On January 3, 2022 Oncorus, Inc. (NASDAQ: ONCR), a viral immunotherapies company focused on driving innovation to transform outcomes for cancer patients, reported that President and Chief Executive Officer, Theodore (Ted) Ashburn, M.D., Ph.D., will participate in a fireside chat at the H.C. Wainwright BioConnect Conference (Press release, Oncorus, JAN 3, 2022, View Source [SID1234597968]).

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The fireside chat will be available for on-demand viewing beginning Monday, January 10, 2022 at 7:00am ET under the Investors & Media section of Oncorus’ website at View Source A replay of the presentation will be archived on Oncorus’ site for 90 days following the event.

On January 3, 2022 GC Cell (KOSDAQ:144510) and Rivaara Immune Private Limited reported that they have entered into an exclusive licensing agreement, pursuant to which Rivaara Immune has agreed to develop and commercialize Immuncell-LC in India, Sri Lanka, and Bangladeshi (Press release, GC Cell, JAN 3, 2022, View Source [SID1234597985]). Developed by GC Cell, Immuncell-LC is a patient-derived autologous T-cell immunotherapy for liver cancer, which was approved by the Korean MFDS back in 2007.

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Under the terms of the agreement, Rivaara Immune has obtained the exclusive right to develop and commercialize Immuncell-LC within India for liver cancer. In return, GC Cell is entitled to receive an undisclosed upfront payment, as well as payments for the achievement of commercial milestones, with royalties based upon the sales.

In addition, GC Cell will also receive a partial stake of Rivaara Immune and exclusive rights to supply media which is essential for the production of Immuncell-LC.

The number of cancer patients in India is more than 1.3 million, about 6 times that of Korea, and India’s liver cancer market is 2.3 times that of Korea’s. Notably, 5-year liver cancer survival rate is 4%, which is very low compared to 37% of Korea, so new treatments are urgently needed.

"Immuncell-LC’s overseas expansion is based on its domestic success, pushing for technology transfer by country, and signing contract with Rivaara Immune in India is the first outcome," said Dae-woo Park, CEO of GC Cell. "Both companies will cooperate in a win-win strategic partnership, and are also closely discussing with a number of partners in China and other countries in the Middle East."

"Rivaara Immune is pleased to partner with GC Cell, a leader in Immune Cell Therapy in Korea. With this partnership we will be among the first, to bring to the Indian market, customized solutions to cater to the unmet needs of the liver cancer sufferers," said Syd Daftary, Director of Rivaara Immune.

About Immuncell-LC

Immuncell-LC is a customized anti-cancer drug that is made from a patient’s blood. Professionals extract a sample of a patient’s T-cells from the blood and genetically modify it into a robust immune cell that has maximized anticancer functions and is incubated for about two weeks before they infuse it into the patient. Immuncell-LC received approval for the liver cancer immunotherapy from the Korean MFDS in 2007. It also received FDA Orphan Drug Designation for the Treatment of liver cancer, brain tumor, and pancreatic cancer. More than 7800 individuals have been treated with Immuncell-LC which recorded the highest selling of anti-cancer immune cell therapy in Korea.

On January 3, 2022 Genmab A/S (Nasdaq: GMAB) reported that its CEO, Jan van de Winkel, Ph.D., will present a company update at the 40th Annual J.P. Morgan Healthcare Conference at 9:00 AM EST / 3.00 PM CET on January 12, 2022 (Press release, Genmab, JAN 3, 2022, View Source [SID1234597969]). The live and archived webcast of the presentation will be available on Genmab’s website at View Source

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On January 3, 2022 Akeso (09926.HK) reported that Cadonilimab (PD-1/ CTLA-4 bi-specific antibody), the first-inclass novel immuno-oncology drug independently developed by the Company, combined with concurrent chemoradiotherapy obtained approval from the Center for Drug Evaluation (‘CDE’) of the National Medical Products Administration of the People’s Republic of China (”China”) to initiate a phase III clinical trial for the treatment of locally advanced cervical cancer (Press release, Akeso Biopharma, JAN 3, 2022, View Source [SID1234597986]). This is the first phase III clinical trial for locally advanced cervical cancer immunotherapy in China.

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According to the data in the Guidelines for the Diagnosis and Treatment of Cervical Cancer (2021) issued by the Gynecological Oncology Committee of the Chinese Anti-Cancer Association (中國抗癌協會婦科腫瘤專業委員會), there are about 604,000 new cases of cervical cancer and 341,000 deaths each year, both of which rank fourth in the incidence and mortality of gynecological tumors.

Relevant statistics also show that the incidence of locally advanced cervical cancer accounts for about 44.9% of those of all cervical cancers, and most of them recur within two to three years after treatment. In particular, the five-year survival rate of stage IIIA-IVA locally advanced cervical cancer is less than 60%, where currently concurrent chemoradiotherapy is considered to be the standard treatment for such patients.

Immune checkpoint inhibitors combined with radiotherapy for solid tumors have been proved to prolong patient survival, but no immune checkpoint inhibitors for locally advanced cervical cancer have been approved globally. The initiation of the phase III clinical trial of Cadonilimab combined with concurrent chemoradiotherapy for the treatment of locally advanced cervical cancer is expected to achieve higher clinical benefits, further improving the survival of patients with locally advanced cervical cancer, and becoming a better targeted treatment option for the majority of cervical cancer patients in the near future.At the same time, the initiation of this clinical trial will further improve the indications layout of Cadonilimab in the field of cervical cancer.

Based on the positive effects of Cadonilimab obtained in the clinical trial of recurrent/ metastatic cervical cancer, CDE accepted the new drug application of Cadonilimab for the treatment of recurrent/metastatic cervical cancer in September 2021 and granted priority review designation. Cadonilimab is therefore expected to be the world’s first-in-class PD-1 based bi-specific antibody approved for market launch.

In addition, a global phase III clinical trial of Cadonilimab plus platinum-based chemotherapy combined with/without bevacizumab in the first-line treatment of persistent, recurrent or metastatic cervical cancer was initiated in May 2021. This is the first phase III clinical trial of first-line bi-specific antibody immunotherapy for cervical cancer in China.

On January 3, 2022 iTeos Therapeutics, Inc. (Nasdaq: ITOS), a clinical-stage biopharmaceutical company pioneering the discovery and development of a new generation of highly differentiated immuno-oncology therapeutics for patients, reported that Michel Detheux, Ph.D., President and Chief Executive Officer, will present at the 40th Annual J.P. Morgan Conference being held virtually on Tuesday, January 11, 2022 at 11:15 a.m. ET (Press release, iTeos Therapeutics, JAN 3, 2022, View Source [SID1234598104]).

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A live webcast of the presentation will be available on the Investors section of the company’s website at View Source An archived replay will be available for approximately 30 days following the presentation.