On March 10, 2022 ImmunoGen, Inc. (Nasdaq: IMGN), a leader in the expanding field of antibody-drug conjugates (ADCs) for the treatment of cancer, reported that multiple abstracts were selected for oral and poster presentations at the Society of Gynecologic Oncology (SGO) Annual Meeting on Women’s Cancer to be held on March 18-21, 2022 in Phoenix, Arizona (Press release, ImmunoGen, MAR 10, 2022, View Source [SID1234609895]).

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ORAL PRESENTATION
Full results from the pivotal SORAYA trial of mirvetuximab soravtansine (mirvetuximab) in ovarian cancer will be shared in a late-breaking oral presentation.

Title: Efficacy and Safety of Mirvetuximab Soravtansine in Patients with Platinum-Resistant Ovarian Cancer with High Folate Receptor Alpha Expression: Results from the SORAYA Study
Presenter: Dr. Ursula Matulonis, Chief of the Division of Gynecologic Oncology at the Dana-Farber Cancer Institute, Professor of Medicine at the Harvard Medical School, and SORAYA Co-Principal Investigator
Session: Scientific Plenary IV: Late-Breaking Abstracts
Session Date: Saturday, March 19, 2022
Session Time: 4:15 pm to 5:45 pm MST

POSTER PRESENTATIONS
Trial in progress posters from ImmunoGen’s MIRASOL and PICCOLO trials of mirvetuximab in ovarian cancer and a Phase 2 investigator-sponsored combination trial of mirvetuximab with carboplatin in the neoadjuvant setting will also be presented.

Title: MIRASOL: A Randomized, Open-Label, Phase 3 Study of Mirvetuximab Soravtansine vs. Investigator’s Choice of Chemotherapy in Advanced High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers with High Folate Receptor Alpha Expression
Presenter: Dr. Kathleen Moore, Director of the Oklahoma TSET Phase I Program, Associate Professor of the Section of Gynecologic Oncology at The University of Oklahoma College of Medicine, and MIRASOL Principal Investigator

Title: PICCOLO: An Open-Label, Single Arm, Phase 2 Study of Mirvetuximab Soravtansine in Recurrent Platinum-Sensitive, High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers with High Folate Receptor Alpha Expression
Presenter: Dr. Angeles Alvarez Secord, Professor of Obstetrics and Gynecology at Duke University School of Medicine in Durham, North Carolina

Title: Single-Arm Phase II Trial of Carboplatin and Mirvetuximab Soravtansine as Neoadjuvant Chemotherapy for Advanced-Stage Ovarian, Fallopian Tube or Primary Peritoneal Cancer who are Folate Receptor α Positive
Presenter: Dr. Jhalak Dholakia, Department of Obstetrics and Gynecology at the University of Alabama

OTHER PRESENTATIONS
Final data from the mirvetuximab plus bevacizumab platinum-agnostic combination study, which were originally shared at ASCO (Free ASCO Whitepaper) 2021, will be re-presented.

Title: Mirvetuximab Soravtansine, a Folate Receptor Alpha-Targeting Antibody Drug Conjugate in Combination with Bevacizumab in Patients with Platinum-Agnostic Ovarian Cancer: Final Analysis
Session: Seminal Abstracts: The Best of ASCO (Free ASCO Whitepaper), ESMO (Free ESMO Whitepaper), IGCS, and ESGO
Presenter: Dr. David O’Malley, Professor, Director of Gynecologic Oncology and the Director of the Division of Gynecologic Oncology at The Ohio State University and the James Cancer Center

Additional information can be found on the SGO website.

INVESTOR EVENT INFORMATION

ImmunoGen will hold an investor event to discuss the SORAYA data, featuring a roundtable with key opinion leaders, on Sunday, March 20 at 7:30 am MST/10:30 am EDT in the Moly Meeting Room at the Westin Phoenix Downtown. To access the live event by phone, dial (877) 621-5803; the conference ID is 1986619. The event may also be accessed via webstream on the Investors and Media section of the Company’s website, www.immunogen.com. Following the call, a replay will be available at the same location.

On March 10, 2022 Cue Biopharma, Inc. (Nasdaq: CUE), a clinical-stage biopharmaceutical company developing a novel class of injectable biologics to selectively engage and modulate targeted T cells directly within the patient’s body, reported that it will present at the Oppenheimer 32nd Annual Healthcare Conference being held virtually March 15-17 (Press release, Cue Biopharma, MAR 10, 2022, View Source [SID1234609912]).

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The Company will provide an updated corporate overview and discuss clinical progress from its ongoing clinical trials with CUE-101, its lead and representative drug product candidate from the IL-2 based CUE-100 series in development for the treatment of patients with HPV+ recurrent/metastatic head and neck cancer. The Company will also discuss anticipated milestones and additional IL-2 based CUE-100 series pipeline progress, including its second IL-2 based candidate CUE-102 with an Investigational New Drug (IND) filing planned for the end of the first quarter 2022.

Presentation Details

Oppenheimer 32nd Annual Healthcare Conference
Date and Time: Thursday, March 17, 2022 at 11:20 a.m. EDT
Webcast link: View Source
A live and archived webcast of the presentation will be available in the Investor and Media section of the Company’s website at www.cuebiopharma.com. The webcast will be archived for 30 days.

On March 10, 2022 Perimeter Medical Imaging AI, Inc. (TSX-V:PINK) (OTC:PYNKF) (FSE:4PC) ("Perimeter" or the "Company"), a medical technology company driven to transform cancer surgery with ultra-high-resolution, real-time, advanced imaging tools to address high unmet medical needs, reported that it will participate in the following upcoming industry events and conferences (Press release, Perimeter Medical Imaging AI, MAR 10, 2022, View Source [SID1234609928]):

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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SSO 2022 – Society of Surgical Oncology’s International Conference on Surgical Cancer Care in Dallas, TX from March 9-12, 2022.
Spotlight Presentation: "A New Paradigm for Intraoperative Margin Visualization with OCT + Future AI" on Friday, March 11, 2022 at 12-12:15 pm CT by Dr. Beth Dupree and Dr. Amelia Tower. Learn more.
NCoBC 2022 – National Consortium of Breast Centers’ 31st Interdisciplinary Breast Center Conference in Las Vegas, NV from March 11-16, 2022. Learn more.
ASBrS 2022 – 23rd Annual Meeting of the American Society of Breast Surgeons in Las Vegas, NV from April 6-10, 2022.
Breakfast Symposium: "OCT + Future AI: Changing the Paradigm for Intraoperative Margin Visualization" on Friday, April 8, 2022 from 6:15-7:45 am PT by Dr. Richard Fine (Moderator), Dr. Amelia Tower, and Dr. Maryam Elmi. Learn more.
The above listed dates and times are subject to change. Details on company presentations and webcasts can be found on the "Investors" section of Perimeter’s website at View Source When available, webcasts will be posted for replay following the event.

On March 10, 2022 Shorla Pharma reported that Our new name is better suited to our mission of re-thinking, re-imagining, and improving on existing, proven oncology treatments (Press release, Shorla Pharma, MAR 10, 2022, View Source;utm_medium=rss&utm_campaign=company-name-change-shorla-pharma-is-now-shorla-oncology [SID1234610027]). Shorla Oncology remains committed to the field of oncology and bringing our products to patients in need.

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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On March 10, 2022 RAPT Therapeutics, Inc. (Nasdaq: RAPT), a clinical-stage, immunology-based biopharmaceutical company focused on discovering, developing and commercializing oral small molecule therapies for patients with significant unmet needs in inflammatory diseases and oncology, reported financial results for the fourth quarter and year ended December 31, 2021 (Press release, RAPT Therapeutics, MAR 10, 2022, https://investors.rapt.com/news-releases/news-release-details/rapt-therapeutics-reports-fourth-quarter-and-year-end-2021 [SID1234609864]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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"2021 was a significant year for RAPT, with progress in both of our lead programs," said Brian Wong, M.D., Ph.D., President and Chief Executive Officer of RAPT Therapeutics. "We reported positive results for RPT193 from our Phase 1b clinical trial in atopic dermatitis and are excited about RPT193’s potential as a safe, once-daily oral drug for multiple inflammatory diseases. Based on those promising data, we plan to initiate a Phase 2b clinical trial of RPT193 in atopic dermatitis in the first half of 2022, as well as a Phase 2a trial in asthma in the second half of the year. For FLX475, we are continuing development in several indications including EBV+ lymphoma, nasopharyngeal cancer and head and neck cancer. We plan to provide an update on FLX475 in 2022 when we have data that are sufficiently mature from the ongoing cohorts."

Financial Results for the Fourth Quarter and Year Ended December 31, 2021

Fourth Quarter Ended December 31, 2021

Net loss for the fourth quarter of 2021 was $17.9 million, compared to $12.7 million for the fourth quarter of 2020.

Research and development expenses for the fourth quarter of 2021 were $14.3 million, compared to $10.9 million for the same period in 2020. The increase in research and development expenses was primarily due to higher costs for the FLX475 and RPT193 clinical trials, personnel, facilities and laboratory supplies, partially offset by a decrease in stock-based compensation expense.

General and administrative expenses for the fourth quarter of 2021 were $4.5 million, compared to $3.5 million for the same period in 2020. The increase in general and administrative expenses was primarily due to increases in professional fees, personnel costs and insurance expenses, partially offset by a decrease in stock-based compensation expense.

Year Ended December 31, 2021

Net loss for the year ended December 31, 2021 was $69.2 million, compared to $52.9 million for the same period in 2020.

Research and development expenses for the year ended December 31, 2021 were $57.0 million, compared to $45.5 million for the same period in 2020. The increase in research and development expenses was primarily due to higher costs for the FLX475 and RPT193 clinical trials, personnel, facilities, stock-based compensation expense and laboratory supplies.

General and administrative expenses for the year ended December 31, 2021 were $16.0 million, compared to $12.8 million for the same period of 2020. The increase in general and administrative expenses was primarily due to increases in professional fees, insurance expense, personnel costs and stock-based compensation expense.

As of December 31, 2021, the Company had cash, cash equivalents and marketable securities of $189.7 million.