On January 4, 2022 TG Therapeutics, Inc. (NASDAQ: TGTX), reported that its existing term loan facility agreement with Hercules Capital, Inc. (NYSE: HTGC), has been amended to increase the size of the facility to $200 million, with $70 million funded at closing (Press release, TG Therapeutics, JAN 4, 2022, View Source [SID1234598168]). Michael S. Weiss, Chairman and Chief Executive Officer of TG Therapeutics stated, "We are pleased to announce the expansion of our term loan facility with Hercules Capital and the immediate draw of $70 million. Hercules has been a great partner of ours, and we believe this expansion provides us with the financial flexibility we need in the short-term. With the funds immediately drawn we strengthened our year-end 2021 balance sheet and believe we are now positioned well financially."

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Michael Dutra, Managing Director at Hercules Capital shared, "Hercules is excited to continue and expand our partnership with TG Therapeutics as they advance their pipeline and work to bring their treatments to patients. The new increased commitment from Hercules exemplifies our ability to be long-term capital partners to our portfolio companies and reflects our dedication to financing innovative life sciences companies through development and into commercialization."

Under the terms of the amendment, the size of the term loan facility was increased to $200 million, with $70 million available and drawn at closing on December 30, 2021. The remaining $130 million may be drawn at the Company’s option, in three subsequent tranches. The first tranche is available upon U.S. Food and Drug Administration (FDA) approval of the supplemental New Drug Application (sNDA)/ Biologics License Agreement (BLA) for the combination of ublituximab and umbralisib (referred to as "U2") for the treatment of chronic lymphocytic leukemia (CLL), the second tranche is available upon FDA approval of the BLA for ublituximab for the treatment of relapsing forms of multiple sclerosis (RMS), and the third tranche is available to fund future initiatives, subject to the approval of the Hercules Investment Committee.

Additional details of the loan amendment will be filed with the Securities and Exchange Commission on Form 8-K.

On January 4, 2022 Sangamo Therapeutics, Inc. (Nasdaq: SGMO), a genomic medicine company, reported that management will provide a corporate presentation at the H.C. Wainwright BIOCONNECT Virtual Conference on Monday, January 10th at 7:00 a.m. Eastern Time (Press release, Sangamo Therapeutics, JAN 4, 2022, View Source [SID1234598251]).

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The virtual session may be accessed on the Sangamo Therapeutics website in the Investors and Media section under Events and Presentations. The presentation will also be available on the Sangamo Therapeutics website after the event.

On January 4, 2022 Ascendis Pharma A/S (Nasdaq: ASND) reported that the Company is scheduled to participate in the upcoming 40th Annual J.P. Morgan Healthcare Conference (Press release, Ascendis Pharma, JAN 4, 2022, View Source [SID1234598028]). Company executives will provide a business overview and update on the company’s pipeline programs.

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Details

Event 40th Annual J.P. Morgan Healthcare Conference
Location Virtual
Date Monday, January 10, 2022
Time 3:00 p.m.-3:40 p.m. Eastern Time
A live webcast of the event will be available on the Investors & News section of the Ascendis Pharma website at View Source A webcast replay will be available on the site shortly after conclusion of the event and will stay available for 30 days.

On January 4, 2022 BioCryst Pharmaceuticals, Inc. (Nasdaq: BCRX) reported that the company will present at the 40th Annual J.P. Morgan Healthcare Conference, which is being conducted as a virtual event, on Monday, January 10, 2022 at 9:45 a.m. ET (Press release, BioCryst Pharmaceuticals, JAN 4, 2022, View Source [SID1234598053]).

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Links to a live audio webcast and replay of the presentation may be accessed in the Investors section of BioCryst’s website at http://www.biocryst.com.

On January 4, 2022 Genmab A/S (Nasdaq: GMAB) and Synaffix B.V., reported that Genmab and Synaffix have signed a license agreement providing Genmab broad access to Synaffix’s ADC technologies (Press release, Genmab, JAN 4, 2022, View Source [SID1234598070]). Genmab is granted exclusive research rights to utilize Synaffix ADC technologies for one drug target with the option for the worldwide development and commercialization of the resulting ADCs. Genmab has the option to exercise exclusive research and commercial licenses for additional targets.

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For each specific target nominated under the license agreement, Genmab gains exclusive access to Synaffix’s clinical-stage GlycoConnect antibody conjugation technology, HydraSpace polar spacer technology, as well as select toxSYN linker-payloads, each designed to enable ADCs with best-in-class efficacy and tolerability for the development of multiple potential therapies.

Genmab will be responsible for the research, development, manufacturing and commercialization of any resulting ADC therapies. At the same time, Synaffix will support Genmab’s research activities, including manufacturing of components that are specifically related to its proprietary ADC technologies.

"At Genmab, we are committed to bringing differentiated medicines to patients, and we believe collaborations are foundational to accelerate innovation," said Jan van de Winkel, Ph.D., Chief Executive Officer, Genmab. "We look forward to working with Synaffix toward our shared goal of developing best-in-class or first-in-class antibody therapies and make an impact on the lives of patients."

"In what represents our fifth out-licensing deal in the last six months, we are thrilled to partner with Genmab, an international biotechnology company," said Peter van de Sande, Chief Executive Officer of Synaffix. "In deploying our cutting-edge ADC technology platform together with Genmab’s robust antibody development capabilities, Synaffix is privileged to once more play an essential role in strengthening a partner’s pipeline with our innovative ADC technologies thereby aiding the transformation of cancer treatment."

Financial Terms
Under the terms of the agreement, Synaffix will receive an upfront payment of USD $4.5 million and, on a target-by-target basis, is eligible to receive option-exercise, development-, regulatory- and commercial milestone payments. The total potential deal value is USD $415 million plus tiered, mid-single digit royalties on commercial sales.