bio, Inc., a Seattle-based biotech company pioneering advanced cell therapies. This partnership aims to develop cutting-edge cell therapies to address some of the most challenging and difficult-to-treat cancers.

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Dr. Yuelei Shen, President and CEO of Biocytogen, said, "We are thrilled to partner with Moonlight Bio, a pioneering leader in advanced cell therapies. This strategic collaboration leverages our proprietary off-the-shelf fully human antibody library to accelerate the development of cutting-edge cell therapies for difficult-to-treat cancers. It also demonstrates the versatility and broad applicability of Biocytogen’s antibody discovery platforms beyond traditional drug modalities. By combining our expertise, we are poised to accelerate the development of transformative cell therapies that could overcome resistance and offer new hope to patients battling the toughest cancers.

Under the terms of the agreement, Biocytogen will provide its off-the-shelf antibody binders against therapeutic targets, and Moonlight Bio will oversee the preclinical development of cell therapies.

(Press release, Biocytogen, MAR 23, 2026, View Source [SID1234663847])