On March 7, 2022 Alchemab Therapeutics – a biotechnology company focused on the discovery and development of naturally-occurring protective antibodies in neurodegeneration and oncology, reported an extension of its collaboration with Medicines Discovery Catapult (MDC), a national facility enabling the UK’s community to accelerate innovative drug discovery (Press release, Alchemab Therapeutics, MAR 7, 2022, View Source [SID1234609611]).

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The collaboration will functionally characterize antibodies from resilient patients with Alzheimer’s disease and frontotemporal dementia, previously discovered using Alchemab’s pioneering platform.

Under the agreement, Alchemab and MDC will evaluate antibodies using innovative technologies, including the use of high content imaging, high resolution microscopy, and spatial transcriptomics to assess endpoints using induced pluripotent stem cell (iPSC) derived neuronal and glial cells.

Alchemab and MDC initially entered a collaboration in March of 2021 to develop a novel antibody therapy for Huntington’s disease, exploring adaptive immunity and characterizing naturally-occuring protective antibodies in resilient patients.

"We are extremely pleased to extend our collaboration with Medicines Discovery Catapult," said Dr. Douglas A. Treco, PhD, Chief Executive Officer of Alchemab Therapeutics. "With great progress in our Huntington’s disease program, we are positioned to advance potentially transformative therapies. Continuing our collaboration provides Alchemab with state of the art technologies to support the expansion of our neurodegenerative pipeline into patients with Alzheimer’s disease and frontotemporal dementia."

Dr. Jane Osbourn, PhD, Co-founder and Chief Scientific Officer of Alchemab, commented: "Neurodegenerative conditions, especially Alzheimer’s disease, are impacting a larger patient population every year with behavioral, cognitive, and psychiatric disorders. Combining Alchemab’s pioneering platform with Medicines Discovery Catapult’s specialized neurodegeneration research capabilities will enable us to further understand the complex biology underpinning these devastating conditions and move closer to identifying novel drug targets and disease modifying therapies. We are delighted to continue the collaboration with Medicines Discovery Catapult and believe it will be integral in finding functional cures for these diseases."

Dr. Martin Main, Head of Molecular Technologies at Medicines Discovery Catapult said: "The continuation of this collaboration will build upon our previous success applying the learnings from our Huntington’s disease focused project to a new disease area with significant unmet patient need. We look forward to expanding world-leading innovation in the neurodegenerative space to ultimately help improve the lives of patients living with frontotemporal dementia and Alzheimer’s Disease."

Participant samples used in the study have been collected by University College London (UCL) and the EPAD Consortium, the largest global Alzheimer’s disease repository, and curated at the EPAD BioResource at the University of Edinburgh.

On March 7, 2022 MARKER THERAPEUTICS, INC. (NASDAQ:MRKR), a clinical-stage immuno-oncology company specializing in the development of next-generation T cell-based immunotherapies for the treatment of hematological malignancies and solid tumor indications, reported that Anthony H. Kim, Chief Financial Officer of Marker Therapeutics, will present at two upcoming investor conferences in March (Press release, Marker Therapeutics, MAR 7, 2022, View Source [SID1234609683]).

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Conference Details

ROTH Annual Conference
Fireside Chat
Date: Monday, March 14, 2022
Time: 11:00 a.m. ET

Oppenheimer Virtual Annual Healthcare Conference
Presentation
Date: Thursday, March 17, 2022
Time: 10:40 a.m. ET

Webcasts of the presentations will be accessible in the Investors section of the Company’s website at MARKERTHERAPEUTICS.COM and will be available for replay following the events.

On March 7, 2022 Shuwen Biotech, an integrated in vitro diagnostic company with focuses on breast cancer and reproductive health, reported that it has entered into a distribution agreement with Devyser Diagnostics AB, a Stockholm, Sweden-based diagnostic company, to market and support Devyser BRCA NGS and other oncology kits in China (Press release, Shuwen Biotech, MAR 7, 2022, View Source [SID1234609735]). Under the terms of the agreement, Shuwen will distribute the Devyser kits in China and also offer testing and NGS data analysis services with the Devyser kits in its CAP-accredited clinical labs in China.

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Devyser BRCA NGS is a CE-certified next-generation sequencing (NGS) library prep kit for fast and complete characterization of BRCA1 and BRCA2. The kit employs a unique single-tube approach which simplifies the workflow, reduces hands-on time and minimizes the risk of sample mix-up and contamination. The kit provides full and uniform coverage of BRCA1 and BRCA2, covering all exons and exon/intron junctions, and also allows downstream CNV analysis, thus enabling detection of point mutations, indels, and large rearrangements based on a single-tube reaction.

"We are pleased to add Devyser BRCA NGS and other oncology kits to our portfolio of cancer testing products. They further strengthen our leading position in breast cancer product and service offerings in China, which already feature MammaTyper and EndoPredict, and other tests for precision medicine in breast cancer," commented Jay Z. Zhang, Chairman and CEO of Shuwen Biotech.

On March 7, 2022 NeuBase Therapeutics, Inc. (Nasdaq: NBSE) ("NeuBase" or the "Company"), a biotechnology platform company Drugging the Genome to address disease at the base level using a new class of precision genetic medicines, announced today that company management will participate in a fireside chat and will be available for one-on-one meetings at Oppenheimer’s 32nd Annual Healthcare Conference being held virtually March 15 – 17, 2022 (Press release, NeuBase Therapeutics, MAR 7, 2022, View Source [SID1234609576]).

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Details of NeuBase’s Virtual Company Presentation

Date: Wednesday, March 16
Time: 2:40pm – 3:10pm ET
Webcast:
Registration Link
A replay of the webcast will be available following the presentation for 90 days. Please contact your representative at Oppenheimer to schedule a virtual one-on-one meeting with NeuBase management during the conference. For information about the 32nd Annual Oppenheimer Healthcare Conference, please refer to the conference website.

On March 7, 2022 AnaptysBio, Inc. (Nasdaq: ANAB), a clinical-stage biotechnology company developing first-in-class antibody product candidates focused on emerging immune control mechanisms applicable to inflammation and immuno-oncology indications, reported operating results for the fourth quarter and year ended December 31, 2021 and provided pipeline updates (Press release, AnaptysBio, MAR 7, 2022, View Source [SID1234609594]).

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"We advanced our wholly-owned antibody product pipeline and completed a $250 million royalty monetization transaction during 2021," said Hamza Suria, president and chief executive officer of AnaptysBio. "We look forward to multiple clinical data readouts during 2022 and remain focused on developing first-in-class therapeutic antibodies using a capital-efficient business model."

Imsidolimab (Anti-IL-36 Receptor) Program

Following an end-of-Phase 2 meeting with the FDA, we initiated our GEMINI-1 Phase 3 trial of imsidolimab in generalized pustular psoriasis (GPP) where the primary endpoint is the proportion of patients achieving a score of clear (0) or almost clear (1) skin on the Generalized Pustular Psoriasis Physician’s Global Assessment (GPPPGA) at week 4 in 45 patients randomized against placebo. These same patients will subsequently be enrolled into GEMINI-2, which will assess 6 months of monthly subcutaneous dosing and safety follow-up.
We anticipate top-line data from the ACORN Phase 2 trial of imsidolimab in moderate-to-severe acne in H1 2022 and from the HARP Phase 2 trial in moderate-to-severe hidradenitis suppurativa in H2 2022.
Rosnilimab (Anti-PD-1 Agonist) Program

We announced positive top-line data from a randomized placebo-controlled healthy volunteer single and multiple ascending dose Phase 1 trial of rosnilimab, our investigational wholly-owned anti-PD-1 agonist therapeutic antibody, previously known as ANB030. Top-line data demonstrated favorable safety, pharmacokinetics and pharmacodynamic results, which supported initiation of our Phase 2 AZURE clinical trial of rosnilimab in alopecia areata.
ANB032 (Anti-BTLA Modulator) Program

We are advancing ANB032, our wholly-owned BTLA modulator antibody, in a healthy volunteer Phase 1 single and multiple ascending dose clinical trial where top-line data is anticipated during the first half of 2022.
GSK Partnered Programs

We completed a royalty monetization agreement with Sagard Healthcare Royalty Partners where AnaptysBio received a $250 million payment in exchange for JEMPERLI royalties due to AnaptysBio on annual commercial sales below $1 billion and certain future milestones starting October 2021. The aggregate JEMPERLI royalties and milestones to be received by Sagard under this Agreement is capped at certain fixed multiples of the upfront payment.
Fourth Quarter Financial Results

Cash, cash equivalents and investments totaled $615.2 million as of December 31, 2021, compared to $411.2 million as of December 31, 2020, for an increase of $204.0 million. The increase relates primarily to cash received from the royalty monetization transaction with Sagard Healthcare Partners offset by cash used for operating activities.
Collaboration revenue was $1.0 million and $63.2 million for the three and twelve months ended December 31, 2021. The $1.0 million earned during the fourth quarter primarily relates to royalty revenue earned for sales of JEMPERLI (dostarlimab) and Zejula by GSK, compared to $60.0 million and $75 million of milestone revenue for the three and twelve months ended December 31, 2020.
Research and development expenses were $26.8 million and $98.5 million for the three and twelve months ended December 31, 2021, compared to $21.6 million and $80.0 million for the three and twelve months ended December 31, 2020. The increase was due primarily to continued advancement of the Company’s clinical programs.
General and administrative expenses were $5.4 million and $21.5 million for the three and twelve months ended December 31, 2021, compared to $5.1 million and $18.9 million for the three and twelve months ended December 31, 2020. The increase was due primarily to personnel-related expenses, including share-based compensation.
Net loss was $32.5 million and $57.8 million for the three and twelve months ended December 31, 2021, or a net loss per share of $1.18, and $2.11, compared to net income of $33.6 million for the three months ended December 31, 2020 or net income per share of $1.23 and a net loss of $19.9 million for the twelve months ended December 31, 2020, or net loss per share of $0.73.