On March 23, 2022 Centenaire Biosciences reported the company had attracted a total of 20 billion won in Series A investment from SD Biosensor’s affiliates Bionote and SDB Investment on the 18th (Press release, Centenaire Biosciences, MAR 23, 2022, View Source [SID1234643838]).

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Sanctnaire, which is developing an innovative antibody platform centered on the field of anti-cancer and immune disease treatment, has succeeded in attracting large-scale investment within 10 months of its establishment, and is developing, pipeline expansion, and additional platforms for clinical entry of its core pipeline ‘CTN001’. We plan to use the investment for technology development.

Centenaire, which has the goal of ‘development of innovative new drugs for the era of average lifespan of 100 years’ with the French word ‘Centenaire’ meaning 100 years as its motif, is based on its proprietary antibody platform technology to treat cancer, autoimmune diseases, and brain nerve diseases. We are building pipelines in various fields, including therapeutics.

Santnaire’s core pipeline, the next-generation HER2-targeting antibody ‘CTN001’, is indicated for HER2-low-expressing breast cancer, not HER2-positive breast cancer, which is targeted by existing HER2-targeting antibodies. HER2 low-expression breast cancer is a newly classified cancer type that accounts for more than 50% of all breast cancers, but has great market potential as there is no approved target treatment.

Yang Ki-hyuk, CEO of Sanctnaire, said, "With this Series A investment, we will begin full-scale development and expansion of the antibody pipeline using platform technology," and added, "We will develop safe and effective antibody drugs, starting with our flagship pipeline ‘CTN001’. "We will prove Nair’s differentiated value," he said.

He continued, "CTN001 showed strong efficacy in HER2-low-expressing carcinomas that do not respond to the HER2-targeting antibody Herceptin in preclinical trials," adding, "Antibody-drug complex (ADC) and T-cell engage, which have recently shown positive results and are expanding treatment options for cancer patients. "As there are limits to its use as a combination treatment for early-stage cancer due to safety issues, CTN001 will be an alternative to overcome this," he emphasized.

Meanwhile, Sanctnair is a new bio company established by researchers, including CEO Yang Ki-hyuk, who was a founding member of Medytox and oversaw R&D, to develop a next-generation antibody platform based on innovative antibody technology introduced from Medytox. Sanctnaire is discussing collaboration in various fields with BioNote, which participated in the Series A investment, along with cooperation with its affiliate Medytox, and is pursuing the establishment of a network with several domestic universities and research institutes to improve the efficiency of research and development.

On March 23, 2022 Genprex, Inc. ("Genprex" or the "Company") (NASDAQ: GNPX), a clinical-stage gene therapy company focused on developing life-changing therapies for patients with cancer and diabetes, reported that its President and Chief Executive Officer, Rodney Varner, will provide an overview of the Company’s gene therapies for cancer and diabetes to investors at the 2022 BIO Europe Spring Investor Conference (Press release, Genprex, MAR 23, 2022, View Source [SID1234610741]).

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Conference Details:

Event: BIO Europe Spring Investor Conference

Conference Dates: March 28-31, 2022

Presentation Time: Available on-demand throughout duration of the conference

Presenter: Rodney Varner, President and Chief Executive Officer

Conference Registration: https://bit.ly/3hNGjcW

At the event, Mr. Varner will be available to participate in virtual one-on-one meetings with registered participants. A recording of this presentation will be available for replay on Genprex’s website for a period of time.

On March 23, 2022 Novocure (NASDAQ: NVCR) reported the results of a pre-specified interim analysis for the phase 3 pivotal INNOVATE-3 study evaluating the safety and efficacy of Tumor Treating Fields (TTFields) together with paclitaxel for the treatment of patients with platinum-resistant ovarian cancer (Press release, NovoCure, MAR 23, 2022, View Source [SID1234610761]).

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An independent data monitoring committee (DMC) reviewed the safety data for all platinum-resistant ovarian cancer patients enrolled on the trial. In addition, an analysis of overall survival was performed on the first 540 patients randomized. The interim analysis did not indicate a need to increase the sample size and the DMC recommended that the study should continue to final analysis as planned.

"Completion of the DMC interim analysis represents the next milestone in our journey to address the significant unmet need for patients diagnosed with platinum-resistant ovarian cancer," said Dr. Ely Benaim, Novocure’s Chief Medical Officer. "I would like to thank our investigators and collaborators, ENGOT and The GOG Foundation, as well as our patients for their passion and bravery. We look forward to reviewing final data next year."

The INNOVATE-3 study is designed to evaluate the safety and effectiveness of TTFields together with paclitaxel in patients with platinum-resistant ovarian cancer. There remains a significant unmet need for treatments for platinum-resistant ovarian cancer, for which approximately 16,000 patients are diagnosed each year in the U.S. The primary endpoint of INNOVATE-3 is overall survival. Secondary endpoints include progression-free survival, objective response rate, severity and frequency of adverse events, time to undisputable deterioration in health-related quality of life or death, and quality of life. The study accrued 540 patients as of October 2021 and data will be reviewed in 2023, following an 18 month follow-up period.

The European Network for Gynaecological Oncological Trial groups ("ENGOT") and The GOG Foundation, Inc. ("GOG"), third-party clinical trial networks, are collaborating with Novocure on the trial. Both ENGOT and GOG were involved in the development and facilitation of the trial at leading cancer centers in Europe and the United States.

About Ovarian Cancer
In the U.S., ovarian cancer ranks fifth in cancer deaths among women, with approximately 24,000 women diagnosed each year. Ovarian cancer incidence increases with age, and the median age at time of diagnosis is 63 years old.

Physicians use different combinations of surgery and pharmacological therapies to treat ovarian cancer, depending on the stage of the disease. Surgery is usually used in early stages of the disease and is usually combined with chemotherapy, including paclitaxel and platinum-based chemotherapy. Unfortunately, the majority of patients are diagnosed at an advanced stage when the cancer has spread outside of the ovaries to include regional tissue involvement and/or metastases. Platinum-based chemotherapy remains part of the standard of care in advanced ovarian cancer, but most patients with advanced ovarian cancer will have tumor progression or, more commonly, recurrence. Almost all patients with recurrent disease ultimately develop platinum resistance, and the prognosis for this population remains poor.

About Tumor Treating Fields
Tumor Treating Fields, or TTFields, are electric fields that disrupt cancer cell division. Fundamental scientific research extends across more than two decades and, in all preclinical research to date, TTFields have demonstrated a consistent anti-mitotic effect. TTFields therapy is intended principally for use together with other standard-of-care cancer treatments. There is a growing body of evidence that supports TTFields’ broad applicability with certain other cancer therapies, including radiation therapy, certain chemotherapies and certain immunotherapies. In clinical research and commercial experience to date, TTFields therapy has exhibited no systemic toxicity, with mild to moderate skin irritation being the most common side effect. The TTFields global development program includes a network of preclinical collaborators and a broad range of clinical trials across all phases, including four phase 3 pivotal trials in a variety of tumor types. To date, more than 22,000 patients have been treated with TTFields therapy.

On March 23, 2022 TRACON Pharmaceuticals (NASDAQ: TCON), a clinical stage biopharmaceutical company focused on the development and commercialization of novel targeted cancer therapeutics and utilizing a cost efficient, CRO-independent product development platform to partner with ex-U.S. companies to develop and commercialize innovative products in the U.S., reported that Charles Theuer, M.D., Ph.D., President and Chief Executive Officer, will participate in a fireside chat hosted by Jason McCarthy, at the Maxim Group 2022 Virtual Growth Conference on Wednesday, March 30, 2022 at 1:30pm Eastern Time (Press release, Tracon Pharmaceuticals, MAR 23, 2022, View Source [SID1234610742]).

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This conference will be live on M-Vest. To attend, sign up to become an M-Vest member.

On March 23, 2022 BiomX Inc. (NYSE American: PHGE) ("BiomX" or the "Company"), a clinical-stage microbiome company advancing novel natural and engineered phage therapies that target specific pathogenic bacteria, reported that the Company will host a conference call and a live audio webcast on Wednesday, March 30th, 2022, at 8:00 a.m. EDT, to report fourth quarter and full year 2021 financial results and provide business updates (Press release, BiomX, MAR 23, 2022, View Source [SID1234610762]). To participate in the conference call, please dial 1-877-407-0724 (U.S.), 1-809-406-247 (Israel) or 1-201-389-0898 (International). The live and archived webcast will be available in the Investors section of the Company’s website at www.biomx.com.

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