Invitae to Acquire Ciitizen to Strengthen its Patient-Consented Health Data Platform to Improve Personal Outcomes and Global Research

On September 7, 2021 Invitae (NYSE: NVTA), a leading medical genetics company, reported it has entered into a definitive agreement to acquire Ciitizen, a patient-centric consumer health tech company (Press release, Invitae, SEP 7, 2021, View Source [SID1234587385]). Backed by a16z, Section 32 and Verily, Ciitizen is working to build a global platform to help patients collect, organize, store and share their medical records digitally. The acquisition would enhance Invitae’s platform by providing patients an easy-to-use, centralized hub for their genomic and clinical information, which together comprise a powerful dataset with the potential to drive research and improve healthcare decision making.

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Invitae’s (NVTA) mission is to bring comprehensive genetic information into mainstream medical practice to improve the quality of healthcare for billions of people. www.invitae.com (PRNewsFoto/Invitae Corporation)

"Invitae is relentlessly pursuing a day when genetics is used routinely to improve healthcare for billions of people around the globe. We believe combining Ciitizen’s state-of-the-art, transparent and patient-consented platform with our technologies and services will accelerate our evolution into a genome information company that informs healthcare throughout one’s life. This would give us the ability to engage patients, create an innovative patient-centered data ecosystem and deliver better outcomes for everyone. Invitae views the acquisition of Ciitizen as an important part of its strategy to be the industry leader across the genetic testing, software and health information technology spaces," said Sean George, Ph.D., co-founder and CEO of Invitae.

"Ciitizen has already helped patients take ownership of their medical records to optimize therapy for themselves and contribute their data towards a variety of goals, including research on rare diseases," said Anil Sethi, CEO and founder of Ciitizen. "Patients leave a breadcrumb trail of records behind them, and we believe access to this real-world data is key to personalized therapeutics in the future. The combination of lifelong health history together with Invitae’s world-class genetic and data services would enable a digital ecosystem of personalized services for each patient. Democratization of patient-consented data is expected to improve outcomes by providing access to third-parties for whom the patient has granted consent. Unlike many health data companies, we operate on the premise that it’s the patient’s data, not ours."

Dr. George continued, "Genomics is currently a laboratory testing-based industry, but in the future it will look very much like an information industry. Developing an open-ended patient-centric platform of genomic, clinical and reported outcomes creates a thriving and purposeful network that truly advances healthcare. Patient control is the big differentiator at Ciitizen and at Invitae; and we believe combining forces is the right strategy for our businesses going forward."

Empowering patients to combine their genomic and clinical information to improve clinical care

Invitae is working to aggregate results from the world’s genetic tests into a single, easy-to-use service that makes genetic information accessible to all who can benefit from it – always with patient consent. Over the past five years, Invitae has completed 13 acquisitions that have expanded its testing menu, lowered the cost of its tests, improved its customer experience and enhanced its ability to attract partners. Invitae raised more than $1.4 billion since the beginning of 2021, in part to identify and acquire key assets that bring the company closer to delivering on its vision.

The addition of Ciitizen is expected to empower Invitae to more quickly extend its platform, adding a complementary patient service that streamlines the process of collecting and organizing health information from any source and uses machine learning to transform the unstructured (and largely untapped) health information to enable better care decisions, find clinical trials, and power research using real-world evidence. In addition, as the use of Invitae testing and the Ciitizen service expands, third-party access to consented genomic and other clinical data can be democratized to power a variety of applications that can enhance Invitae’s business and growth strategy.

Transaction Terms

Under the terms of the agreement, Invitae will acquire Ciitizen for approximately $325 million (subject to adjustment), consisting of (i) approximately $125 million in cash and (ii) approximately 7,070,000 shares of Invitae common stock (based upon a trailing average closing price prior to the agreement date). Invitae will also issue approximately $225 million in restricted stock units (RSUs) to new employees who join Invitae in connection with its acquisition of Ciitizen. These RSUs will be granted under Invitae’s 2015 Stock Incentive Plan, which is being amended and restated to increase a pool of shares of Invitae common stock thereunder which is used exclusively for the grant of inducement awards in compliance with New York Stock Exchange Rule 303A.08 ("Rule 303A.08"). These RSUs have been approved by the Invitae Board of Directors and will be made as an inducement material to each employee entering into employment with Invitae in reliance on the employment inducement exemption under Rule 303A.08. These RSUs will cover up to a total of approximately 8,125,000 shares of Invitae common stock (based upon a trailing average closing price prior to the agreement date) and will vest in tranches of one-third upon each of the first, second and third anniversaries of the date of grant, subject to acceleration in the event of a termination without cause by Invitae or a termination with good reason by a recipient. A total of 99 recipients will receive these RSUs, and Anil Sethi, the CEO and founder of Ciitizen, will receive RSUs with respect to approximately 2,011,000 shares of Invitae common stock.

The transaction, which has been unanimously approved by the Boards of Directors of both companies, is expected to close this month.

Conference Call and Webcast today at 8:30 a.m. ET / 5:30 a.m. PT

Management will host a conference call and webcast today at 8:30 a.m. ET / 5:30 a.m. PT to discuss the transaction. To register for the conference call, please use the link below. Upon registering, each participant will be provided with call details and a registrant ID.

Online registration: View Source

The live webcast of the call and slide deck may be accessed here or by visiting the investors section of the company’s website at ir.invitae.com. A replay of the webcast and conference call will be available shortly after the conclusion of the call and will be archived on the company’s website.

Panbela to Present at Upcoming Investor Conferences

On September 7, 2021 Panbela Therapeutics, Inc. (Nasdaq: PBLA), a clinical stage biopharmaceutical company developing disruptive therapeutics for the treatment of patients with cancer reported that it will present at upcoming investor conferences (Press release, Panbela Therapeutics, SEP 7, 2021, View Source;utm_medium=rss&utm_campaign=panbela-to-present-at-upcoming-investor-conferences [SID1234587284]):

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H.C. Wainwright 23rd Annual Global Investment Conference: September 13th to 15th, 2021

Presentation will be available on-demand beginning September 13, 2021
Webcast: View Source
Management will also host 1×1 investor meetings during the conference.

Oppenheimer Fall Healthcare Life Sciences & MedTech Summit: September 20-23

Presentation Date and Time: September 21, 2021, at 9:55am ET
Event link: View Source
Management will also host 1×1 investor meetings during the conference.

To learn more or to schedule a one-on-one meeting with management, please contact your conference representative or [email protected].

About SBP-101
SBP-101 is a proprietary polyamine analogue designed to induce polyamine metabolic inhibition (PMI) by exploiting an observed high affinity of the compound for pancreatic ductal adenocarcinoma and other tumors. The molecule has shown signals of tumor growth inhibition in clinical studies of US and Australian metastatic pancreatic cancer patients, suggesting potential complementary activity with an existing FDA-approved standard chemotherapy regimen. In data evaluated from clinical studies to date, SBP-101 has not shown exacerbation of bone marrow suppression and peripheral neuropathy, which can be chemotherapy-related adverse events. Recently observed serious visual adverse events have been evaluated and patients with a history of retinopathy or at risk of retinal detachment will be excluded from future SBP-101 studies. The safety data and PMI profile observed in the current Panbela sponsored clinical trial provides support for continued evaluation of SBP-101 in a randomized clinical trial. For more information, please visit View Source

iBio Announces Participation in H.C. Wainwright 23rd Annual Global Investment Conference

On September 7, 2021 iBio, Inc. (NYSEA:IBIO) ("iBio" or the "Company"), a developer of next-generation biopharmaceuticals and pioneer of the sustainable, plant-based FastPharming Manufacturing System, reported that it will participate in the H.C. Wainwright 23rd Annual Global Investment Conference, to be held virtually September 13-15, 2021 (Press release, iBioPharma, SEP 7, 2021, View Source [SID1234587301]).

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iBio’s pre-recorded presentation will be available on demand during the event for all registered attendees. Beginning on Monday, September 13, 2021, the presentation will also be available on the Company’s website at www.ibioinc.com under "News & Events" in the Investors section.

Crinetics Pharmaceuticals to Participate in September Investor Conferences

On September 7, 2021 Crinetics Pharmaceuticals, Inc. (Nasdaq: CRNX), a clinical-stage pharmaceutical company focused on the discovery, development, and commercialization of novel therapeutics for rare endocrine diseases and endocrine-related tumors, reported that management will participate in the following investor conferences in the month of September (Press release, Crinetics Pharmaceuticals, SEP 7, 2021, View Source [SID1234587317]):

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H.C. Wainwright: 23rd Annual Global Investment Conference (September 13-15, 2021): A pre-recorded company presentation by Dr. Scott Struthers, Founder & CEO, will be available on-demand for approximately 30 days beginning September 13, 2021 at 7:00 am ET. Company management will also be available for one-on-one meetings at the conference on September 13, 2021.
SVB Leerink CybeRx Series: Neuromuscular, Rare Diseases & Genetic Medicines 1×1 Event (September 22-23, 2021): Company management will be available for one-on-one meetings on September 22, 2021.
Cantor Fitzgerald Global Healthcare Conference (September 27-30, 2021): Dr. Struthers and Dr. Alan Krasner, CMO, will present on September 27, 2021 at 3:20 pm ET and participate in one-on-one meetings on September 27-28, 2021.
WEBCAST LINKS:
Links to live and archived webcasts will be accessible on the Events & Presentations page in the Investors section on the Company’s website.

Telix to Collaborate With Kettering Health on Diagnostic PSMA Imaging & Targeting Theranostics

On September 7, 2021 Telix Pharmaceuticals Limited (ASX: TLX, Telix, the Company) reported it has commenced a collaboration with Kettering Health (KH), a faith-based network of 13 hospitals, emergency centers, and outpatient facilities located in Southwest Ohio; headquartered at the Kettering Memorial Hospital in Kettering, Ohio, United States (Press release, Telix Pharmaceuticals, SEP 7, 2021, View Source [SID1234587333]).

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The parties have signed a Memorandum of Understanding ("MOU") formalising their intent to work together to foster late-stage clinical research into Telix’s investigational PSMA1-targeting radiopharmaceuticals, illuccix (Kit for the preparation of 68Ga-PSMA-11 injection, for diagnostic imaging with positron emission tomography, (PET) and Lu-177 PSMA (TLX591, for radioligand therapy), and to establish Kettering Health as a regional centre of excellence for PET Molecular Imaging (Ml) and Theranostics, with an initial focus on the diagnosis and treatment of prostate cancer.

The MOU outlines the principles of the collaboration between Kettering Health and Telix. The parties intend to develop binding agreements for each aspect of the collaboration, based on the principles set out in the MOU.

Telix and Kettering Health plan to work closely with multiple industry leaders, culminating in the rapid implementation of PET MI technologies (imaging and theranostics) into clinical services for patients in the region. The aim is to capitalize on the growing demand for PET MI, catalysed by the exponential growth of new radiopharmaceuticals in the short term, and over the longer-term, develop a continuous pipeline of new technologies for diagnosis and treatment of multiple diseases.

Dr Martin Satter, Senior Molecular Imaging Scientist at Kettering Health said, "We believe PET Molecular Imaging has the potential to quickly redefine, reimagine and reinvent the diagnosis and treatment of cancer, Alzheimer’s, Parkinson’s, cardiac and other diseases. This belief has evolved and crystalized over our 30-year history in PET MI, and our current re-commitment to this technology including our recent upgrades of a medical cyclotron, radiochemistry lab and clean room, as well as a digital PET/CT2 scanner.

"We are excited to work with Telix – a global leader in the field of radiopharmaceuticals and radioligand therapy to foster research and innovation in a non-academic setting. Telix shares our commitment to bring personalized medicine to our region through these disruptive technologies."

Dr Bernard Lambert, President of Telix Americas said, "This is a collaboration that brings together leading industry, technical, academic and clinical resources to further explore the potential of our PSMA-targeting radiopharmaceuticals. It reinforces Telix’s position as a leading innovator in this field, with a commitment to driving forward both clinical development alongside the supply chain, to support the commercialisation journey."