Personalis Announces Collaboration with UC San Diego Moores Cancer Center for Clinical Genomic Testing and Research into Composite Biomarkers and Minimal Residual Disease Detection

On February 15, 2022 Personalis, Inc. (Nasdaq: PSNL), a leader in advanced genomics for precision oncology, reported a strategic collaboration with the Moores Cancer Center at University of California San Diego Health, a National Cancer Institute-designated Comprehensive Cancer Center, to support clinical diagnostic testing in patients with advanced solid tumors and hematological malignancies (Press release, Personalis, FEB 15, 2022, View Source [SID1234608140]). The collaboration will bring Personalis’ leading comprehensive genomic tumor profiling test to UC San Diego health care professionals and their cancer patients to help guide FDA-approved therapy decisions, as well as clinical trial treatment options.

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"We are excited to collaborate with Moores Cancer Center to provide a comprehensive tumor immunogenomic profiling test to guide cancer patient treatment. This collaboration reaffirms our commitment to accelerate access to diagnostic testing for patients with advanced cancer, as well as to work with investigators to develop novel composite biomarkers to improve patient outcomes in the future," said Richard Chen, M.D., Chief Medical Officer and SVP of R&D of Personalis.

The Personalis test is one of the most advanced tumor profiling tests available today, providing full exome and transcriptome information across all human genes, and offering clinically important information to help identify appropriate therapies and clinical trials for individual cancer patients. The comprehensiveness of the test, and its unique ability to simultaneously characterize both tumor and immune genomics, will deliver better options for current cancer patients, while enabling UC San Diego and Personalis to work together on developing advanced composite biomarkers and on clinical research that may improve care in the future.

In addition to advanced biomarker work, the collaboration will include research studies for high sensitivity minimal residual disease (MRD) and cancer recurrence detection with a newly launched liquid biopsy assay. The Personalis liquid biopsy assay is designed to achieve MRD sensitivity down to the 1 part-per-million range, an approximately 10- to 100-fold improvement over other available technologies. This is expected to enable earlier detection across a broader variety of cancers and stages, including typically challenging early-stage cancers.

Paige and Mindpeak Announce Partnership to Expand Access to Industry-Leading AI Software for Breast Cancer

On February 15, 2022 Paige, the global leader in AI-based diagnostic software in pathology, and Mindpeak, the European leader for AI-based software for image analysis in pathology, reported a distribution partnership, which will enable pathologists to use Mindpeak’s BreastIHC* within the Paige Platform (Press release, Paige AI, FEB 15, 2022, View Source [SID1234608158]). Mindpeak’s BreastIHC is an AI software that reliably and accurately detects, classifies and quantifies breast cancer cells. This partnership enhances the utility of the Paige Platform by providing real-time results for routine breast cancer immunohistochemistry (IHC) biomarkers.

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The detection and quantification of IHC markers is an important step in treatment planning for breast cancer. Mindpeak’s BreastIHC is the first-ever plug-and-play AI solution for reliable HER2, Ki-67, estrogen (ER) and progesterone receptor (PR) quantification, without the need for complex set-up and calibration procedures. The product helps to differentiate between tumorous and non-tumorous structures on a single-cell basis, improving the specificity of the scoring.

"By combining MindPeak’s products for IHC with Paige’s AI products for H&E, our partnership will allow pathologists to drive efficient routine clinical cancer diagnostics in breast cancer," said Andy Moye, Ph.D., Chief Executive Officer at Paige. "We are excited to offer Mindpeak’s industry-leading BreastIHC directly within the Paige Platform to improve patient care. We believe integrating our products will drive the adoption of digital pathology technologies more broadly."

Paige Platform is a comprehensive digital pathology software platform that is inclusive of a viewer and storage capabilities and is compatible with existing digital pathology solutions, including most scanners, monitors, and laboratory information systems (LIS).

"This partnership brings us a big step closer to our shared goal of making pathological diagnosis of breast cancer quicker, more accurate and more reproducible," said Felix Faber, CEO at Mindpeak. "I am extremely excited that we will combine our respective strengths in analyzing H&E and IHC-stained tissue samples to make this vision of utilizing AI within pathology a reality."

* Mindpeak’s BreastIHC is available in the EU as a CE-IVD marked medical device. Outside the EU, BreastIHC is Research Use Only, not for use in diagnostic procedures.

Intellia and ONK to collaborate

On February 15, 2022 Intellia Therapeutics Inc is to out-license rights to its ex vivo Crispr/Cas9 genome editing platform to ONK Therapeutics Ltd enabling the Irish company to develop engineered natural killer (NK) cell therapies for cancer (Press release, ONK Therapeutics, FEB 15, 2022, View Source [SID1234613904]). ONK is developing off-the-shelf NK cell therapies. In addition to the genome editing platform, ONK will also have access to the US company’s lipid nanoparticle delivery technologies. The agreement will enable the development of up to five allogeneic NK cell therapies.

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MacroGenics Announces Date of Fourth Quarter 2021 Financial Results Conference Call

On February 14, 2022 MacroGenics, Inc. (Nasdaq: MGNX), a biopharmaceutical company focused on developing and commercializing innovative monoclonal antibody-based therapeutics for the treatment of cancer, reported that the Company will release its financial results for the fourth quarter of 2021 after the market closes on Thursday, February 24, 2022 (Press release, MacroGenics, FEB 14, 2022, View Source [SID1234608064]). MacroGenics will host a conference call to discuss the financial results and recent corporate progress on Thursday, February 24, 2022, at 4:30 pm ET. The conference call can be accessed by dialing (877) 303-6253 (domestic) or (973) 409-9610 (international) five minutes prior to the start of the call and providing the Conference ID# 1067087.

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The listen-only webcast of the conference call can be accessed under "Events & Presentations" in the Investor Relations section of the Company’s website at View Source A recorded replay of the webcast will be available shortly after the conclusion of the call and archived on the Company’s website for 30 days following the call.

2seventy bio to Participate in Upcoming Healthcare Conferences

On February 14, 2022 2seventy bio, Inc. (Nasdaq: TSVT) reported that it will present at the following upcoming investor conferences (Press release, 2seventy bio, FEB 14, 2022, View Source [SID1234608080]):

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SVB Leerink 10th Annual Global Healthcare Conference; Fireside chat, Wednesday, February 16, 2022, at 2:20pm ET
Cowen Virtual 42nd Annual Healthcare Conference; "Novel Oncology Targets" panel, Monday, March 7, 2022, at 12:50pm ET
Live webcasts of presentations will be available via the Investors and Media section of 2seventy bio’s website at View Source A replay of each presentation will be archived on 2seventy bio’s site for 30 days following the event.