Scholar Rock to Present at the 40th Annual J.P. Morgan Healthcare Conference

On January 4, 2022 Scholar Rock (NASDAQ: SRRK), a clinical-stage biopharmaceutical company focused on the treatment of serious diseases in which protein growth factors play a fundamental role, reported that management will present at the 40th Annual J.P. Morgan Healthcare Conference on Tuesday, January 11, 2022 at 7:30 a.m. ET (Press release, Scholar Rock, JAN 4, 2022, View Source [SID1234598130]).

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A live webcast of the presentation may be accessed by visiting the Investors & Media section of the Scholar Rock website at View Source An archived replay of the webcast will be available on the Company’s website for approximately 90 days following the presentation.

Caris Life Sciences to Present at the 40th Annual J.P. Morgan Healthcare Conference

On January 4, 2022 Caris Life Sciences (Caris), the leading molecular science and technology company actively developing and delivering innovative solutions to revolutionize healthcare, reported that the Company will present at the 40th Annual J.P. Morgan Healthcare Conference, which is being held virtually on January 10-13, 2022 (Press release, Caris Life Sciences, JAN 4, 2022, View Source [SID1234598154]). Caris will be presenting via the live conference webcast on January 11, at 11:30 a.m. ET, and will provide an overview of the business and discuss recent corporate achievements that position the organization to further extend its leadership position in the market.

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Caris will be represented by David D. Halbert, Chairman and Chief Executive Officer, Brian J. Brille, Vice Chairman, David Spetzler, MS, MBA, Ph.D., President and Chief Scientific Officer, Mike Weinstein, Executive Vice President and Chief Financial Officer and Brian Lamon, Ph.D., Chief Business Officer, Head of BioPharma Business Development.

Onxeo appoints Julien Miara as new interim CEO

On January 3, 2022 Onxeo S.A. (Euronext Growth Paris: ALONX, First North Copenhagen: ONXEO), ("Onxeo" or "the Company"), a clinical-stage biotechnology company specializing in the development of innovative drugs targeting tumor DNA Damage response (DDR), reported the appointment of Julien Miara as interim Chief Executive Officer, effective January 3rd, 2022, following approval from the Board of Directors (Press release, Onxeo, JAN 3, 2022, View Source [SID1234597960]).

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Julien Miara is a Principal at Invus SAS, the independent adviser to Invus Public Equities, L.P. He is also member of the Board of Directors of Onxeo. He has more than 10 years of experience in Finance and biotechnology. Julien Miara will work closely with Dr. Shefali Agarwal, Chairwoman of the Board of Directors who has extensive experience in drug development, to ensure that the company is progressing according to the strategic plan laid out by the Board of Directors and prepare for a successful transition to the next CEO.

The company’s Board of Directors is actively working on recruiting Onxeo’s next CEO who will focus on bringing expeditiously AsiDNA to the patients to respond to their high unmet medical need, develop the rich pre-clinical pipeline such as OX401 and provide Onxeo with international visibility.

Dr. Agarwal said: "I look forward to working with the high performing team under the supervision of Julien Miara, in the next phase of research and development for AsiDNA. I believe that Onxeo’s scientific vision and approach will drive the continued success of the company, as we work together to deliver promising new options for patients"

CytRx Announces the Appointment of Dr. Stephen Snowdy as Chief Executive Officer

On January 3, 2022 CytRx Corporation (OTCQB:CYTR) ("CytRx" or the "Company"), a specialized biopharmaceutical company focused on research and development in oncology and neurodegenerative diseases, reported that it has appointed Dr. Stephen Snowdy to the role of Chief Executive Officer, effective January 10, 2022 (Press release, CytRx, JAN 3, 2022, View Source [SID1234597977]). Dr. Louis Ignarro succeeded Steven A. Kriegsman as Chairman of the Board of Directors (the "Board") on January 3, 2022.

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Dr. Snowdy is a scientist, serial entrepreneur and medical venture capitalist with two decades of experience in life science investing and executive management. He joins from Visioneering Technologies, Inc. (ASX: VTI), where he was Chief Executive Officer and Executive Director. He previously served as Chief Executive Officer at Abby Med LLC, a start-up pharmaceutical company dedicated to the development of a novel class of cancer drugs. Prior to that, he was Chairman and Chief Executive Officer of Calosyn Pharma, Inc., a Phase 2 osteoarthritis company, and was a partner for several years at a top-tier medical venture capital firm. Dr. Snowdy simultaneously earned a PhD in Neurobiology and an MBA from the University of North Carolina. He studied Chemical Engineering and Chemistry at the University of Florida, where he also completed two years of postbaccalaureate study in cardiopharmacology. His academic training followed service in the United States Navy Special Forces.

Mr. Kriegsman commented:

"It has been a pleasure to get to know Stephen, who is a proven, high-integrity leader in the sector with a tremendous vision for helping CytRx evolve and unlock long-term value for shareholders. Our Board of Directors is confident that he is the right leader to build on the culture of innovation that has been established at the Company. In particular, we are very excited that Stephen recognizes the potential of Centurion BioPharma’s LADR platform for cancer therapeutics and accompanying diagnostics. I also want to take this opportunity to thank my past and present colleagues at CytRx, who have helped me establish our high-potential licensing agreements and pursue innovative cancer and rare disease treatments over the years."

Dr. Ignarro, Chairman of the Board, said:

"On behalf of the Board, I want to thank Steven for his visionary leadership and relentless dedication to CytRx. Steven turned the Company around at the most critical time and we all appreciate the progress he has made. We wish him nothing but success in any future endeavors."

Dr. Snowdy added:

"I appreciate the confidence that Steven and the Board of Directors have placed in me. This is the beginning of a new day at CytRx, and I am happy to bring to CytRx my leadership philosophy which is built on the core values of integrity, communication, strong corporate governance and rigorous science. I believe my relationships in the capital markets and broader biopharmaceutical sector can help open new doors for the Company. I look forward to engaging with our existing shareholders, partners and other stakeholders to chart new paths to innovation and value creation. Thanks to CytRx’s licensing agreements and Centurion BioPharma’s promising assets, we have a strong foundation on which to build value for shareholders."

Ascletis Announces U.S. IND Filing for In-House Developed Oral PD-L1 Small Molecule Inhibitor ASC61 for Treatment of Advanced Solid Tumors

On January 3, 2022 Ascletis Pharma Inc. (HKEX: 1672) reported the filing of the U.S. Investigational New Drug (IND) application for in-house developed oral PD-L1 small molecule inhibitor, ASC61, for the treatment of advanced solid tumors (Press release, Ascletis, JAN 3, 2022, View Source [SID1234598446]).

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ASC61 is an oral potent and highly selective PD-L1 small molecule inhibitor and blocks PD-1/PD-L1 interaction through inducing PD-L1 dimerization and internalization. As a single agent, ASC61 demonstrated significant antitumor efficacy in multiple animal models such as the humanized mouse model. Preclinical studies showed ASC61 has good safety and pharmacokinetic profiles in animal models. ASC61 oral tablets, which will be used in the clinical trial, were developed with the in-house proprietary technology.

Compared to injectable PD-1/PD-L1 antibodies, ASC61, as an oral PD-L1 inhibitor, has the following benefits: (1) ease of dosing and no need for hospital visits for injections; (2) all-oral combinations with other oral anti-tumor drugs; and (3) rapid titration of doses for better management of immune-related adverse events (irAEs).

"We are excited about filing U.S. IND of ASC61." said Dr. Jinzi J. Wu, Founder, Chairman and CEO of Ascletis. "As we are advancing the phase III clinical trial of ASC40, a fatty acid synthase (FASN) inhibitor, in combination with Bevacizumab for the treatment of recurrent glioblastoma (rGBM), ASC61, as an oral PD-L1 small molecule inhibitor, will further strengthen the Company’s oncology pipeline."