On February 22, 2022 Sumitomo Dainippon Pharma Oncology, Inc., a clinical-stage pharmaceutical company focused on research and development for novel cancer therapeutics, reported the appointment of Jatin J. Shah, M.D. as Executive Vice President, Chief Medical Officer and Global Head of Development (Press release, Sumitomo Dainippon Pharma, FEB 22, 2022, View Source [SID1234608844]). In this new position Dr. Shah will lead strategic and operational clinical development of the company’s diverse pipeline.

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"Dr. Shah brings significant industry and clinical oncology experience, which is well-aligned with our future growth and success priorities," said Patricia S. Andrews, Chief Executive Officer, Global Head of Oncology, Sumitomo Dainippon Pharma Oncology (SDP Oncology). "We are pleased to have such an accomplished physician and researcher join us in our mission to discover and develop meaningful treatments for patients with cancer."

Dr. Shah brings over 20 years of medical and industry experience to SDP Oncology. Most recently, he served as Chief Medical Officer and Executive Vice President at Karyopharm Therapeutics where he led clinical research efforts that resulted in three successful sNDAs, multiple IND submissions and the development of a comprehensive solid tumor and hematological pipeline. At the University of Texas MD Anderson Cancer Center, Dr. Shah was an Associate Professor and Associate Program Director of the Malignant Hematology Fellowship, as well as Director of Myeloma Clinical and Translational Research in the Department of Lymphoma/Myeloma, Division of Cancer Medicine.

"I am excited to join the talented team at SDP Oncology and work with researchers and scientists who share a commitment to patients with cancer," said Jatin J. Shah, M.D. "I look forward to contributing to the next phase of SDP Oncology’s growth as we work to address unmet needs in oncology and advance the development of our clinical and pre-clinical assets."

Dr. Shah received his undergraduate degree in Mechanical Engineering from Ohio State University and earned his medical degree from the Ohio State University College of Medicine. He completed an internship and residency in internal medicine at the Cleveland Clinic Foundation and a fellowship in hematology/oncology at the University of Alabama at Birmingham.

On February 22, 2022 Biodesix, Inc. (NASDAQ: BDSX) a leading data-driven diagnostic solutions company with a focus in lung disease, reported that its Chief Executive Officer was named in The Healthcare Technology Report’s list of Top 25 Biotech CEOs of 2022 (Press release, Biodesix, FEB 22, 2022, View Source [SID1234608795]). The annual list recognizes the most accomplished executives in the biotech industry.

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An extensive process was run to evaluate the hundreds of CEOs who were nominated this year. These CEOs lead exemplary organizations in the fields of gene therapy to vaccine development, cancer treatment, proteomics, diagnostics, mRNA-based therapeutics, and other related areas. Read the full report here.

Hutton’s profile provides insight as to how his personal leadership philosophy emphasizes ‘helping people, giving back, and positively impacting and improving people’s health and lives’. Under his direction and leadership, Biodesix has grown into a leading patient-centric lung disease diagnostics company with a mission to unite biopharma, physicians, and patients to transform the standard of care and improve outcomes with personalized diagnostics.

"I am honored to be named as a leading CEO in The Healthcare Technology Report and included on a list with so many resilient, entrepreneurial industry leaders who are making a meaningful impact on patients," said Hutton. "The recognition also highlights the commitment and work that the entire team at Biodesix accomplishes every day to impact patients with critical diseases."

On February 22, 2022 Revolution Medicines, Inc. (Nasdaq: RVMD), a clinical-stage oncology company developing novel targeted therapies for RAS-addicted cancers, reported that it will report financial results for the fourth quarter and full year 2021 on February 28, 2022, after market close (Press release, Revolution Medicines, FEB 22, 2022, View Source [SID1234608811]). The company will host a conference call and webcast at 4:30 p.m. Eastern Time during which members of Revolution Medicines’ senior management team will discuss financial results for the quarter and full year, and review recent corporate developments.

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To listen to the live webcast, or access the archived webcast, please visit the "Events & Presentations" page of Revolution Medicines’ website at: View Source Following the live webcast, a replay will be available on the Company’s website for at least 14 days.

To listen to the live conference call, please dial (833) 423-0425 or (918) 922-3069 and request the Revolution Medicines call (conference ID: 9672794).

On February 22, 2022 Boundless Bio, a next-generation precision oncology company developing innovative therapeutics directed against extrachromosomal DNA (ecDNA) in oncogene amplified cancers, reported that Dr. Klaus Wagner has been appointed as Chief Medical Officer (Press release, Boundless Bio, FEB 22, 2022, View Source [SID1234608829]).

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"We are excited to have Klaus join at this pivotal time as we advance the first ecDNA therapeutics towards the clinic," said Zachary Hornby, President and Chief Executive Officer of Boundless Bio. "Klaus brings extensive experience in oncology drug development from both industry and clinical research settings. Over the course of his career, he has developed a deep understanding of how cancer targeted therapies and immunotherapies perform in the clinic. His leadership over Boundless Bio’s clinical development will bring significant value to our ecDNA-directed therapeutic (ecDTx) programs and importantly, help us bring new treatment options to patients with oncogene amplified cancer."

Dr. Wagner comes to Boundless Bio previously serving as Executive Vice President and Chief Medical Officer at Inhibrx, Inc. At Inhibrx, Dr. Wagner built and led an integrated clinical development organization responsible for advancing four therapeutic candidates, including three oncology programs, from pre-IND into the clinic. Dr. Wagner previously served as Medical Oncologist at Banner MD Anderson Cancer Center and as Adjunct Assistant Professor in the Department of Thoracic, Head & Neck Medical Oncology at MD Anderson Cancer Center, where he led molecularly targeted therapy and cancer immunotherapy trials in non-small cell lung cancer as a local principal investigator. Before that, Dr. Wagner trained at MD Anderson Cancer Center as a fellow in Medical Oncology. Prior to that Dr. Wagner’s scientific work at Genentech, Inc. and the Genomics Institute of the Novartis Research Foundation focused on cancer drug discovery and predictive biomarker development. Dr. Wagner was a scholar of the German National Academic Scholarship Foundation. Dr. Wagner received his M.D. and Ph.D. from the Friedrich-Alexander University of Erlangen in Germany.

"It is a privilege to join Boundless Bio, a company founded on interrogating a fundamental and important area of cancer biology, ecDNA that appears to play a significant role in the poor prognosis and treatment challenges associated with oncogene amplified cancers," said Dr. Wagner. "In my career as a scientist and clinician, I have always been excited to bring innovative treatments to patients with high unmet needs cancer. There are very few therapies that effectively address oncogene amplification. Boundless Bio’s pipeline is uniquely tailored to develop treatments for these patients."

On February 22, 2022, Amgen Inc. (the "Company") reported that issued and sold $750,000,000 aggregate principal amount of the Company’s 3.000% Senior Notes due 2029 (the "2029 Notes"), $1,000,000,000 aggregate principal amount of the Company’s 3.350% Senior Notes due 2032 (the "2032 Notes"), $1,000,000,000 aggregate principal amount of the Company’s 4.200% Senior Notes due 2052 (the "2052 Notes"), and $1,250,000,000 aggregate principal amount of the Company’s 4.400% Senior Notes due 2062 (the "2062 Notes" and, together with the 2029 Notes, the 2032 Notes and the 2052 Notes, the "Notes") (Filing, 8-K, Amgen, FEB 22, 2022, View Source [SID1234608848]). The Notes are registered under an effective Registration Statement on Form S-3 (Registration No. 333-236351) (the "Registration Statement"), filed on February 10, 2020, and were issued pursuant to an indenture, dated as of May 22, 2014 (the "Indenture"), between the Company and The Bank of New York Mellon Trust Company, N.A., as trustee, and an officer’s certificate, dated as of February 22, 2022 (the "Officer’s Certificate"), setting forth the terms of the Notes. Net proceeds to the Company from the offering were approximately $3,949,135,700, after deducting underwriters’ discounts and estimated offering expenses payable by the Company.

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The relevant terms of the Notes are set forth in the Indenture, included as Exhibit 4.1 of the Company’s Current Report on Form 8-K, filed on May 22, 2014, and incorporated herein by reference, and the Officer’s Certificate (including the forms of the Notes) attached hereto as Exhibit 4.2 and incorporated herein by reference.

The 2029 Notes will pay interest at the rate of 3.000% per annum, the 2032 Notes will pay interest at the rate of 3.350% per annum, the 2052 Notes will pay interest at the rate of 4.200% per annum and the 2062 Notes will pay interest at the rate of 4.400% per annum, which shall be payable in cash semi-annually in arrears on February 22 and August 22 of each year, beginning on August 22, 2022. The 2029 Notes will mature on February 22, 2029, the 2032 Notes will mature on February 22, 2032, the 2052 Notes will mature on February 22, 2052 and the 2062 Notes will mature on February 22, 2062.

In the event of a change in control triggering event, as defined in the Officer’s Certificate, the holders of the Notes may require the Company to purchase for cash all or a portion of their Notes at a purchase price equal to 101% of the principal amount of Notes, plus accrued and unpaid interest, if any. The descriptions of the Indenture, the Officer’s Certificate and the Notes in this report are summaries and are qualified in their entirety by the terms of the Indenture, the Officer’s Certificate and the Notes, respectively.

The Notes will rank equal in right of payment to all of the Company’s other existing and future senior unsecured indebtedness, senior in right of payment to all of the Company’s existing and future subordinated indebtedness, effectively subordinated in right of payment to all of the Company’s subsidiaries’ obligations (including secured and unsecured obligations) and subordinated in right of payment to the Company’s secured obligations, to the extent of the assets securing such obligations.